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Protein

C-X-C motif chemokine 6

Gene

CXCL6

Organism
Bos taurus (Bovine)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Chemotactic for neutrophil granulocytes. Signals through binding and activation of its receptors (CXCR1 and CXCR2). In addition to its chemotactic and angiogenic properties, it has strong antibacterial activity against Gram-positive and Gram-negative bacteria (90-fold-higher when compared to CXCL5 and CXCL7) (By similarity).By similarity1 Publication

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Antibiotic, Antimicrobial, Cytokine

Keywords - Biological processi

Chemotaxis

Keywords - Ligandi

Heparin-binding

Enzyme and pathway databases

ReactomeiR-BTA-380108. Chemokine receptors bind chemokines.
R-BTA-418594. G alpha (i) signalling events.

Names & Taxonomyi

Protein namesi
Recommended name:
C-X-C motif chemokine 6
Alternative name(s):
Granulocyte chemotactic protein 2
Short name:
GCP-2
Small-inducible cytokine B6
Gene namesi
Name:CXCL6
Synonyms:GCP2, SCYB6
OrganismiBos taurus (Bovine)
Taxonomic identifieri9913 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
Proteomesi
  • UP000009136 Componenti: Chromosome 6

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 36361 PublicationAdd
BLAST
Chaini37 – 11276C-X-C motif chemokine 6PRO_0000005082Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi48 ↔ 74By similarity
Disulfide bondi50 ↔ 90By similarity

Keywords - PTMi

Disulfide bond

Proteomic databases

PaxDbiP80221.

Expressioni

Developmental stagei

Expressed in high amounts from endometria of day 18-21 pregnant cows.

Inductioni

By interferon tau and phorbol ester.

Interactioni

GO - Molecular functioni

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000012939.

Structurei

3D structure databases

ProteinModelPortaliP80221.
SMRiP80221. Positions 45-106.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG410J4TR. Eukaryota.
ENOG41117DC. LUCA.
GeneTreeiENSGT00530000062901.
HOGENOMiHOG000220915.
HOVERGENiHBG107789.
InParanoidiP80221.
KOiK05506.
OMAiLRCVCLQ.
OrthoDBiEOG7B5WZS.
TreeFamiTF333433.

Family and domain databases

InterProiIPR001089. Chemokine_CXC.
IPR018048. Chemokine_CXC_CS.
IPR001811. Chemokine_IL8-like_dom.
[Graphical view]
PANTHERiPTHR10179. PTHR10179. 1 hit.
PfamiPF00048. IL8. 1 hit.
[Graphical view]
PRINTSiPR00437. SMALLCYTKCXC.
SMARTiSM00199. SCY. 1 hit.
[Graphical view]
SUPFAMiSSF54117. SSF54117. 1 hit.
PROSITEiPS00471. SMALL_CYTOKINES_CXC. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P80221-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MRLLSSRAAR VSGPSGSLCA LLALLLLTPP GPLASAGPVA AVVRELRCVC
60 70 80 90 100
LTTTPGIHPK TVSDLQVIAA GPQCSKVEVI ATLKNGREVC LDPEAPLIKK
110
IVQKILDSGK NN
Length:112
Mass (Da):11,589
Last modified:May 4, 2001 - v2
Checksum:i6ED8148B96A7C082
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti37 – 459Missing in N-terminal processing variant.
Natural varianti37 – 448Missing in N-terminal processing variant.
Natural varianti37 – 437Missing in N-terminal processing variant.
Natural varianti37 – 382Missing in N-terminal processing variant.

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF149249 mRNA. Translation: AAG35212.1.
BC142108 mRNA. Translation: AAI42109.1.
PIRiB54188.
RefSeqiNP_776725.1. NM_174300.2.
UniGeneiBt.7165.

Genome annotation databases

EnsembliENSBTAT00000012939; ENSBTAP00000012939; ENSBTAG00000009812.
GeneIDi281735.
KEGGibta:281735.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF149249 mRNA. Translation: AAG35212.1.
BC142108 mRNA. Translation: AAI42109.1.
PIRiB54188.
RefSeqiNP_776725.1. NM_174300.2.
UniGeneiBt.7165.

3D structure databases

ProteinModelPortaliP80221.
SMRiP80221. Positions 45-106.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000012939.

Proteomic databases

PaxDbiP80221.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSBTAT00000012939; ENSBTAP00000012939; ENSBTAG00000009812.
GeneIDi281735.
KEGGibta:281735.

Organism-specific databases

CTDi6374.

Phylogenomic databases

eggNOGiENOG410J4TR. Eukaryota.
ENOG41117DC. LUCA.
GeneTreeiENSGT00530000062901.
HOGENOMiHOG000220915.
HOVERGENiHBG107789.
InParanoidiP80221.
KOiK05506.
OMAiLRCVCLQ.
OrthoDBiEOG7B5WZS.
TreeFamiTF333433.

Enzyme and pathway databases

ReactomeiR-BTA-380108. Chemokine receptors bind chemokines.
R-BTA-418594. G alpha (i) signalling events.

Family and domain databases

InterProiIPR001089. Chemokine_CXC.
IPR018048. Chemokine_CXC_CS.
IPR001811. Chemokine_IL8-like_dom.
[Graphical view]
PANTHERiPTHR10179. PTHR10179. 1 hit.
PfamiPF00048. IL8. 1 hit.
[Graphical view]
PRINTSiPR00437. SMALLCYTKCXC.
SMARTiSM00199. SCY. 1 hit.
[Graphical view]
SUPFAMiSSF54117. SSF54117. 1 hit.
PROSITEiPS00471. SMALL_CYTOKINES_CXC. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "The bovine granulocyte chemotactic protein-2 cDNA."
    Austin K.J., Perry D.J., Hansen T.R.
    Submitted (MAY-1999) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Endometrium.
  2. NIH - Mammalian Gene Collection (MGC) project
    Submitted (JUN-2007) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: Hereford.
    Tissue: Thymus.
  3. "Human and bovine granulocyte chemotactic protein-2: complete amino acid sequence and functional characterization as chemokines."
    Proost P., Wuyts A., Conings R., Lenaerts J.-P., Billiau A., Opdenakker G., van Damme J.
    Biochemistry 32:10170-10177(1993) [PubMed] [Europe PMC] [Abstract]
    Cited for: PROTEIN SEQUENCE OF 37-111, FUNCTION, PROTEOLYTIC PROCESSING OF N-TERMINAL.
    Tissue: Kidney.

Entry informationi

Entry nameiCXCL6_BOVIN
AccessioniPrimary (citable) accession number: P80221
Secondary accession number(s): A5PJH0, Q9GKP5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 1, 1994
Last sequence update: May 4, 2001
Last modified: June 8, 2016
This is version 116 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.