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P80334 - COX7C_ONCMY

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Cytochrome c oxidase polypeptide VIIc

Oncorhynchus mykiss (Rainbow trout) (Salmo gairdneri)
Reviewed - Annotation score: 2 out of 5- Experimental evidence at protein leveli


This protein is one of the nuclear-coded polypeptide chains of cytochrome c oxidase, the terminal oxidase in mitochondrial electron transport.

Catalytic activityi

4 ferrocytochrome c + O2 + 4 H+ = 4 ferricytochrome c + 2 H2O.

GO - Molecular functioni

  1. cytochrome-c oxidase activity Source: UniProtKB-EC
Complete GO annotation...

Keywords - Molecular functioni


Names & Taxonomyi

Protein namesi
Recommended name:
Cytochrome c oxidase polypeptide VIIc (EC:
OrganismiOncorhynchus mykiss (Rainbow trout) (Salmo gairdneri)
Taxonomic identifieri8022 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiActinopterygiiNeopterygiiTeleosteiProtacanthopterygiiSalmoniformesSalmonidaeSalmoninaeOncorhynchus

Subcellular locationi

GO - Cellular componenti

  1. mitochondrial inner membrane Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Membrane, Mitochondrion, Mitochondrion inner membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – ›25›25Cytochrome c oxidase polypeptide VIIcPRO_0000197045Add

Family & Domainsi

Sequence similaritiesi

Belongs to the cytochrome c oxidase VIIc family.Curated

Family and domain databases

Gene3Di4.10.49.10. 1 hit.
InterProiIPR004202. COX7C/Cox8.
[Graphical view]
PfamiPF02935. COX7C. 1 hit.
[Graphical view]
SUPFAMiSSF81427. SSF81427. 1 hit.


Sequence statusi: Fragment.

P80334-1 [UniParc]FASTAAdd to Basket

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        10         20 
Mass (Da):2,802
Last modified:October 1, 1994 - v1

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Non-terminal residuei25 – 251

Sequence databases



Sequence databases

PIRi S43633.

3D structure databases

ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Family and domain databases

Gene3Di 1 hit.
InterProi IPR004202. COX7C/Cox8.
[Graphical view ]
Pfami PF02935. COX7C. 1 hit.
[Graphical view ]
SUPFAMi SSF81427. SSF81427. 1 hit.
ProtoNeti Search...


  1. "Identification of tissue-specific isoforms for subunits Vb and VIIa of cytochrome c oxidase isolated from rainbow trout."
    Freund R., Kadenbach B.
    Eur. J. Biochem. 221:1111-1116(1994) [PubMed] [Europe PMC] [Abstract]
    Cited for: PROTEIN SEQUENCE.
    Tissue: Liver.

Entry informationi

Entry nameiCOX7C_ONCMY
AccessioniPrimary (citable) accession number: P80334
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 1, 1994
Last sequence update: October 1, 1994
Last modified: January 7, 2015
This is version 67 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program


Keywords - Technical termi

Direct protein sequencing


  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.