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P80217 (IN35_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 118. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (5) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Interactions·Alt products·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Interferon-induced 35 kDa protein

Short name=IFP 35
Short name=Ifi-35
Gene names
Name:IFI35
Synonyms:IFP35
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length286 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Not yet known.

Subunit structure

Homodimer. Also interacts with B-ATF.

Subcellular location

Nucleus. Note: Nuclear following IFN treatment.

Tissue specificity

In a wide range of cell types, including fibroblasts, macrophages, and epithelial cells.

Induction

By interferon gamma.

Sequence similarities

Belongs to the NMI family.

Sequence caution

The sequence AAB61703.1 differs from that shown. Reason: Contaminating sequence. Sequence of unknown origin in the N-terminal part.

Ontologies

Keywords
   Cellular componentNucleus
   Coding sequence diversityAlternative splicing
Polymorphism
   Technical termComplete proteome
Direct protein sequencing
Reference proteome
Gene Ontology (GO)
   Biological_processcytokine-mediated signaling pathway

Traceable author statement. Source: Reactome

type I interferon signaling pathway

Traceable author statement. Source: Reactome

   Cellular_componentcytosol

Traceable author statement. Source: Reactome

nucleus

Inferred from direct assay Ref.1. Source: UniProtKB

   Molecular_functionprotein binding

Inferred from physical interaction Ref.2. Source: UniProtKB

Complete GO annotation...

Binary interactions

With

Entry

#Exp.

IntAct

Notes

CLEC4GQ6UXB44EBI-2115067,EBI-2114729

Alternative products

This entry describes 2 isoforms produced by alternative splicing. [Align] [Select]
Isoform 1 (identifier: P80217-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
Note: No experimental confirmation available.
Isoform 2 (identifier: P80217-2)

The sequence of this isoform differs from the canonical sequence as follows:
     126-126: M → VMM
Note: Due to a polymorphism at the 3'-splice acceptor site of intron 4.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Initiator methionine11Removed Ref.6
Chain2 – 286285Interferon-induced 35 kDa protein
PRO_0000159704

Regions

Region5 – 2622Leucine-zipper

Natural variations

Alternative sequence1261M → VMM in isoform 2.
VSP_003569
Natural variant1261M → V. Ref.5
Corresponds to variant rs588703 [ dbSNP | Ensembl ].
VAR_063758
Isoform 2:
Natural variant1281M → V.
Corresponds to variant rs588703 [ dbSNP | Ensembl ].

Experimental info

Sequence conflict264 – 28623EVEAL…TSESG → GRGPDSRTPRTAGPSSLHL no nucleotide entry Ref.1

Sequences

Sequence LengthMass (Da)Tools
Isoform 1 [UniParc].

Last modified November 2, 2010. Version 5.
Checksum: 3FCAB26E97317508

FASTA28631,546
        10         20         30         40         50         60 
MSAPLDAALH ALQEEQARLK MRLWDLQQLR KELGDSPKDK VPFSVPKIPL VFRGHTQQDP 

        70         80         90        100        110        120 
EVPKSLVSNL RIHCPLLAGS ALITFDDPKV AEQVLQQKEH TINMEECRLR VQVQPLELPM 

       130        140        150        160        170        180 
VTTIQMSSQL SGRRVLVTGF PASLRLSEEE LLDKLEIFFG KTRNGGGDVD VRELLPGSVM 

       190        200        210        220        230        240 
LGFARDGVAQ RLCQIGQFTV PLGGQQVPLR VSPYVNGEIQ KAEIRSQPVP RSVLVLNIPD 

       250        260        270        280 
ILDGPELHDV LEIHFQKPTR GGGEVEALTV VPQGQQGLAV FTSESG 

« Hide

Isoform 2 [UniParc].

Checksum: F8C385872AF39D6D
Show »

