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Protein

Interferon-induced 35 kDa protein

Gene

IFI35

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Not yet known.

GO - Biological processi

  1. cytokine-mediated signaling pathway Source: Reactome
  2. type I interferon signaling pathway Source: Reactome
Complete GO annotation...

Enzyme and pathway databases

ReactomeiREACT_25162. Interferon alpha/beta signaling.

Names & Taxonomyi

Protein namesi
Recommended name:
Interferon-induced 35 kDa protein
Short name:
IFP 35
Short name:
Ifi-35
Gene namesi
Name:IFI35
Synonyms:IFP35
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 17

Organism-specific databases

HGNCiHGNC:5399. IFI35.

Subcellular locationi

Nucleus
Note: Nuclear following IFN treatment.

GO - Cellular componenti

  1. cytosol Source: Reactome
  2. nucleus Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA29645.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Initiator methioninei1 – 11Removed1 Publication
Chaini2 – 286285Interferon-induced 35 kDa proteinPRO_0000159704Add
BLAST

Proteomic databases

MaxQBiP80217.
PaxDbiP80217.
PRIDEiP80217.

PTM databases

PhosphoSiteiP80217.

Expressioni

Tissue specificityi

In a wide range of cell types, including fibroblasts, macrophages, and epithelial cells.

Inductioni

By interferon gamma.

Gene expression databases

BgeeiP80217.
CleanExiHS_IFI35.
GenevestigatoriP80217.

Interactioni

Subunit structurei

Homodimer. Also interacts with B-ATF.

Binary interactionsi

WithEntry#Exp.IntActNotes
CLEC4GQ6UXB44EBI-2115067,EBI-2114729

Protein-protein interaction databases

BioGridi109656. 7 interactions.
IntActiP80217. 5 interactions.
MINTiMINT-2804911.
STRINGi9606.ENSP00000246911.

Structurei

3D structure databases

ProteinModelPortaliP80217.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni5 – 2622Leucine-zipperAdd
BLAST

Sequence similaritiesi

Belongs to the NMI family.Curated

Phylogenomic databases

eggNOGiNOG28883.
GeneTreeiENSGT00530000063686.
HOGENOMiHOG000230968.
HOVERGENiHBG052125.
InParanoidiP80217.
OMAiLVFRGHT.
OrthoDBiEOG7SR4N0.
PhylomeDBiP80217.
TreeFamiTF332752.

Family and domain databases

InterProiIPR009909. Nmi/IFP35_dom.
IPR009938. Nmi/IFP35_N.
[Graphical view]
PfamiPF07334. IFP_35_N. 1 hit.
PF07292. NID. 2 hits.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by alternative splicing. Align

Isoform 1 (identifier: P80217-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MSAPLDAALH ALQEEQARLK MRLWDLQQLR KELGDSPKDK VPFSVPKIPL
60 70 80 90 100
VFRGHTQQDP EVPKSLVSNL RIHCPLLAGS ALITFDDPKV AEQVLQQKEH
110 120 130 140 150
TINMEECRLR VQVQPLELPM VTTIQMSSQL SGRRVLVTGF PASLRLSEEE
160 170 180 190 200
LLDKLEIFFG KTRNGGGDVD VRELLPGSVM LGFARDGVAQ RLCQIGQFTV
210 220 230 240 250
PLGGQQVPLR VSPYVNGEIQ KAEIRSQPVP RSVLVLNIPD ILDGPELHDV
260 270 280
LEIHFQKPTR GGGEVEALTV VPQGQQGLAV FTSESG

Note: No experimental confirmation available.

Length:286
Mass (Da):31,546
Last modified:November 2, 2010 - v5
Checksum:i3FCAB26E97317508
GO
Isoform 2 (identifier: P80217-2) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     126-126: M → VMM

Note: Due to a polymorphism at the 3'-splice acceptor site of intron 4.

Show »
Length:288
Mass (Da):31,777
Checksum:iF8C385872AF39D6D
GO

Sequence cautioni

The sequence AAB61703.1 differs from that shown.Contaminating sequence. Sequence of unknown origin in the N-terminal part.Curated

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti264 – 28623EVEAL…TSESG → GRGPDSRTPRTAGPSSLHL no nucleotide entry (PubMed:8288566)CuratedAdd
BLAST

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti126 – 1261M → V.1 Publication
Corresponds to variant rs588703 [ dbSNP | Ensembl ].
VAR_063758
Isoform 2 (identifier: P80217-2)
Natural varianti128 – 1281M → V.
Corresponds to variant rs588703 [ dbSNP | Ensembl ].

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei126 – 1261M → VMM in isoform 2. 2 PublicationsVSP_003569

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U72882 mRNA. Translation: AAB61703.1. Sequence problems.
AC055866 Genomic DNA. No translation available.
BC001356 mRNA. Translation: AAH01356.1.
L78833 Genomic DNA. Translation: AAC37597.1.
CCDSiCCDS11450.1. [P80217-2]
PIRiJC5262.
RefSeqiNP_005524.2. NM_005533.4. [P80217-2]
XP_005257359.1. XM_005257302.2. [P80217-1]
UniGeneiHs.632258.

Genome annotation databases

EnsembliENST00000415816; ENSP00000394579; ENSG00000068079. [P80217-1]
ENST00000438323; ENSP00000395590; ENSG00000068079. [P80217-2]
GeneIDi3430.
KEGGihsa:3430.
UCSCiuc021txx.1. human. [P80217-2]

Polymorphism databases

DMDMi311033494.

