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P80298

- BLAC_PROVU

UniProt

P80298 - BLAC_PROVU

Protein

Beta-lactamase

Gene
N/A
Organism
Proteus vulgaris
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 58 (01 Oct 2014)
      Sequence version 1 (01 Feb 1994)
      Previous versions | rss
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    • Comment

    Functioni

    Hydrolyzes broad-spectrum beta-lactam antibiotics. Active against cephalosporins.

    Catalytic activityi

    A beta-lactam + H2O = a substituted beta-amino acid.PROSITE-ProRule annotation

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei46 – 461Acyl-ester intermediatePROSITE-ProRule annotation

    GO - Molecular functioni

    1. beta-lactamase activity Source: UniProtKB-EC

    GO - Biological processi

    1. beta-lactam antibiotic catabolic process Source: InterPro
    2. response to antibiotic Source: UniProtKB-KW

    Keywords - Molecular functioni

    Hydrolase

    Keywords - Biological processi

    Antibiotic resistance

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Beta-lactamase (EC:3.5.2.6)
    Alternative name(s):
    Penicillinase
    OrganismiProteus vulgaris
    Taxonomic identifieri585 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeProteus

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 271271Beta-lactamasePRO_0000195441Add
    BLAST

    Interactioni

    Subunit structurei

    Monomer.

    Structurei

    3D structure databases

    ProteinModelPortaliP80298.
    SMRiP80298. Positions 4-267.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni210 – 2123Substrate bindingBy similarity

    Sequence similaritiesi

    Belongs to the class-A beta-lactamase family.Curated

    Family and domain databases

    Gene3Di3.40.710.10. 1 hit.
    InterProiIPR001466. Beta-lactam-related.
    IPR012338. Beta-lactam/transpept-like.
    IPR000871. Beta-lactam_class-A/D.
    IPR023650. Beta-lactam_class-A_AS.
    [Graphical view]
    PfamiPF00144. Beta-lactamase. 1 hit.
    [Graphical view]
    PRINTSiPR00118. BLACTAMASEA.
    SUPFAMiSSF56601. SSF56601. 1 hit.
    PROSITEiPS00146. BETA_LACTAMASE_A. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    P80298-1 [UniParc]FASTAAdd to Basket

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    NTNNTIEEQL STLEKYSQGR LGVALINTED NSQITYRGEE RFAMASTSKV    50
    MAVAAILKES EKQAGLLDKN IIITKSDLVA YSPITEKHLA TGMSLAQLSA 100
    ATLQYSDNTA MNKILDYLGG PSKVTQFARS INDVTYRLDR KEPELNTAIH 150
    GDPRDTTSPI AMAKSLQALT LGDALGQSQR QQLVTWLKGN TTGDHSIKAG 200
    LPKHWIVGDK TGSGDYGTTN DIAVIWPKNH APLILVVYFT QQEQDAKYRK 250
    DIIVKATEIV TKEFSNTSQK K 271
    Length:271
    Mass (Da):29,803
    Last modified:February 1, 1994 - v1
    Checksum:iC6148E4F2500DDFF
    GO

    Sequence databases

    PIRiS47620.

    Cross-referencesi

    Sequence databases

    PIRi S47620.

    3D structure databases

    ProteinModelPortali P80298.
    SMRi P80298. Positions 4-267.
    ModBasei Search...
    MobiDBi Search...

    Chemistry

    ChEMBLi CHEMBL4782.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Family and domain databases

    Gene3Di 3.40.710.10. 1 hit.
    InterProi IPR001466. Beta-lactam-related.
    IPR012338. Beta-lactam/transpept-like.
    IPR000871. Beta-lactam_class-A/D.
    IPR023650. Beta-lactam_class-A_AS.
    [Graphical view ]
    Pfami PF00144. Beta-lactamase. 1 hit.
    [Graphical view ]
    PRINTSi PR00118. BLACTAMASEA.
    SUPFAMi SSF56601. SSF56601. 1 hit.
    PROSITEi PS00146. BETA_LACTAMASE_A. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Chromosomally encoded cephalosporin-hydrolyzing beta-lactamase of Proteus vulgaris RO104 belongs to Ambler's class A."
      Peduzzi J., Reynaud A., Barthelemy M., Baron P., Labia R.
      Biochim. Biophys. Acta 1207:31-39(1994) [PubMed] [Europe PMC] [Abstract]
      Cited for: PROTEIN SEQUENCE.
      Strain: RO104.

    Entry informationi

    Entry nameiBLAC_PROVU
    AccessioniPrimary (citable) accession number: P80298
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: February 1, 1994
    Last sequence update: February 1, 1994
    Last modified: October 1, 2014
    This is version 58 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Direct protein sequencing

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3