FASTA28831,777

References

« Hide 'large scale' references
[1]"IFP 35 is an interferon-induced leucine zipper protein that undergoes interferon-regulated cellular redistribution."
Bange F.-C., Vogel U., Flohr T., Kiekenbeck M., Denecke B., Boettger E.C.
J. Biol. Chem. 269:1091-1098(1994) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE (ISOFORM 1).
[2]"IFP 35 forms complexes with B-ATF, a member of the AP1 family of transcription factors."
Wang X., Johansen L.M., Tae H.-J., Taparowsky E.J.
Biochem. Biophys. Res. Commun. 229:316-322(1996) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2), VARIANT VAL-128 (ISOFORM 2).
[3]"DNA sequence of human chromosome 17 and analysis of rearrangement in the human lineage."
Zody M.C., Garber M., Adams D.J., Sharpe T., Harrow J., Lupski J.R., Nicholson C., Searle S.M., Wilming L., Young S.K., Abouelleil A., Allen N.R., Bi W., Bloom T., Borowsky M.L., Bugalter B.E., Butler J., Chang J.L. expand/collapse author list , Chen C.-K., Cook A., Corum B., Cuomo C.A., de Jong P.J., DeCaprio D., Dewar K., FitzGerald M., Gilbert J., Gibson R., Gnerre S., Goldstein S., Grafham D.V., Grocock R., Hafez N., Hagopian D.S., Hart E., Norman C.H., Humphray S., Jaffe D.B., Jones M., Kamal M., Khodiyar V.K., LaButti K., Laird G., Lehoczky J., Liu X., Lokyitsang T., Loveland J., Lui A., Macdonald P., Major J.E., Matthews L., Mauceli E., McCarroll S.A., Mihalev A.H., Mudge J., Nguyen C., Nicol R., O'Leary S.B., Osoegawa K., Schwartz D.C., Shaw-Smith C., Stankiewicz P., Steward C., Swarbreck D., Venkataraman V., Whittaker C.A., Yang X., Zimmer A.R., Bradley A., Hubbard T., Birren B.W., Rogers J., Lander E.S., Nusbaum C.
Nature 440:1045-1049(2006) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[4]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2), VARIANT VAL-128 (ISOFORM 2).
Tissue: Skin.
[5]"Complete genomic sequence and analysis of 117 kb of human DNA containing the gene BRCA1."
Smith T.M., Lee M.K., Szabo C.I., Jerome N., McEuen M., Taylor M., Hood L., King M.-C.
Genome Res. 6:1029-1049(1996) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 41-283 (ISOFORM 1), VARIANT VAL-126.
[6]"Exploring proteomes and analyzing protein processing by mass spectrometric identification of sorted N-terminal peptides."
Gevaert K., Goethals M., Martens L., Van Damme J., Staes A., Thomas G.R., Vandekerckhove J.
Nat. Biotechnol. 21:566-569(2003) [PubMed] [Europe PMC] [Abstract]
Cited for: PROTEIN SEQUENCE OF 2-18.
Tissue: Platelet.
[7]"Initial characterization of the human central proteome."
Burkard T.R., Planyavsky M., Kaupe I., Breitwieser F.P., Buerckstuemmer T., Bennett K.L., Superti-Furga G., Colinge J.
BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]
Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
U72882 mRNA. Translation: AAB61703.1. Sequence problems.
AC055866 Genomic DNA. No translation available.
BC001356 mRNA. Translation: AAH01356.1.
L78833 Genomic DNA. Translation: AAC37597.1.
CCDSCCDS11450.1. [P80217-2]
PIRJC5262.
RefSeqNP_005524.2. NM_005533.4. [P80217-2]
XP_005257359.1. XM_005257302.2. [P80217-1]
UniGeneHs.632258.

3D structure databases

ProteinModelPortalP80217.
SMRP80217. Positions 76-284.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid109656. 7 interactions.
IntActP80217. 4 interactions.
MINTMINT-2804911.
STRING9606.ENSP00000246911.

PTM databases

PhosphoSiteP80217.

Polymorphism databases

DMDM311033494.

Proteomic databases

MaxQBP80217.
PaxDbP80217.
PRIDEP80217.

Protocols and materials databases

DNASU3430.
StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000415816; ENSP00000394579; ENSG00000068079. [P80217-1]
ENST00000438323; ENSP00000395590; ENSG00000068079. [P80217-2]
GeneID3430.
KEGGhsa:3430.
UCSCuc021txx.1. human. [P80217-2]

Organism-specific databases

CTD3430.
GeneCardsGC17P041158.
HGNCHGNC:5399. IFI35.
MIM600735. gene.
neXtProtNX_P80217.
PharmGKBPA29645.
GenAtlasSearch...

Phylogenomic databases

eggNOGNOG28883.
HOGENOMHOG000230968.
HOVERGENHBG052125.
InParanoidP80217.
OMALVFRGHT.
OrthoDBEOG7SR4N0.
PhylomeDBP80217.
TreeFamTF332752.

Enzyme and pathway databases

ReactomeREACT_6900. Immune System.

Gene expression databases

BgeeP80217.
CleanExHS_IFI35.
GenevestigatorP80217.

Family and domain databases

InterProIPR009909. Nmi/IFP35_dom.
IPR009938. Nmi/IFP35_N.
[Graphical view]
PfamPF07334. IFP_35_N. 1 hit.
PF07292. NID. 2 hits.
[Graphical view]
ProtoNetSearch...

Other

GeneWikiIFI35.
GenomeRNAi3430.
NextBio13524.
PROP80217.
SOURCESearch...

Entry information

Entry nameIN35_HUMAN
AccessionPrimary (citable) accession number: P80217
Secondary accession number(s): C9JGX1 expand/collapse secondary AC list , Q92984, Q99537, Q9BV98
Entry history
Integrated into UniProtKB/Swiss-Prot: February 1, 1994
Last sequence update: November 2, 2010
Last modified: July 9, 2014
This is version 118 of the entry and version 5 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Human polymorphisms and disease mutations

Index of human polymorphisms and disease mutations

Human entries with polymorphisms or disease mutations

List of human entries with polymorphisms or disease mutations

Human chromosome 17

Human chromosome 17: entries, gene names and cross-references to MIM