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Protein

Alcohol dehydrogenase 1

Gene

ADH1

Organism
Struthio camelus (Common ostrich)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Catalytic activityi

An alcohol + NAD+ = an aldehyde or ketone + NADH.

Cofactori

Zn2+By similarityNote: Binds 2 Zn2+ ions per subunit.By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi46Zinc 1; catalyticBy similarity1
Metal bindingi67Zinc 1; catalyticBy similarity1
Metal bindingi97Zinc 2By similarity1
Metal bindingi100Zinc 2By similarity1
Metal bindingi103Zinc 2By similarity1
Metal bindingi111Zinc 2By similarity1
Metal bindingi174Zinc 1; catalyticBy similarity1
Binding sitei223NADBy similarity1
Binding sitei228NADBy similarity1
Binding sitei369NADBy similarity1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi199 – 204NADBy similarity6
Nucleotide bindingi292 – 294NADBy similarity3

GO - Molecular functioni

Keywordsi

Molecular functionOxidoreductase
LigandMetal-binding, NAD, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Alcohol dehydrogenase 1 (EC:1.1.1.1)
Alternative name(s):
Alcohol dehydrogenase I
Gene namesi
Name:ADH1
OrganismiStruthio camelus (Common ostrich)
Taxonomic identifieri8801 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiArchelosauriaArchosauriaDinosauriaSaurischiaTheropodaCoelurosauriaAvesPalaeognathaeStruthioniformesStruthionidaeStruthio

Subcellular locationi

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001606741 – 374Alcohol dehydrogenase 1Add BLAST374

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei1N-acetylserine2 Publications1

Keywords - PTMi

Acetylation

Proteomic databases

PRIDEiP80338.

Interactioni

Subunit structurei

Homodimer.

Structurei

3D structure databases

ProteinModelPortaliP80338.
SMRiP80338.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

HOVERGENiHBG000195.

Family and domain databases

Gene3Di3.90.180.10. 1 hit.
InterProiView protein in InterPro
IPR013149. ADH_C.
IPR013154. ADH_N.
IPR002328. ADH_Zn_CS.
IPR011032. GroES-like.
IPR016040. NAD(P)-bd_dom.
IPR020843. PKS_ER.
PfamiView protein in Pfam
PF08240. ADH_N. 1 hit.
PF00107. ADH_zinc_N. 1 hit.
SMARTiView protein in SMART
SM00829. PKS_ER. 1 hit.
SUPFAMiSSF50129. SSF50129. 2 hits.
SSF51735. SSF51735. 1 hit.
PROSITEiView protein in PROSITE
PS00059. ADH_ZINC. 1 hit.

Sequencei

Sequence statusi: Complete.

P80338-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
STAGKVIKCK AAVLWEPKKP FSIEEVEVAP PKAHEVRVKI IATGICRSDD
60 70 80 90 100
HVISGVLVMP FPIILGHEAA GVVESVGEGV TSVKPGDKVI PLFVPQCGEC
110 120 130 140 150
SVCLSTKGNL CRKNDIGPAS ALMPDGTSRF TCKGKAIHHF AGTSTFTEYT
160 170 180 190 200
VLHETAVAKI DAAAPLEKVC LIGCGFSTGY GAALQTAKVE PGSTCAVFGL
210 220 230 240 250
GGVGLSVVMG CKAAGASRII GVDINKDKFA KAKELGATDC VNPKDFTKPI
260 270 280 290 300
HEVLMEMTGL GVDYSFEVIG HTETMAAALA SCHFNYGVSV IVGVPPAAEK
310 320 330 340 350
LSFDPMLLFS GRTWKGSVFG GWKSKDSVPK LVADYMEKKF VLDPLITHTL
360 370
PFHKINEGFD LLRTGKSIRS VLLF
Length:374
Mass (Da):39,583
Last modified:February 1, 1995 - v1
Checksum:i3ACC5386332EEC3C
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural varianti112R → C. 1

Sequence databases

PIRiS48157.

Cross-referencesi

Sequence databases

PIRiS48157.

3D structure databases

ProteinModelPortaliP80338.
SMRiP80338.
ModBaseiSearch...
MobiDBiSearch...

Proteomic databases

PRIDEiP80338.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Phylogenomic databases

HOVERGENiHBG000195.

Family and domain databases

Gene3Di3.90.180.10. 1 hit.
InterProiView protein in InterPro
IPR013149. ADH_C.
IPR013154. ADH_N.
IPR002328. ADH_Zn_CS.
IPR011032. GroES-like.
IPR016040. NAD(P)-bd_dom.
IPR020843. PKS_ER.
PfamiView protein in Pfam
PF08240. ADH_N. 1 hit.
PF00107. ADH_zinc_N. 1 hit.
SMARTiView protein in SMART
SM00829. PKS_ER. 1 hit.
SUPFAMiSSF50129. SSF50129. 2 hits.
SSF51735. SSF51735. 1 hit.
PROSITEiView protein in PROSITE
PS00059. ADH_ZINC. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiADH1_STRCA
AccessioniPrimary (citable) accession number: P80338
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 1, 1995
Last sequence update: February 1, 1995
Last modified: April 12, 2017
This is version 90 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Direct protein sequencing

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.