Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Eotaxin

Gene

CCL11

Organism
Cavia porcellus (Guinea pig)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

In response to the presence of allergens, this protein directly promotes the accumulation of eosinophils, a prominent feature of allergic inflammatory reactions.

GO - Biological processi

  1. branching involved in mammary gland duct morphogenesis Source: Ensembl
  2. cytoskeleton organization Source: Ensembl
  3. eosinophil chemotaxis Source: Ensembl
  4. immune response Source: InterPro
  5. inflammatory response Source: UniProtKB-KW
  6. mammary duct terminal end bud growth Source: Ensembl
  7. positive regulation of actin filament polymerization Source: Ensembl
  8. positive regulation of angiogenesis Source: Ensembl
  9. positive regulation of cell migration Source: Ensembl
  10. positive regulation of endothelial cell proliferation Source: Ensembl
  11. positive regulation of Rac GTPase activity Source: Ensembl
  12. regulation of cell shape Source: Ensembl
Complete GO annotation...

Keywords - Molecular functioni

Cytokine

Keywords - Biological processi

Chemotaxis, Inflammatory response

Names & Taxonomyi

Protein namesi
Recommended name:
Eotaxin
Alternative name(s):
C-C motif chemokine 11
Eosinophil chemotactic protein
Small-inducible cytokine A11
Gene namesi
Name:CCL11
Synonyms:SCYA11
OrganismiCavia porcellus (Guinea pig)
Taxonomic identifieri10141 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaHystricognathiCaviidaeCavia
ProteomesiUP000005447 Componenti: Unplaced

Subcellular locationi

GO - Cellular componenti

  1. extracellular space Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 23231 PublicationAdd
BLAST
Chaini24 – 9673EotaxinPRO_0000005193Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi31 ↔ 56By similarity
Disulfide bondi32 ↔ 72By similarity
Glycosylationi93 – 931O-linked (GalNAc...)By similarity

Keywords - PTMi

Disulfide bond, Glycoprotein

Expressioni

Tissue specificityi

Lung.

Interactioni

Protein-protein interaction databases

STRINGi10141.ENSCPOP00000012128.

Structurei

3D structure databases

SMRiP80325. Positions 27-96.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiNOG46290.
GeneTreeiENSGT00730000110714.
HOGENOMiHOG000036686.
HOVERGENiHBG017871.
InParanoidiP80325.
OMAiRITNNRC.
OrthoDBiEOG7C5MC2.
TreeFamiTF334888.

Family and domain databases

InterProiIPR000827. Chemokine_CC_CS.
IPR001811. Chemokine_IL8-like_dom.
[Graphical view]
PfamiPF00048. IL8. 1 hit.
[Graphical view]
SMARTiSM00199. SCY. 1 hit.
[Graphical view]
SUPFAMiSSF54117. SSF54117. 1 hit.
PROSITEiPS00472. SMALL_CYTOKINES_CC. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P80325-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKVSTAFLCL LLTVSAFSAQ VLAHPGIPSA CCFRVTNKKI SFQRLKSYKI
60 70 80 90
ITSSKCPQTA IVFEIKPDKM ICADPKKKWV QDAKKYLDQI SQTTKP
Length:96
Mass (Da):10,753
Last modified:September 30, 1996 - v2
Checksum:i62C856645BC6AC99
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti88 – 881D → G in CAA54698 (PubMed:7999113).Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U18941 mRNA. Translation: AAC52180.1.
X77603 mRNA. Translation: CAA54698.1.
PIRiI48099.
JC2478.
RefSeqiNP_001166295.1. NM_001172824.1.

Genome annotation databases

EnsembliENSCPOT00000013603; ENSCPOP00000012128; ENSCPOG00000013470.
GeneIDi100135493.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U18941 mRNA. Translation: AAC52180.1.
X77603 mRNA. Translation: CAA54698.1.
PIRiI48099.
JC2478.
RefSeqiNP_001166295.1. NM_001172824.1.

3D structure databases

SMRiP80325. Positions 27-96.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10141.ENSCPOP00000012128.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSCPOT00000013603; ENSCPOP00000012128; ENSCPOG00000013470.
GeneIDi100135493.

Organism-specific databases

CTDi6356.

Phylogenomic databases

eggNOGiNOG46290.
GeneTreeiENSGT00730000110714.
HOGENOMiHOG000036686.
HOVERGENiHBG017871.
InParanoidiP80325.
OMAiRITNNRC.
OrthoDBiEOG7C5MC2.
TreeFamiTF334888.

Family and domain databases

InterProiIPR000827. Chemokine_CC_CS.
IPR001811. Chemokine_IL8-like_dom.
[Graphical view]
PfamiPF00048. IL8. 1 hit.
[Graphical view]
SMARTiSM00199. SCY. 1 hit.
[Graphical view]
SUPFAMiSSF54117. SSF54117. 1 hit.
PROSITEiPS00472. SMALL_CYTOKINES_CC. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Constitutive and allergen-induced expression of eotaxin mRNA in the guinea pig lung."
    Rothenberg M.E., Luster A.D., Lilly C.M., Drazen J.M., Leder P.
    J. Exp. Med. 181:1211-1216(1994) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Lung.
  2. "Eotaxin: cloning of an eosinophil chemoattractant cytokine and increased mRNA expression in allergen-challenged guinea-pig lungs."
    Jose P.J., Adcock I.M., Griffiths-Johnson D.A., Berkman N., Wells T.C., Williams T.J., Power C.A.
    Biochem. Biophys. Res. Commun. 205:788-794(1993) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  3. "Eotaxin: a potent eosinophil chemoattractant cytokine detected in a guinea pig model of allergic airways inflammation."
    Jose P.J., Griffiths-Johnson D.A., Collins P.D., Walsh D.T., Moqbel R., Totty N.F., Truong O., Hsuan J.J., Williams T.J.
    J. Exp. Med. 179:881-887(1993) [PubMed] [Europe PMC] [Abstract]
    Cited for: PROTEIN SEQUENCE OF 24-96.
    Strain: Hartley.
    Tissue: Lung.

Entry informationi

Entry nameiCCL11_CAVPO
AccessioniPrimary (citable) accession number: P80325
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 31, 1994
Last sequence update: September 30, 1996
Last modified: March 31, 2015
This is version 92 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.