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Protein

NADH dehydrogenase [ubiquinone] iron-sulfur protein 2

Gene

NAD7

Organism
Solanum tuberosum (Potato)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) that is believed to belong to the minimal assembly required for catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone (By similarity). Component of the iron-sulfur (IP) fragment of the enzyme.By similarity

Catalytic activityi

NADH + ubiquinone + 5 H+(In) = NAD+ + ubiquinol + 4 H+(Out).
NADH + acceptor = NAD+ + reduced acceptor.

GO - Molecular functioni

Keywordsi

Molecular functionOxidoreductase
Biological processElectron transport, Respiratory chain, Transport
LigandNAD, Ubiquinone

Names & Taxonomyi

Protein namesi
Recommended name:
NADH dehydrogenase [ubiquinone] iron-sulfur protein 2 (EC:1.6.5.3, EC:1.6.99.3)
Alternative name(s):
Complex I-42.5kD
Short name:
CI-42.5kD
NADH dehydrogenase subunit 7
NADH-ubiquinone oxidoreductase 42.5 kDa subunit
Gene namesi
Name:NAD7
Encoded oniMitochondrion
OrganismiSolanum tuberosum (Potato)
Taxonomic identifieri4113 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaeasteridslamiidsSolanalesSolanaceaeSolanoideaeSolaneaeSolanum
Proteomesi
  • UP000011115 Componenti: Unassembled WGS sequence

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Chloroplast Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertion Graphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Membrane, Mitochondrion, Mitochondrion inner membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemoved1 Publication
ChainiPRO_00001185862 – ›47NADH dehydrogenase [ubiquinone] iron-sulfur protein 2Add BLAST›46

Expressioni

Gene expression databases

ExpressionAtlasiP80264 baseline

Interactioni

Subunit structurei

Complex I is composed of about 45 different subunits. This is a component of the iron-sulfur (IP) fragment of the enzyme (By similarity).By similarity

Structurei

3D structure databases

ProteinModelPortaliP80264
SMRiP80264
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the complex I 49 kDa subunit family.Curated

Phylogenomic databases

InParanoidiP80264

Family and domain databases

Gene3Di1.10.645.20, 1 hit
InterProiView protein in InterPro
IPR038290 NADH_Q_OxRdtase_suD_sf
IPR029014 NiFe-Hase_large
SUPFAMiSSF56762 SSF56762, 1 hit

Sequencei

Sequence statusi: Fragment.

Sequence processingi: The displayed sequence is further processed into a mature form.

P80264-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40 
MTTKNRQIQN FTLNFGPQHP AAHGVLRLVL EMNGEVVERA EPHIGLL
Length:47
Mass (Da):5,278
Last modified:January 23, 2007 - v3
Checksum:i0494931B92D06A87
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Non-terminal residuei471

RNA editingi

Edited at positions 13, 26 and 28.1 Publication

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X75579 Genomic DNA Translation: CAA53256.1 Sequence problems.
PIRiS46439 S38586

Keywords - Coding sequence diversityi

RNA editing

Similar proteinsi

Entry informationi

Entry nameiNDUS2_SOLTU
AccessioniPrimary (citable) accession number: P80264
Secondary accession number(s): Q43185
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 1, 1994
Last sequence update: January 23, 2007
Last modified: March 28, 2018
This is version 95 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome
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Main funding by: National Institutes of Health