Reviewed, UniProtKB/Swiss-Prot P80254 (DOPD_RAT)

Names and origin

Protein names

Recommended name:
D-dopachrome decarboxylase
EC=4.1.1.84

Alternative name(s):
D-dopachrome tautomerase

Gene names

Name:

Ddt

Organism

Rattus norvegicus (Rat)

Taxonomic identifier

10116 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Rattus

Protein attributes

Sequence length	118 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at protein level.

General annotation (Comments)

Function	Tautomerization of D-dopachrome with decarboxylation to give 5,6-dihydroxyindole (DHI).
Catalytic activity	D-dopachrome = 5,6-dihydroxyindole + CO2.
Subunit structure	Homotrimer.
Subcellular location	Cytoplasm.
Tissue specificity	In all organs tested, highest levels in liver.
Sequence similarities	Belongs to the MIF family.

Ontologies

Keywords
Biological process	Melanin biosynthesis
Cellular component	Cytoplasm
Molecular function	Lyase
PTM	Acetylation
Technical term	Direct protein sequencing
Gene Ontology (GO)
Biological process	inflammatory response Non-traceable author statement. Source: RGD melanin biosynthetic process Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	D-dopachrome decarboxylase activity Inferred from electronic annotation. Source: EC dopachrome isomerase activity Traceable author statement. Source: RGD
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Initiator methionine	1	1	Removed Ref.2
	Chain	2 – 118	117	D-dopachrome decarboxylase		PRO_0000158072
Amino acid modifications
	Modified residue	2	1	N-acetylproline By similarity

Sequences

	Sequence		Length	Mass (Da)
	P80254-1 [UniParc]. Last modified January 23, 2007. Version 3. Checksum: 9D841584907B8548	FASTA	118	13,133
	10 20 30 40 50 60 MPFVELETNL PASRIPAGLE NRLCAATATI LDKPEDRVSV TIRPGMTLLM NKSTEPCAHL 70 80 90 100 110 LISSIGVVGT AEQNRSHSSS FFKFLTEELS LDQDRIIIRF FPLEPWQIGK KGTVMTFL

References

[1]	"Cloning and sequencing of a cDNA encoding rat D-dopachrome tautomerase." Zhang M., Aman P., Grubb A., Panagopoulos I., Hindemith A., Rosengren E., Rorsman H. FEBS Lett. 373:203-206(1995) [PubMed: 7589466] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA]. Tissue: Liver.
[2]	"Isolation of a new tautomerase monitored by the conversion of D-dopachrome to 5,6-dihydroxyindole." Odh G., Hindemith A., Rosengren A.-M., Rosengren E., Rorsman H. Biochem. Biophys. Res. Commun. 197:619-624(1993) [PubMed: 8267597] [Abstract] Cited for: PROTEIN SEQUENCE OF 2-12. Strain: Sprague-Dawley. Tissue: Liver.
[3]	Lubec G., Afjehi-Sadat L. Submitted (NOV-2006) to UniProtKB Cited for: PROTEIN SEQUENCE OF 53-75; 84-95 AND 100-110, MASS SPECTROMETRY. Strain: Sprague-Dawley. Tissue: Spinal cord.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	Z36980 mRNA. Translation: CAA85429.1.
IPI	IPI00231963.
PIR	S68237.
RefSeq	NP_077045.1.
UniGene	Rn.3464
3D structure databases
SMR	P80254. Positions 2-118.
ModBase	Search...
Protein-protein interaction databases
STRING	P80254.
Proteomic databases
PRIDE	P80254.
Genome annotation databases
Ensembl	ENSRNOT00000001664; ENSRNOP00000001664; ENSRNOG00000001239; Rattus norvegicus. [Genome view]
GeneID	29318.
KEGG	rno:29318.
UCSC	NM_024131. rat.
Organism-specific databases
CTD	29318.
RGD	61923. Ddt.
Phylogenomic databases
eggNOG	roNOG17526.
HOVERGEN	HBG003240.
InParanoid	P80254.
OMA	SMGKPRE.
OrthoDB	EOG9DJNGC.
PhylomeDB	P80254.
Enzyme and pathway databases
BRENDA	4.1.1.84. 248.
Gene expression databases
ArrayExpress	P80254.
Genevestigator	P80254.
GermOnline	ENSRNOG00000001239. Rattus norvegicus.
Family and domain databases
InterPro	IPR001398. Macrophage_inhib_fac. IPR019829. Macrophage_inhib_fac_CS. IPR014347. Tautomerase. [Graphical view]
Gene3D	G3DSA:3.30.429.10. Tautomerase. 1 hit.
PANTHER	PTHR11954. MIF. 1 hit.
Pfam	PF01187. MIF. 1 hit. [Graphical view]
ProDom	PD004816. Macrophage_inhib_fac. 1 hit. [Graphical view] [Entries sharing at least one domain]
PROSITE	PS01158. MIF. 1 hit. [Graphical view]
ProtoNet	Search...
Other Resources
NextBio	608768.

Entry information

Entry name

DOPD_RAT

Accession

Primary (citable) accession number: P80254

Entry history

Integrated into UniProtKB/Swiss-Prot:	February 1, 1995
Last sequence update:	January 23, 2007
Last modified:	March 2, 2010
This is version 73 of the entry and version 3 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HPI (Human Proteome Initiative)