ID   NDUS2_SOLTU             Reviewed;          47 AA.
AC   P80264; Q43185;
DT   01-FEB-1994, integrated into UniProtKB/Swiss-Prot.
DT   23-JAN-2007, sequence version 3.
DT   24-JAN-2024, entry version 114.
DE   RecName: Full=NADH dehydrogenase [ubiquinone] iron-sulfur protein 2;
DE            EC=7.1.1.2;
DE   AltName: Full=Complex I-42.5kD;
DE            Short=CI-42.5kD;
DE   AltName: Full=NADH dehydrogenase subunit 7;
DE   AltName: Full=NADH-ubiquinone oxidoreductase 42.5 kDa subunit;
DE   Flags: Fragment;
GN   Name=NAD7;
OS   Solanum tuberosum (Potato).
OG   Mitochondrion.
OC   Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC   Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC   asterids; lamiids; Solanales; Solanaceae; Solanoideae; Solaneae; Solanum.
OX   NCBI_TaxID=4113;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA], AND RNA EDITING.
RC   TISSUE=Tuber;
RX   PubMed=8041359; DOI=10.1007/bf00280184;
RA   Gabler L., Herz U., Liddell A., Leaver C.J., Schroeder W., Brennicke A.,
RA   Grohmann L.;
RT   "The 42.5 kDa subunit of the NADH: ubiquinone oxidoreductase (complex I) in
RT   higher plants is encoded by the mitochondrial nad7 gene.";
RL   Mol. Gen. Genet. 244:33-40(1994).
RN   [2]
RP   PROTEIN SEQUENCE OF 2-37.
RC   STRAIN=cv. Bintje; TISSUE=Tuber;
RX   PubMed=8294484; DOI=10.1016/s0021-9258(17)42163-6;
RA   Herz U., Schroeder W., Liddell A., Leaver C.J., Brennicke A., Grohmann L.;
RT   "Purification of the NADH:ubiquinone oxidoreductase (complex I) of the
RT   respiratory chain from the inner mitochondrial membrane of Solanum
RT   tuberosum.";
RL   J. Biol. Chem. 269:2263-2269(1994).
CC   -!- FUNCTION: Core subunit of the mitochondrial membrane respiratory chain
CC       NADH dehydrogenase (Complex I) that is believed to belong to the
CC       minimal assembly required for catalysis. Complex I functions in the
CC       transfer of electrons from NADH to the respiratory chain. The immediate
CC       electron acceptor for the enzyme is believed to be ubiquinone (By
CC       similarity). Component of the iron-sulfur (IP) fragment of the enzyme.
CC       {ECO:0000250}.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=a ubiquinone + 5 H(+)(in) + NADH = a ubiquinol + 4 H(+)(out) +
CC         NAD(+); Xref=Rhea:RHEA:29091, Rhea:RHEA-COMP:9565, Rhea:RHEA-
CC         COMP:9566, ChEBI:CHEBI:15378, ChEBI:CHEBI:16389, ChEBI:CHEBI:17976,
CC         ChEBI:CHEBI:57540, ChEBI:CHEBI:57945; EC=7.1.1.2;
CC   -!- SUBUNIT: Complex I is composed of about 45 different subunits. This is
CC       a component of the iron-sulfur (IP) fragment of the enzyme (By
CC       similarity). {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Mitochondrion inner membrane; Peripheral membrane
CC       protein; Matrix side.
CC   -!- RNA EDITING: Modified_positions=13 {ECO:0000269|PubMed:8041359}, 26
CC       {ECO:0000269|PubMed:8041359}, 28 {ECO:0000269|PubMed:8041359};
CC   -!- SIMILARITY: Belongs to the complex I 49 kDa subunit family.
CC       {ECO:0000305}.
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DR   EMBL; X75579; CAA53256.1; ALT_SEQ; Genomic_DNA.
DR   PIR; S46439; S38586.
DR   AlphaFoldDB; P80264; -.
DR   SMR; P80264; -.
DR   STRING; 4113.P80264; -.
DR   PaxDb; 4113-PGSC0003DMT400034339; -.
DR   eggNOG; KOG2870; Eukaryota.
DR   InParanoid; P80264; -.
DR   Proteomes; UP000011115; Unassembled WGS sequence.
DR   ExpressionAtlas; P80264; baseline and differential.
DR   GO; GO:0005743; C:mitochondrial inner membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0070469; C:respirasome; IEA:UniProtKB-KW.
DR   GO; GO:0008137; F:NADH dehydrogenase (ubiquinone) activity; IEA:UniProtKB-EC.
DR   Gene3D; 1.10.645.10; Cytochrome-c3 Hydrogenase, chain B; 1.
DR   InterPro; IPR022885; NDH1_su_D/H.
DR   InterPro; IPR029014; NiFe-Hase_large.
DR   PANTHER; PTHR11993:SF10; NADH DEHYDROGENASE [UBIQUINONE] IRON-SULFUR PROTEIN 2, MITOCHONDRIAL; 1.
DR   PANTHER; PTHR11993; NADH-UBIQUINONE OXIDOREDUCTASE 49 KDA SUBUNIT; 1.
DR   SUPFAM; SSF56762; HydB/Nqo4-like; 1.
PE   1: Evidence at protein level;
KW   Direct protein sequencing; Electron transport; Membrane; Mitochondrion;
KW   Mitochondrion inner membrane; NAD; Oxidoreductase; Reference proteome;
KW   Respiratory chain; RNA editing; Translocase; Transport; Ubiquinone.
FT   INIT_MET        1
FT                   /note="Removed"
FT                   /evidence="ECO:0000269|PubMed:8294484"
FT   CHAIN           2..>47
FT                   /note="NADH dehydrogenase [ubiquinone] iron-sulfur protein
FT                   2"
FT                   /id="PRO_0000118586"
FT   NON_TER         47
SQ   SEQUENCE   47 AA;  5278 MW;  0494931B92D06A87 CRC64;
     MTTKNRQIQN FTLNFGPQHP AAHGVLRLVL EMNGEVVERA EPHIGLL
//