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Protein

T-complex protein 1 subunit eta

Gene

Cct7

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Molecular chaperone; assists the folding of proteins upon ATP hydrolysis. Known to play a role, in vitro, in the folding of actin and tubulin.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionChaperone
LigandATP-binding, Nucleotide-binding

Enzyme and pathway databases

ReactomeiR-MMU-390471. Association of TriC/CCT with target proteins during biosynthesis.
R-MMU-6814122. Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding.

Names & Taxonomyi

Protein namesi
Recommended name:
T-complex protein 1 subunit eta
Short name:
TCP-1-eta
Alternative name(s):
CCT-eta
Gene namesi
Name:Cct7
Synonyms:Ccth
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 6

Organism-specific databases

MGIiMGI:107184. Cct7.

Subcellular locationi

GO - Cellular componenti

  • cell body Source: MGI
  • chaperonin-containing T-complex Source: MGI
  • extracellular exosome Source: MGI
  • microtubule Source: MGI
  • mitochondrion Source: MGI
  • zona pellucida receptor complex Source: MGI

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001283661 – 544T-complex protein 1 subunit etaAdd BLAST544

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei1N-acetylmethionineBy similarity1
Modified residuei67N6-acetyllysineBy similarity1
Modified residuei250N6-acetyllysineCombined sources1
Modified residuei320N6-acetyllysineBy similarity1
Cross-linki430Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity
Modified residuei536Omega-N-methylarginineCombined sources1

Post-translational modificationi

The N-terminus is blocked.

Keywords - PTMi

Acetylation, Isopeptide bond, Methylation, Ubl conjugation

Proteomic databases

EPDiP80313.
PaxDbiP80313.
PeptideAtlasiP80313.
PRIDEiP80313.

2D gel databases

REPRODUCTION-2DPAGEiP80313.

PTM databases

iPTMnetiP80313.
PhosphoSitePlusiP80313.
SwissPalmiP80313.

Expressioni

Gene expression databases

BgeeiENSMUSG00000030007.
CleanExiMM_CCT7.
ExpressionAtlasiP80313. baseline and differential.
GenevisibleiP80313. MM.

Interactioni

Subunit structurei

Heterooligomeric complex of about 850 to 900 kDa that forms two stacked rings, 12 to 16 nm in diameter. Interacts with PACRG (By similarity).By similarity

GO - Molecular functioni

Protein-protein interaction databases

BioGridi198571. 26 interactors.
IntActiP80313. 29 interactors.
MINTiMINT-218099.
STRINGi10090.ENSMUSP00000032078.

Structurei

3D structure databases

ProteinModelPortaliP80313.
SMRiP80313.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the TCP-1 chaperonin family.Curated

Phylogenomic databases

eggNOGiKOG0360. Eukaryota.
COG0459. LUCA.
GeneTreeiENSGT00550000074832.
HOGENOMiHOG000226730.
HOVERGENiHBG001052.
InParanoidiP80313.
KOiK09499.
OMAiQGCPNAK.
OrthoDBiEOG091G05UO.
PhylomeDBiP80313.
TreeFamiTF105641.

Family and domain databases

CDDicd03340. TCP1_eta. 1 hit.
Gene3Di1.10.560.10. 2 hits.
3.50.7.10. 1 hit.
InterProiView protein in InterPro
IPR012720. Chap_CCT_eta.
IPR017998. Chaperone_TCP-1.
IPR002194. Chaperonin_TCP-1_CS.
IPR002423. Cpn60/TCP-1.
IPR027409. GroEL-like_apical_dom.
IPR027413. GROEL-like_equatorial.
PANTHERiPTHR11353:SF139. PTHR11353:SF139. 1 hit.
PfamiView protein in Pfam
PF00118. Cpn60_TCP1. 1 hit.
PRINTSiPR00304. TCOMPLEXTCP1.
SUPFAMiSSF52029. SSF52029. 1 hit.
TIGRFAMsiTIGR02345. chap_CCT_eta. 1 hit.
PROSITEiView protein in PROSITE
PS00750. TCP1_1. 1 hit.
PS00751. TCP1_2. 1 hit.
PS00995. TCP1_3. 1 hit.

Sequencei

Sequence statusi: Complete.

P80313-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MMPTPVILLK EGTDSSQGIP QLVSNISACQ VIAEAVRTTL GPRGMDKLIV
60 70 80 90 100
DGRGKATISN DGATILKLLD VVHPAAKTLV DIAKSQDAEV GDGTTSVTLL
110 120 130 140 150
AAEFLKQVKP YVEEGLHPQI IIRAFRTATQ LAVNKIKEIA VTVKKQDKVE
160 170 180 190 200
QRKMLEKCAM TALSSKLISQ QKVFFAKMVV DAVMMLDELL QLKMIGIKKV
210 220 230 240 250
QGGALEESQL VAGVAFKKTF SYAGFEMQPK KYKNPKIALL NVELELKAEK
260 270 280 290 300
DNAEIRVHTV EDYQAIVDAE WNILYDKLEK IHQSGAKVIL SKLPIGDVAT
310 320 330 340 350
QYFADRDMFC AGRVPEEDLK RTMMACGGSI QTSVNALVPD VLGHCQVFEE
360 370 380 390 400
TQIGGERYNF FTGCPKAKTC TIILRGGAEQ FMEETERSLH DAIMIVRRAI
410 420 430 440 450
KNDSVVAGGG AIEMELSKYL RDYSRTIPGK QQLLIGAYAK ALEIIPRQLC
460 470 480 490 500
DNAGFDATNI LNKLRARHAQ GGMWYGVDIN NENIADNFQA FVWEPAMVRI
510 520 530 540
NALTAASEAA CLIVSVDETI KNPRSTVDPP APSAGRGRGQ ARFH
Length:544
Mass (Da):59,652
Last modified:June 1, 1994 - v1
Checksum:i0BD7AD35456EE677
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z31399 mRNA. Translation: CAA83274.1.
AB022160 Genomic DNA. Translation: BAA81878.1.
BC008255 mRNA. Translation: AAH08255.1.
CCDSiCCDS20295.1.
PIRiS43058.
RefSeqiNP_031664.3. NM_007638.4.
UniGeneiMm.289900.
Mm.456037.

Genome annotation databases

EnsembliENSMUST00000032078; ENSMUSP00000032078; ENSMUSG00000030007.
GeneIDi12468.
KEGGimmu:12468.
UCSCiuc009cpv.2. mouse.

Similar proteinsi

Entry informationi

Entry nameiTCPH_MOUSE
AccessioniPrimary (citable) accession number: P80313
Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 1, 1994
Last sequence update: June 1, 1994
Last modified: August 30, 2017
This is version 155 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families