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P80264

- NDUS2_SOLTU

UniProt

P80264 - NDUS2_SOLTU

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Protein

NADH dehydrogenase [ubiquinone] iron-sulfur protein 2

Gene

NAD7

Organism
Solanum tuberosum (Potato)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at protein leveli

Functioni

Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) that is believed to belong to the minimal assembly required for catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone (By similarity). Component of the iron-sulfur (IP) fragment of the enzyme.By similarity

Catalytic activityi

NADH + ubiquinone + 5 H+(In) = NAD+ + ubiquinol + 4 H+(Out).
NADH + acceptor = NAD+ + reduced acceptor.

GO - Molecular functioni

  1. NADH dehydrogenase (ubiquinone) activity Source: UniProtKB-EC
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Biological processi

Electron transport, Respiratory chain, Transport

Keywords - Ligandi

NAD, Ubiquinone

Names & Taxonomyi

Protein namesi
Recommended name:
NADH dehydrogenase [ubiquinone] iron-sulfur protein 2 (EC:1.6.5.3, EC:1.6.99.3)
Alternative name(s):
Complex I-42.5kD
Short name:
CI-42.5kD
NADH dehydrogenase subunit 7
NADH-ubiquinone oxidoreductase 42.5 kDa subunit
Gene namesi
Name:NAD7
Encoded oniMitochondrion
OrganismiSolanum tuberosum (Potato)
Taxonomic identifieri4113 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaeasteridslamiidsSolanalesSolanaceaeSolanoideaeSolaneaeSolanum
ProteomesiUP000011115: Unplaced

Subcellular locationi

GO - Cellular componenti

  1. mitochondrial inner membrane Source: UniProtKB-KW
  2. respiratory chain Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Membrane, Mitochondrion, Mitochondrion inner membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Initiator methioninei1 – 11Removed1 Publication
Chaini2 – ›47›46NADH dehydrogenase [ubiquinone] iron-sulfur protein 2PRO_0000118586Add
BLAST

Interactioni

Subunit structurei

Complex I is composed of about 45 different subunits. This is a component of the iron-sulfur (IP) fragment of the enzyme (By similarity).By similarity

Structurei

3D structure databases

ProteinModelPortaliP80264.
SMRiP80264. Positions 20-47.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the complex I 49 kDa subunit family.Curated

Phylogenomic databases

InParanoidiP80264.

Family and domain databases

Gene3Di1.10.645.10. 1 hit.
InterProiIPR029014. NiFe_Hase-like.
[Graphical view]
SUPFAMiSSF56762. SSF56762. 1 hit.

Sequencei

Sequence statusi: Fragment.

Sequence processingi: The displayed sequence is further processed into a mature form.

P80264-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40
MTTKNRQIQN FTLNFGPQHP AAHGVLRLVL EMNGEVVERA EPHIGLL
Length:47
Mass (Da):5,278
Last modified:January 23, 2007 - v3
Checksum:i0494931B92D06A87
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Non-terminal residuei47 – 471

RNA editingi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
X75579 Genomic DNA. Translation: CAA53256.1. Sequence problems.
PIRiS46439. S38586.

Keywords - Coding sequence diversityi

RNA editing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
X75579 Genomic DNA. Translation: CAA53256.1 . Sequence problems.
PIRi S46439. S38586.

3D structure databases

ProteinModelPortali P80264.
SMRi P80264. Positions 20-47.
ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Phylogenomic databases

InParanoidi P80264.

Family and domain databases

Gene3Di 1.10.645.10. 1 hit.
InterProi IPR029014. NiFe_Hase-like.
[Graphical view ]
SUPFAMi SSF56762. SSF56762. 1 hit.
ProtoNeti Search...

Publicationsi

  1. "The 42.5 kDa subunit of the NADH: ubiquinone oxidoreductase (complex I) in higher plants is encoded by the mitochondrial nad7 gene."
    Gabler L., Herz U., Liddell A., Leaver C.J., Schroeder W., Brennicke A., Grohmann L.
    Mol. Gen. Genet. 244:33-40(1994) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], RNA EDITING.
    Tissue: Tuber.
  2. "Purification of the NADH:ubiquinone oxidoreductase (complex I) of the respiratory chain from the inner mitochondrial membrane of Solanum tuberosum."
    Herz U., Schroeder W., Liddell A., Leaver C.J., Brennicke A., Grohmann L.
    J. Biol. Chem. 269:2263-2269(1994) [PubMed] [Europe PMC] [Abstract]
    Cited for: PROTEIN SEQUENCE OF 2-37.
    Strain: cv. Bintje.
    Tissue: Tuber.

Entry informationi

Entry nameiNDUS2_SOLTU
AccessioniPrimary (citable) accession number: P80264
Secondary accession number(s): Q43185
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 1, 1994
Last sequence update: January 23, 2007
Last modified: October 29, 2014
This is version 84 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3