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P80317 (TCPZ_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 119. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
T-complex protein 1 subunit zeta

Short name=TCP-1-zeta
Alternative name(s):
CCT-zeta-1
Gene names
Name:Cct6a
Synonyms:Cct6, Cctz, Cctz1
OrganismMus musculus (Mouse) [Reference proteome]
Taxonomic identifier10090 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus

Protein attributes

Sequence length531 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Molecular chaperone; assists the folding of proteins upon ATP hydrolysis. Known to play a role, in vitro, in the folding of actin and tubulin.

Subunit structure

Heterooligomeric complex of about 850 to 900 kDa that forms two stacked rings, 12 to 16 nm in diameter. Interacts with PACRG By similarity.

Subcellular location

Cytoplasm.

Tissue specificity

Expressed in all tissues examined.

Post-translational modification

The N-terminus is blocked.

Sequence similarities

Belongs to the TCP-1 chaperonin family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Initiator methionine11Removed By similarity
Chain2 – 531530T-complex protein 1 subunit zeta
PRO_0000128356

Amino acid modifications

Modified residue21N-acetylalanine Ref.4
Modified residue51N6-acetyllysine Ref.4
Modified residue1991N6-acetyllysine Ref.4
Modified residue2871N6-acetyllysine Ref.4
Modified residue3651N6-acetyllysine Ref.4
Modified residue3771N6-acetyllysine By similarity
Modified residue3881N6-acetyllysine By similarity

Sequences

Sequence LengthMass (Da)Tools
P80317 [UniParc].

Last modified January 23, 2007. Version 3.
Checksum: D68C606D67F29642

FASTA53158,004
        10         20         30         40         50         60 
MAAVKTLNPK AEVARAQAAL AVNISAARGL QDVLRTNLGP KGTMKMLVSG AGDIKLTKDG 

        70         80         90        100        110        120 
NVLLHEMQIQ HPTASLIAKV ATAQDDITGD GTTSNVLIIG ELLKQADLYI SEGLHPRIIT 

       130        140        150        160        170        180 
EGFEAAKEKA LQFLEQVKVS KEMDRETLID VARTSLRTKV HAELADVLTE AVVDSILAIR 

       190        200        210        220        230        240 
KKDEPIDLFM VEIMEMKHKS ETDTSLIRGL VLDHGARHPD MKKRVENAYI LTCNVSLEYE 

       250        260        270        280        290        300 
KTEVNSGFFY KSAEEREKLV KAERKFIEDR VKKIIELKKK VCGDSDKGFV VINQKGIDPF 

       310        320        330        340        350        360 
SLDALAKEGI VALRRAKRRN MERLTLACGG IALNSFDDLN PDCLGHAGLV YEYTLGEEKF 

       370        380        390        400        410        420 
TFIEKCNNPR SVTLLVKGPN KHTLTQIKDA IRDGLRAVKN AIDDGCVVPG AGAVEVALAE 

       430        440        450        460        470        480 
ALIKYKPSVK GRAQLGVQAF ADALLIIPKV LAQNSGFDLQ ETLVKVQAEH SESGQLVGVD 

       490        500        510        520        530 
LSTGEPMVAA EMGVWDNYCV KKQLLHSCTV IATNILLVDE IMRAGMSSLK G 

« Hide

References

« Hide 'large scale' references
[1]"Identification of six Tcp-1-related genes encoding divergent subunits of the TCP-1-containing chaperonin."
Kubota H., Hynes G., Carne A., Ashworth A., Willison K.R.
Curr. Biol. 4:89-99(1994) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA], PARTIAL PROTEIN SEQUENCE.
Strain: 129/Sv.
[2]"Structures and co-regulated expression of the genes encoding mouse cytosolic chaperonin CCT subunits."
Kubota H., Yokota S., Yanagi H., Yura T.
Eur. J. Biochem. 262:492-500(1999) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
Strain: 129/Sv.
[3]Lubec G., Klug S., Kang S.U., Sunyer B., Chen W.-Q.
Submitted (JAN-2009) to UniProtKB
Cited for: PROTEIN SEQUENCE OF 16-28; 106-127; 130-138; 160-180; 200-208; 242-251 AND 524-530, IDENTIFICATION BY MASS SPECTROMETRY.
Strain: C57BL/6 and OF1.
Tissue: Brain and Hippocampus.
[4]"SIRT5-mediated lysine desuccinylation impacts diverse metabolic pathways."
Park J., Chen Y., Tishkoff D.X., Peng C., Tan M., Dai L., Xie Z., Zhang Y., Zwaans B.M., Skinner M.E., Lombard D.B., Zhao Y.
Mol. Cell 50:919-930(2013) [PubMed] [Europe PMC] [Abstract]
Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT ALA-2; LYS-5; LYS-199; LYS-287 AND LYS-365, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS], CLEAVAGE OF INITIATOR METHIONINE [LARGE SCALE ANALYSIS].
Tissue: Embryonic fibroblast.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
Z31557 mRNA. Translation: CAA83432.1.
AB022159 Genomic DNA. Translation: BAA81877.1.
PIRS43063.
RefSeqNP_033968.1. NM_009838.2.
UniGeneMm.153159.
Mm.360232.

3D structure databases

ProteinModelPortalP80317.
SMRP80317. Positions 4-525.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid198569. 4 interactions.
IntActP80317. 8 interactions.
MINTMINT-1870008.

PTM databases

PhosphoSiteP80317.

2D gel databases

REPRODUCTION-2DPAGEIPI00116281.
P80317.
UCD-2DPAGEP80317.

Proteomic databases

PaxDbP80317.
PRIDEP80317.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID12466.
KEGGmmu:12466.
UCSCuc029vow.1. mouse.

Organism-specific databases

CTD908.
MGIMGI:107943. Cct6a.

Phylogenomic databases

eggNOGCOG0459.
HOGENOMHOG000226733.
HOVERGENHBG103725.
InParanoidP80317.
KOK09498.
PhylomeDBP80317.

Gene expression databases

CleanExMM_CCT6A.
GenevestigatorP80317.

Family and domain databases

Gene3D1.10.560.10. 2 hits.
3.30.260.10. 2 hits.
3.50.7.10. 1 hit.
InterProIPR012722. Chap_CCT_zeta.
IPR017998. Chaperone_TCP-1.
IPR002194. Chaperonin_TCP-1_CS.
IPR002423. Cpn60/TCP-1.
IPR027409. GroEL-like_apical_dom.
IPR027413. GROEL-like_equatorial.
IPR027410. TCP-1-like_intermed.
[Graphical view]
PANTHERPTHR11353. PTHR11353. 1 hit.
PTHR11353:SF21. PTHR11353:SF21. 1 hit.
PfamPF00118. Cpn60_TCP1. 1 hit.
[Graphical view]
PRINTSPR00304. TCOMPLEXTCP1.
SUPFAMSSF48592. SSF48592. 2 hits.
SSF52029. SSF52029. 1 hit.
TIGRFAMsTIGR02347. chap_CCT_zeta. 1 hit.
PROSITEPS00750. TCP1_1. 1 hit.
PS00751. TCP1_2. 1 hit.
PS00995. TCP1_3. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

ChiTaRSCCT6A. mouse.
NextBio281338.
PROP80317.
SOURCESearch...

Entry information

Entry nameTCPZ_MOUSE
AccessionPrimary (citable) accession number: P80317
Entry history
Integrated into UniProtKB/Swiss-Prot: June 1, 1994
Last sequence update: January 23, 2007
Last modified: April 16, 2014
This is version 119 of the entry and version 3 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

MGD cross-references

Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot