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Protein

Bacteriocin plantaricin-A

Gene

plnA

Organism
Lactobacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

This heat stable bacteriocin inhibits the growth of closely related Lactobacillus species. It may act as a pore-forming protein, creating a channel in the cell membrane through a "barrel stave" mechanism.

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Antibiotic, Antimicrobial, Bacteriocin

Protein family/group databases

TCDBi1.C.22.1.6. the lactococcin a (lactococcin a) family.

Names & Taxonomyi

Protein namesi
Recommended name:
Bacteriocin plantaricin-A
Gene namesi
Name:plnA
Ordered Locus Names:lp_0415
OrganismiLactobacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)
Taxonomic identifieri220668 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliLactobacillalesLactobacillaceaeLactobacillus
Proteomesi
  • UP000000432 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
PropeptideiPRO_00000027761 – 251 PublicationAdd BLAST25
PeptideiPRO_000000277726 – 48Bacteriocin plantaricin-AAdd BLAST23

Interactioni

Subunit structurei

Active plantaricin A is composed of an alpha chain and a beta chain.

Protein-protein interaction databases

STRINGi220668.lp_0415.

Structurei

Secondary structure

148
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi31 – 33Combined sources3
Helixi34 – 43Combined sources10

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1YTRNMR-A23-48[»]
ProteinModelPortaliP80214.
SMRiP80214.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP80214.

Family & Domainsi

Family and domain databases

InterProiIPR010133. Bacteriocin_signal_seq.
[Graphical view]
TIGRFAMsiTIGR01847. bacteriocin_sig. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P80214-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40 
MKIQIKGMKQ LSNKEMQKIV GGKSSAYSLQ MGATAIKQVK KLFKKWGW
Length:48
Mass (Da):5,458
Last modified:November 1, 1995 - v2
Checksum:i6C584810DE50D3F5
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural varianti26Missing in the alpha chain. 1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X75323 Genomic DNA. Translation: CAA53069.1.
X94434 Genomic DNA. Translation: CAA64204.1.
AL935263 Genomic DNA. Translation: CCC77922.1.
PIRiA45913.
RefSeqiWP_003641979.1. NC_004567.2.
YP_004888436.1. NC_004567.2.

Genome annotation databases

EnsemblBacteriaiCCC77922; CCC77922; lp_0415.
GeneIDi1064174.
KEGGilpl:lp_0415.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X75323 Genomic DNA. Translation: CAA53069.1.
X94434 Genomic DNA. Translation: CAA64204.1.
AL935263 Genomic DNA. Translation: CCC77922.1.
PIRiA45913.
RefSeqiWP_003641979.1. NC_004567.2.
YP_004888436.1. NC_004567.2.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1YTRNMR-A23-48[»]
ProteinModelPortaliP80214.
SMRiP80214.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi220668.lp_0415.

Protein family/group databases

TCDBi1.C.22.1.6. the lactococcin a (lactococcin a) family.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiCCC77922; CCC77922; lp_0415.
GeneIDi1064174.
KEGGilpl:lp_0415.

Miscellaneous databases

EvolutionaryTraceiP80214.

Family and domain databases

InterProiIPR010133. Bacteriocin_signal_seq.
[Graphical view]
TIGRFAMsiTIGR01847. bacteriocin_sig. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiPLNA_LACPL
AccessioniPrimary (citable) accession number: P80214
Secondary accession number(s): F9UU02
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 1, 1994
Last sequence update: November 1, 1995
Last modified: November 2, 2016
This is version 87 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Miscellaneous

The beta chain sequence is shown.

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.