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P80217

- IN35_HUMAN

UniProt

P80217 - IN35_HUMAN

Protein

Interferon-induced 35 kDa protein

Gene

IFI35

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 120 (01 Oct 2014)
      Sequence version 5 (02 Nov 2010)
      Previous versions | rss
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    Functioni

    Not yet known.

    GO - Molecular functioni

    1. protein binding Source: UniProtKB

    GO - Biological processi

    1. cytokine-mediated signaling pathway Source: Reactome
    2. type I interferon signaling pathway Source: Reactome

    Enzyme and pathway databases

    ReactomeiREACT_25162. Interferon alpha/beta signaling.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Interferon-induced 35 kDa protein
    Short name:
    IFP 35
    Short name:
    Ifi-35
    Gene namesi
    Name:IFI35
    Synonyms:IFP35
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 17

    Organism-specific databases

    HGNCiHGNC:5399. IFI35.

    Subcellular locationi

    Nucleus
    Note: Nuclear following IFN treatment.

    GO - Cellular componenti

    1. cytosol Source: Reactome
    2. nucleus Source: UniProtKB

    Keywords - Cellular componenti

    Nucleus

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA29645.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Initiator methioninei1 – 11Removed1 Publication
    Chaini2 – 286285Interferon-induced 35 kDa proteinPRO_0000159704Add
    BLAST

    Proteomic databases

    MaxQBiP80217.
    PaxDbiP80217.
    PRIDEiP80217.

    PTM databases

    PhosphoSiteiP80217.

    Expressioni

    Tissue specificityi

    In a wide range of cell types, including fibroblasts, macrophages, and epithelial cells.

    Inductioni

    By interferon gamma.

    Gene expression databases

    BgeeiP80217.
    CleanExiHS_IFI35.
    GenevestigatoriP80217.

    Interactioni

    Subunit structurei

    Homodimer. Also interacts with B-ATF.

    Binary interactionsi

    WithEntry#Exp.IntActNotes
    CLEC4GQ6UXB44EBI-2115067,EBI-2114729

    Protein-protein interaction databases

    BioGridi109656. 7 interactions.
    IntActiP80217. 4 interactions.
    MINTiMINT-2804911.
    STRINGi9606.ENSP00000246911.

    Structurei

    3D structure databases

    ProteinModelPortaliP80217.
    SMRiP80217. Positions 76-284.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni5 – 2622Leucine-zipperAdd
    BLAST

    Sequence similaritiesi

    Belongs to the NMI family.Curated

    Phylogenomic databases

    eggNOGiNOG28883.
    HOGENOMiHOG000230968.
    HOVERGENiHBG052125.
    InParanoidiP80217.
    OMAiLVFRGHT.
    OrthoDBiEOG7SR4N0.
    PhylomeDBiP80217.
    TreeFamiTF332752.

    Family and domain databases

    InterProiIPR009909. Nmi/IFP35_dom.
    IPR009938. Nmi/IFP35_N.
    [Graphical view]
    PfamiPF07334. IFP_35_N. 1 hit.
    PF07292. NID. 2 hits.
    [Graphical view]

    Sequences (2)i

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    This entry describes 2 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: P80217-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MSAPLDAALH ALQEEQARLK MRLWDLQQLR KELGDSPKDK VPFSVPKIPL    50
    VFRGHTQQDP EVPKSLVSNL RIHCPLLAGS ALITFDDPKV AEQVLQQKEH 100
    TINMEECRLR VQVQPLELPM VTTIQMSSQL SGRRVLVTGF PASLRLSEEE 150
    LLDKLEIFFG KTRNGGGDVD VRELLPGSVM LGFARDGVAQ RLCQIGQFTV 200
    PLGGQQVPLR VSPYVNGEIQ KAEIRSQPVP RSVLVLNIPD ILDGPELHDV 250
    LEIHFQKPTR GGGEVEALTV VPQGQQGLAV FTSESG 286

    Note: No experimental confirmation available.

    Length:286
    Mass (Da):31,546
    Last modified:November 2, 2010 - v5
    Checksum:i3FCAB26E97317508
    GO
    Isoform 2 (identifier: P80217-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         126-126: M → VMM

    Note: Due to a polymorphism at the 3'-splice acceptor site of intron 4.

    Show »
    Length:288
    Mass (Da):31,777
    Checksum:iF8C385872AF39D6D
    GO

    Sequence cautioni

    The sequence AAB61703.1 differs from that shown. Reason: Contaminating sequence. Sequence of unknown origin in the N-terminal part.

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti264 – 28623EVEAL…TSESG → GRGPDSRTPRTAGPSSLHL no nucleotide entry (PubMed:8288566)CuratedAdd
    BLAST

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti126 – 1261M → V.1 Publication
    Corresponds to variant rs588703 [ dbSNP | Ensembl ].
    VAR_063758
    Isoform 2 (identifier: P80217-2)
    Natural varianti128 – 1281M → V.
    Corresponds to variant rs588703 [ dbSNP | Ensembl ].

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei126 – 1261M → VMM in isoform 2. 2 PublicationsVSP_003569

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U72882 mRNA. Translation: AAB61703.1. Sequence problems.
    AC055866 Genomic DNA. No translation available.
    BC001356 mRNA. Translation: AAH01356.1.
    L78833 Genomic DNA. Translation: AAC37597.1.
    CCDSiCCDS11450.1. [P80217-2]
    PIRiJC5262.
    RefSeqiNP_005524.2. NM_005533.4. [P80217-2]
    XP_005257359.1. XM_005257302.2. [P80217-1]
    UniGeneiHs.632258.

    Genome annotation databases

    EnsembliENST00000415816; ENSP00000394579; ENSG00000068079. [P80217-1]
    ENST00000438323; ENSP00000395590; ENSG00000068079. [P80217-2]
    GeneIDi3430.
    KEGGihsa:3430.
    UCSCiuc021txx.1. human. [P80217-2]

    Polymorphism databases

    DMDMi311033494.

    Keywords - Coding sequence diversityi

    Alternative splicing, Polymorphism

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U72882 mRNA. Translation: AAB61703.1 . Sequence problems.
    AC055866 Genomic DNA. No translation available.
    BC001356 mRNA. Translation: AAH01356.1 .
    L78833 Genomic DNA. Translation: AAC37597.1 .
    CCDSi CCDS11450.1. [P80217-2 ]
    PIRi JC5262.
    RefSeqi NP_005524.2. NM_005533.4. [P80217-2 ]
    XP_005257359.1. XM_005257302.2. [P80217-1 ]
    UniGenei Hs.632258.

    3D structure databases

    ProteinModelPortali P80217.
    SMRi P80217. Positions 76-284.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 109656. 7 interactions.
    IntActi P80217. 4 interactions.
    MINTi MINT-2804911.
    STRINGi 9606.ENSP00000246911.

    PTM databases

    PhosphoSitei P80217.

    Polymorphism databases

    DMDMi 311033494.

    Proteomic databases

    MaxQBi P80217.
    PaxDbi P80217.
    PRIDEi P80217.

    Protocols and materials databases

    DNASUi 3430.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000415816 ; ENSP00000394579 ; ENSG00000068079 . [P80217-1 ]
    ENST00000438323 ; ENSP00000395590 ; ENSG00000068079 . [P80217-2 ]
    GeneIDi 3430.
    KEGGi hsa:3430.
    UCSCi uc021txx.1. human. [P80217-2 ]

    Organism-specific databases

    CTDi 3430.
    GeneCardsi GC17P041158.
    HGNCi HGNC:5399. IFI35.
    MIMi 600735. gene.
    neXtProti NX_P80217.
    PharmGKBi PA29645.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG28883.
    HOGENOMi HOG000230968.
    HOVERGENi HBG052125.
    InParanoidi P80217.
    OMAi LVFRGHT.
    OrthoDBi EOG7SR4N0.
    PhylomeDBi P80217.
    TreeFami TF332752.

    Enzyme and pathway databases

    Reactomei REACT_25162. Interferon alpha/beta signaling.

    Miscellaneous databases

    GeneWikii IFI35.
    GenomeRNAii 3430.
    NextBioi 13524.
    PROi P80217.
    SOURCEi Search...

    Gene expression databases

    Bgeei P80217.
    CleanExi HS_IFI35.
    Genevestigatori P80217.

    Family and domain databases

    InterProi IPR009909. Nmi/IFP35_dom.
    IPR009938. Nmi/IFP35_N.
    [Graphical view ]
    Pfami PF07334. IFP_35_N. 1 hit.
    PF07292. NID. 2 hits.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "IFP 35 is an interferon-induced leucine zipper protein that undergoes interferon-regulated cellular redistribution."
      Bange F.-C., Vogel U., Flohr T., Kiekenbeck M., Denecke B., Boettger E.C.
      J. Biol. Chem. 269:1091-1098(1994) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE (ISOFORM 1).
    2. "IFP 35 forms complexes with B-ATF, a member of the AP1 family of transcription factors."
      Wang X., Johansen L.M., Tae H.-J., Taparowsky E.J.
      Biochem. Biophys. Res. Commun. 229:316-322(1996) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2), VARIANT VAL-128 (ISOFORM 2).
    3. "DNA sequence of human chromosome 17 and analysis of rearrangement in the human lineage."
      Zody M.C., Garber M., Adams D.J., Sharpe T., Harrow J., Lupski J.R., Nicholson C., Searle S.M., Wilming L., Young S.K., Abouelleil A., Allen N.R., Bi W., Bloom T., Borowsky M.L., Bugalter B.E., Butler J., Chang J.L.
      , Chen C.-K., Cook A., Corum B., Cuomo C.A., de Jong P.J., DeCaprio D., Dewar K., FitzGerald M., Gilbert J., Gibson R., Gnerre S., Goldstein S., Grafham D.V., Grocock R., Hafez N., Hagopian D.S., Hart E., Norman C.H., Humphray S., Jaffe D.B., Jones M., Kamal M., Khodiyar V.K., LaButti K., Laird G., Lehoczky J., Liu X., Lokyitsang T., Loveland J., Lui A., Macdonald P., Major J.E., Matthews L., Mauceli E., McCarroll S.A., Mihalev A.H., Mudge J., Nguyen C., Nicol R., O'Leary S.B., Osoegawa K., Schwartz D.C., Shaw-Smith C., Stankiewicz P., Steward C., Swarbreck D., Venkataraman V., Whittaker C.A., Yang X., Zimmer A.R., Bradley A., Hubbard T., Birren B.W., Rogers J., Lander E.S., Nusbaum C.
      Nature 440:1045-1049(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2), VARIANT VAL-128 (ISOFORM 2).
      Tissue: Skin.
    5. "Complete genomic sequence and analysis of 117 kb of human DNA containing the gene BRCA1."
      Smith T.M., Lee M.K., Szabo C.I., Jerome N., McEuen M., Taylor M., Hood L., King M.-C.
      Genome Res. 6:1029-1049(1996) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 41-283 (ISOFORM 1), VARIANT VAL-126.
    6. "Exploring proteomes and analyzing protein processing by mass spectrometric identification of sorted N-terminal peptides."
      Gevaert K., Goethals M., Martens L., Van Damme J., Staes A., Thomas G.R., Vandekerckhove J.
      Nat. Biotechnol. 21:566-569(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: PROTEIN SEQUENCE OF 2-18.
      Tissue: Platelet.
    7. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

    Entry informationi

    Entry nameiIN35_HUMAN
    AccessioniPrimary (citable) accession number: P80217
    Secondary accession number(s): C9JGX1
    , Q92984, Q99537, Q9BV98
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: February 1, 1994
    Last sequence update: November 2, 2010
    Last modified: October 1, 2014
    This is version 120 of the entry and version 5 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Direct protein sequencing, Reference proteome

    Documents

    1. Human chromosome 17
      Human chromosome 17: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    5. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3