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P80325 (CCL11_CAVPO) Reviewed, UniProtKB/Swiss-Prot

Last modified February 19, 2014. Version 89. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Eotaxin
Alternative name(s):
C-C motif chemokine 11
Eosinophil chemotactic protein
Small-inducible cytokine A11
Gene names
Name:CCL11
Synonyms:SCYA11
OrganismCavia porcellus (Guinea pig) [Reference proteome]
Taxonomic identifier10141 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaHystricognathiCaviidaeCavia

Protein attributes

Sequence length96 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

In response to the presence of allergens, this protein directly promotes the accumulation of eosinophils, a prominent feature of allergic inflammatory reactions.

Subcellular location

Secreted.

Tissue specificity

Lung.

Sequence similarities

Belongs to the intercrine beta (chemokine CC) family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 2323 Ref.3
Chain24 – 9673Eotaxin
PRO_0000005193

Amino acid modifications

Glycosylation931O-linked (GalNAc...) By similarity
Disulfide bond31 ↔ 56 By similarity
Disulfide bond32 ↔ 72 By similarity

Experimental info

Sequence conflict881D → G in CAA54698. Ref.2

Sequences

Sequence LengthMass (Da)Tools
P80325 [UniParc].

Last modified October 1, 1996. Version 2.
Checksum: 62C856645BC6AC99

FASTA9610,753
        10         20         30         40         50         60 
MKVSTAFLCL LLTVSAFSAQ VLAHPGIPSA CCFRVTNKKI SFQRLKSYKI ITSSKCPQTA 

        70         80         90 
IVFEIKPDKM ICADPKKKWV QDAKKYLDQI SQTTKP 

« Hide

References

[1]"Constitutive and allergen-induced expression of eotaxin mRNA in the guinea pig lung."
Rothenberg M.E., Luster A.D., Lilly C.M., Drazen J.M., Leder P.
J. Exp. Med. 181:1211-1216(1995) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
Tissue: Lung.
[2]"Eotaxin: cloning of an eosinophil chemoattractant cytokine and increased mRNA expression in allergen-challenged guinea-pig lungs."
Jose P.J., Adcock I.M., Griffiths-Johnson D.A., Berkman N., Wells T.C., Williams T.J., Power C.A.
Biochem. Biophys. Res. Commun. 205:788-794(1994) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[3]"Eotaxin: a potent eosinophil chemoattractant cytokine detected in a guinea pig model of allergic airways inflammation."
Jose P.J., Griffiths-Johnson D.A., Collins P.D., Walsh D.T., Moqbel R., Totty N.F., Truong O., Hsuan J.J., Williams T.J.
J. Exp. Med. 179:881-887(1994) [PubMed] [Europe PMC] [Abstract]
Cited for: PROTEIN SEQUENCE OF 24-96.
Strain: Hartley.
Tissue: Lung.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
U18941 mRNA. Translation: AAC52180.1.
X77603 mRNA. Translation: CAA54698.1.
PIRI48099.
JC2478.
RefSeqNP_001166295.1. NM_001172824.1.

3D structure databases

ProteinModelPortalP80325.
SMRP80325. Positions 27-96.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING10141.ENSCPOP00000012128.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSCPOT00000013603; ENSCPOP00000012128; ENSCPOG00000013470.
GeneID100135493.

Organism-specific databases

CTD6356.

Phylogenomic databases

eggNOGNOG46290.
GeneTreeENSGT00730000110714.
HOGENOMHOG000036686.
HOVERGENHBG017871.
InParanoidP80325.
OMATKEICAD.
OrthoDBEOG7C5MC2.
TreeFamTF334888.

Family and domain databases

InterProIPR000827. Chemokine_CC_CS.
IPR001811. Chemokine_IL8-like_dom.
[Graphical view]
PfamPF00048. IL8. 1 hit.
[Graphical view]
SMARTSM00199. SCY. 1 hit.
[Graphical view]
SUPFAMSSF54117. SSF54117. 1 hit.
PROSITEPS00472. SMALL_CYTOKINES_CC. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameCCL11_CAVPO
AccessionPrimary (citable) accession number: P80325
Entry history
Integrated into UniProtKB/Swiss-Prot: June 1, 1994
Last sequence update: October 1, 1996
Last modified: February 19, 2014
This is version 89 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families