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Protein

Aldose reductase

Gene

AKR1B1

Organism
Sus scrofa (Pig)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Catalyzes the NADPH-dependent reduction of a wide variety of carbonyl-containing compounds to their corresponding alcohols with a broad range of catalytic efficiencies.

Catalytic activityi

Alditol + NAD(P)+ = aldose + NAD(P)H.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei49Proton donor1
Sitei78Lowers pKa of active site TyrBy similarity1
Binding sitei111Substrate1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi10 – 19NADPSequence analysis10
Nucleotide bindingi211 – 273NADPAdd BLAST63

GO - Molecular functioni

Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Ligandi

NADP

Enzyme and pathway databases

SABIO-RKP80276.

Names & Taxonomyi

Protein namesi
Recommended name:
Aldose reductase (EC:1.1.1.21)
Short name:
AR
Alternative name(s):
Aldehyde reductase
Gene namesi
Name:AKR1B1
Synonyms:ALR2
OrganismiSus scrofa (Pig)
Taxonomic identifieri9823 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaSuinaSuidaeSus
Proteomesi
  • UP000008227 Componenti: Unplaced

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

Pathology & Biotechi

Chemistry databases

ChEMBLiCHEMBL4559.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemoved1 Publication
ChainiPRO_00001246252 – 316Aldose reductaseAdd BLAST315

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei2N-acetylalanine1 Publication1
Modified residuei3PhosphoserineBy similarity1
Modified residuei222N6-acetyllysineBy similarity1
Modified residuei263N6-acetyllysineBy similarity1

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

PaxDbiP80276.
PeptideAtlasiP80276.
PRIDEiP80276.

Expressioni

Gene expression databases

BgeeiENSSSCG00000016539.
GenevisibleiP80276. SS.

Interactioni

Subunit structurei

Monomer.

Protein-protein interaction databases

STRINGi9823.ENSSSCP00000017525.

Chemistry databases

BindingDBiP80276.

Structurei

Secondary structure

1316
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi4 – 6Combined sources3
Beta strandi12 – 16Combined sources5
Helixi25 – 38Combined sources14
Beta strandi42 – 44Combined sources3
Helixi47 – 49Combined sources3
Helixi52 – 64Combined sources13
Helixi70 – 72Combined sources3
Beta strandi74 – 79Combined sources6
Helixi81 – 83Combined sources3
Helixi86 – 88Combined sources3
Helixi89 – 100Combined sources12
Beta strandi105 – 110Combined sources6
Beta strandi118 – 120Combined sources3
Beta strandi129 – 131Combined sources3
Helixi138 – 150Combined sources13
Beta strandi153 – 155Combined sources3
Beta strandi157 – 161Combined sources5
Helixi164 – 171Combined sources8
Beta strandi181 – 186Combined sources6
Helixi194 – 203Combined sources10
Beta strandi206 – 210Combined sources5
Beta strandi223 – 225Combined sources3
Helixi228 – 230Combined sources3
Helixi232 – 241Combined sources10
Helixi245 – 255Combined sources11
Helixi267 – 272Combined sources6
Turni273 – 278Combined sources6
Helixi283 – 290Combined sources8
Helixi302 – 304Combined sources3
Helixi311 – 313Combined sources3

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1AH0X-ray2.30A2-316[»]
1AH3X-ray2.30A2-316[»]
1AH4X-ray2.00A2-316[»]
1DLAX-ray3.00A/B/C/D3-316[»]
1EKOX-ray2.20A2-316[»]
ProteinModelPortaliP80276.
SMRiP80276.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP80276.

Family & Domainsi

Sequence similaritiesi

Belongs to the aldo/keto reductase family.Curated

Phylogenomic databases

eggNOGiKOG1577. Eukaryota.
COG0656. LUCA.
HOGENOMiHOG000250272.
HOVERGENiHBG000020.
InParanoidiP80276.
KOiK00011.
OrthoDBiEOG091G0D69.
TreeFamiTF106492.

