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Protein

T-complex protein 1 subunit beta

Gene

Cct2

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Molecular chaperone; assists the folding of proteins upon ATP hydrolysis. As part of the BBS/CCT complex may play a role in the assembly of BBSome, a complex involved in ciliogenesis regulating transports vesicles to the cilia. Known to play a role, in vitro, in the folding of actin and tubulin.By similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Chaperone

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

ReactomeiR-MMU-390471. Association of TriC/CCT with target proteins during biosynthesis.
R-MMU-6798695. Neutrophil degranulation.
R-MMU-6814122. Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding.

Names & Taxonomyi

Protein namesi
Recommended name:
T-complex protein 1 subunit beta
Short name:
TCP-1-beta
Alternative name(s):
CCT-beta
Gene namesi
Name:Cct2
Synonyms:Cctb
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 10

Organism-specific databases

MGIiMGI:107186. Cct2.

Subcellular locationi

  • Cytoplasm By similarity

GO - Cellular componenti

  • cell body Source: MGI
  • chaperonin-containing T-complex Source: MGI
  • cytoplasm Source: MGI
  • extracellular exosome Source: MGI
  • extracellular matrix Source: MGI
  • microtubule Source: MGI
  • myelin sheath Source: UniProtKB
  • zona pellucida receptor complex Source: MGI
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedBy similarity
ChainiPRO_00001283172 – 535T-complex protein 1 subunit betaAdd BLAST534

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei2N-acetylalanineBy similarity1
Modified residuei3PhosphoserineBy similarity1
Modified residuei13N6-acetyllysineBy similarity1
Modified residuei181N6-acetyllysineBy similarity1
Modified residuei260PhosphoserineBy similarity1
Modified residuei261PhosphothreonineBy similarity1

Post-translational modificationi

The N-terminus is blocked.

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

EPDiP80314.
PaxDbiP80314.
PeptideAtlasiP80314.
PRIDEiP80314.

2D gel databases

REPRODUCTION-2DPAGEP80314.

PTM databases

iPTMnetiP80314.
PhosphoSitePlusiP80314.
SwissPalmiP80314.

Expressioni

Gene expression databases

BgeeiENSMUSG00000034024.
CleanExiMM_CCT2.
ExpressionAtlasiP80314. baseline and differential.
GenevisibleiP80314. MM.

Interactioni

Subunit structurei

Heterooligomeric complex of about 850 to 900 kDa that forms two stacked rings, 12 to 16 nm in diameter. Interacts with PACRG. Component of the BBS/CCT complex composed at least of MKKS, BBS10, BBS12, TCP1, CCT2, CCT3, CCT4, CCT5 AND CCT8. Interacts with FLCN.By similarity

GO - Molecular functioni

Protein-protein interaction databases

BioGridi198564. 45 interactors.
DIPiDIP-32343N.
IntActiP80314. 48 interactors.
MINTiMINT-1862332.
STRINGi10090.ENSMUSP00000036288.

Structurei

3D structure databases

ProteinModelPortaliP80314.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the TCP-1 chaperonin family.Curated

Phylogenomic databases

eggNOGiKOG0363. Eukaryota.
COG0459. LUCA.
GeneTreeiENSGT00550000074930.
HOGENOMiHOG000226736.
HOVERGENiHBG001052.
InParanoidiP80314.
KOiK09494.
OMAiYNYPEQI.
OrthoDBiEOG091G07BP.
PhylomeDBiP80314.
TreeFamiTF105645.

Family and domain databases

CDDicd03336. TCP1_beta. 1 hit.
Gene3Di1.10.560.10. 2 hits.
3.30.260.10. 2 hits.
3.50.7.10. 1 hit.
InterProiIPR012716. Chap_CCT_beta.
IPR017998. Chaperone_TCP-1.
IPR002194. Chaperonin_TCP-1_CS.
IPR002423. Cpn60/TCP-1.
IPR027409. GroEL-like_apical_dom.
IPR027413. GROEL-like_equatorial.
IPR027410. TCP-1-like_intermed.
[Graphical view]
PfamiPF00118. Cpn60_TCP1. 1 hit.
[Graphical view]
PRINTSiPR00304. TCOMPLEXTCP1.
SUPFAMiSSF52029. SSF52029. 1 hit.
TIGRFAMsiTIGR02341. chap_CCT_beta. 1 hit.
PROSITEiPS00750. TCP1_1. 1 hit.
PS00751. TCP1_2. 1 hit.
PS00995. TCP1_3. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P80314-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MASLSLAPVN IFKAGADEER AETARLSSFI GAIAIGDLVK STLGPKGMDK
60 70 80 90 100
ILLSSGRDAA LMVTNDGATI LKNIGVDNPA AKVLVDMSRV QDDEVGDGTT
110 120 130 140 150
SVTVLAAELL REAESLIAKK IHPQTIISGW REATKAAREA LLSSAVDHGS
160 170 180 190 200
DEARFWQDLM NIAGTTLSSK LLTHHKDHFT KLAVEAVLRL KGSGNLEAIH
210 220 230 240 250
VIKKLGGSLA DSYLDEGFLL DKKIGVNQPK RIENAKILIA NTGMDTDKIK
260 270 280 290 300
IFGSRVRVDS TAKVAEIEHA EKEKMKEKVE RILKHGINCF INRQLIYNYP
310 320 330 340 350
EQLFGAAGVM AIEHADFAGV ERLALVTGGE IASTFDHPEL VKLGSCKLIE
360 370 380 390 400
EVMIGEDKLI HFSGVALGEA CTIVLRGATQ QILDEAERSL HDALCVLAQT
410 420 430 440 450
VKDPRTVYGG GCSEMLMAHA VTQLANRTPG KEAVAMESFA KALRMLPTII
460 470 480 490 500
ADNAGYDSAD LVAQLRAAHS EGHITAGLDM KEGTIGDMAV LGITESFQVK
510 520 530
RQVLLSAAEA AEVILRVDNI IKAAPRKRVP DHHPC
Length:535
Mass (Da):57,477
Last modified:January 23, 2007 - v4
Checksum:i605744DF068BB192
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti23T → I in CAA83428 (PubMed:7953530).Curated1
Sequence conflicti187V → G in CAA83428 (PubMed:7953530).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z31553 mRNA. Translation: CAA83428.1.
AB022156 Genomic DNA. Translation: BAA81874.1.
BC007470 mRNA. Translation: AAH07470.1.
BC026918 mRNA. Translation: AAH26918.1.
CCDSiCCDS36067.1.
PIRiS43059.
RefSeqiNP_031662.2. NM_007636.2.
XP_006513224.1. XM_006513161.2.
UniGeneiMm.247788.

