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Protein

Interferon-induced 35 kDa protein

Gene

IFI35

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Not yet known.

GO - Biological processi

Enzyme and pathway databases

ReactomeiR-HSA-909733 Interferon alpha/beta signaling

Names & Taxonomyi

Protein namesi
Recommended name:
Interferon-induced 35 kDa protein
Short name:
IFP 35
Short name:
Ifi-35
Gene namesi
Name:IFI35
Synonyms:IFP35
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 17

Organism-specific databases

EuPathDBiHostDB:ENSG00000068079.7
HGNCiHGNC:5399 IFI35
MIMi600735 gene
neXtProtiNX_P80217

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

DisGeNETi3430
OpenTargetsiENSG00000068079
PharmGKBiPA29645

Polymorphism and mutation databases

BioMutaiIFI35
DMDMi311033494

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemoved1 Publication
ChainiPRO_00001597042 – 286Interferon-induced 35 kDa proteinAdd BLAST285

Proteomic databases

EPDiP80217
MaxQBiP80217
PaxDbiP80217
PeptideAtlasiP80217
PRIDEiP80217
ProteomicsDBi57673
57674 [P80217-2]

PTM databases

iPTMnetiP80217
PhosphoSitePlusiP80217

Expressioni

Tissue specificityi

In a wide range of cell types, including fibroblasts, macrophages, and epithelial cells.

Inductioni

By interferon gamma.

Gene expression databases

BgeeiENSG00000068079
CleanExiHS_IFI35
GenevisibleiP80217 HS

Organism-specific databases

HPAiHPA045946

Interactioni

Subunit structurei

Homodimer. Also interacts with B-ATF.

Binary interactionsi

WithEntry#Exp.IntActNotes
CLEC4GQ6UXB44EBI-2115067,EBI-2114729

Protein-protein interaction databases

BioGridi109656, 7 interactors
CORUMiP80217
IntActiP80217, 9 interactors
MINTiP80217
STRINGi9606.ENSP00000395590

Structurei

3D structure databases

ProteinModelPortaliP80217
SMRiP80217
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni5 – 26Leucine-zipperAdd BLAST22

Sequence similaritiesi

Belongs to the NMI family.Curated

Phylogenomic databases

eggNOGiENOG410IZG7 Eukaryota
ENOG4111RNW LUCA
GeneTreeiENSGT00530000063686
HOGENOMiHOG000230968
HOVERGENiHBG052125
InParanoidiP80217
OMAiHFQKPTR
OrthoDBiEOG091G0CE6
PhylomeDBiP80217
TreeFamiTF332752

Family and domain databases

Gene3Di3.30.70.330, 2 hits
InterProiView protein in InterPro
IPR034460 IFP35
IPR009909 Nmi/IFP35_dom
IPR009938 Nmi/IFP35_N
IPR012677 Nucleotide-bd_a/b_plait_sf
PANTHERiPTHR15225:SF1 PTHR15225:SF1, 1 hit
PfamiView protein in Pfam
PF07334 IFP_35_N, 1 hit
PF07292 NID, 2 hits

Sequences (2)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: P80217-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MSAPLDAALH ALQEEQARLK MRLWDLQQLR KELGDSPKDK VPFSVPKIPL
60 70 80 90 100
VFRGHTQQDP EVPKSLVSNL RIHCPLLAGS ALITFDDPKV AEQVLQQKEH
110 120 130 140 150
TINMEECRLR VQVQPLELPM VTTIQMSSQL SGRRVLVTGF PASLRLSEEE
160 170 180 190 200
LLDKLEIFFG KTRNGGGDVD VRELLPGSVM LGFARDGVAQ RLCQIGQFTV
210 220 230 240 250
PLGGQQVPLR VSPYVNGEIQ KAEIRSQPVP RSVLVLNIPD ILDGPELHDV
260 270 280
LEIHFQKPTR GGGEVEALTV VPQGQQGLAV FTSESG
Note: No experimental confirmation available.
Length:286
Mass (Da):31,546
Last modified:November 2, 2010 - v5
Checksum:i3FCAB26E97317508
GO
Isoform 2 (identifier: P80217-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     126-126: M → VMM

Note: Due to a polymorphism at the 3'-splice acceptor site of intron 4.
Show »
Length:288
Mass (Da):31,777
Checksum:iF8C385872AF39D6D
GO

Sequence cautioni

The sequence AAB61703 differs from that shown. Contaminating sequence. Sequence of unknown origin in the N-terminal part.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti264 – 286EVEAL…TSESG → GRGPDSRTPRTAGPSSLHL no nucleotide entry (PubMed:8288566).CuratedAdd BLAST23

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_063758126M → V1 PublicationCorresponds to variant dbSNP:rs588703Ensembl.1
Isoform 2 (identifier: P80217-2)
Natural varianti128M → V. Corresponds to variant dbSNP:rs588703Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_003569126M → VMM in isoform 2. 2 Publications1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U72882 mRNA Translation: AAB61703.1 Sequence problems.
AC055866 Genomic DNA No translation available.
BC001356 mRNA Translation: AAH01356.1
L78833 Genomic DNA Translation: AAC37597.1
CCDSiCCDS11450.1 [P80217-2]
CCDS82134.1 [P80217-1]
PIRiJC5262
RefSeqiNP_001317159.1, NM_001330230.1 [P80217-1]
NP_005524.2, NM_005533.4 [P80217-2]
UniGeneiHs.632258

Genome annotation databases

EnsembliENST00000415816; ENSP00000394579; ENSG00000068079 [P80217-1]
ENST00000438323; ENSP00000395590; ENSG00000068079 [P80217-2]
GeneIDi3430
KEGGihsa:3430
UCSCiuc021txx.2 human [P80217-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Similar proteinsi

Entry informationi

Entry nameiIN35_HUMAN
AccessioniPrimary (citable) accession number: P80217
Secondary accession number(s): C9JGX1
, Q92984, Q99537, Q9BV98
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 1, 1994
Last sequence update: November 2, 2010
Last modified: June 20, 2018
This is version 146 of the entry and version 5 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

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