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P80297

- MT1X_HUMAN

UniProt

P80297 - MT1X_HUMAN

Protein

Metallothionein-1X

Gene

MT1X

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
  1. Functioni

    Metallothioneins have a high content of cysteine residues that bind various heavy metals; these proteins are transcriptionally regulated by both heavy metals and glucocorticoids.

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Metal bindingi5 – 51Divalent metal cation; cluster B
    Metal bindingi7 – 71Divalent metal cation; cluster B
    Metal bindingi13 – 131Divalent metal cation; cluster B
    Metal bindingi15 – 151Divalent metal cation; cluster B
    Metal bindingi19 – 191Divalent metal cation; cluster B
    Metal bindingi21 – 211Divalent metal cation; cluster B
    Metal bindingi24 – 241Divalent metal cation; cluster B
    Metal bindingi26 – 261Divalent metal cation; cluster B
    Metal bindingi29 – 291Divalent metal cation; cluster B
    Metal bindingi33 – 331Divalent metal cation; cluster A
    Metal bindingi34 – 341Divalent metal cation; cluster A
    Metal bindingi36 – 361Divalent metal cation; cluster A
    Metal bindingi37 – 371Divalent metal cation; cluster A
    Metal bindingi41 – 411Divalent metal cation; cluster A
    Metal bindingi44 – 441Divalent metal cation; cluster A
    Metal bindingi48 – 481Divalent metal cation; cluster A
    Metal bindingi50 – 501Divalent metal cation; cluster A
    Metal bindingi57 – 571Divalent metal cation; cluster A
    Metal bindingi59 – 591Divalent metal cation; cluster A
    Metal bindingi60 – 601Divalent metal cation; cluster A

    GO - Molecular functioni

    1. metal ion binding Source: ProtInc
    2. zinc ion binding Source: UniProtKB

    GO - Biological processi

    1. cellular response to cadmium ion Source: UniProtKB
    2. cellular response to erythropoietin Source: UniProtKB
    3. cellular response to zinc ion Source: UniProtKB
    4. negative regulation of growth Source: UniProtKB
    5. response to metal ion Source: ProtInc

    Keywords - Ligandi

    Cadmium, Copper, Metal-binding, Metal-thiolate cluster, Zinc

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Metallothionein-1X
    Short name:
    MT-1X
    Alternative name(s):
    Metallothionein-IX
    Short name:
    MT-IX
    Gene namesi
    Name:MT1X
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 16

    Organism-specific databases

    HGNCiHGNC:7405. MT1X.

    Subcellular locationi

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB
    2. nucleus Source: UniProtKB
    3. perinuclear region of cytoplasm Source: UniProtKB

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA31213.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 6161Metallothionein-1XPRO_0000197243Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei1 – 11N-acetylmethionine2 Publications

    Keywords - PTMi

    Acetylation

    Proteomic databases

    MaxQBiP80297.
    PaxDbiP80297.
    PRIDEiP80297.

    PTM databases

    PhosphoSiteiP80297.

    Expressioni

    Gene expression databases

    BgeeiP80297.
    CleanExiHS_MT1X.
    GenevestigatoriP80297.

    Interactioni

    Subunit structurei

    Monomer.

    Protein-protein interaction databases

    BioGridi110607. 6 interactions.
    STRINGi9606.ENSP00000377995.

    Structurei

    3D structure databases

    ProteinModelPortaliP80297.
    SMRiP80297. Positions 1-61.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni1 – 2929BetaAdd
    BLAST
    Regioni30 – 6132AlphaAdd
    BLAST

    Domaini

    Class I metallothioneins contain 2 metal-binding domains: four divalent ions are chelated within cluster A of the alpha domain and are coordinated via cysteinyl thiolate bridges to 11 cysteine ligands. Cluster B, the corresponding region within the beta domain, can ligate three divalent ions to 9 cysteines.

    Sequence similaritiesi

    Phylogenomic databases

    eggNOGiNOG327133.
    HOGENOMiHOG000236262.
    HOVERGENiHBG094464.
    KOiK14739.
    OMAiETECCIS.
    OrthoDBiEOG7PZS1X.
    PhylomeDBiP80297.
    TreeFamiTF336054.

