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Protein

D-dopachrome decarboxylase

Gene

Ddt

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Tautomerization of D-dopachrome with decarboxylation to give 5,6-dihydroxyindole (DHI).

Catalytic activityi

D-dopachrome = 5,6-dihydroxyindole + CO2.

GO - Molecular functioni

  • D-dopachrome decarboxylase activity Source: UniProtKB-EC
  • dopachrome isomerase activity Source: RGD
  • protease binding Source: Ensembl

GO - Biological processi

Keywordsi

Molecular functionLyase
Biological processMelanin biosynthesis

Enzyme and pathway databases

BRENDAi4.1.1.84 5301
5.3.3.12 5301

Names & Taxonomyi

Protein namesi
Recommended name:
D-dopachrome decarboxylase (EC:4.1.1.84)
Alternative name(s):
D-dopachrome tautomerase
Gene namesi
Name:Ddt
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 20

Organism-specific databases

RGDi61923 Ddt

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedBy similarity1 Publication
ChainiPRO_00001580722 – 118D-dopachrome decarboxylaseAdd BLAST117

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei2N-acetylprolineBy similarity1
Modified residuei33N6-acetyllysineBy similarity1
Modified residuei90PhosphoserineCombined sources1

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

PaxDbiP80254
PRIDEiP80254

PTM databases

iPTMnetiP80254
PhosphoSitePlusiP80254
SwissPalmiP80254

Expressioni

Tissue specificityi

In all organs tested, highest levels in liver.

Gene expression databases

BgeeiENSRNOG00000001239
ExpressionAtlasiP80254 baseline and differential
GenevisibleiP80254 RN

Interactioni

Subunit structurei

Homotrimer.

GO - Molecular functioni

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000001664

Structurei

3D structure databases

ProteinModelPortaliP80254
SMRiP80254
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the MIF family.Curated

Phylogenomic databases

eggNOGiKOG1759 Eukaryota
ENOG41122MF LUCA
GeneTreeiENSGT00910000144293
HOGENOMiHOG000112325
HOVERGENiHBG003240
InParanoidiP80254
KOiK10028
OMAiPLERWQI
OrthoDBiEOG091G0ZNJ
PhylomeDBiP80254
TreeFamiTF313853

Family and domain databases

Gene3Di3.30.429.10, 1 hit
InterProiView protein in InterPro
IPR001398 Macrophage_inhib_fac
IPR019829 Macrophage_inhib_fac_CS
IPR014347 Tautomerase/MIF_sf
PANTHERiPTHR11954 PTHR11954, 1 hit
PfamiView protein in Pfam
PF01187 MIF, 1 hit
ProDomiView protein in ProDom or Entries sharing at least one domain
PD004816 Macrophage_inhib_fac, 1 hit
SUPFAMiSSF55331 SSF55331, 1 hit
PROSITEiView protein in PROSITE
PS01158 MIF, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P80254-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MPFVELETNL PASRIPAGLE NRLCAATATI LDKPEDRVSV TIRPGMTLLM
60 70 80 90 100
NKSTEPCAHL LISSIGVVGT AEQNRSHSSS FFKFLTEELS LDQDRIIIRF
110
FPLEPWQIGK KGTVMTFL
Length:118
Mass (Da):13,133
Last modified:January 23, 2007 - v3
Checksum:i9D841584907B8548
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z36980 mRNA Translation: CAA85429.1
PIRiS68237
RefSeqiNP_077045.1, NM_024131.1
UniGeneiRn.3464

Genome annotation databases

EnsembliENSRNOT00000001664; ENSRNOP00000001664; ENSRNOG00000001239
GeneIDi29318
KEGGirno:29318
UCSCiRGD:61923 rat

Similar proteinsi

Entry informationi

Entry nameiDOPD_RAT
AccessioniPrimary (citable) accession number: P80254
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 1, 1995
Last sequence update: January 23, 2007
Last modified: May 23, 2018
This is version 125 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

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