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P80206

- OTX2_MOUSE

UniProt

P80206 - OTX2_MOUSE

Protein

Homeobox protein OTX2

Gene

Otx2

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 115 (01 Oct 2014)
      Sequence version 1 (01 Oct 1993)
      Previous versions | rss
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    Functioni

    Probably plays a role in the development of the brain and the sense organs. Can bind to the BCD target sequence (BTS): 5'-TCTAATCCC-3'.

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    DNA bindingi38 – 9760HomeoboxPROSITE-ProRule annotationAdd
    BLAST

    GO - Molecular functioni

    1. protein binding Source: MGI
    2. protein heterodimerization activity Source: MGI
    3. sequence-specific DNA binding Source: InterPro
    4. sequence-specific DNA binding transcription factor activity Source: InterPro

    GO - Biological processi

    1. anatomical structure development Source: MGI
    2. anterior/posterior pattern specification Source: MGI
    3. cell differentiation Source: MGI
    4. cell fate commitment Source: MGI
    5. cell fate specification Source: MGI
    6. central nervous system development Source: MGI
    7. diencephalon morphogenesis Source: MGI
    8. dorsal/ventral pattern formation Source: MGI
    9. endoderm development Source: MGI
    10. eye photoreceptor cell fate commitment Source: MGI
    11. forebrain development Source: MGI
    12. inner ear morphogenesis Source: MGI
    13. metencephalon development Source: MGI
    14. midbrain development Source: MGI
    15. neuron differentiation Source: MGI
    16. neuron fate commitment Source: MGI
    17. neuron fate determination Source: MGI
    18. organ morphogenesis Source: MGI
    19. positive regulation of embryonic development Source: UniProtKB
    20. positive regulation of gastrulation Source: UniProtKB
    21. positive regulation of transcription, DNA-templated Source: UniProtKB
    22. positive regulation of transcription from RNA polymerase II promoter Source: MGI
    23. primitive streak formation Source: UniProtKB
    24. regulation of transcription from RNA polymerase II promoter Source: MGI
    25. somite rostral/caudal axis specification Source: MGI

    Keywords - Molecular functioni

    Developmental protein

    Keywords - Ligandi

    DNA-binding

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Homeobox protein OTX2
    Alternative name(s):
    Orthodenticle homolog 2
    Gene namesi
    Name:Otx2
    Synonyms:Otx-2
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Unplaced

    Organism-specific databases

    MGIiMGI:97451. Otx2.

    Subcellular locationi

    Nucleus Curated

    GO - Cellular componenti

    1. cytoplasm Source: MGI
    2. nucleus Source: MGI

    Keywords - Cellular componenti

    Nucleus

    Pathology & Biotechi

    Mutagenesis

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Mutagenesisi225 – 2251N → S: Has a dominant negative effect on the proximal promoter region of HESX1 gene; represses reporter expression. 1 Publication

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 289289Homeobox protein OTX2PRO_0000049211Add
    BLAST

    Proteomic databases

    PRIDEiP80206.

    PTM databases

    PhosphoSiteiP80206.

    Expressioni

    Tissue specificityi

    Brain: restricted regions of the developing rostral brain including the presumptive cerebral cortex and olfactory bulbs; expressed in the developing olfactory, auricolar and ocular systems, including the covering of the optic nerve.

    Developmental stagei

    Embryo.

    Gene expression databases

    CleanExiMM_OTX2.
    GenevestigatoriP80206.

    Interactioni

    Protein-protein interaction databases

    MINTiMINT-1347226.

    Structurei

    Secondary structure

    1
    289
    Legend: HelixTurnBeta strand
    Show more details
    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Helixi47 – 5913
    Helixi65 – 7410
    Helixi79 – 9012
    Helixi92 – 954

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    EntryMethodResolution (Å)ChainPositionsPDBsum
    2DMSNMR-A39-105[»]
    ProteinModelPortaliP80206.
    SMRiP80206. Positions 39-106.
    ModBaseiSearch...
    MobiDBiSearch...