    Family and domain databases

    Gene3Di4.10.10.10. 1 hit.
    InterProiIPR017854. Metalthion_dom.
    IPR023587. Metalthion_dom_vert.
    IPR003019. Metalthion_sfam_euk.
    IPR000006. Metalthion_vert.
    IPR018064. Metalthion_vert_metal_BS.
    [Graphical view]
    PANTHERiPTHR23299. PTHR23299. 1 hit.
    PfamiPF00131. Metallothio. 1 hit.
    [Graphical view]
    PRINTSiPR00860. MTVERTEBRATE.
    SUPFAMiSSF57868. SSF57868. 1 hit.
    PROSITEiPS00203. METALLOTHIONEIN_VRT. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    P80297-1 [UniParc]FASTAAdd to Basket

    « Hide

    MDPNCSCSPV GSCACAGSCK CKECKCTSCK KSCCSCCPVG CAKCAQGCIC   50
    KGTSDKCSCC A 61
    Length:61
    Mass (Da):6,068
    Last modified:February 1, 1994 - v1
    Checksum:i381966F942E986B2
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X76717 mRNA. Translation: CAA54136.1.
    X65607 Genomic DNA. Translation: CAA46557.1.
    AC026461 Genomic DNA. No translation available.
    BC032338 mRNA. Translation: AAH32338.1.
    S68956 mRNA. Translation: AAB30084.1.
    CCDSiCCDS10768.1.
    PIRiS47652.
    RefSeqiNP_005943.1. NM_005952.3.
    UniGeneiHs.374950.

    Genome annotation databases

    EnsembliENST00000394485; ENSP00000377995; ENSG00000187193.
    GeneIDi4501.
    KEGGihsa:4501.
    UCSCiuc002ejy.3. human.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X76717 mRNA. Translation: CAA54136.1 .
    X65607 Genomic DNA. Translation: CAA46557.1 .
    AC026461 Genomic DNA. No translation available.
    BC032338 mRNA. Translation: AAH32338.1 .
    S68956 mRNA. Translation: AAB30084.1 .
    CCDSi CCDS10768.1.
    PIRi S47652.
    RefSeqi NP_005943.1. NM_005952.3.
    UniGenei Hs.374950.

    3D structure databases

    ProteinModelPortali P80297.
    SMRi P80297. Positions 1-61.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 110607. 6 interactions.
    STRINGi 9606.ENSP00000377995.

    PTM databases

    PhosphoSitei P80297.

    Proteomic databases

    MaxQBi P80297.
    PaxDbi P80297.
    PRIDEi P80297.

    Protocols and materials databases

    DNASUi 4501.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000394485 ; ENSP00000377995 ; ENSG00000187193 .
    GeneIDi 4501.
    KEGGi hsa:4501.
    UCSCi uc002ejy.3. human.

    Organism-specific databases

    CTDi 4501.
    GeneCardsi GC16P056719.
    HGNCi HGNC:7405. MT1X.
    MIMi 156359. gene.
    neXtProti NX_P80297.
    PharmGKBi PA31213.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG327133.
    HOGENOMi HOG000236262.
    HOVERGENi HBG094464.
    KOi K14739.
    OMAi ETECCIS.
    OrthoDBi EOG7PZS1X.
    PhylomeDBi P80297.
    TreeFami TF336054.

    Miscellaneous databases

    ChiTaRSi MT1X. human.
    GeneWikii MT1X.
    GenomeRNAii 4501.
    NextBioi 17402.
    PROi P80297.
    SOURCEi Search...

    Gene expression databases

    Bgeei P80297.
    CleanExi HS_MT1X.
    Genevestigatori P80297.

