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Protein

Interferon-induced 35 kDa protein

Gene

IFI35

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Not yet known.

GO - Biological processi

Complete GO annotation...

Enzyme and pathway databases

BioCyciZFISH:ENSG00000068079-MONOMER.
ReactomeiR-HSA-909733. Interferon alpha/beta signaling.

Names & Taxonomyi

Protein namesi
Recommended name:
Interferon-induced 35 kDa protein
Short name:
IFP 35
Short name:
Ifi-35
Gene namesi
Name:IFI35
Synonyms:IFP35
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 17

Organism-specific databases

HGNCiHGNC:5399. IFI35.

Subcellular locationi

  • Nucleus

  • Note: Nuclear following IFN treatment.

GO - Cellular componenti

  • cytosol Source: Reactome
  • nucleus Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

DisGeNETi3430.
OpenTargetsiENSG00000068079.
PharmGKBiPA29645.

Polymorphism and mutation databases

BioMutaiIFI35.
DMDMi311033494.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemoved1 Publication
ChainiPRO_00001597042 – 286Interferon-induced 35 kDa proteinAdd BLAST285

Proteomic databases

EPDiP80217.
MaxQBiP80217.
PaxDbiP80217.
PeptideAtlasiP80217.
PRIDEiP80217.

PTM databases

iPTMnetiP80217.
PhosphoSitePlusiP80217.

Expressioni

Tissue specificityi

In a wide range of cell types, including fibroblasts, macrophages, and epithelial cells.

Inductioni

By interferon gamma.

Gene expression databases

BgeeiENSG00000068079.
CleanExiHS_IFI35.
GenevisibleiP80217. HS.

Interactioni

Subunit structurei

Homodimer. Also interacts with B-ATF.

Binary interactionsi

WithEntry#Exp.IntActNotes
CLEC4GQ6UXB44EBI-2115067,EBI-2114729

Protein-protein interaction databases

BioGridi109656. 7 interactors.
IntActiP80217. 5 interactors.
MINTiMINT-2804911.
STRINGi9606.ENSP00000395590.

Structurei

3D structure databases

ProteinModelPortaliP80217.
SMRiP80217.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni5 – 26Leucine-zipperAdd BLAST22

Sequence similaritiesi

Belongs to the NMI family.Curated

Phylogenomic databases

eggNOGiENOG410IZG7. Eukaryota.
ENOG4111RNW. LUCA.
GeneTreeiENSGT00530000063686.
HOGENOMiHOG000230968.
HOVERGENiHBG052125.
InParanoidiP80217.
OMAiQQKEHTI.
OrthoDBiEOG091G0CE6.
PhylomeDBiP80217.
TreeFamiTF332752.

Family and domain databases

InterProiIPR009909. Nmi/IFP35_dom.
IPR009938. Nmi/IFP35_N.
[Graphical view]
PfamiPF07334. IFP_35_N. 1 hit.
PF07292. NID. 2 hits.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: P80217-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MSAPLDAALH ALQEEQARLK MRLWDLQQLR KELGDSPKDK VPFSVPKIPL
60 70 80 90 100
VFRGHTQQDP EVPKSLVSNL RIHCPLLAGS ALITFDDPKV AEQVLQQKEH
110 120 130 140 150
TINMEECRLR VQVQPLELPM VTTIQMSSQL SGRRVLVTGF PASLRLSEEE
160 170 180 190 200
LLDKLEIFFG KTRNGGGDVD VRELLPGSVM LGFARDGVAQ RLCQIGQFTV
210 220 230 240 250
PLGGQQVPLR VSPYVNGEIQ KAEIRSQPVP RSVLVLNIPD ILDGPELHDV
260 270 280
LEIHFQKPTR GGGEVEALTV VPQGQQGLAV FTSESG
Note: No experimental confirmation available.
Length:286
Mass (Da):31,546
Last modified:November 2, 2010 - v5
Checksum:i3FCAB26E97317508
GO
Isoform 2 (identifier: P80217-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     126-126: M → VMM

Note: Due to a polymorphism at the 3'-splice acceptor site of intron 4.
Show »
Length:288
Mass (Da):31,777
Checksum:iF8C385872AF39D6D
GO

