Reviewed, UniProtKB/Swiss-Prot P80297 (MT1X_HUMAN)

Names and origin

Protein names

Recommended name:
    Metallothionein-1X
      Short name=MT-1X
Alternative name(s):
    Metallothionein-IX
      Short name=MT-IX

Gene names

Name:

MT1X

Organism

Homo sapiens (Human) [Complete proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

Protein attributes

Sequence length	61 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Evidence at protein level.

General annotation (Comments)

Function	Metallothioneins have a high content of cysteine residues that bind various heavy metals; these proteins are transcriptionally regulated by both heavy metals and glucocorticoids.
Subunit structure	Monomer.
Domain	Class I metallothioneins contain 2 metal-binding domains: four divalent ions are chelated within cluster A of the alpha domain and are coordinated via cysteinyl thiolate bridges to 11 cysteine ligands. Cluster B, the corresponding region within the beta domain, can ligate three divalent ions to 9 cysteines.
Sequence similarities	Belongs to the metallothionein superfamily. Type 1 family.

Ontologies

Keywords
Ligand	Cadmium Copper Metal-binding Metal-thiolate cluster Zinc
PTM	Acetylation
Technical term	Complete proteome Direct protein sequencing
Gene Ontology (GO)
Biological process	response to metal ion Traceable author statement. Source: ProtInc
Molecular function	cadmium ion binding Inferred from electronic annotation. Source: UniProtKB-KW copper ion binding Inferred from electronic annotation. Source: UniProtKB-KW zinc ion binding Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 61	61	Metallothionein-1X		PRO_0000197243
Regions
	Region	1 – 29	29	Beta
	Region	30 – 61	32	Alpha
Sites
	Metal binding	5	1	Cluster B
	Metal binding	7	1	Cluster B
	Metal binding	13	1	Cluster B
	Metal binding	15	1	Cluster B
	Metal binding	19	1	Cluster B
	Metal binding	21	1	Cluster B
	Metal binding	24	1	Cluster B
	Metal binding	26	1	Cluster B
	Metal binding	29	1	Cluster B
	Metal binding	33	1	Cluster A
	Metal binding	34	1	Cluster A
	Metal binding	36	1	Cluster A
	Metal binding	37	1	Cluster A
	Metal binding	41	1	Cluster A
	Metal binding	44	1	Cluster A
	Metal binding	48	1	Cluster A
	Metal binding	50	1	Cluster A
	Metal binding	57	1	Cluster A
	Metal binding	59	1	Cluster A
	Metal binding	60	1	Cluster A
Amino acid modifications
	Modified residue	1	1	N-acetylmethionine Ref.5

Sequences

	Sequence		Length	Mass (Da)
	P80297-1 [UniParc]. Last modified February 1, 1994. Version 1. Checksum: 381966F942E986B2	FASTA	61	6,068
	10 20 30 40 50 60 MDPNCSCSPV GSCACAGSCK CKECKCTSCK KSCCSCCPVG CAKCAQGCIC KGTSDKCSCC A

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	Soumillion A., van Weyenbergh J., de Ley M. Submitted (DEC-1993) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [MRNA]. Tissue: Liver.
[2]	Hunziker P.E. Submitted (NOV-1993) to UniProtKB Cited for: PROTEIN SEQUENCE. Tissue: Liver.
[3]	"Characterisation of six additional human metallothionein genes." Stennard F.A., Holloway A.F., Hamilton J., West A.K. Biochim. Biophys. Acta 1218:357-365(1994) [PubMed: 8049263] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]. Tissue: Placenta.
[4]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Colon.
[5]	"Induction by zinc of specific metallothionein isoforms in human monocytes." Pauwels M., van Weyenbergh J., Soumillion A., Proost P., Ley M. Eur. J. Biochem. 220:105-110(1994) [PubMed: 8119276] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 1-31.

Cross-references

Sequence databases
EMBLGenBankDDBJ	X76717 mRNA. Translation: CAA54136.1. X65607 Genomic DNA. Translation: CAA46557.1. BC032338 mRNA. Translation: AAH32338.1. S68956 mRNA. Translation: AAB30084.1.
IPI	IPI00008753.
PIR	S47652.
RefSeq	NP_005943.1.
UniGene	Hs.374950
3D structure databases
HSSP	HSSP built from PDB template 1MHU based on UniProtKB P02795.
SMR	P80297. Positions 1-61.
ModBase	Search...
Protein-protein interaction databases
STRING	P80297.
PTM databases
PhosphoSite	P80297.
Proteomic databases
PRIDE	P80297.
Genome annotation databases
Ensembl	ENST00000290704; ENSP00000290704; ENSG00000187193; Homo sapiens. [Genome view] ENST00000394485; ENSP00000377995; ENSG00000187193; Homo sapiens. [Genome view] ENST00000394490; ENSP00000378000; ENSG00000187193; Homo sapiens. [Genome view]
GeneID	4501.
KEGG	hsa:4501.
UCSC	uc002ejy.1. human.
Organism-specific databases
CTD	4501.
GeneCards	GC16P055267.
H-InvDB	HIX0021646.
HGNC	HGNC:7405. MT1X.
MIM	156359. gene.
PharmGKB	PA31213.
GenAtlas	Search...
Phylogenomic databases
HOGENOM	P80297.
HOVERGEN	P80297.
Gene expression databases
ArrayExpress	P80297.
Bgee	P80297.
CleanEx	HS_MT1X.
Genevestigator	P80297.
GermOnline	ENSG00000187193. Homo sapiens.
Family and domain databases
InterPro	IPR003019. Metallothionein_sfam_euk. IPR000006. Metallothionein_vert. IPR018064. Metallothionein_vert_metal_BS. [Graphical view]
Gene3D	G3DSA:4.10.10.10. Metallothionein_vert. 1 hit.
PANTHER	PTHR23299. Metallothionein_vert. 1 hit.
Pfam	PF00131. Metallothio. 1 hit. [Graphical view]
PRINTS	PR00860. MTVERTEBRATE.
PROSITE	PS00203. METALLOTHIONEIN_VRT. 1 hit. [Graphical view]
ProtoNet	Search...
Other Resources
NextBio	17402.
SOURCE	Search...

Entry information

Entry name

MT1X_HUMAN

Accession

Primary (citable) accession number: P80297

Entry history

Integrated into UniProtKB/Swiss-Prot:	February 1, 1994
Last sequence update:	February 1, 1994
Last modified:	October 13, 2009
This is version 80 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HPI (Human Proteome Initiative)

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.