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U72882 mRNA. Translation: AAB61703.1. Sequence problems.
AC055866 Genomic DNA. No translation available.
BC001356 mRNA. Translation: AAH01356.1.
L78833 Genomic DNA. Translation: AAC37597.1.
CCDSiCCDS11450.1. [P80217-2]
PIRiJC5262.
RefSeqiNP_005524.2. NM_005533.4. [P80217-2]
XP_005257359.1. XM_005257302.2. [P80217-1]
UniGeneiHs.632258.

3D structure databases

ProteinModelPortaliP80217.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi109656. 7 interactions.
IntActiP80217. 5 interactions.
MINTiMINT-2804911.
STRINGi9606.ENSP00000246911.

PTM databases

PhosphoSiteiP80217.

Polymorphism databases

DMDMi311033494.

Proteomic databases

MaxQBiP80217.
PaxDbiP80217.
PRIDEiP80217.

Protocols and materials databases

DNASUi3430.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000415816; ENSP00000394579; ENSG00000068079. [P80217-1]
ENST00000438323; ENSP00000395590; ENSG00000068079. [P80217-2]
GeneIDi3430.
KEGGihsa:3430.
UCSCiuc021txx.1. human. [P80217-2]

Organism-specific databases

CTDi3430.
GeneCardsiGC17P041158.
HGNCiHGNC:5399. IFI35.
MIMi600735. gene.
neXtProtiNX_P80217.
PharmGKBiPA29645.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiNOG28883.
GeneTreeiENSGT00530000063686.
HOGENOMiHOG000230968.
HOVERGENiHBG052125.
InParanoidiP80217.
OMAiLVFRGHT.
OrthoDBiEOG7SR4N0.
PhylomeDBiP80217.
TreeFamiTF332752.

Enzyme and pathway databases

ReactomeiREACT_25162. Interferon alpha/beta signaling.

Miscellaneous databases

ChiTaRSiIFI35. human.
GeneWikiiIFI35.
GenomeRNAii3430.
NextBioi13524.
PROiP80217.
SOURCEiSearch...

Gene expression databases

BgeeiP80217.
CleanExiHS_IFI35.
GenevestigatoriP80217.

Family and domain databases

InterProiIPR009909. Nmi/IFP35_dom.
IPR009938. Nmi/IFP35_N.
[Graphical view]
PfamiPF07334. IFP_35_N. 1 hit.
PF07292. NID. 2 hits.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "IFP 35 is an interferon-induced leucine zipper protein that undergoes interferon-regulated cellular redistribution."
    Bange F.-C., Vogel U., Flohr T., Kiekenbeck M., Denecke B., Boettger E.C.
    J. Biol. Chem. 269:1091-1098(1994) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE (ISOFORM 1).
  2. "IFP 35 forms complexes with B-ATF, a member of the AP1 family of transcription factors."
    Wang X., Johansen L.M., Tae H.-J., Taparowsky E.J.
    Biochem. Biophys. Res. Commun. 229:316-322(1996) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2), VARIANT VAL-128 (ISOFORM 2).
  3. "DNA sequence of human chromosome 17 and analysis of rearrangement in the human lineage."
    Zody M.C., Garber M., Adams D.J., Sharpe T., Harrow J., Lupski J.R., Nicholson C., Searle S.M., Wilming L., Young S.K., Abouelleil A., Allen N.R., Bi W., Bloom T., Borowsky M.L., Bugalter B.E., Butler J., Chang J.L.
    , Chen C.-K., Cook A., Corum B., Cuomo C.A., de Jong P.J., DeCaprio D., Dewar K., FitzGerald M., Gilbert J., Gibson R., Gnerre S., Goldstein S., Grafham D.V., Grocock R., Hafez N., Hagopian D.S., Hart E., Norman C.H., Humphray S., Jaffe D.B., Jones M., Kamal M., Khodiyar V.K., LaButti K., Laird G., Lehoczky J., Liu X., Lokyitsang T., Loveland J., Lui A., Macdonald P., Major J.E., Matthews L., Mauceli E., McCarroll S.A., Mihalev A.H., Mudge J., Nguyen C., Nicol R., O'Leary S.B., Osoegawa K., Schwartz D.C., Shaw-Smith C., Stankiewicz P., Steward C., Swarbreck D., Venkataraman V., Whittaker C.A., Yang X., Zimmer A.R., Bradley A., Hubbard T., Birren B.W., Rogers J., Lander E.S., Nusbaum C.
    Nature 440:1045-1049(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2), VARIANT VAL-128 (ISOFORM 2).
    Tissue: Skin.
  5. "Complete genomic sequence and analysis of 117 kb of human DNA containing the gene BRCA1."
    Smith T.M., Lee M.K., Szabo C.I., Jerome N., McEuen M., Taylor M., Hood L., King M.-C.
    Genome Res. 6:1029-1049(1996) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 41-283 (ISOFORM 1), VARIANT VAL-126.
  6. "Exploring proteomes and analyzing protein processing by mass spectrometric identification of sorted N-terminal peptides."
    Gevaert K., Goethals M., Martens L., Van Damme J., Staes A., Thomas G.R., Vandekerckhove J.
    Nat. Biotechnol. 21:566-569(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: PROTEIN SEQUENCE OF 2-18.
    Tissue: Platelet.
  7. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

Entry informationi

Entry nameiIN35_HUMAN
AccessioniPrimary (citable) accession number: P80217
Secondary accession number(s): C9JGX1
, Q92984, Q99537, Q9BV98
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 1, 1994
Last sequence update: November 2, 2010
Last modified: January 7, 2015
This is version 123 of the entry and version 5 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Human chromosome 17
    Human chromosome 17: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.