P80268 (NUO2_SOLTU) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names	Recommended name: NADH-ubiquinone oxidoreductase 18 kDa subunit EC=1.6.5.3 EC=1.6.99.3 Alternative name(s): Complex I-18kD Short name=CI-18kD
Organism	Solanum tuberosum (Potato) [Reference proteome]
Taxonomic identifier	4113 [NCBI]
Taxonomic lineage	cellular organisms › Eukaryota › Viridiplantae › Streptophyta › Streptophytina › Embryophyta › Tracheophyta › Euphyllophyta › Spermatophyta › Magnoliophyta › eudicotyledons › core eudicotyledons › asterids › lamiids › Solanales › Solanaceae › Solanoideae › Solaneae › Solanum

Protein attributes

Sequence length	30 AA.
Sequence status	Fragment.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	Transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.
Catalytic activity	NADH + ubiquinone = NAD+ + ubiquinol. NADH + acceptor = NAD+ + reduced acceptor.
Subunit structure	Complex I is composed of about 45 different subunits By similarity.
Subcellular location	Mitochondrion inner membrane; Peripheral membrane protein; Matrix side.

Ontologies

Keywords
Cellular component	Membrane Mitochondrion Mitochondrion inner membrane
Ligand	NAD Ubiquinone
Molecular function	Oxidoreductase
Technical term	Complete proteome Direct protein sequencing Reference proteome
Gene Ontology (GO)
Cellular_component	mitochondrial inner membrane Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular_function	NADH dehydrogenase (ubiquinone) activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – ›30	›30	NADH-ubiquinone oxidoreductase 18 kDa subunit		PRO_0000118850
Experimental info
	Non-terminal residue	30	1

Sequences

	Sequence		Length	Mass (Da)
	P80268 [UniParc]. Last modified February 1, 1996. Version 2. Checksum: 21AA88B3FAEDFE1D	FASTA	30	3,263
	10 20 30 ASEALVEIKP GEIGMVSGIP DEHLRRFVVI

References

[1]	"New insights into the composition, molecular mass and stoichiometry of the protein complexes of plant mitochondria." Jansch L., Kruft V., Schmitz U.K., Braun H.P. Plant J. 9:357-368(1996) [PubMed] [Europe PMC] [Abstract] Cited for: PROTEIN SEQUENCE. Tissue: Tuber.
[2]	"Purification of the NADH:ubiquinone oxidoreductase (complex I) of the respiratory chain from the inner mitochondrial membrane of Solanum tuberosum." Herz U., Schroeder W., Liddell A., Leaver C.J., Brennicke A., Grohmann L. J. Biol. Chem. 269:2263-2269(1994) [PubMed] [Europe PMC] [Abstract] Cited for: PROTEIN SEQUENCE OF 1-22. Strain: cv. Bintje. Tissue: Tuber.

Cross-references

Sequence databases
PIR	H49732.
3D structure databases
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Family and domain databases
ProtoNet	Search...

Entry information

Entry name

NUO2_SOLTU

Accession

Primary (citable) accession number: P80268

Entry history

Integrated into UniProtKB/Swiss-Prot:	February 1, 1994
Last sequence update:	February 1, 1996
Last modified:	May 1, 2013
This is version 55 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Plant Protein Annotation Program