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P80317

- TCPZ_MOUSE

UniProt

P80317 - TCPZ_MOUSE

Protein

T-complex protein 1 subunit zeta

Gene

Cct6a

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 122 (01 Oct 2014)
      Sequence version 3 (23 Jan 2007)
      Previous versions | rss
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    Functioni

    Molecular chaperone; assists the folding of proteins upon ATP hydrolysis. Known to play a role, in vitro, in the folding of actin and tubulin.

    GO - Molecular functioni

    1. ATP binding Source: UniProtKB-KW
    2. protein binding Source: MGI

    GO - Biological processi

    1. binding of sperm to zona pellucida Source: MGI
    2. protein folding Source: InterPro

    Keywords - Molecular functioni

    Chaperone

    Keywords - Ligandi

    ATP-binding, Nucleotide-binding

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    T-complex protein 1 subunit zeta
    Short name:
    TCP-1-zeta
    Alternative name(s):
    CCT-zeta-1
    Gene namesi
    Name:Cct6a
    Synonyms:Cct6, Cctz, Cctz1
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Unplaced

    Organism-specific databases

    MGIiMGI:107943. Cct6a.

    Subcellular locationi

    GO - Cellular componenti

    1. acrosomal vesicle Source: MGI
    2. cell body Source: MGI
    3. chaperonin-containing T-complex Source: MGI
    4. zona pellucida receptor complex Source: MGI

    Keywords - Cellular componenti

    Cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Initiator methioninei1 – 11RemovedBy similarity
    Chaini2 – 531530T-complex protein 1 subunit zetaPRO_0000128356Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei2 – 21N-acetylalanine1 Publication
    Modified residuei5 – 51N6-acetyllysine1 Publication
    Modified residuei199 – 1991N6-acetyllysine1 Publication
    Modified residuei287 – 2871N6-acetyllysine1 Publication
    Modified residuei365 – 3651N6-acetyllysine1 Publication
    Modified residuei377 – 3771N6-acetyllysineBy similarity
    Modified residuei388 – 3881N6-acetyllysineBy similarity

    Post-translational modificationi

    The N-terminus is blocked.

    Keywords - PTMi

    Acetylation

    Proteomic databases

    MaxQBiP80317.
    PaxDbiP80317.
    PRIDEiP80317.

    2D gel databases

    REPRODUCTION-2DPAGEIPI00116281.
    P80317.
    UCD-2DPAGEP80317.

    PTM databases

    PhosphoSiteiP80317.

    Expressioni

    Tissue specificityi

    Expressed in all tissues examined.

    Gene expression databases

    CleanExiMM_CCT6A.
    GenevestigatoriP80317.

    Interactioni

    Subunit structurei

    Heterooligomeric complex of about 850 to 900 kDa that forms two stacked rings, 12 to 16 nm in diameter. Interacts with PACRG By similarity.By similarity

    Protein-protein interaction databases

    BioGridi198569. 5 interactions.
    IntActiP80317. 8 interactions.
    MINTiMINT-1870008.

    Structurei

    3D structure databases

    ProteinModelPortaliP80317.
    SMRiP80317. Positions 4-525.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the TCP-1 chaperonin family.Curated

    Phylogenomic databases

    eggNOGiCOG0459.
    HOGENOMiHOG000226733.
    HOVERGENiHBG103725.
    InParanoidiP80317.
    KOiK09498.
    PhylomeDBiP80317.

    Family and domain databases

    Gene3Di1.10.560.10. 2 hits.
    3.30.260.10. 2 hits.
    3.50.7.10. 1 hit.
    InterProiIPR012722. Chap_CCT_zeta.
    IPR017998. Chaperone_TCP-1.
    IPR002194. Chaperonin_TCP-1_CS.
    IPR002423. Cpn60/TCP-1.
    IPR027409. GroEL-like_apical_dom.
    IPR027413. GROEL-like_equatorial.
    IPR027410. TCP-1-like_intermed.
    [Graphical view]
    PANTHERiPTHR11353. PTHR11353. 1 hit.
    PfamiPF00118. Cpn60_TCP1. 1 hit.
    [Graphical view]
    PRINTSiPR00304. TCOMPLEXTCP1.
    SUPFAMiSSF48592. SSF48592. 2 hits.
    SSF52029. SSF52029. 1 hit.
    TIGRFAMsiTIGR02347. chap_CCT_zeta. 1 hit.
    PROSITEiPS00750. TCP1_1. 1 hit.
    PS00751. TCP1_2. 1 hit.
    PS00995. TCP1_3. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    P80317-1 [UniParc]FASTAAdd to Basket

    « Hide

    MAAVKTLNPK AEVARAQAAL AVNISAARGL QDVLRTNLGP KGTMKMLVSG    50
    AGDIKLTKDG NVLLHEMQIQ HPTASLIAKV ATAQDDITGD GTTSNVLIIG 100
    ELLKQADLYI SEGLHPRIIT EGFEAAKEKA LQFLEQVKVS KEMDRETLID 150
    VARTSLRTKV HAELADVLTE AVVDSILAIR KKDEPIDLFM VEIMEMKHKS 200
    ETDTSLIRGL VLDHGARHPD MKKRVENAYI LTCNVSLEYE KTEVNSGFFY 250
    KSAEEREKLV KAERKFIEDR VKKIIELKKK VCGDSDKGFV VINQKGIDPF 300
    SLDALAKEGI VALRRAKRRN MERLTLACGG IALNSFDDLN PDCLGHAGLV 350
    YEYTLGEEKF TFIEKCNNPR SVTLLVKGPN KHTLTQIKDA IRDGLRAVKN 400
    AIDDGCVVPG AGAVEVALAE ALIKYKPSVK GRAQLGVQAF ADALLIIPKV 450
    LAQNSGFDLQ ETLVKVQAEH SESGQLVGVD LSTGEPMVAA EMGVWDNYCV 500
    KKQLLHSCTV IATNILLVDE IMRAGMSSLK G 531
    Length:531
    Mass (Da):58,004
    Last modified:January 23, 2007 - v3
    Checksum:iD68C606D67F29642
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    Z31557 mRNA. Translation: CAA83432.1.
    AB022159 Genomic DNA. Translation: BAA81877.1.
    PIRiS43063.
    RefSeqiNP_033968.1. NM_009838.2.
    UniGeneiMm.153159.
    Mm.360232.

