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Protein

Putative mitochondrial carnitine O-acetyltransferase

Gene

YAT1

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Involved in the transfer of acetyl-CoA into mitochondria. May also be involved in the metabolism of acetate and of ethanol.

Catalytic activityi

Acetyl-CoA + carnitine = CoA + O-acetylcarnitine.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei346Proton acceptorBy similarity1
Binding sitei481CarnitineBy similarity1
Binding sitei494CarnitineBy similarity1

GO - Molecular functioni

  • carnitine O-acetyltransferase activity Source: SGD

GO - Biological processi

  • alcohol metabolic process Source: SGD
  • carnitine metabolic process Source: SGD
  • fatty acid metabolic process Source: UniProtKB-KW

Keywordsi

Molecular functionAcyltransferase, Transferase
Biological processFatty acid metabolism, Lipid metabolism, Transport

Enzyme and pathway databases

BioCyciYEAST:YAR035W-MONOMER
ReactomeiR-SCE-200425 Import of palmitoyl-CoA into the mitochondrial matrix

Names & Taxonomyi

Protein namesi
Recommended name:
Putative mitochondrial carnitine O-acetyltransferase (EC:2.3.1.7)
Gene namesi
Name:YAT1
Ordered Locus Names:YAR035W
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
Proteomesi
  • UP000002311 Componenti: Chromosome I

Organism-specific databases

EuPathDBiFungiDB:YAR035W
SGDiS000000080 YAT1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Membrane, Mitochondrion, Mitochondrion inner membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002101751 – 687Putative mitochondrial carnitine O-acetyltransferaseAdd BLAST687

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei517PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiP80235
PRIDEiP80235

PTM databases

iPTMnetiP80235

Expressioni

Inductioni

By ethanol and by acetate. Repressed by glucose, and to a lesser extent, by galactose. Derepressed by glycerol.

Interactioni

Protein-protein interaction databases

BioGridi31811, 35 interactors
DIPiDIP-3795N
IntActiP80235, 11 interactors
MINTiP80235
STRINGi4932.YAR035W

Structurei

3D structure databases

ProteinModelPortaliP80235
SMRiP80235
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni446 – 459Coenzyme A bindingBy similarityAdd BLAST14

Sequence similaritiesi

Phylogenomic databases

GeneTreeiENSGT00550000074786
HOGENOMiHOG000206461
InParanoidiP80235
KOiK00624
OMAiYISGPWF
OrthoDBiEOG092C0W5Q

Family and domain databases

InterProiView protein in InterPro
IPR000542 Carn_acyl_trans
PANTHERiPTHR22589 PTHR22589, 1 hit
PfamiView protein in Pfam
PF00755 Carn_acyltransf, 1 hit
PROSITEiView protein in PROSITE
PS00439 ACYLTRANSF_C_1, 1 hit
PS00440 ACYLTRANSF_C_2, 1 hit

Sequencei

Sequence statusi: Complete.

P80235-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MPNLKRLPIP PLQDTLNRYL ARVEPLQDER QNRRTRRTVL SAENLDALNT
60 70 80 90 100
LHERLLEYDA RLAESNPESS YIEQFWYDAY LLYDATVVLN VNPYFQLQDD
110 120 130 140 150
PTIKDTPETA AQGPYGAHTV QVRRAARLTT SILKFIRQIR HGTLRTDTVR
160 170 180 190 200
GKTPLSMDQY ERLFGSSRIP PGPGEPSCHL QTDATSHHVV AMYRGQFYWF
210 220 230 240 250
DVLDTRNEPI FATPEQLEWN LYSIIMDAES AGSGSAPFGV FTTESRRVWS
260 270 280 290 300
NIRDYLFHAD DCTNWRNLKL IDSALFVVCL DDVAFAADQQ DELTRSMLCG
310 320 330 340 350
TSTINLDPHQ HQPPLNVQTG TCLNRWYDKL QLIVTKNGKA GINFEHTGVD
360 370 380 390 400
GHTVLRLATD IYTDSILSFA RGVTKNVVDI FSDDDGKPSS SSLASAAHSA
410 420 430 440 450
NLITIPRKLE WRTDNFLQSS LHFAETRISD LISQYEFVNL DFSNYGASHI
460 470 480 490 500
KTVFKCSPDA FVQQVFQVAY FALYGRFETV YEPAMTKAFQ NGRTEAIRSV
510 520 530 540 550
TGQSKLFVKS LLDQDASDAT KIQLLHDACT AHSQITRECS QGLGQDRHLY
560 570 580 590 600
ALYCLWNQWY KDKLELPPIF RDKSWTTMQN NVLSTSNCGN PCLKSFGFGP
610 620 630 640 650
VTANGFGIGY IIRDHSVSVV VSSRHRQTAR FASLMEKSLL EIDRIFKRQQ
660 670 680
ARAAKPAART TASANTKSED MKYLLSGYDY FDVSVSG
Length:687
Mass (Da):77,766
Last modified:December 6, 2005 - v2
Checksum:iF00B628893B8BB39
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti25P → T in CAA52647 (PubMed:8262985).Curated1
Sequence conflicti392S → SS in CAA52647 (PubMed:8262985).Curated1
Sequence conflicti595 – 596SF → AS in CAA52647 (PubMed:8262985).Curated2
Sequence conflicti653A → T in CAA52647 (PubMed:8262985).Curated1
Sequence conflicti660T → A in CAA52647 (PubMed:8262985).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X74553 Genomic DNA Translation: CAA52647.1
L28920 Genomic DNA Translation: AAC09495.1
BK006935 Genomic DNA Translation: DAA07004.1
PIRiS53485
RefSeqiNP_009420.1, NM_001178226.1

Genome annotation databases

EnsemblFungiiYAR035W; YAR035W; YAR035W
GeneIDi851285
KEGGisce:YAR035W

Similar proteinsi

Entry informationi

Entry nameiCACM_YEAST
AccessioniPrimary (citable) accession number: P80235
Secondary accession number(s): D6VPN4
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 1, 1993
Last sequence update: December 6, 2005
Last modified: May 23, 2018
This is version 156 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
  3. Yeast chromosome I
    Yeast (Saccharomyces cerevisiae) chromosome I: entries and gene names

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