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P80325

- CCL11_CAVPO

UniProt

P80325 - CCL11_CAVPO

Protein

Eotaxin

Gene

CCL11

Organism
Cavia porcellus (Guinea pig)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at protein leveli
  1. Functioni

    In response to the presence of allergens, this protein directly promotes the accumulation of eosinophils, a prominent feature of allergic inflammatory reactions.

    GO - Biological processi

    1. branching involved in mammary gland duct morphogenesis Source: Ensembl
    2. cytoskeleton organization Source: Ensembl
    3. eosinophil chemotaxis Source: Ensembl
    4. immune response Source: InterPro
    5. inflammatory response Source: UniProtKB-KW
    6. mammary duct terminal end bud growth Source: Ensembl
    7. positive regulation of actin filament polymerization Source: Ensembl
    8. positive regulation of angiogenesis Source: Ensembl
    9. positive regulation of cell migration Source: Ensembl
    10. positive regulation of endothelial cell proliferation Source: Ensembl
    11. positive regulation of Rac GTPase activity Source: Ensembl
    12. regulation of cell shape Source: Ensembl

    Keywords - Molecular functioni

    Cytokine

    Keywords - Biological processi

    Chemotaxis, Inflammatory response

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Eotaxin
    Alternative name(s):
    C-C motif chemokine 11
    Eosinophil chemotactic protein
    Small-inducible cytokine A11
    Gene namesi
    Name:CCL11
    Synonyms:SCYA11
    OrganismiCavia porcellus (Guinea pig)
    Taxonomic identifieri10141 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaHystricognathiCaviidaeCavia
    ProteomesiUP000005447: Unplaced

    Subcellular locationi

    GO - Cellular componenti

    1. extracellular space Source: UniProtKB-KW

    Keywords - Cellular componenti

    Secreted

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 23231 PublicationAdd
    BLAST
    Chaini24 – 9673EotaxinPRO_0000005193Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Disulfide bondi31 ↔ 56By similarity
    Disulfide bondi32 ↔ 72By similarity
    Glycosylationi93 – 931O-linked (GalNAc...)By similarity

    Keywords - PTMi

    Disulfide bond, Glycoprotein

    Expressioni

    Tissue specificityi

    Lung.

    Interactioni

    Protein-protein interaction databases

    STRINGi10141.ENSCPOP00000012128.

    Structurei

    3D structure databases

    ProteinModelPortaliP80325.
    SMRiP80325. Positions 27-96.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Keywords - Domaini

    Signal

    Phylogenomic databases

    eggNOGiNOG46290.
    GeneTreeiENSGT00730000110714.
    HOGENOMiHOG000036686.
    HOVERGENiHBG017871.
    InParanoidiP80325.
    OMAiTKEICAD.
    OrthoDBiEOG7C5MC2.
    TreeFamiTF334888.

    Family and domain databases

    InterProiIPR000827. Chemokine_CC_CS.
    IPR001811. Chemokine_IL8-like_dom.
    [Graphical view]
    PfamiPF00048. IL8. 1 hit.
    [Graphical view]
    SMARTiSM00199. SCY. 1 hit.
    [Graphical view]
    SUPFAMiSSF54117. SSF54117. 1 hit.
    PROSITEiPS00472. SMALL_CYTOKINES_CC. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    P80325-1 [UniParc]FASTAAdd to Basket

    « Hide

    MKVSTAFLCL LLTVSAFSAQ VLAHPGIPSA CCFRVTNKKI SFQRLKSYKI   50
    ITSSKCPQTA IVFEIKPDKM ICADPKKKWV QDAKKYLDQI SQTTKP 96
    Length:96
    Mass (Da):10,753
    Last modified:October 1, 1996 - v2
    Checksum:i62C856645BC6AC99
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti88 – 881D → G in CAA54698. (PubMed:7999113)Curated

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U18941 mRNA. Translation: AAC52180.1.
    X77603 mRNA. Translation: CAA54698.1.
    PIRiI48099.
    JC2478.
    RefSeqiNP_001166295.1. NM_001172824.1.

    Genome annotation databases

    EnsembliENSCPOT00000013603; ENSCPOP00000012128; ENSCPOG00000013470.
    GeneIDi100135493.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U18941 mRNA. Translation: AAC52180.1 .
    X77603 mRNA. Translation: CAA54698.1 .
    PIRi I48099.
    JC2478.
    RefSeqi NP_001166295.1. NM_001172824.1.

    3D structure databases

    ProteinModelPortali P80325.
    SMRi P80325. Positions 27-96.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 10141.ENSCPOP00000012128.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSCPOT00000013603 ; ENSCPOP00000012128 ; ENSCPOG00000013470 .
    GeneIDi 100135493.

    Organism-specific databases

    CTDi 6356.

    Phylogenomic databases

    eggNOGi NOG46290.
    GeneTreei ENSGT00730000110714.
    HOGENOMi HOG000036686.
    HOVERGENi HBG017871.
    InParanoidi P80325.
    OMAi TKEICAD.
    OrthoDBi EOG7C5MC2.
    TreeFami TF334888.

    Family and domain databases

    InterProi IPR000827. Chemokine_CC_CS.
    IPR001811. Chemokine_IL8-like_dom.
    [Graphical view ]
    Pfami PF00048. IL8. 1 hit.
    [Graphical view ]
    SMARTi SM00199. SCY. 1 hit.
    [Graphical view ]
    SUPFAMi SSF54117. SSF54117. 1 hit.
    PROSITEi PS00472. SMALL_CYTOKINES_CC. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Constitutive and allergen-induced expression of eotaxin mRNA in the guinea pig lung."
      Rothenberg M.E., Luster A.D., Lilly C.M., Drazen J.M., Leder P.
      J. Exp. Med. 181:1211-1216(1995) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Tissue: Lung.
    2. "Eotaxin: cloning of an eosinophil chemoattractant cytokine and increased mRNA expression in allergen-challenged guinea-pig lungs."
      Jose P.J., Adcock I.M., Griffiths-Johnson D.A., Berkman N., Wells T.C., Williams T.J., Power C.A.
      Biochem. Biophys. Res. Commun. 205:788-794(1994) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    3. "Eotaxin: a potent eosinophil chemoattractant cytokine detected in a guinea pig model of allergic airways inflammation."
      Jose P.J., Griffiths-Johnson D.A., Collins P.D., Walsh D.T., Moqbel R., Totty N.F., Truong O., Hsuan J.J., Williams T.J.
      J. Exp. Med. 179:881-887(1994) [PubMed] [Europe PMC] [Abstract]
      Cited for: PROTEIN SEQUENCE OF 24-96.
      Strain: Hartley.
      Tissue: Lung.

    Entry informationi

    Entry nameiCCL11_CAVPO
    AccessioniPrimary (citable) accession number: P80325
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: June 1, 1994
    Last sequence update: October 1, 1996
    Last modified: October 1, 2014
    This is version 90 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Direct protein sequencing, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3