    Genome annotation databases

    GeneIDi12466.
    KEGGimmu:12466.
    UCSCiuc029vow.1. mouse.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    Z31557 mRNA. Translation: CAA83432.1 .
    AB022159 Genomic DNA. Translation: BAA81877.1 .
    PIRi S43063.
    RefSeqi NP_033968.1. NM_009838.2.
    UniGenei Mm.153159.
    Mm.360232.

    3D structure databases

    ProteinModelPortali P80317.
    SMRi P80317. Positions 4-525.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 198569. 5 interactions.
    IntActi P80317. 8 interactions.
    MINTi MINT-1870008.

    PTM databases

    PhosphoSitei P80317.

    2D gel databases

    REPRODUCTION-2DPAGE IPI00116281.
    P80317.
    UCD-2DPAGE P80317.

    Proteomic databases

    MaxQBi P80317.
    PaxDbi P80317.
    PRIDEi P80317.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    GeneIDi 12466.
    KEGGi mmu:12466.
    UCSCi uc029vow.1. mouse.

    Organism-specific databases

    CTDi 908.
    MGIi MGI:107943. Cct6a.

    Phylogenomic databases

    eggNOGi COG0459.
    HOGENOMi HOG000226733.
    HOVERGENi HBG103725.
    InParanoidi P80317.
    KOi K09498.
    PhylomeDBi P80317.

    Miscellaneous databases

    ChiTaRSi CCT6A. mouse.
    NextBioi 281338.
    PROi P80317.
    SOURCEi Search...

    Gene expression databases

    CleanExi MM_CCT6A.
    Genevestigatori P80317.

    Family and domain databases

    Gene3Di 1.10.560.10. 2 hits.
    3.30.260.10. 2 hits.
    3.50.7.10. 1 hit.
    InterProi IPR012722. Chap_CCT_zeta.
    IPR017998. Chaperone_TCP-1.
    IPR002194. Chaperonin_TCP-1_CS.
    IPR002423. Cpn60/TCP-1.
    IPR027409. GroEL-like_apical_dom.
    IPR027413. GROEL-like_equatorial.
    IPR027410. TCP-1-like_intermed.
    [Graphical view ]
    PANTHERi PTHR11353. PTHR11353. 1 hit.
    Pfami PF00118. Cpn60_TCP1. 1 hit.
    [Graphical view ]
    PRINTSi PR00304. TCOMPLEXTCP1.
    SUPFAMi SSF48592. SSF48592. 2 hits.
    SSF52029. SSF52029. 1 hit.
    TIGRFAMsi TIGR02347. chap_CCT_zeta. 1 hit.
    PROSITEi PS00750. TCP1_1. 1 hit.
    PS00751. TCP1_2. 1 hit.
    PS00995. TCP1_3. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Identification of six Tcp-1-related genes encoding divergent subunits of the TCP-1-containing chaperonin."
      Kubota H., Hynes G., Carne A., Ashworth A., Willison K.R.
      Curr. Biol. 4:89-99(1994) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA], PARTIAL PROTEIN SEQUENCE.
      Strain: 129/Sv.
    2. "Structures and co-regulated expression of the genes encoding mouse cytosolic chaperonin CCT subunits."
      Kubota H., Yokota S., Yanagi H., Yura T.
      Eur. J. Biochem. 262:492-500(1999) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
      Strain: 129/Sv.
    3. Lubec G., Klug S., Kang S.U., Sunyer B., Chen W.-Q.
      Submitted (JAN-2009) to UniProtKB
      Cited for: PROTEIN SEQUENCE OF 16-28; 106-127; 130-138; 160-180; 200-208; 242-251 AND 524-530, IDENTIFICATION BY MASS SPECTROMETRY.
      Strain: C57BL/6 and OF1.
      Tissue: Brain and Hippocampus.
    4. "SIRT5-mediated lysine desuccinylation impacts diverse metabolic pathways."
      Park J., Chen Y., Tishkoff D.X., Peng C., Tan M., Dai L., Xie Z., Zhang Y., Zwaans B.M., Skinner M.E., Lombard D.B., Zhao Y.
      Mol. Cell 50:919-930(2013) [PubMed] [Europe PMC] [Abstract]
      Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT ALA-2; LYS-5; LYS-199; LYS-287 AND LYS-365, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS], CLEAVAGE OF INITIATOR METHIONINE [LARGE SCALE ANALYSIS].
      Tissue: Embryonic fibroblast.

    Entry informationi

    Entry nameiTCPZ_MOUSE
    AccessioniPrimary (citable) accession number: P80317
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: June 1, 1994
    Last sequence update: January 23, 2007
    Last modified: October 1, 2014
    This is version 122 of the entry and version 3 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Direct protein sequencing, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3