Sequence cautioni

The sequence AAB61703 differs from that shown. Contaminating sequence. Sequence of unknown origin in the N-terminal part.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti264 – 286EVEAL…TSESG → GRGPDSRTPRTAGPSSLHL no nucleotide entry (PubMed:8288566).CuratedAdd BLAST23

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_063758126M → V.1 PublicationCorresponds to variant rs588703dbSNPEnsembl.1
Isoform 2 (identifier: P80217-2)
Natural varianti128M → V.Corresponds to variant rs588703dbSNPEnsembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_003569126M → VMM in isoform 2. 2 Publications1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U72882 mRNA. Translation: AAB61703.1. Sequence problems.
AC055866 Genomic DNA. No translation available.
BC001356 mRNA. Translation: AAH01356.1.
L78833 Genomic DNA. Translation: AAC37597.1.
CCDSiCCDS11450.1. [P80217-2]
CCDS82134.1. [P80217-1]
PIRiJC5262.
RefSeqiNP_001317159.1. NM_001330230.1.
NP_005524.2. NM_005533.4. [P80217-2]
UniGeneiHs.632258.

Genome annotation databases

EnsembliENST00000415816; ENSP00000394579; ENSG00000068079. [P80217-1]
ENST00000438323; ENSP00000395590; ENSG00000068079. [P80217-2]
GeneIDi3430.
KEGGihsa:3430.
UCSCiuc021txx.2. human. [P80217-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U72882 mRNA. Translation: AAB61703.1. Sequence problems.
AC055866 Genomic DNA. No translation available.
BC001356 mRNA. Translation: AAH01356.1.
L78833 Genomic DNA. Translation: AAC37597.1.
CCDSiCCDS11450.1. [P80217-2]
CCDS82134.1. [P80217-1]
PIRiJC5262.
RefSeqiNP_001317159.1. NM_001330230.1.
NP_005524.2. NM_005533.4. [P80217-2]
UniGeneiHs.632258.

3D structure databases

ProteinModelPortaliP80217.
SMRiP80217.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi109656. 7 interactors.
IntActiP80217. 5 interactors.
MINTiMINT-2804911.
STRINGi9606.ENSP00000395590.

PTM databases

iPTMnetiP80217.
PhosphoSitePlusiP80217.

Polymorphism and mutation databases

BioMutaiIFI35.
DMDMi311033494.

Proteomic databases

EPDiP80217.
MaxQBiP80217.
PaxDbiP80217.
PeptideAtlasiP80217.
PRIDEiP80217.

Protocols and materials databases

DNASUi3430.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000415816; ENSP00000394579; ENSG00000068079. [P80217-1]
ENST00000438323; ENSP00000395590; ENSG00000068079. [P80217-2]
GeneIDi3430.
KEGGihsa:3430.
UCSCiuc021txx.2. human. [P80217-1]

Organism-specific databases

CTDi3430.
DisGeNETi3430.
GeneCardsiIFI35.
HGNCiHGNC:5399. IFI35.
MIMi600735. gene.
neXtProtiNX_P80217.
OpenTargetsiENSG00000068079.
PharmGKBiPA29645.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IZG7. Eukaryota.
ENOG4111RNW. LUCA.
GeneTreeiENSGT00530000063686.
HOGENOMiHOG000230968.
HOVERGENiHBG052125.
InParanoidiP80217.
OMAiQQKEHTI.
OrthoDBiEOG091G0CE6.
PhylomeDBiP80217.
TreeFamiTF332752.

Enzyme and pathway databases

BioCyciZFISH:ENSG00000068079-MONOMER.
ReactomeiR-HSA-909733. Interferon alpha/beta signaling.

Miscellaneous databases

ChiTaRSiIFI35. human.
GeneWikiiIFI35.
GenomeRNAii3430.
PROiP80217.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000068079.
CleanExiHS_IFI35.
GenevisibleiP80217. HS.

Family and domain databases

InterProiIPR009909. Nmi/IFP35_dom.
IPR009938. Nmi/IFP35_N.
[Graphical view]
PfamiPF07334. IFP_35_N. 1 hit.
PF07292. NID. 2 hits.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiIN35_HUMAN
AccessioniPrimary (citable) accession number: P80217
Secondary accession number(s): C9JGX1
, Q92984, Q99537, Q9BV98
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 1, 1994
Last sequence update: November 2, 2010
Last modified: November 30, 2016
This is version 137 of the entry and version 5 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Human chromosome 17
    Human chromosome 17: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.