Family and domain databases

CDDicd06660. Aldo_ket_red. 1 hit.
Gene3Di3.20.20.100. 1 hit.
InterProiIPR001395. Aldo/ket_red/Kv-b.
IPR018170. Aldo/ket_reductase_CS.
IPR020471. Aldo/keto_reductase.
IPR023210. NADP_OxRdtase_dom.
[Graphical view]
PANTHERiPTHR11732. PTHR11732. 2 hits.
PfamiPF00248. Aldo_ket_red. 1 hit.
[Graphical view]
PIRSFiPIRSF000097. AKR. 1 hit.
PRINTSiPR00069. ALDKETRDTASE.
SUPFAMiSSF51430. SSF51430. 1 hit.
PROSITEiPS00798. ALDOKETO_REDUCTASE_1. 1 hit.
PS00062. ALDOKETO_REDUCTASE_2. 1 hit.
PS00063. ALDOKETO_REDUCTASE_3. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P80276-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MASHLVLYTG AKMPILGLGT WKSPPGKVTE AVKVAIDLGY RHIDCAHVYQ
60 70 80 90 100
NENEVGLGLQ EKLQGQVVKR EDLFIVSKLW CTDHEKNLVK GACQTTLRDL
110 120 130 140 150
KLDYLDLYLI HWPTGFKPGK DPFPLDGDGN VVPDESDFVE TWEAMEELVD
160 170 180 190 200
EGLVKAIGVS NFNHLQVEKI LNKPGLKYKP AVNQIEVHPY LTQEKLIEYC
210 220 230 240 250
KSKGIVVTAY SPLGSPDRPW AKPEDPSLLE DPRIKAIAAK YNKTTAQVLI
260 270 280 290 300
RFPMQRNLIV IPKSVTPERI AENFQVFDFE LSPEDMNTLL SYNRNWRVCA
310
LMSCASHKDY PFHEEY
Length:316
Mass (Da):35,868
Last modified:January 23, 2007 - v2
Checksum:i7218B663AC1B4E92
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti99D → N in AAA30989 (PubMed:8493902).Curated1
Sequence conflicti99D → N in AAC48515 (PubMed:8493902).Curated1

Mass spectrometryi

Molecular mass is 35778±3 Da from positions 2 - 316. Determined by ESI. 1 Publication

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L14950 mRNA. Translation: AAA30989.1.
U46065 mRNA. Translation: AAC48515.1.
PIRiA59021.
RefSeqiNP_001001539.1. NM_001001539.2.
UniGeneiSsc.3059.

Genome annotation databases

GeneIDi396816.
KEGGissc:396816.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L14950 mRNA. Translation: AAA30989.1.
U46065 mRNA. Translation: AAC48515.1.
PIRiA59021.
RefSeqiNP_001001539.1. NM_001001539.2.
UniGeneiSsc.3059.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1AH0X-ray2.30A2-316[»]
1AH3X-ray2.30A2-316[»]
1AH4X-ray2.00A2-316[»]
1DLAX-ray3.00A/B/C/D3-316[»]
1EKOX-ray2.20A2-316[»]
ProteinModelPortaliP80276.
SMRiP80276.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9823.ENSSSCP00000017525.

Chemistry databases

BindingDBiP80276.
ChEMBLiCHEMBL4559.

Proteomic databases

PaxDbiP80276.
PeptideAtlasiP80276.
PRIDEiP80276.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi396816.
KEGGissc:396816.

Organism-specific databases

CTDi231.

Phylogenomic databases

eggNOGiKOG1577. Eukaryota.
COG0656. LUCA.
HOGENOMiHOG000250272.
HOVERGENiHBG000020.
InParanoidiP80276.
KOiK00011.
OrthoDBiEOG091G0D69.
TreeFamiTF106492.

Enzyme and pathway databases

SABIO-RKP80276.

Miscellaneous databases

EvolutionaryTraceiP80276.
PROiP80276.

Gene expression databases

BgeeiENSSSCG00000016539.
GenevisibleiP80276. SS.

Family and domain databases

CDDicd06660. Aldo_ket_red. 1 hit.
Gene3Di3.20.20.100. 1 hit.
InterProiIPR001395. Aldo/ket_red/Kv-b.
IPR018170. Aldo/ket_reductase_CS.
IPR020471. Aldo/keto_reductase.
IPR023210. NADP_OxRdtase_dom.
[Graphical view]
PANTHERiPTHR11732. PTHR11732. 2 hits.
PfamiPF00248. Aldo_ket_red. 1 hit.
[Graphical view]
PIRSFiPIRSF000097. AKR. 1 hit.
PRINTSiPR00069. ALDKETRDTASE.
SUPFAMiSSF51430. SSF51430. 1 hit.
PROSITEiPS00798. ALDOKETO_REDUCTASE_1. 1 hit.
PS00062. ALDOKETO_REDUCTASE_2. 1 hit.
PS00063. ALDOKETO_REDUCTASE_3. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiALDR_PIG
AccessioniPrimary (citable) accession number: P80276
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 1, 1994
Last sequence update: January 23, 2007
Last modified: November 2, 2016
This is version 128 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.