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P80298 (BLAC_PROVU) Reviewed, UniProtKB/Swiss-Prot

Last modified October 16, 2013. Version 57. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Beta-lactamase

EC=3.5.2.6
Alternative name(s):
Penicillinase
OrganismProteus vulgaris
Taxonomic identifier585 [NCBI]
Taxonomic lineageBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeProteus

Protein attributes

Sequence length271 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Hydrolyzes broad-spectrum beta-lactam antibiotics. Active against cephalosporins.

Catalytic activity

A beta-lactam + H2O = a substituted beta-amino acid.

Subunit structure

Monomer.

Sequence similarities

Belongs to the class-A beta-lactamase family.

Ontologies

Keywords
   Biological processAntibiotic resistance
   Molecular functionHydrolase
   Technical termDirect protein sequencing
Gene Ontology (GO)
   Biological_processbeta-lactam antibiotic catabolic process

Inferred from electronic annotation. Source: InterPro

response to antibiotic

Inferred from electronic annotation. Source: UniProtKB-KW

   Molecular_functionbeta-lactamase activity

Inferred from electronic annotation. Source: UniProtKB-EC

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 271271Beta-lactamase
PRO_0000195441

Regions

Region210 – 2123Substrate binding By similarity

Sites

Active site461Acyl-ester intermediate By similarity

Sequences

Sequence LengthMass (Da)Tools
P80298 [UniParc].

Last modified February 1, 1994. Version 1.
Checksum: C6148E4F2500DDFF

FASTA27129,803
        10         20         30         40         50         60 
NTNNTIEEQL STLEKYSQGR LGVALINTED NSQITYRGEE RFAMASTSKV MAVAAILKES 

        70         80         90        100        110        120 
EKQAGLLDKN IIITKSDLVA YSPITEKHLA TGMSLAQLSA ATLQYSDNTA MNKILDYLGG 

       130        140        150        160        170        180 
PSKVTQFARS INDVTYRLDR KEPELNTAIH GDPRDTTSPI AMAKSLQALT LGDALGQSQR 

       190        200        210        220        230        240 
QQLVTWLKGN TTGDHSIKAG LPKHWIVGDK TGSGDYGTTN DIAVIWPKNH APLILVVYFT 

       250        260        270 
QQEQDAKYRK DIIVKATEIV TKEFSNTSQK K 

« Hide

References

[1]"Chromosomally encoded cephalosporin-hydrolyzing beta-lactamase of Proteus vulgaris RO104 belongs to Ambler's class A."
Peduzzi J., Reynaud A., Barthelemy M., Baron P., Labia R.
Biochim. Biophys. Acta 1207:31-39(1994) [PubMed] [Europe PMC] [Abstract]
Cited for: PROTEIN SEQUENCE.
Strain: RO104.

Cross-references

Sequence databases

PIRS47620.

3D structure databases

ProteinModelPortalP80298.
SMRP80298. Positions 4-267.
ModBaseSearch...
MobiDBSearch...

Chemistry

ChEMBLCHEMBL4782.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Family and domain databases

Gene3D3.40.710.10. 1 hit.
InterProIPR001466. Beta-lactam-related.
IPR012338. Beta-lactam/transpept-like.
IPR000871. Beta-lactam_class-A/D.
IPR023650. Beta-lactam_class-A_AS.
[Graphical view]
PfamPF00144. Beta-lactamase. 1 hit.
[Graphical view]
PRINTSPR00118. BLACTAMASEA.
SUPFAMSSF56601. SSF56601. 1 hit.
PROSITEPS00146. BETA_LACTAMASE_A. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameBLAC_PROVU
AccessionPrimary (citable) accession number: P80298
Entry history
Integrated into UniProtKB/Swiss-Prot: February 1, 1994
Last sequence update: February 1, 1994
Last modified: October 16, 2013
This is version 57 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families