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Protein

Fatty acid-binding protein, liver

Gene

FABP1

Organism
Gallus gallus (Chicken)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Binds free fatty acids and their coenzyme A derivatives, bilirubin, and some other small molecules in the cytoplasm. May be involved in intracellular lipid transport. Binds 2 molecules of cholate per subunit.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei56Cholate 11 Publication1
Binding sitei57Cholate 11 Publication1
Binding sitei77Cholate 21 Publication1
Binding sitei99Cholate 21 Publication1
Binding sitei101Cholate 21 Publication1

GO - Molecular functioni

Complete GO annotation...

Keywords - Biological processi

Transport

Keywords - Ligandi

Lipid-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Fatty acid-binding protein, liver
Alternative name(s):
Fatty acid-binding protein 1
Liver basic FABP
Short name:
LB-FABP
Liver bile acid-binding protein
Short name:
L-BABP
Liver-type fatty acid-binding protein
Short name:
L-FABP
Gene namesi
Name:FABP1
OrganismiGallus gallus (Chicken)
Taxonomic identifieri9031 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiArchelosauriaArchosauriaDinosauriaSaurischiaTheropodaCoelurosauriaAvesNeognathaeGalloanseraeGalliformesPhasianidaePhasianinaeGallus
Proteomesi
  • UP000000539 Componenti: Unplaced

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemoved1 Publication
ChainiPRO_00000673382 – 126Fatty acid-binding protein, liverAdd BLAST125

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei2N-acetylalanine1 Publication1

Keywords - PTMi

Acetylation

Proteomic databases

PaxDbiP80226.

Expressioni

Gene expression databases

BgeeiENSGALG00000004141.

Interactioni

Protein-protein interaction databases

STRINGi9031.ENSGALP00000006574.

Structurei

Secondary structure

1126
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi5 – 14Combined sources10
Helixi15 – 21Combined sources7
Beta strandi22 – 24Combined sources3
Helixi26 – 32Combined sources7
Beta strandi38 – 44Combined sources7
Beta strandi47 – 53Combined sources7
Beta strandi58 – 64Combined sources7
Beta strandi69 – 72Combined sources4
Turni74 – 76Combined sources3
Beta strandi78 – 81Combined sources4
Beta strandi84 – 86Combined sources3
Beta strandi89 – 94Combined sources6
Beta strandi97 – 104Combined sources8
Beta strandi107 – 114Combined sources8
Beta strandi117 – 125Combined sources9

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1MVGNMR-A2-126[»]
1TVQX-ray2.00A2-126[»]
1TW4X-ray2.00A/B2-126[»]
1ZRYNMR-A2-126[»]
2JN3NMR-A2-126[»]
2K62NMR-A2-126[»]
2LFONMR-A2-126[»]
ProteinModelPortaliP80226.
SMRiP80226.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP80226.

Family & Domainsi

Domaini

Forms a beta-barrel structure that accommodates hydrophobic ligands in its interior.

Sequence similaritiesi

Phylogenomic databases

eggNOGiKOG4015. Eukaryota.
ENOG4111US8. LUCA.
HOGENOMiHOG000004830.
HOVERGENiHBG005633.
InParanoidiP80226.
OrthoDBiEOG091G16BV.
PhylomeDBiP80226.
TreeFamiTF330348.

Family and domain databases

Gene3Di2.40.128.20. 1 hit.
InterProiIPR012674. Calycin.
IPR011038. Calycin-like.
IPR000463. Fatty_acid-bd.
IPR031259. iLBP.
IPR031276. Lb-FABP.
[Graphical view]
PANTHERiPTHR11955. PTHR11955. 1 hit.
PTHR11955:SF67. PTHR11955:SF67. 1 hit.
PRINTSiPR00178. FATTYACIDBP.
SUPFAMiSSF50814. SSF50814. 1 hit.
PROSITEiPS00214. FABP. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P80226-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAFSGTWQVY AQENYEEFLK ALALPEDLIK MARDIKPIVE IQQKGDDFVV
60 70 80 90 100
TSKTPRQTVT NSFTLGKEAD ITTMDGKKLK CTVHLANGKL VTKSEKFSHE
110 120
QEVKGNEMVE TITFGGVTLI RRSKRV
Length:126
Mass (Da):14,210
Last modified:January 23, 2007 - v2
Checksum:i537022389AC431FF
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti92T → C in AAK58094 (Ref. 1) Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF380998 mRNA. Translation: AAK58094.1.
RefSeqiNP_989965.1. NM_204634.1.
UniGeneiGga.40.

Genome annotation databases

GeneIDi395345.
KEGGigga:395345.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF380998 mRNA. Translation: AAK58094.1.
RefSeqiNP_989965.1. NM_204634.1.
UniGeneiGga.40.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1MVGNMR-A2-126[»]
1TVQX-ray2.00A2-126[»]
1TW4X-ray2.00A/B2-126[»]
1ZRYNMR-A2-126[»]
2JN3NMR-A2-126[»]
2K62NMR-A2-126[»]
2LFONMR-A2-126[»]
ProteinModelPortaliP80226.
SMRiP80226.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9031.ENSGALP00000006574.

Proteomic databases

PaxDbiP80226.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi395345.
KEGGigga:395345.

Organism-specific databases

CTDi395345.

Phylogenomic databases

eggNOGiKOG4015. Eukaryota.
ENOG4111US8. LUCA.
HOGENOMiHOG000004830.
HOVERGENiHBG005633.
InParanoidiP80226.
OrthoDBiEOG091G16BV.
PhylomeDBiP80226.
TreeFamiTF330348.

Miscellaneous databases

EvolutionaryTraceiP80226.
PROiP80226.

Gene expression databases

BgeeiENSGALG00000004141.

Family and domain databases

Gene3Di2.40.128.20. 1 hit.
InterProiIPR012674. Calycin.
IPR011038. Calycin-like.
IPR000463. Fatty_acid-bd.
IPR031259. iLBP.
IPR031276. Lb-FABP.
[Graphical view]
PANTHERiPTHR11955. PTHR11955. 1 hit.
PTHR11955:SF67. PTHR11955:SF67. 1 hit.
PRINTSiPR00178. FATTYACIDBP.
SUPFAMiSSF50814. SSF50814. 1 hit.
PROSITEiPS00214. FABP. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiFABPL_CHICK
AccessioniPrimary (citable) accession number: P80226
Secondary accession number(s): Q90WB0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 1, 1994
Last sequence update: January 23, 2007
Last modified: November 2, 2016
This is version 124 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.