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Protein

T-complex protein 1 subunit eta

Gene

Cct7

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Molecular chaperone; assists the folding of proteins upon ATP hydrolysis. Known to play a role, in vitro, in the folding of actin and tubulin.

GO - Molecular functioni

  • ATP binding Source: UniProtKB-KW
  • identical protein binding Source: MGI

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Chaperone

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

ReactomeiR-MMU-390471. Association of TriC/CCT with target proteins during biosynthesis.
R-MMU-6814122. Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding.

Names & Taxonomyi

Protein namesi
Recommended name:
T-complex protein 1 subunit eta
Short name:
TCP-1-eta
Alternative name(s):
CCT-eta
Cleaved into the following chain:
Gene namesi
Name:Cct7
Synonyms:Ccth
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 6

Organism-specific databases

MGIiMGI:107184. Cct7.

Subcellular locationi

GO - Cellular componenti

  • cell body Source: MGI
  • chaperonin-containing T-complex Source: MGI
  • extracellular exosome Source: MGI
  • microtubule Source: MGI
  • mitochondrion Source: MGI
  • zona pellucida receptor complex Source: MGI
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 544544T-complex protein 1 subunit etaPRO_0000128366Add
BLAST
Initiator methionineiRemoved; alternateBy similarity
Chaini2 – 544543T-complex protein 1 subunit eta, N-terminally processedPRO_0000434392Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei1 – 11N-acetylmethionineBy similarity
Modified residuei67 – 671N6-acetyllysineBy similarity
Modified residuei250 – 2501N6-acetyllysineCombined sources
Modified residuei320 – 3201N6-acetyllysineBy similarity

Post-translational modificationi

The N-terminus is blocked.

Keywords - PTMi

Acetylation

Proteomic databases

EPDiP80313.
PaxDbiP80313.
PRIDEiP80313.

2D gel databases

REPRODUCTION-2DPAGEP80313.

PTM databases

iPTMnetiP80313.
PhosphoSiteiP80313.
SwissPalmiP80313.

Expressioni

Gene expression databases

BgeeiP80313.
CleanExiMM_CCT7.
ExpressionAtlasiP80313. baseline and differential.
GenevisibleiP80313. MM.

Interactioni

Subunit structurei

Heterooligomeric complex of about 850 to 900 kDa that forms two stacked rings, 12 to 16 nm in diameter. Interacts with PACRG (By similarity).By similarity

GO - Molecular functioni

  • identical protein binding Source: MGI

Protein-protein interaction databases

BioGridi198571. 26 interactions.
IntActiP80313. 28 interactions.
MINTiMINT-218099.
STRINGi10090.ENSMUSP00000032078.

Structurei

3D structure databases

ProteinModelPortaliP80313.
SMRiP80313. Positions 6-523.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the TCP-1 chaperonin family.Curated

Phylogenomic databases

eggNOGiKOG0360. Eukaryota.
COG0459. LUCA.
HOGENOMiHOG000226730.
HOVERGENiHBG001052.
InParanoidiP80313.
KOiK09499.
OMAiIANNMER.
OrthoDBiEOG7V49Z2.
PhylomeDBiP80313.
TreeFamiTF105641.

Family and domain databases

Gene3Di1.10.560.10. 2 hits.
3.30.260.10. 2 hits.
3.50.7.10. 1 hit.
InterProiIPR012720. Chap_CCT_eta.
IPR017998. Chaperone_TCP-1.
IPR002194. Chaperonin_TCP-1_CS.
IPR002423. Cpn60/TCP-1.
IPR027409. GroEL-like_apical_dom.
IPR027413. GROEL-like_equatorial.
IPR027410. TCP-1-like_intermed.
[Graphical view]
PfamiPF00118. Cpn60_TCP1. 1 hit.
[Graphical view]
PRINTSiPR00304. TCOMPLEXTCP1.
SUPFAMiSSF52029. SSF52029. 1 hit.
TIGRFAMsiTIGR02345. chap_CCT_eta. 1 hit.
PROSITEiPS00750. TCP1_1. 1 hit.
PS00751. TCP1_2. 1 hit.
PS00995. TCP1_3. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P80313-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MMPTPVILLK EGTDSSQGIP QLVSNISACQ VIAEAVRTTL GPRGMDKLIV
60 70 80 90 100
DGRGKATISN DGATILKLLD VVHPAAKTLV DIAKSQDAEV GDGTTSVTLL
110 120 130 140 150
AAEFLKQVKP YVEEGLHPQI IIRAFRTATQ LAVNKIKEIA VTVKKQDKVE
160 170 180 190 200
QRKMLEKCAM TALSSKLISQ QKVFFAKMVV DAVMMLDELL QLKMIGIKKV
210 220 230 240 250
QGGALEESQL VAGVAFKKTF SYAGFEMQPK KYKNPKIALL NVELELKAEK
260 270 280 290 300
DNAEIRVHTV EDYQAIVDAE WNILYDKLEK IHQSGAKVIL SKLPIGDVAT
310 320 330 340 350
QYFADRDMFC AGRVPEEDLK RTMMACGGSI QTSVNALVPD VLGHCQVFEE
360 370 380 390 400
TQIGGERYNF FTGCPKAKTC TIILRGGAEQ FMEETERSLH DAIMIVRRAI
410 420 430 440 450
KNDSVVAGGG AIEMELSKYL RDYSRTIPGK QQLLIGAYAK ALEIIPRQLC
460 470 480 490 500
DNAGFDATNI LNKLRARHAQ GGMWYGVDIN NENIADNFQA FVWEPAMVRI
510 520 530 540
NALTAASEAA CLIVSVDETI KNPRSTVDPP APSAGRGRGQ ARFH
Length:544
Mass (Da):59,652
Last modified:June 1, 1994 - v1
Checksum:i0BD7AD35456EE677
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z31399 mRNA. Translation: CAA83274.1.
AB022160 Genomic DNA. Translation: BAA81878.1.
BC008255 mRNA. Translation: AAH08255.1.
CCDSiCCDS20295.1.
PIRiS43058.
RefSeqiNP_031664.3. NM_007638.4.
UniGeneiMm.289900.
Mm.456037.