    Family and domain databases

    Gene3Di 4.10.10.10. 1 hit.
    InterProi IPR017854. Metalthion_dom.
    IPR023587. Metalthion_dom_vert.
    IPR003019. Metalthion_sfam_euk.
    IPR000006. Metalthion_vert.
    IPR018064. Metalthion_vert_metal_BS.
    [Graphical view ]
    PANTHERi PTHR23299. PTHR23299. 1 hit.
    Pfami PF00131. Metallothio. 1 hit.
    [Graphical view ]
    PRINTSi PR00860. MTVERTEBRATE.
    SUPFAMi SSF57868. SSF57868. 1 hit.
    PROSITEi PS00203. METALLOTHIONEIN_VRT. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Soumillion A., van Weyenbergh J., de Ley M.
      Submitted (DEC-1993) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Tissue: Liver.
    2. Hunziker P.E.
      Submitted (NOV-1993) to UniProtKB
      Cited for: PROTEIN SEQUENCE.
      Tissue: Liver.
    3. "Characterisation of six additional human metallothionein genes."
      Stennard F.A., Holloway A.F., Hamilton J., West A.K.
      Biochim. Biophys. Acta 1218:357-365(1994) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
      Tissue: Placenta.
    4. "The sequence and analysis of duplication-rich human chromosome 16."
      Martin J., Han C., Gordon L.A., Terry A., Prabhakar S., She X., Xie G., Hellsten U., Chan Y.M., Altherr M., Couronne O., Aerts A., Bajorek E., Black S., Blumer H., Branscomb E., Brown N.C., Bruno W.J.
      , Buckingham J.M., Callen D.F., Campbell C.S., Campbell M.L., Campbell E.W., Caoile C., Challacombe J.F., Chasteen L.A., Chertkov O., Chi H.C., Christensen M., Clark L.M., Cohn J.D., Denys M., Detter J.C., Dickson M., Dimitrijevic-Bussod M., Escobar J., Fawcett J.J., Flowers D., Fotopulos D., Glavina T., Gomez M., Gonzales E., Goodstein D., Goodwin L.A., Grady D.L., Grigoriev I., Groza M., Hammon N., Hawkins T., Haydu L., Hildebrand C.E., Huang W., Israni S., Jett J., Jewett P.B., Kadner K., Kimball H., Kobayashi A., Krawczyk M.-C., Leyba T., Longmire J.L., Lopez F., Lou Y., Lowry S., Ludeman T., Manohar C.F., Mark G.A., McMurray K.L., Meincke L.J., Morgan J., Moyzis R.K., Mundt M.O., Munk A.C., Nandkeshwar R.D., Pitluck S., Pollard M., Predki P., Parson-Quintana B., Ramirez L., Rash S., Retterer J., Ricke D.O., Robinson D.L., Rodriguez A., Salamov A., Saunders E.H., Scott D., Shough T., Stallings R.L., Stalvey M., Sutherland R.D., Tapia R., Tesmer J.G., Thayer N., Thompson L.S., Tice H., Torney D.C., Tran-Gyamfi M., Tsai M., Ulanovsky L.E., Ustaszewska A., Vo N., White P.S., Williams A.L., Wills P.L., Wu J.-R., Wu K., Yang J., DeJong P., Bruce D., Doggett N.A., Deaven L., Schmutz J., Grimwood J., Richardson P., Rokhsar D.S., Eichler E.E., Gilna P., Lucas S.M., Myers R.M., Rubin E.M., Pennacchio L.A.
      Nature 432:988-994(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Colon.
    6. "Induction by zinc of specific metallothionein isoforms in human monocytes."
      Pauwels M., van Weyenbergh J., Soumillion A., Proost P., Ley M.
      Eur. J. Biochem. 220:105-110(1994) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 1-31.
    7. "Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach."
      Gauci S., Helbig A.O., Slijper M., Krijgsveld J., Heck A.J., Mohammed S.
      Anal. Chem. 81:4493-4501(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT MET-1, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

    Entry informationi

    Entry nameiMT1X_HUMAN
    AccessioniPrimary (citable) accession number: P80297
    Secondary accession number(s): A8MUC7
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: February 1, 1994
    Last sequence update: February 1, 1994
    Last modified: October 1, 2014
    This is version 122 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Direct protein sequencing, Reference proteome

    Documents

    1. Human chromosome 16
      Human chromosome 16: entries, gene names and cross-references to MIM
    2. Metallothioneins
      Classification of metallothioneins and list of entries
    3. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    4. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3