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P80294

- MT1H_HUMAN

UniProt

P80294 - MT1H_HUMAN

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Protein

Metallothionein-1H

Gene

MT1H

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli

Functioni

Metallothioneins have a high content of cysteine residues that bind various heavy metals; these proteins are transcriptionally regulated by both heavy metals and glucocorticoids.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi5 – 51Divalent metal cation; cluster B
Metal bindingi7 – 71Divalent metal cation; cluster B
Metal bindingi13 – 131Divalent metal cation; cluster B
Metal bindingi15 – 151Divalent metal cation; cluster B
Metal bindingi19 – 191Divalent metal cation; cluster B
Metal bindingi21 – 211Divalent metal cation; cluster B
Metal bindingi24 – 241Divalent metal cation; cluster B
Metal bindingi26 – 261Divalent metal cation; cluster B
Metal bindingi29 – 291Divalent metal cation; cluster B
Metal bindingi33 – 331Divalent metal cation; cluster A
Metal bindingi34 – 341Divalent metal cation; cluster A
Metal bindingi36 – 361Divalent metal cation; cluster A
Metal bindingi37 – 371Divalent metal cation; cluster A
Metal bindingi41 – 411Divalent metal cation; cluster A
Metal bindingi44 – 441Divalent metal cation; cluster A
Metal bindingi48 – 481Divalent metal cation; cluster A
Metal bindingi50 – 501Divalent metal cation; cluster A
Metal bindingi57 – 571Divalent metal cation; cluster A
Metal bindingi59 – 591Divalent metal cation; cluster A
Metal bindingi60 – 601Divalent metal cation; cluster A

GO - Molecular functioni

  1. zinc ion binding Source: UniProtKB

GO - Biological processi

  1. cellular response to cadmium ion Source: UniProtKB
  2. cellular response to zinc ion Source: UniProtKB
  3. negative regulation of growth Source: UniProtKB
Complete GO annotation...

Keywords - Ligandi

Cadmium, Copper, Metal-binding, Metal-thiolate cluster, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Metallothionein-1H
Short name:
MT-1H
Alternative name(s):
Metallothionein-0
Short name:
MT-0
Metallothionein-IH
Short name:
MT-IH
Gene namesi
Name:MT1H
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 16

Organism-specific databases

HGNCiHGNC:7400. MT1H.

Subcellular locationi

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB
  2. nucleus Source: UniProtKB
  3. perinuclear region of cytoplasm Source: UniProtKB
Complete GO annotation...

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA31205.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 6161Metallothionein-1HPRO_0000197239Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei1 – 11N-acetylmethionine2 Publications

Keywords - PTMi

Acetylation

Proteomic databases

PaxDbiP80294.
PRIDEiP80294.

Expressioni

Gene expression databases

BgeeiP80294.
CleanExiHS_MT1H.
ExpressionAtlasiP80294. baseline and differential.
GenevestigatoriP80294.

Organism-specific databases

HPAiCAB032277.

Interactioni

Subunit structurei

Monomer.

Binary interactionsi

WithEntry#Exp.IntActNotes
SPINK7P580623EBI-296567,EBI-1182445

Protein-protein interaction databases

BioGridi110602. 2 interactions.
IntActiP80294. 2 interactions.
STRINGi9606.ENSP00000330587.

Structurei

3D structure databases

ProteinModelPortaliP80294.
SMRiP80294. Positions 1-61.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni1 – 2929BetaAdd
BLAST
Regioni30 – 6132AlphaAdd
BLAST

Domaini

Class I metallothioneins contain 2 metal-binding domains: four divalent ions are chelated within cluster A of the alpha domain and are coordinated via cysteinyl thiolate bridges to 11 cysteine ligands. Cluster B, the corresponding region within the beta domain, can ligate three divalent ions to 9 cysteines.

Sequence similaritiesi

Phylogenomic databases

eggNOGiNOG138665.
GeneTreeiENSGT00730000110883.
HOGENOMiHOG000236262.
HOVERGENiHBG094463.
InParanoidiP80294.
KOiK14739.
OMAiFLLIRIG.
TreeFamiTF336054.

Family and domain databases

Gene3Di4.10.10.10. 1 hit.
InterProiIPR017854. Metalthion_dom.
IPR023587. Metalthion_dom_vert.
IPR003019. Metalthion_sfam_euk.
IPR000006. Metalthion_vert.
IPR018064. Metalthion_vert_metal_BS.
[Graphical view]
PANTHERiPTHR23299. PTHR23299. 1 hit.
PfamiPF00131. Metallothio. 1 hit.
[Graphical view]
PRINTSiPR00860. MTVERTEBRATE.
SUPFAMiSSF57868. SSF57868. 1 hit.
PROSITEiPS00203. METALLOTHIONEIN_VRT. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P80294-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MDPNCSCEAG GSCACAGSCK CKKCKCTSCK KSCCSCCPLG CAKCAQGCIC
60
KGASEKCSCC A
Length:61
Mass (Da):6,039
Last modified:February 1, 1994 - v1
Checksum:i03D866E4F437A2CC
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
X64834 Genomic DNA. Translation: CAA46046.1.
X64177 mRNA. Translation: CAA45516.1.
BT007171 mRNA. Translation: AAP35835.1.
CH471092 Genomic DNA. Translation: EAW82884.1.
BC008408 mRNA. Translation: AAH08408.1.
BC059780 mRNA. Translation: AAH59780.1.
BC146930 mRNA. Translation: AAI46931.1.
BC146934 mRNA. Translation: AAI46935.1.
S68948 mRNA. Translation: AAB30081.1.
CCDSiCCDS10767.1.
PIRiS47651.
RefSeqiNP_005942.1. NM_005951.2.
UniGeneiHs.438462.

