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Protein

T-complex protein 1 subunit beta

Gene

Cct2

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Molecular chaperone; assists the folding of proteins upon ATP hydrolysis. As part of the BBS/CCT complex may play a role in the assembly of BBSome, a complex involved in ciliogenesis regulating transports vesicles to the cilia. Known to play a role, in vitro, in the folding of actin and tubulin.By similarity

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionChaperone
LigandATP-binding, Nucleotide-binding

Enzyme and pathway databases

ReactomeiR-MMU-390471 Association of TriC/CCT with target proteins during biosynthesis
R-MMU-6798695 Neutrophil degranulation
R-MMU-6814122 Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding

Names & Taxonomyi

Protein namesi
Recommended name:
T-complex protein 1 subunit beta
Short name:
TCP-1-beta
Alternative name(s):
CCT-beta
Gene namesi
Name:Cct2
Synonyms:Cctb
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 10

Organism-specific databases

MGIiMGI:107186 Cct2

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedBy similarity
ChainiPRO_00001283172 – 535T-complex protein 1 subunit betaAdd BLAST534

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei2N-acetylalanineBy similarity1
Modified residuei3PhosphoserineBy similarity1
Modified residuei13N6-acetyllysineBy similarity1
Modified residuei181N6-acetyllysineBy similarity1
Cross-linki248Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity
Modified residuei260PhosphoserineBy similarity1
Modified residuei261PhosphothreonineBy similarity1

Post-translational modificationi

The N-terminus is blocked.

Keywords - PTMi

Acetylation, Isopeptide bond, Phosphoprotein, Ubl conjugation

Proteomic databases

EPDiP80314
PaxDbiP80314
PeptideAtlasiP80314
PRIDEiP80314

2D gel databases

REPRODUCTION-2DPAGEiP80314

PTM databases

iPTMnetiP80314
PhosphoSitePlusiP80314
SwissPalmiP80314

Expressioni

Gene expression databases

BgeeiENSMUSG00000034024
CleanExiMM_CCT2
ExpressionAtlasiP80314 baseline and differential
GenevisibleiP80314 MM

Interactioni

Subunit structurei

Heterooligomeric complex of about 850 to 900 kDa that forms two stacked rings, 12 to 16 nm in diameter. Interacts with PACRG. Component of the BBS/CCT complex composed at least of MKKS, BBS10, BBS12, TCP1, CCT2, CCT3, CCT4, CCT5 AND CCT8. Interacts with FLCN.By similarity

GO - Molecular functioni

Protein-protein interaction databases

BioGridi198564, 47 interactors
CORUMiP80314
DIPiDIP-32343N
IntActiP80314, 49 interactors
MINTiP80314
STRINGi10090.ENSMUSP00000036288

Structurei

3D structure databases

ProteinModelPortaliP80314
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the TCP-1 chaperonin family.Curated

Phylogenomic databases

eggNOGiKOG0363 Eukaryota
COG0459 LUCA
GeneTreeiENSGT00550000074930
HOGENOMiHOG000226736
HOVERGENiHBG001052
InParanoidiP80314
KOiK09494
OMAiPGVHQPQ
OrthoDBiEOG091G07BP
PhylomeDBiP80314
TreeFamiTF105645

Family and domain databases

CDDicd03336 TCP1_beta, 1 hit
Gene3Di1.10.560.10, 2 hits
3.30.260.10, 2 hits
3.50.7.10, 1 hit
InterProiView protein in InterPro
IPR012716 Chap_CCT_beta
IPR017998 Chaperone_TCP-1
IPR002194 Chaperonin_TCP-1_CS
IPR002423 Cpn60/TCP-1
IPR027409 GroEL-like_apical_dom_sf
IPR027413 GROEL-like_equatorial_sf
IPR027410 TCP-1-like_intermed_sf
PANTHERiPTHR11353:SF23 PTHR11353:SF23, 1 hit
PfamiView protein in Pfam
PF00118 Cpn60_TCP1, 1 hit
PRINTSiPR00304 TCOMPLEXTCP1
SUPFAMiSSF48592 SSF48592, 2 hits
SSF52029 SSF52029, 1 hit
SSF54849 SSF54849, 2 hits
TIGRFAMsiTIGR02341 chap_CCT_beta, 1 hit
PROSITEiView protein in PROSITE
PS00750 TCP1_1, 1 hit
PS00751 TCP1_2, 1 hit
PS00995 TCP1_3, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P80314-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MASLSLAPVN IFKAGADEER AETARLSSFI GAIAIGDLVK STLGPKGMDK
60 70 80 90 100
ILLSSGRDAA LMVTNDGATI LKNIGVDNPA AKVLVDMSRV QDDEVGDGTT
110 120 130 140 150
SVTVLAAELL REAESLIAKK IHPQTIISGW REATKAAREA LLSSAVDHGS
160 170 180 190 200
DEARFWQDLM NIAGTTLSSK LLTHHKDHFT KLAVEAVLRL KGSGNLEAIH
210 220 230 240 250
VIKKLGGSLA DSYLDEGFLL DKKIGVNQPK RIENAKILIA NTGMDTDKIK
260 270 280 290 300
IFGSRVRVDS TAKVAEIEHA EKEKMKEKVE RILKHGINCF INRQLIYNYP
310 320 330 340 350
EQLFGAAGVM AIEHADFAGV ERLALVTGGE IASTFDHPEL VKLGSCKLIE
360 370 380 390 400
EVMIGEDKLI HFSGVALGEA CTIVLRGATQ QILDEAERSL HDALCVLAQT
410 420 430 440 450
VKDPRTVYGG GCSEMLMAHA VTQLANRTPG KEAVAMESFA KALRMLPTII
460 470 480 490 500
ADNAGYDSAD LVAQLRAAHS EGHITAGLDM KEGTIGDMAV LGITESFQVK
510 520 530
RQVLLSAAEA AEVILRVDNI IKAAPRKRVP DHHPC
Length:535
Mass (Da):57,477
Last modified:January 23, 2007 - v4
Checksum:i605744DF068BB192
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti23T → I in CAA83428 (PubMed:7953530).Curated1
Sequence conflicti187V → G in CAA83428 (PubMed:7953530).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z31553 mRNA Translation: CAA83428.1
AB022156 Genomic DNA Translation: BAA81874.1
BC007470 mRNA Translation: AAH07470.1
BC026918 mRNA Translation: AAH26918.1
CCDSiCCDS36067.1
PIRiS43059
RefSeqiNP_031662.2, NM_007636.2
XP_006513224.1, XM_006513161.2
UniGeneiMm.247788

Genome annotation databases

EnsembliENSMUST00000047672; ENSMUSP00000036288; ENSMUSG00000034024
GeneIDi12461
KEGGimmu:12461
UCSCiuc007hcs.1 mouse

Similar proteinsi

Entry informationi

Entry nameiTCPB_MOUSE
AccessioniPrimary (citable) accession number: P80314
Secondary accession number(s): Q9R1U0
Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 1, 1994
Last sequence update: January 23, 2007
Last modified: June 20, 2018
This is version 167 of the entry and version 4 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

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