Genome annotation databases

EnsembliENSMUST00000047672; ENSMUSP00000036288; ENSMUSG00000034024.
GeneIDi12461.
KEGGimmu:12461.
UCSCiuc007hcs.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z31553 mRNA. Translation: CAA83428.1.
AB022156 Genomic DNA. Translation: BAA81874.1.
BC007470 mRNA. Translation: AAH07470.1.
BC026918 mRNA. Translation: AAH26918.1.
CCDSiCCDS36067.1.
PIRiS43059.
RefSeqiNP_031662.2. NM_007636.2.
XP_006513224.1. XM_006513161.2.
UniGeneiMm.247788.

3D structure databases

ProteinModelPortaliP80314.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi198564. 45 interactors.
DIPiDIP-32343N.
IntActiP80314. 48 interactors.
MINTiMINT-1862332.
STRINGi10090.ENSMUSP00000036288.

PTM databases

iPTMnetiP80314.
PhosphoSitePlusiP80314.
SwissPalmiP80314.

2D gel databases

REPRODUCTION-2DPAGEP80314.

Proteomic databases

EPDiP80314.
PaxDbiP80314.
PeptideAtlasiP80314.
PRIDEiP80314.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000047672; ENSMUSP00000036288; ENSMUSG00000034024.
GeneIDi12461.
KEGGimmu:12461.
UCSCiuc007hcs.1. mouse.

Organism-specific databases

CTDi10576.
MGIiMGI:107186. Cct2.

Phylogenomic databases

eggNOGiKOG0363. Eukaryota.
COG0459. LUCA.
GeneTreeiENSGT00550000074930.
HOGENOMiHOG000226736.
HOVERGENiHBG001052.
InParanoidiP80314.
KOiK09494.
OMAiYNYPEQI.
OrthoDBiEOG091G07BP.
PhylomeDBiP80314.
TreeFamiTF105645.

Enzyme and pathway databases

ReactomeiR-MMU-390471. Association of TriC/CCT with target proteins during biosynthesis.
R-MMU-6798695. Neutrophil degranulation.
R-MMU-6814122. Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding.

Miscellaneous databases

ChiTaRSiCct2. mouse.
PROiP80314.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000034024.
CleanExiMM_CCT2.
ExpressionAtlasiP80314. baseline and differential.
GenevisibleiP80314. MM.

Family and domain databases

CDDicd03336. TCP1_beta. 1 hit.
Gene3Di1.10.560.10. 2 hits.
3.30.260.10. 2 hits.
3.50.7.10. 1 hit.
InterProiIPR012716. Chap_CCT_beta.
IPR017998. Chaperone_TCP-1.
IPR002194. Chaperonin_TCP-1_CS.
IPR002423. Cpn60/TCP-1.
IPR027409. GroEL-like_apical_dom.
IPR027413. GROEL-like_equatorial.
IPR027410. TCP-1-like_intermed.
[Graphical view]
PfamiPF00118. Cpn60_TCP1. 1 hit.
[Graphical view]
PRINTSiPR00304. TCOMPLEXTCP1.
SUPFAMiSSF52029. SSF52029. 1 hit.
TIGRFAMsiTIGR02341. chap_CCT_beta. 1 hit.
PROSITEiPS00750. TCP1_1. 1 hit.
PS00751. TCP1_2. 1 hit.
PS00995. TCP1_3. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiTCPB_MOUSE
AccessioniPrimary (citable) accession number: P80314
Secondary accession number(s): Q9R1U0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 1, 1994
Last sequence update: January 23, 2007
Last modified: November 30, 2016
This is version 154 of the entry and version 4 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.