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P80235

- CACM_YEAST

UniProt

P80235 - CACM_YEAST

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Protein
Putative mitochondrial carnitine O-acetyltransferase
Gene
YAT1, YAR035W
Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at protein leveli

Functioni

Involved in the transfer of acetyl-CoA into mitochondria. May also be involved in the metabolism of acetate and of ethanol.

Catalytic activityi

Acetyl-CoA + carnitine = CoA + O-acetylcarnitine.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei346 – 3461Proton acceptor By similarity
Binding sitei481 – 4811Carnitine By similarity
Binding sitei494 – 4941Carnitine By similarity

GO - Molecular functioni

  1. carnitine O-acetyltransferase activity Source: SGD

GO - Biological processi

  1. alcohol metabolic process Source: SGD
  2. carnitine metabolic process Source: SGD
  3. fatty acid metabolic process Source: UniProtKB-KW
  4. transport Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Acyltransferase, Transferase

Keywords - Biological processi

Fatty acid metabolism, Lipid metabolism, Transport

Enzyme and pathway databases

BioCyciYEAST:YAR035W-MONOMER.
ReactomeiREACT_188984. PPARA activates gene expression.

Names & Taxonomyi

Protein namesi
Recommended name:
Putative mitochondrial carnitine O-acetyltransferase (EC:2.3.1.7)
Gene namesi
Name:YAT1
Ordered Locus Names:YAR035W
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
ProteomesiUP000002311: Chromosome I

Organism-specific databases

CYGDiYAR035w.
SGDiS000000080. YAT1.

Subcellular locationi

GO - Cellular componenti

  1. mitochondrial inner membrane Source: UniProtKB-SubCell
  2. mitochondrion Source: SGD
Complete GO annotation...

Keywords - Cellular componenti

Membrane, Mitochondrion, Mitochondrion inner membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 687687Putative mitochondrial carnitine O-acetyltransferase
PRO_0000210175Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei517 – 5171Phosphoserine1 Publication

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiP80235.
PeptideAtlasiP80235.

Expressioni

Inductioni

By ethanol and by acetate. Repressed by glucose, and to a lesser extent, by galactose. Derepressed by glycerol.

Gene expression databases

GenevestigatoriP80235.

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
ACS1Q015741EBI-3928,EBI-2128

Protein-protein interaction databases

BioGridi31811. 14 interactions.
DIPiDIP-3795N.
IntActiP80235. 9 interactions.
MINTiMINT-541328.
STRINGi4932.YAR035W.

Structurei

3D structure databases

ProteinModelPortaliP80235.
SMRiP80235. Positions 3-655.

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni446 – 45914Coenzyme A binding By similarity
Add
BLAST

Sequence similaritiesi

Phylogenomic databases

eggNOGiNOG70127.
GeneTreeiENSGT00550000074786.
HOGENOMiHOG000206461.
KOiK00624.
OMAiENTYEPA.
OrthoDBiEOG7T7H2J.

Family and domain databases

InterProiIPR000542. Carn_acyl_trans.
[Graphical view]
PANTHERiPTHR22589. PTHR22589. 1 hit.
PfamiPF00755. Carn_acyltransf. 1 hit.
[Graphical view]
PROSITEiPS00439. ACYLTRANSF_C_1. 1 hit.
PS00440. ACYLTRANSF_C_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P80235-1 [UniParc]FASTAAdd to Basket

« Hide

MPNLKRLPIP PLQDTLNRYL ARVEPLQDER QNRRTRRTVL SAENLDALNT    50
LHERLLEYDA RLAESNPESS YIEQFWYDAY LLYDATVVLN VNPYFQLQDD 100
PTIKDTPETA AQGPYGAHTV QVRRAARLTT SILKFIRQIR HGTLRTDTVR 150
GKTPLSMDQY ERLFGSSRIP PGPGEPSCHL QTDATSHHVV AMYRGQFYWF 200
DVLDTRNEPI FATPEQLEWN LYSIIMDAES AGSGSAPFGV FTTESRRVWS 250
NIRDYLFHAD DCTNWRNLKL IDSALFVVCL DDVAFAADQQ DELTRSMLCG 300
TSTINLDPHQ HQPPLNVQTG TCLNRWYDKL QLIVTKNGKA GINFEHTGVD 350
GHTVLRLATD IYTDSILSFA RGVTKNVVDI FSDDDGKPSS SSLASAAHSA 400
NLITIPRKLE WRTDNFLQSS LHFAETRISD LISQYEFVNL DFSNYGASHI 450
KTVFKCSPDA FVQQVFQVAY FALYGRFETV YEPAMTKAFQ NGRTEAIRSV 500
TGQSKLFVKS LLDQDASDAT KIQLLHDACT AHSQITRECS QGLGQDRHLY 550
ALYCLWNQWY KDKLELPPIF RDKSWTTMQN NVLSTSNCGN PCLKSFGFGP 600
VTANGFGIGY IIRDHSVSVV VSSRHRQTAR FASLMEKSLL EIDRIFKRQQ 650
ARAAKPAART TASANTKSED MKYLLSGYDY FDVSVSG 687
Length:687
Mass (Da):77,766
Last modified:December 6, 2005 - v2
Checksum:iF00B628893B8BB39
GO

