Reviewed,
UniProtKB/Swiss-Prot P80290 (MT2C_RABIT)
Last modified
November 24, 2009.
Version 50.
History...
Clusters with 100%,
90%,
50% identity |
 Documents (2) |
 Third-party data |
 Customize display | text xml rdf/xml gff fasta |
Names and origin
| Protein names | Recommended name: Metallothionein-2C Short name=MT-2C Alternative name(s): Metallothionein-IIC Short name=MT-IIC |
| Organism | Oryctolagus cuniculus (Rabbit) |
| Taxonomic identifier | 9986 [NCBI] |
| Taxonomic lineage | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Lagomorpha › Leporidae › Oryctolagus |
Protein attributes
| Sequence length | 62 AA. |
| Sequence status | Complete. |
| Sequence processing | The displayed sequence is not processed. |
| Protein existence | Evidence at protein level. |
General annotation (Comments)
| Function | Metallothioneins have a high content of cysteine residues that bind various heavy metals; these proteins are transcriptionally regulated by both heavy metals and glucocorticoids. |
| Subunit structure | Monomer. |
| Domain | Class I metallothioneins contain 2 metal-binding domains: four divalent ions are chelated within cluster A of the alpha domain and are coordinated via cysteinyl thiolate bridges to 11 cysteine ligands. Cluster B, the corresponding region within the beta domain, can ligate three divalent ions to 9 cysteines. |
| Sequence similarities | Belongs to the metallothionein superfamily. Type 1 family. |
Ontologies
| Keywords | |
|---|---|
| Ligand | Cadmium Copper Metal-binding Metal-thiolate cluster Zinc |
| PTM | Acetylation |
| Technical term | Direct protein sequencing |
| Gene Ontology (GO) | |
| Molecular function | cadmium ion binding Inferred from electronic annotation. Source: UniProtKB-KW copper ion bindingInferred from electronic annotation. Source: UniProtKB-KW zinc ion bindingInferred from electronic annotation. Source: UniProtKB-KW |
| Complete GO annotation... | |
Sequence annotation (Features)
| Feature key | Position(s) | Length | Description | Graphical view | Feature identifier | ||||
Molecule processing | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Chain | 1 – 62 | 62 | Metallothionein-2C | PRO_0000197218 | |||||
Regions | |||||||||
| Region | 1 – 30 | 30 | Beta | ||||||
| Region | 31 – 62 | 32 | Alpha | ||||||
Sites | |||||||||
| Metal binding | 5 | 1 | Cluster B | ||||||
| Metal binding | 7 | 1 | Cluster B | ||||||
| Metal binding | 14 | 1 | Cluster B | ||||||
| Metal binding | 16 | 1 | Cluster B | ||||||
| Metal binding | 20 | 1 | Cluster B | ||||||
| Metal binding | 22 | 1 | Cluster B | ||||||
| Metal binding | 25 | 1 | Cluster B | ||||||
| Metal binding | 27 | 1 | Cluster B | ||||||
| Metal binding | 30 | 1 | Cluster B | ||||||
| Metal binding | 34 | 1 | Cluster A | ||||||
| Metal binding | 35 | 1 | Cluster A | ||||||
| Metal binding | 37 | 1 | Cluster A | ||||||
| Metal binding | 38 | 1 | Cluster A | ||||||
| Metal binding | 42 | 1 | Cluster A | ||||||
| Metal binding | 45 | 1 | Cluster A | ||||||
| Metal binding | 49 | 1 | Cluster A | ||||||
| Metal binding | 51 | 1 | Cluster A | ||||||
| Metal binding | 58 | 1 | Cluster A | ||||||
| Metal binding | 60 | 1 | Cluster A | ||||||
| Metal binding | 61 | 1 | Cluster A | ||||||
Amino acid modifications | |||||||||
| Modified residue | 1 | 1 | N-acetylmethionine | ||||||
Sequences
References
| [1] | "Primary structures of seven metallothioneins from rabbit tissue." Hunziker P.E., Kaur P., Wan M., Kaenzig A. Biochem. J. 306:265-270(1995) [PubMed: 7864820] [Abstract] Cited for: PROTEIN SEQUENCE. Strain: New Zealand white. Tissue: Kidney and Liver. |
| + | Additional computationally mapped references. |
Cross-references
Sequence databases | |
|---|---|
| PIR | A37425. S54335. |
3D structure databases | |
| ModBase | Search... |
Phylogenomic databases | |
| HOVERGEN | P80290. |
Family and domain databases | |
| InterPro | IPR017854. Metallothionein_sfam. IPR003019. Metallothionein_sfam_euk. IPR000006. Metallothionein_vert. IPR018064. Metallothionein_vert_metal_BS. [Graphical view] |
| Gene3D | G3DSA:4.10.10.10. Metallothionein_vert. 1 hit. |
| PANTHER | PTHR23299. Metallothionein_vert. 1 hit. |
| Pfam | PF00131. Metallothio. 1 hit. [Graphical view] |
| PRINTS | PR00860. MTVERTEBRATE. |
| PROSITE | PS00203. METALLOTHIONEIN_VRT. 1 hit. [Graphical view] |
| ProtoNet | Search... |
Entry information
| Entry name | MT2C_RABIT | ||||||||
| Accession | Primary (citable) accession number: P80290 | ||||||||
| Entry history |
| ||||||||
| Entry status | Reviewed (UniProtKB/Swiss-Prot) | ||||||||
| Annotation project | HPI (Human Proteome Initiative) | ||||||||
Relevant documents
| Metallothioneins Classification of metallothioneins and list of entries |
| SIMILARITY comments Index of protein domains and families |