Genome annotation databases

EnsembliENST00000332374; ENSP00000330587; ENSG00000205358.
GeneIDi4496.
KEGGihsa:4496.
UCSCiuc002ejw.3. human.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
X64834 Genomic DNA. Translation: CAA46046.1 .
X64177 mRNA. Translation: CAA45516.1 .
BT007171 mRNA. Translation: AAP35835.1 .
CH471092 Genomic DNA. Translation: EAW82884.1 .
BC008408 mRNA. Translation: AAH08408.1 .
BC059780 mRNA. Translation: AAH59780.1 .
BC146930 mRNA. Translation: AAI46931.1 .
BC146934 mRNA. Translation: AAI46935.1 .
S68948 mRNA. Translation: AAB30081.1 .
CCDSi CCDS10767.1.
PIRi S47651.
RefSeqi NP_005942.1. NM_005951.2.
UniGenei Hs.438462.

3D structure databases

ProteinModelPortali P80294.
SMRi P80294. Positions 1-61.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 110602. 2 interactions.
IntActi P80294. 2 interactions.
STRINGi 9606.ENSP00000330587.

Proteomic databases

PaxDbi P80294.
PRIDEi P80294.

Protocols and materials databases

DNASUi 4496.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000332374 ; ENSP00000330587 ; ENSG00000205358 .
GeneIDi 4496.
KEGGi hsa:4496.
UCSCi uc002ejw.3. human.

Organism-specific databases

CTDi 4496.
GeneCardsi GC16P056703.
H-InvDB HIX0028598.
HGNCi HGNC:7400. MT1H.
HPAi CAB032277.
MIMi 156354. gene.
neXtProti NX_P80294.
PharmGKBi PA31205.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG138665.
GeneTreei ENSGT00730000110883.
HOGENOMi HOG000236262.
HOVERGENi HBG094463.
InParanoidi P80294.
KOi K14739.
OMAi FLLIRIG.
TreeFami TF336054.

Miscellaneous databases

GeneWikii MT1H.
GenomeRNAii 4496.
NextBioi 17387.
PROi P80294.
SOURCEi Search...

Gene expression databases

Bgeei P80294.
CleanExi HS_MT1H.
ExpressionAtlasi P80294. baseline and differential.
Genevestigatori P80294.

Family and domain databases

Gene3Di 4.10.10.10. 1 hit.
InterProi IPR017854. Metalthion_dom.
IPR023587. Metalthion_dom_vert.
IPR003019. Metalthion_sfam_euk.
IPR000006. Metalthion_vert.
IPR018064. Metalthion_vert_metal_BS.
[Graphical view ]
PANTHERi PTHR23299. PTHR23299. 1 hit.
Pfami PF00131. Metallothio. 1 hit.
[Graphical view ]
PRINTSi PR00860. MTVERTEBRATE.
SUPFAMi SSF57868. SSF57868. 1 hit.
PROSITEi PS00203. METALLOTHIONEIN_VRT. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. Hunziker P.E.
    Submitted (NOV-1993) to UniProtKB
    Cited for: PROTEIN SEQUENCE, ACETYLATION AT MET-1.
    Tissue: Liver.
  2. "Cloning and specific polymerised-chain-reaction amplification of a third charge-separable human metallothionein isoform."
    Soumillion A., van Damme J., de Ley M.
    Eur. J. Biochem. 209:999-1004(1992) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], PROTEIN SEQUENCE OF 3-22.
    Tissue: Embryonic liver.
  3. "Characterisation of six additional human metallothionein genes."
    Stennard F.A., Holloway A.F., Hamilton J., West A.K.
    Biochim. Biophys. Acta 1218:357-365(1994) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  4. "Cloning of human full-length CDSs in BD Creator(TM) system donor vector."
    Kalnine N., Chen X., Rolfs A., Halleck A., Hines L., Eisenstein S., Koundinya M., Raphael J., Moreira D., Kelley T., LaBaer J., Lin Y., Phelan M., Farmer A.
    Submitted (MAY-2003) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
  5. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  6. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Brain, Pancreas and Prostate.
  7. "Induction by zinc of specific metallothionein isoforms in human monocytes."
    Pauwels M., van Weyenbergh J., Soumillion A., Proost P., Ley M.
    Eur. J. Biochem. 220:105-110(1994) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 1-31, PROTEIN SEQUENCE OF 1-30.
    Tissue: Monocyte.

Entry informationi

Entry nameiMT1H_HUMAN
AccessioniPrimary (citable) accession number: P80294
Secondary accession number(s): B2RUY6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 1, 1994
Last sequence update: February 1, 1994
Last modified: October 29, 2014
This is version 132 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Human chromosome 16
    Human chromosome 16: entries, gene names and cross-references to MIM
  2. Metallothioneins
    Classification of metallothioneins and list of entries
  3. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  4. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3