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Protein

Superoxide dismutase [Mn/Fe]

Gene

sodA

Organism
Propionibacterium freudenreichii subsp. shermanii
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Destroys superoxide anion radicals which are normally produced within the cells and which are toxic to biological systems.

Catalytic activityi

2 superoxide + 2 H+ = O2 + H2O2.

Cofactori

Mn2+, Fe2+Note: Binds 1 Mn2+ or Fe2+ ion per subunit.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi27Manganese or iron1
Metal bindingi75Manganese or iron1
Metal bindingi161Manganese or iron1
Metal bindingi165Manganese or iron1

GO - Molecular functioni

Keywordsi

Molecular functionOxidoreductase
LigandIron, Manganese, Metal-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Superoxide dismutase [Mn/Fe] (EC:1.15.1.1)
Gene namesi
Name:sodA
OrganismiPropionibacterium freudenreichii subsp. shermanii
Taxonomic identifieri1752 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaPropionibacterialesPropionibacteriaceaePropionibacterium

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001600661 – 201Superoxide dismutase [Mn/Fe]Add BLAST201

Interactioni

Subunit structurei

Homotetramer.

Structurei

Secondary structure

1201
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Turni12 – 18Combined sources7
Helixi21 – 29Combined sources9
Helixi31 – 52Combined sources22
Helixi58 – 80Combined sources23
Helixi94 – 104Combined sources11
Helixi107 – 119Combined sources13
Beta strandi122 – 132Combined sources11
Turni133 – 136Combined sources4
Beta strandi137 – 144Combined sources8
Turni145 – 147Combined sources3
Beta strandi155 – 161Combined sources7
Helixi164 – 166Combined sources3
Helixi168 – 171Combined sources4
Helixi175 – 183Combined sources9
Helixi188 – 197Combined sources10
Turni198 – 200Combined sources3

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1AR4X-ray1.90A/B1-201[»]
1AR5X-ray1.60A/B1-201[»]
1AVMX-ray1.55A/B1-201[»]
1BS3X-ray1.55A/B1-201[»]
1BSMX-ray1.35A/B1-201[»]
1BT8X-ray1.85A/B1-201[»]
ProteinModelPortaliP80293
SMRiP80293
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP80293

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiENOG4105CK4 Bacteria
COG0605 LUCA

Family and domain databases

Gene3Di1.10.287.990, 1 hit
2.40.500.20, 1 hit
InterProiView protein in InterPro
IPR001189 Mn/Fe_SOD
IPR019833 Mn/Fe_SOD_BS
IPR019832 Mn/Fe_SOD_C
IPR019831 Mn/Fe_SOD_N
IPR036324 Mn/Fe_SOD_N_sf
IPR036314 SOD_C_sf
PfamiView protein in Pfam
PF02777 Sod_Fe_C, 1 hit
PF00081 Sod_Fe_N, 1 hit
PIRSFiPIRSF000349 SODismutase, 1 hit
PRINTSiPR01703 MNSODISMTASE
SUPFAMiSSF46609 SSF46609, 1 hit
SSF54719 SSF54719, 1 hit
PROSITEiView protein in PROSITE
PS00088 SOD_MN, 1 hit

Sequencei

Sequence statusi: Complete.

P80293-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
AVYTLPELPY DYSALEPYIS GEIMELHHDK HHKAYVDGAN TALDKLAEAR
60 70 80 90 100
DKADFGAINK LEKDLAFNLA GHVNHSVFWK NMAPKGSAPE RPTDELGAAI
110 120 130 140 150
DEFFGSFDNM KAQFTAAATG IQGSGWASLV WDPLGKRINT LQFYDHQNNL
160 170 180 190 200
PAGSIPLLQL DMWEHAFYLQ YKNVKGDYVK SWWNVVNWDD VALRFSEARV

A
Length:201
Mass (Da):22,633
Last modified:February 1, 1994 - v1
Checksum:i5BFEF424C7B32E00
GO

Sequence databases

PIRiJC4396

Similar proteinsi

Entry informationi

Entry nameiSODM_PROFR
AccessioniPrimary (citable) accession number: P80293
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 1, 1994
Last sequence update: February 1, 1994
Last modified: March 28, 2018
This is version 94 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Direct protein sequencing

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families
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