Genome annotation databases

EnsembliENSMUST00000032078; ENSMUSP00000032078; ENSMUSG00000030007.
GeneIDi12468.
KEGGimmu:12468.
UCSCiuc009cpv.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z31399 mRNA. Translation: CAA83274.1.
AB022160 Genomic DNA. Translation: BAA81878.1.
BC008255 mRNA. Translation: AAH08255.1.
CCDSiCCDS20295.1.
PIRiS43058.
RefSeqiNP_031664.3. NM_007638.4.
UniGeneiMm.289900.
Mm.456037.

3D structure databases

ProteinModelPortaliP80313.
SMRiP80313. Positions 6-523.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi198571. 26 interactions.
IntActiP80313. 28 interactions.
MINTiMINT-218099.
STRINGi10090.ENSMUSP00000032078.

PTM databases

iPTMnetiP80313.
PhosphoSiteiP80313.
SwissPalmiP80313.

2D gel databases

REPRODUCTION-2DPAGEP80313.

Proteomic databases

EPDiP80313.
PaxDbiP80313.
PRIDEiP80313.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000032078; ENSMUSP00000032078; ENSMUSG00000030007.
GeneIDi12468.
KEGGimmu:12468.
UCSCiuc009cpv.2. mouse.

Organism-specific databases

CTDi10574.
MGIiMGI:107184. Cct7.

Phylogenomic databases

eggNOGiKOG0360. Eukaryota.
COG0459. LUCA.
HOGENOMiHOG000226730.
HOVERGENiHBG001052.
InParanoidiP80313.
KOiK09499.
OMAiIANNMER.
OrthoDBiEOG7V49Z2.
PhylomeDBiP80313.
TreeFamiTF105641.

Enzyme and pathway databases

ReactomeiR-MMU-390471. Association of TriC/CCT with target proteins during biosynthesis.
R-MMU-6814122. Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding.

Miscellaneous databases

ChiTaRSiCct7. mouse.
PROiP80313.
SOURCEiSearch...

Gene expression databases

BgeeiP80313.
CleanExiMM_CCT7.
ExpressionAtlasiP80313. baseline and differential.
GenevisibleiP80313. MM.

Family and domain databases

Gene3Di1.10.560.10. 2 hits.
3.30.260.10. 2 hits.
3.50.7.10. 1 hit.
InterProiIPR012720. Chap_CCT_eta.
IPR017998. Chaperone_TCP-1.
IPR002194. Chaperonin_TCP-1_CS.
IPR002423. Cpn60/TCP-1.
IPR027409. GroEL-like_apical_dom.
IPR027413. GROEL-like_equatorial.
IPR027410. TCP-1-like_intermed.
[Graphical view]
PfamiPF00118. Cpn60_TCP1. 1 hit.
[Graphical view]
PRINTSiPR00304. TCOMPLEXTCP1.
SUPFAMiSSF52029. SSF52029. 1 hit.
TIGRFAMsiTIGR02345. chap_CCT_eta. 1 hit.
PROSITEiPS00750. TCP1_1. 1 hit.
PS00751. TCP1_2. 1 hit.
PS00995. TCP1_3. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Identification of six Tcp-1-related genes encoding divergent subunits of the TCP-1-containing chaperonin."
    Kubota H., Hynes G., Carne A., Ashworth A., Willison K.R.
    Curr. Biol. 4:89-99(1994) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], PARTIAL PROTEIN SEQUENCE.
    Tissue: Testis.
  2. "Structures and co-regulated expression of the genes encoding mouse cytosolic chaperonin CCT subunits."
    Kubota H., Yokota S., Yanagi H., Yura T.
    Eur. J. Biochem. 262:492-500(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: 129/Sv.
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: FVB/N.
    Tissue: Mammary gland.
  4. Lubec G., Kang S.U., Klug S., Yang J.W., Zigmond M., Sunyer B., Chen W.-Q.
    Submitted (JAN-2009) to UniProtKB
    Cited for: PROTEIN SEQUENCE OF 11-37; 54-67; 85-106; 199-217; 219-230; 237-247; 293-306; 358-366; 376-397; 402-418 AND 431-447, IDENTIFICATION BY MASS SPECTROMETRY.
    Strain: C57BL/6J and OF1.
    Tissue: Brain and Hippocampus.
  5. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Brain, Brown adipose tissue, Heart, Kidney, Liver, Lung, Pancreas, Spleen and Testis.
  6. "SIRT5-mediated lysine desuccinylation impacts diverse metabolic pathways."
    Park J., Chen Y., Tishkoff D.X., Peng C., Tan M., Dai L., Xie Z., Zhang Y., Zwaans B.M., Skinner M.E., Lombard D.B., Zhao Y.
    Mol. Cell 50:919-930(2013) [PubMed] [Europe PMC] [Abstract]
    Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT LYS-250, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Embryonic fibroblast.

Entry informationi

Entry nameiTCPH_MOUSE
AccessioniPrimary (citable) accession number: P80313
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 1, 1994
Last sequence update: June 1, 1994
Last modified: June 8, 2016
This is version 144 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.