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P80235 (CACM_YEAST) Reviewed, UniProtKB/Swiss-Prot

Last modified May 14, 2014. Version 123. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Interactions·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Putative mitochondrial carnitine O-acetyltransferase

EC=2.3.1.7
Gene names
Name:YAT1
Ordered Locus Names:YAR035W
OrganismSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) [Reference proteome]
Taxonomic identifier559292 [NCBI]
Taxonomic lineageEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces

Protein attributes

Sequence length687 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Involved in the transfer of acetyl-CoA into mitochondria. May also be involved in the metabolism of acetate and of ethanol.

Catalytic activity

Acetyl-CoA + carnitine = CoA + O-acetylcarnitine.

Subcellular location

Mitochondrion inner membrane; Peripheral membrane protein; Intermembrane side.

Induction

By ethanol and by acetate. Repressed by glucose, and to a lesser extent, by galactose. Derepressed by glycerol.

Sequence similarities

Belongs to the carnitine/choline acetyltransferase family.

Binary interactions

With

Entry

#Exp.

IntAct

Notes

ACS1Q015741EBI-3928,EBI-2128

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 687687Putative mitochondrial carnitine O-acetyltransferase
PRO_0000210175

Regions

Region446 – 45914Coenzyme A binding By similarity

Sites

Active site3461Proton acceptor By similarity
Binding site4811Carnitine By similarity
Binding site4941Carnitine By similarity

Amino acid modifications

Modified residue5171Phosphoserine Ref.5

Experimental info

Sequence conflict251P → T in CAA52647. Ref.1
Sequence conflict3921S → SS in CAA52647. Ref.1
Sequence conflict595 – 5962SF → AS in CAA52647. Ref.1
Sequence conflict6531A → T in CAA52647. Ref.1
Sequence conflict6601T → A in CAA52647. Ref.1

Sequences

Sequence LengthMass (Da)Tools
P80235 [UniParc].

Last modified December 6, 2005. Version 2.
Checksum: F00B628893B8BB39

FASTA68777,766
        10         20         30         40         50         60 
MPNLKRLPIP PLQDTLNRYL ARVEPLQDER QNRRTRRTVL SAENLDALNT LHERLLEYDA 

        70         80         90        100        110        120 
RLAESNPESS YIEQFWYDAY LLYDATVVLN VNPYFQLQDD PTIKDTPETA AQGPYGAHTV 

       130        140        150        160        170        180 
QVRRAARLTT SILKFIRQIR HGTLRTDTVR GKTPLSMDQY ERLFGSSRIP PGPGEPSCHL 

       190        200        210        220        230        240 
QTDATSHHVV AMYRGQFYWF DVLDTRNEPI FATPEQLEWN LYSIIMDAES AGSGSAPFGV 

       250        260        270        280        290        300 
FTTESRRVWS NIRDYLFHAD DCTNWRNLKL IDSALFVVCL DDVAFAADQQ DELTRSMLCG 

       310        320        330        340        350        360 
TSTINLDPHQ HQPPLNVQTG TCLNRWYDKL QLIVTKNGKA GINFEHTGVD GHTVLRLATD 

       370        380        390        400        410        420 
IYTDSILSFA RGVTKNVVDI FSDDDGKPSS SSLASAAHSA NLITIPRKLE WRTDNFLQSS 

       430        440        450        460        470        480 
LHFAETRISD LISQYEFVNL DFSNYGASHI KTVFKCSPDA FVQQVFQVAY FALYGRFETV 

       490        500        510        520        530        540 
YEPAMTKAFQ NGRTEAIRSV TGQSKLFVKS LLDQDASDAT KIQLLHDACT AHSQITRECS 

       550        560        570        580        590        600 
QGLGQDRHLY ALYCLWNQWY KDKLELPPIF RDKSWTTMQN NVLSTSNCGN PCLKSFGFGP 

       610        620        630        640        650        660 
VTANGFGIGY IIRDHSVSVV VSSRHRQTAR FASLMEKSLL EIDRIFKRQQ ARAAKPAART 