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti25 – 251P → T in CAA52647. 1 Publication
Sequence conflicti392 – 3921S → SS in CAA52647. 1 Publication
Sequence conflicti595 – 5962SF → AS in CAA52647. 1 Publication
Sequence conflicti653 – 6531A → T in CAA52647. 1 Publication
Sequence conflicti660 – 6601T → A in CAA52647. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
X74553 Genomic DNA. Translation: CAA52647.1.
L28920 Genomic DNA. Translation: AAC09495.1.
BK006935 Genomic DNA. Translation: DAA07004.1.
PIRiS53485.
RefSeqiNP_009420.1. NM_001178226.1.

Genome annotation databases

EnsemblFungiiYAR035W; YAR035W; YAR035W.
GeneIDi851285.
KEGGisce:YAR035W.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
X74553 Genomic DNA. Translation: CAA52647.1 .
L28920 Genomic DNA. Translation: AAC09495.1 .
BK006935 Genomic DNA. Translation: DAA07004.1 .
PIRi S53485.
RefSeqi NP_009420.1. NM_001178226.1.

3D structure databases

ProteinModelPortali P80235.
SMRi P80235. Positions 3-655.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 31811. 14 interactions.
DIPi DIP-3795N.
IntActi P80235. 9 interactions.
MINTi MINT-541328.
STRINGi 4932.YAR035W.

Proteomic databases

PaxDbi P80235.
PeptideAtlasi P80235.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblFungii YAR035W ; YAR035W ; YAR035W .
GeneIDi 851285.
KEGGi sce:YAR035W.

Organism-specific databases

CYGDi YAR035w.
SGDi S000000080. YAT1.

Phylogenomic databases

eggNOGi NOG70127.
GeneTreei ENSGT00550000074786.
HOGENOMi HOG000206461.
KOi K00624.
OMAi ENTYEPA.
OrthoDBi EOG7T7H2J.

Enzyme and pathway databases

BioCyci YEAST:YAR035W-MONOMER.
Reactomei REACT_188984. PPARA activates gene expression.

Miscellaneous databases

NextBioi 968285.
PROi P80235.

Gene expression databases

Genevestigatori P80235.

Family and domain databases

InterProi IPR000542. Carn_acyl_trans.
[Graphical view ]
PANTHERi PTHR22589. PTHR22589. 1 hit.
Pfami PF00755. Carn_acyltransf. 1 hit.
[Graphical view ]
PROSITEi PS00439. ACYLTRANSF_C_1. 1 hit.
PS00440. ACYLTRANSF_C_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "The ethanol-inducible YAT1 gene from yeast encodes a presumptive mitochondrial outer carnitine acetyltransferase."
    Schmalix W.A., Bandlow W.
    J. Biol. Chem. 268:27428-27439(1993) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: DL-1.
  2. "Sequencing of chromosome I of Saccharomyces cerevisiae: analysis of the 52 Kbp CDC15-FLO1-PHO11-YAR074 region."
    Bussey H., Keng T., Storms R.K., Vo D., Zhong W., Fortin N., Barton A.B., Kaback D.B., Clark M.W.
    Submitted (FEB-1994) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: ATCC 204511 / S288c / AB972.
  3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 204508 / S288c.
  4. Cited for: GENOME REANNOTATION.
    Strain: ATCC 204508 / S288c.
  5. "Profiling phosphoproteins of yeast mitochondria reveals a role of phosphorylation in assembly of the ATP synthase."
    Reinders J., Wagner K., Zahedi R.P., Stojanovski D., Eyrich B., van der Laan M., Rehling P., Sickmann A., Pfanner N., Meisinger C.
    Mol. Cell. Proteomics 6:1896-1906(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-517, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Strain: ATCC 76625 / YPH499.

Entry informationi

Entry nameiCACM_YEAST
AccessioniPrimary (citable) accession number: P80235
Secondary accession number(s): D6VPN4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 1, 1993
Last sequence update: December 6, 2005
Last modified: September 3, 2014
This is version 124 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
  3. Yeast chromosome I
    Yeast (Saccharomyces cerevisiae) chromosome I: entries and gene names

External Data

Dasty 3

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