ID   DOPD_RAT                Reviewed;         118 AA.
AC   P80254;
DT   01-FEB-1995, integrated into UniProtKB/Swiss-Prot.
DT   23-JAN-2007, sequence version 3.
DT   03-NOV-2009, entry version 69.
DE   RecName: Full=D-dopachrome decarboxylase;
DE            EC=4.1.1.84;
DE   AltName: Full=D-dopachrome tautomerase;
GN   Name=Ddt;
OS   Rattus norvegicus (Rat).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi;
OC   Muroidea; Muridae; Murinae; Rattus.
OX   NCBI_TaxID=10116;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RC   TISSUE=Liver;
RX   MEDLINE=96033973; PubMed=7589466; DOI=10.1016/0014-5793(95)01041-C;
RA   Zhang M., Aman P., Grubb A., Panagopoulos I., Hindemith A.,
RA   Rosengren E., Rorsman H.;
RT   "Cloning and sequencing of a cDNA encoding rat D-dopachrome
RT   tautomerase.";
RL   FEBS Lett. 373:203-206(1995).
RN   [2]
RP   PROTEIN SEQUENCE OF 2-12.
RC   STRAIN=Sprague-Dawley; TISSUE=Liver;
RX   MEDLINE=94092139; PubMed=8267597; DOI=10.1006/bbrc.1993.2524;
RA   Odh G., Hindemith A., Rosengren A.-M., Rosengren E., Rorsman H.;
RT   "Isolation of a new tautomerase monitored by the conversion of D-
RT   dopachrome to 5,6-dihydroxyindole.";
RL   Biochem. Biophys. Res. Commun. 197:619-624(1993).
RN   [3]
RP   PROTEIN SEQUENCE OF 53-75; 84-95 AND 100-110, AND MASS SPECTROMETRY.
RC   STRAIN=Sprague-Dawley; TISSUE=Spinal cord;
RA   Lubec G., Afjehi-Sadat L.;
RL   Submitted (NOV-2006) to UniProtKB.
CC   -!- FUNCTION: Tautomerization of D-dopachrome with decarboxylation to
CC       give 5,6-dihydroxyindole (DHI).
CC   -!- CATALYTIC ACTIVITY: D-dopachrome = 5,6-dihydroxyindole + CO(2).
CC   -!- SUBUNIT: Homotrimer.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm.
CC   -!- TISSUE SPECIFICITY: In all organs tested, highest levels in liver.
CC   -!- SIMILARITY: Belongs to the MIF family.
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DR   EMBL; Z36980; CAA85429.1; -; mRNA.
DR   IPI; IPI00231963; -.
DR   PIR; S68237; S68237.
DR   RefSeq; NP_077045.1; -.
DR   UniGene; Rn.3464; -.
DR   HSSP; P30046; 1DPT.
DR   SMR; P80254; 2-118.
DR   STRING; P80254; -.
DR   PRIDE; P80254; -.
DR   Ensembl; ENSRNOT00000001664; ENSRNOP00000001664; ENSRNOG00000001239; Rattus norvegicus.
DR   GeneID; 29318; -.
DR   KEGG; rno:29318; -.
DR   UCSC; NM_024131; rat.
DR   CTD; 29318; -.
DR   RGD; 61923; Ddt.
DR   HOVERGEN; P80254; -.
DR   OMA; ETNLPAS; -.
DR   BRENDA; 4.1.1.84; 248.
DR   NextBio; 608768; -.
DR   ArrayExpress; P80254; -.
DR   Genevestigator; P80254; -.
DR   GermOnline; ENSRNOG00000001239; Rattus norvegicus.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0033981; F:D-dopachrome decarboxylase activity; IEA:EC.
DR   GO; GO:0004167; F:dopachrome isomerase activity; TAS:RGD.
DR   GO; GO:0006954; P:inflammatory response; NAS:RGD.
DR   GO; GO:0042438; P:melanin biosynthetic process; IEA:UniProtKB-KW.
DR   InterPro; IPR001398; Macrophage_inhib_fac.
DR   InterPro; IPR019829; Macrophage_inhib_fac_CS.
DR   InterPro; IPR014347; Tautomerase.
DR   Gene3D; G3DSA:3.30.429.10; Tautomerase; 1.
DR   PANTHER; PTHR11954; MIF; 1.
DR   Pfam; PF01187; MIF; 1.
DR   ProDom; PD004816; MIF; 1.
DR   PROSITE; PS01158; MIF; 1.
PE   1: Evidence at protein level;
KW   Acetylation; Cytoplasm; Direct protein sequencing; Lyase;
KW   Melanin biosynthesis.
FT   INIT_MET      1      1       Removed.
FT   CHAIN         2    118       D-dopachrome decarboxylase.
FT                                /FTId=PRO_0000158072.
FT   MOD_RES       2      2       N-acetylproline (By similarity).
SQ   SEQUENCE   118 AA;  13133 MW;  9D841584907B8548 CRC64;
     MPFVELETNL PASRIPAGLE NRLCAATATI LDKPEDRVSV TIRPGMTLLM NKSTEPCAHL
     LISSIGVVGT AEQNRSHSSS FFKFLTEELS LDQDRIIIRF FPLEPWQIGK KGTVMTFL
//