       670        680 
TASANTKSED MKYLLSGYDY FDVSVSG 

« Hide

References

« Hide 'large scale' references
[1]"The ethanol-inducible YAT1 gene from yeast encodes a presumptive mitochondrial outer carnitine acetyltransferase."
Schmalix W.A., Bandlow W.
J. Biol. Chem. 268:27428-27439(1993) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
Strain: DL-1.
[2]"Sequencing of chromosome I of Saccharomyces cerevisiae: analysis of the 52 Kbp CDC15-FLO1-PHO11-YAR074 region."
Bussey H., Keng T., Storms R.K., Vo D., Zhong W., Fortin N., Barton A.B., Kaback D.B., Clark M.W.
Submitted (FEB-1994) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
Strain: ATCC 204511 / S288c / AB972.
[3]"The nucleotide sequence of chromosome I from Saccharomyces cerevisiae."
Bussey H., Kaback D.B., Zhong W.-W., Vo D.H., Clark M.W., Fortin N., Hall J., Ouellette B.F.F., Keng T., Barton A.B., Su Y., Davies C.J., Storms R.K.
Proc. Natl. Acad. Sci. U.S.A. 92:3809-3813(1995) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: ATCC 204508 / S288c.
[4]"The reference genome sequence of Saccharomyces cerevisiae: Then and now."
Engel S.R., Dietrich F.S., Fisk D.G., Binkley G., Balakrishnan R., Costanzo M.C., Dwight S.S., Hitz B.C., Karra K., Nash R.S., Weng S., Wong E.D., Lloyd P., Skrzypek M.S., Miyasato S.R., Simison M., Cherry J.M.
G3 (Bethesda) 4:389-398(2014) [PubMed] [Europe PMC] [Abstract]
Cited for: GENOME REANNOTATION.
Strain: ATCC 204508 / S288c.
[5]"Profiling phosphoproteins of yeast mitochondria reveals a role of phosphorylation in assembly of the ATP synthase."
Reinders J., Wagner K., Zahedi R.P., Stojanovski D., Eyrich B., van der Laan M., Rehling P., Sickmann A., Pfanner N., Meisinger C.
Mol. Cell. Proteomics 6:1896-1906(2007) [PubMed] [Europe PMC] [Abstract]
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-517, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
Strain: ATCC 76625 / YPH499.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
X74553 Genomic DNA. Translation: CAA52647.1.
L28920 Genomic DNA. Translation: AAC09495.1.
BK006935 Genomic DNA. Translation: DAA07004.1.
PIRS53485.
RefSeqNP_009420.1. NM_001178226.1.

3D structure databases

ProteinModelPortalP80235.
SMRP80235. Positions 3-655.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid31811. 14 interactions.
DIPDIP-3795N.
IntActP80235. 9 interactions.
MINTMINT-541328.
STRING4932.YAR035W.

Proteomic databases

PaxDbP80235.
PeptideAtlasP80235.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblFungiYAR035W; YAR035W; YAR035W.
GeneID851285.
KEGGsce:YAR035W.

Organism-specific databases

CYGDYAR035w.
SGDS000000080. YAT1.

Phylogenomic databases

eggNOGNOG70127.
GeneTreeENSGT00550000074786.
HOGENOMHOG000206461.
KOK00624.
OMAENTYEPA.
OrthoDBEOG7T7H2J.

Enzyme and pathway databases

BioCycYEAST:YAR035W-MONOMER.

Gene expression databases

GenevestigatorP80235.

Family and domain databases

InterProIPR000542. Carn_acyl_trans.
[Graphical view]
PANTHERPTHR22589. PTHR22589. 1 hit.
PfamPF00755. Carn_acyltransf. 1 hit.
[Graphical view]
PROSITEPS00439. ACYLTRANSF_C_1. 1 hit.
PS00440. ACYLTRANSF_C_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio968285.
PROP80235.

Entry information

Entry nameCACM_YEAST
AccessionPrimary (citable) accession number: P80235
Secondary accession number(s): D6VPN4
Entry history
Integrated into UniProtKB/Swiss-Prot: October 1, 1993
Last sequence update: December 6, 2005
Last modified: May 14, 2014
This is version 123 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Relevant documents

Yeast chromosome I

Yeast (Saccharomyces cerevisiae) chromosome I: entries and gene names

Yeast

Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD

SIMILARITY comments

Index of protein domains and families