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Protein

D-dopachrome decarboxylase

Gene

Ddt

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Tautomerization of D-dopachrome with decarboxylation to give 5,6-dihydroxyindole (DHI).

Catalytic activityi

D-dopachrome = 5,6-dihydroxyindole + CO2.

GO - Molecular functioni

  • D-dopachrome decarboxylase activity Source: UniProtKB-EC
  • dopachrome isomerase activity Source: RGD

GO - Biological processi

  • inflammatory response Source: RGD
  • melanin biosynthetic process Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Lyase

Keywords - Biological processi

Melanin biosynthesis

Enzyme and pathway databases

BRENDAi4.1.1.84. 5301.
5.3.3.12. 5301.

Names & Taxonomyi

Protein namesi
Recommended name:
D-dopachrome decarboxylase (EC:4.1.1.84)
Alternative name(s):
D-dopachrome tautomerase
Gene namesi
Name:Ddt
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 20

Organism-specific databases

RGDi61923. Ddt.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Initiator methionineiRemovedBy similarity1 Publication
Chaini2 – 118117D-dopachrome decarboxylasePRO_0000158072Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei2 – 21N-acetylprolineBy similarity
Modified residuei33 – 331N6-acetyllysineBy similarity
Modified residuei90 – 901PhosphoserineCombined sources

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

PaxDbiP80254.
PRIDEiP80254.

PTM databases

iPTMnetiP80254.
PhosphoSiteiP80254.

Expressioni

Tissue specificityi

In all organs tested, highest levels in liver.

Gene expression databases

ExpressionAtlasiP80254. baseline and differential.
GenevisibleiP80254. RN.

Interactioni

Subunit structurei

Homotrimer.

Protein-protein interaction databases

MINTiMINT-4565935.
STRINGi10116.ENSRNOP00000001664.

Structurei

3D structure databases

ProteinModelPortaliP80254.
SMRiP80254. Positions 2-118.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the MIF family.Curated

Phylogenomic databases

eggNOGiKOG1759. Eukaryota.
ENOG41122MF. LUCA.
GeneTreeiENSGT00840000129866.
HOGENOMiHOG000112325.
HOVERGENiHBG003240.
InParanoidiP80254.
KOiK10028.
OMAiPLERWQI.
OrthoDBiEOG7GXPDN.
PhylomeDBiP80254.
TreeFamiTF313853.

Family and domain databases

InterProiIPR001398. Macrophage_inhib_fac.
IPR019829. Macrophage_inhib_fac_CS.
IPR014347. Tautomerase/MIF_sf.
[Graphical view]
PANTHERiPTHR11954. PTHR11954. 1 hit.
PfamiPF01187. MIF. 1 hit.
[Graphical view]
ProDomiPD004816. Macrophage_inhib_fac. 1 hit.
[Graphical view] [Entries sharing at least one domain]
SUPFAMiSSF55331. SSF55331. 1 hit.
PROSITEiPS01158. MIF. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P80254-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MPFVELETNL PASRIPAGLE NRLCAATATI LDKPEDRVSV TIRPGMTLLM
60 70 80 90 100
NKSTEPCAHL LISSIGVVGT AEQNRSHSSS FFKFLTEELS LDQDRIIIRF
110
FPLEPWQIGK KGTVMTFL
Length:118
Mass (Da):13,133
Last modified:January 23, 2007 - v3
Checksum:i9D841584907B8548
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z36980 mRNA. Translation: CAA85429.1.
PIRiS68237.
RefSeqiNP_077045.1. NM_024131.1.
UniGeneiRn.3464.

Genome annotation databases

EnsembliENSRNOT00000001664; ENSRNOP00000001664; ENSRNOG00000001239.
GeneIDi29318.
KEGGirno:29318.
UCSCiRGD:61923. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z36980 mRNA. Translation: CAA85429.1.
PIRiS68237.
RefSeqiNP_077045.1. NM_024131.1.
UniGeneiRn.3464.

3D structure databases

ProteinModelPortaliP80254.
SMRiP80254. Positions 2-118.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

MINTiMINT-4565935.
STRINGi10116.ENSRNOP00000001664.

PTM databases

iPTMnetiP80254.
PhosphoSiteiP80254.

Proteomic databases

PaxDbiP80254.
PRIDEiP80254.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSRNOT00000001664; ENSRNOP00000001664; ENSRNOG00000001239.
GeneIDi29318.
KEGGirno:29318.
UCSCiRGD:61923. rat.

Organism-specific databases

CTDi1652.
RGDi61923. Ddt.

Phylogenomic databases

eggNOGiKOG1759. Eukaryota.
ENOG41122MF. LUCA.
GeneTreeiENSGT00840000129866.
HOGENOMiHOG000112325.
HOVERGENiHBG003240.
InParanoidiP80254.
KOiK10028.
OMAiPLERWQI.
OrthoDBiEOG7GXPDN.
PhylomeDBiP80254.
TreeFamiTF313853.

Enzyme and pathway databases

BRENDAi4.1.1.84. 5301.
5.3.3.12. 5301.

Miscellaneous databases

PROiP80254.

Gene expression databases

ExpressionAtlasiP80254. baseline and differential.
GenevisibleiP80254. RN.

Family and domain databases

InterProiIPR001398. Macrophage_inhib_fac.
IPR019829. Macrophage_inhib_fac_CS.
IPR014347. Tautomerase/MIF_sf.
[Graphical view]
PANTHERiPTHR11954. PTHR11954. 1 hit.
PfamiPF01187. MIF. 1 hit.
[Graphical view]
ProDomiPD004816. Macrophage_inhib_fac. 1 hit.
[Graphical view] [Entries sharing at least one domain]
SUPFAMiSSF55331. SSF55331. 1 hit.
PROSITEiPS01158. MIF. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Cloning and sequencing of a cDNA encoding rat D-dopachrome tautomerase."
    Zhang M., Aman P., Grubb A., Panagopoulos I., Hindemith A., Rosengren E., Rorsman H.
    FEBS Lett. 373:203-206(1995) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Liver.
  2. "Isolation of a new tautomerase monitored by the conversion of D-dopachrome to 5,6-dihydroxyindole."
    Odh G., Hindemith A., Rosengren A.-M., Rosengren E., Rorsman H.
    Biochem. Biophys. Res. Commun. 197:619-624(1993) [PubMed] [Europe PMC] [Abstract]
    Cited for: PROTEIN SEQUENCE OF 2-12.
    Strain: Sprague-Dawley.
    Tissue: Liver.
  3. Lubec G., Afjehi-Sadat L.
    Submitted (NOV-2006) to UniProtKB
    Cited for: PROTEIN SEQUENCE OF 53-75; 84-95 AND 100-110, IDENTIFICATION BY MASS SPECTROMETRY.
    Strain: Sprague-Dawley.
    Tissue: Spinal cord.
  4. "Quantitative maps of protein phosphorylation sites across 14 different rat organs and tissues."
    Lundby A., Secher A., Lage K., Nordsborg N.B., Dmytriyev A., Lundby C., Olsen J.V.
    Nat. Commun. 3:876-876(2012) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-90, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

Entry informationi

Entry nameiDOPD_RAT
AccessioniPrimary (citable) accession number: P80254
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 1, 1995
Last sequence update: January 23, 2007
Last modified: June 8, 2016
This is version 113 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.