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P80226 (FABPL_CHICK) Reviewed, UniProtKB/Swiss-Prot

Last modified April 3, 2013. Version 99. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
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to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Fatty acid-binding protein, liver
Alternative name(s):
Fatty acid-binding protein 1
Liver basic FABP
Short name=LB-FABP
Liver bile acid-binding protein
Short name=L-BABP
Liver-type fatty acid-binding protein
Short name=L-FABP
Gene names
Name:FABP1
OrganismGallus gallus (Chicken) [Reference proteome]
Taxonomic identifier9031 [NCBI]
Taxonomic lineageEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Archosauria › Dinosauria › Saurischia › Theropoda › Coelurosauria › Aves › Neognathae › Galliformes › Phasianidae › Phasianinae › Gallus

Protein attributes

Sequence length126 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Binds free fatty acids and their coenzyme A derivatives, bilirubin, and some other small molecules in the cytoplasm. May be involved in intracellular lipid transport. Binds 2 molecules of cholate per subunit.

Subcellular location

Cytoplasm.

Domain

Forms a beta-barrel structure that accommodates hydrophobic ligands in its interior.

Sequence similarities

Belongs to the calycin superfamily. Fatty-acid binding protein (FABP) family.

Ontologies

Keywords
   Biological processTransport
   Cellular componentCytoplasm
   LigandLipid-binding
   PTMAcetylation
   Technical term3D-structure
Complete proteome
Direct protein sequencing
Reference proteome
Gene Ontology (GO)
   Cellular_componentcytoplasm

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular_functionlipid binding

Inferred from electronic annotation. Source: UniProtKB-KW

transporter activity

Inferred from electronic annotation. Source: InterPro

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Initiator methionine11Removed Ref.2
Chain2 – 126125Fatty acid-binding protein, liver
PRO_0000067338

Sites

Binding site561Cholate 1
Binding site571Cholate 1
Binding site771Cholate 2
Binding site991Cholate 2
Binding site1011Cholate 2

Amino acid modifications

Modified residue21N-acetylalanine

Experimental info

Sequence conflict921T → C in AAK58094. Ref.1

Secondary structure

1 ............................. 126
Helix Strand Turn

Details...

Sequences

Sequence LengthMass (Da)Tools
P80226 [UniParc].

Last modified January 23, 2007. Version 2.
Checksum: 537022389AC431FF

FASTA12614,210
        10         20         30         40         50         60 
MAFSGTWQVY AQENYEEFLK ALALPEDLIK MARDIKPIVE IQQKGDDFVV TSKTPRQTVT 

        70         80         90        100        110        120 
NSFTLGKEAD ITTMDGKKLK CTVHLANGKL VTKSEKFSHE QEVKGNEMVE TITFGGVTLI 


RRSKRV

« Hide

References

[1]"Regulation of gene expression of two liver type fatty acid binding proteins in chicken."
Murai A., Kusumoto K., Okumura J.
Submitted (MAY-2001) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
Strain: White leghorn.
Tissue: Liver.
[2]"The primary structure of a basic (pI 9.0) fatty acid-binding protein from liver of Gallus domesticus."
Ceciliani F., Monaco H.L., Ronchi S., Faotto L., Spadon P.
Comp. Biochem. Physiol. 109B:261-271(1994) [PubMed] [Europe PMC] [Abstract]
Cited for: PROTEIN SEQUENCE OF 2-126.
Tissue: Liver.
[3]"Crystal structure of chicken liver basic fatty acid-binding protein at 2.7 A resolution."
Scapin G., Spadon P., Mammi M., Zanotti G., Monaco H.L.
Mol. Cell. Biochem. 98:95-99(1990) [PubMed] [Europe PMC] [Abstract]
Cited for: X-RAY CRYSTALLOGRAPHY (2.7 ANGSTROMS).
[4]"Solution structure of chicken liver basic fatty acid binding protein."
Vasile F., Ragona L., Catalano M., Zetta L., Perduca M., Monaco H.L., Molinari H.
J. Biomol. NMR 25:157-160(2003) [PubMed] [Europe PMC] [Abstract]
Cited for: STRUCTURE BY NMR.
[5]"Crystal structure of chicken liver basic fatty acid-binding protein complexed with cholic acid."
Nichesola D., Perduca M., Capaldi S., Carrizo M.E., Righetti P.G., Monaco H.L.
Biochemistry 43:14072-14079(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: X-RAY CRYSTALLOGRAPHY (2.0 ANGSTROMS) IN COMPLEX WITH CHOLATE.
[6]"NMR dynamic studies suggest that allosteric activation regulates ligand binding in chicken liver bile acid-binding protein."
Ragona L., Catalano M., Luppi M., Cicero D., Eliseo T., Foote J., Fogolari F., Zetta L., Molinari H.
J. Biol. Chem. 281:9697-9709(2006) [PubMed] [Europe PMC] [Abstract]
Cited for: STRUCTURE BY NMR.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		AF380998 mRNA. Translation: AAK58094.1.
IPIIPI00595210.
RefSeqNP_989965.1. NM_204634.1.
UniGeneGga.40.

3D structure databases

PDBe
RCSB PDB
PDBj
EntryMethodResolution (Å)ChainPositionsPDBsum
1MVGNMR-A2-126[»]
1TVQX-ray2.00A2-126[»]
1TW4X-ray2.00A/B2-126[»]
1ZRYNMR-A2-126[»]
2JN3NMR-A2-126[»]
2K62NMR-A2-126[»]
2LFONMR-A2-126[»]
ProteinModelPortalP80226.
SMRP80226. Positions 2-126.
ModBaseSearch...

Protein-protein interaction databases

STRING9031.ENSGALP00000006574.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSGALT00000006584; ENSGALP00000006574; ENSGALG00000004141.
GeneID395345.
KEGGgga:395345.

Organism-specific databases

CTD395345.

Phylogenomic databases

eggNOGNOG325336.
GeneTreeENSGT00390000012034.
HOGENOMHOG000004830.
HOVERGENHBG005633.
InParanoidP80226.
OrthoDBEOG47SSG7.

Family and domain databases

Gene3D2.40.128.20. 1 hit.
InterProIPR012674. Calycin.
IPR011038. Calycin-like.
IPR000463. Fatty_acid-bd.
IPR000566. Lipocln_cytosolic_FA-bd_dom.
[Graphical view]
PfamPF00061. Lipocalin. 1 hit.
[Graphical view]
PRINTSPR00178. FATTYACIDBP.
SUPFAMSSF50814. Calycin. 1 hit.
PROSITEPS00214. FABP. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

EvolutionaryTraceP80226.
NextBio20815430.

Entry information

Entry nameFABPL_CHICK
AccessionPrimary (citable) accession number: P80226
Secondary accession number(s): Q90WB0
Entry history
Integrated into UniProtKB/Swiss-Prot: February 1, 1994
Last sequence update: January 23, 2007
Last modified: April 3, 2013
This is version 99 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

PDB cross-references

Index of Protein Data Bank (PDB) cross-references

SIMILARITY comments

Index of protein domains and families

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