    Miscellaneous databases

    EvolutionaryTraceiP80206.

    Family & Domainsi

    Sequence similaritiesi

    Contains 1 homeobox DNA-binding domain.PROSITE-ProRule annotation

    Keywords - Domaini

    Homeobox

    Phylogenomic databases

    eggNOGiNOG245767.
    HOGENOMiHOG000082677.
    HOVERGENiHBG004028.
    PhylomeDBiP80206.

    Family and domain databases

    Gene3Di1.10.10.60. 1 hit.
    InterProiIPR017970. Homeobox_CS.
    IPR001356. Homeobox_dom.
    IPR009057. Homeodomain-like.
    IPR003022. Otx2_TF.
    IPR003025. Otx_TF.
    IPR013851. Otx_TF_C.
    [Graphical view]
    PfamiPF00046. Homeobox. 1 hit.
    PF03529. TF_Otx. 1 hit.
    [Graphical view]
    PRINTSiPR01257. OTX2HOMEOBOX.
    PR01255. OTXHOMEOBOX.
    SMARTiSM00389. HOX. 1 hit.
    [Graphical view]
    SUPFAMiSSF46689. SSF46689. 1 hit.
    PROSITEiPS00027. HOMEOBOX_1. 1 hit.
    PS50071. HOMEOBOX_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    P80206-1 [UniParc]FASTAAdd to Basket

    « Hide

    MMSYLKQPPY AVNGLSLTTS GMDLLHPSVG YPATPRKQRR ERTTFTRAQL    50
    DVLEALFAKT RYPDIFMREE VALKINLPES RVQVWFKNRR AKCRQQQQQQ 100
    QNGGQNKVRP AKKKSSPARE VSSESGTSGQ FTPPSSTSVP TIASSSAPVS 150
    IWSPASISPL SDPLSTSSSC MQRSYPMTYT QASGYSQGYA GSTSYFGGMD 200
    CGSYLTPMHH QLPGPGATLS PMGTNAVTSH LNQSPASLST QGYGASSLGF 250
    NSTTDCLDYK DQTASWKLNF NADCLDYKDQ TSSWKFQVL 289
    Length:289
    Mass (Da):31,622
    Last modified:October 1, 1993 - v1
    Checksum:iB4EA3A5BF83E2D99
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X68884 mRNA. Translation: CAA48755.1.
    CCDSiCCDS49473.1.
    PIRiS35346.
    UniGeneiMm.134516.
    Mm.487292.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X68884 mRNA. Translation: CAA48755.1 .
    CCDSi CCDS49473.1.
    PIRi S35346.
    UniGenei Mm.134516.
    Mm.487292.

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    Entry Method Resolution (Å) Chain Positions PDBsum
    2DMS NMR - A 39-105 [» ]
    ProteinModelPortali P80206.
    SMRi P80206. Positions 39-106.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    MINTi MINT-1347226.

    PTM databases

    PhosphoSitei P80206.

    Proteomic databases

    PRIDEi P80206.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Organism-specific databases

    MGIi MGI:97451. Otx2.

    Phylogenomic databases

    eggNOGi NOG245767.
    HOGENOMi HOG000082677.
    HOVERGENi HBG004028.
    PhylomeDBi P80206.

    Miscellaneous databases

    ChiTaRSi OTX2. mouse.
    EvolutionaryTracei P80206.
    PROi P80206.
    SOURCEi Search...

    Gene expression databases

    CleanExi MM_OTX2.
    Genevestigatori P80206.

    Family and domain databases

    Gene3Di 1.10.10.60. 1 hit.
    InterProi IPR017970. Homeobox_CS.
    IPR001356. Homeobox_dom.
    IPR009057. Homeodomain-like.
    IPR003022. Otx2_TF.
    IPR003025. Otx_TF.
    IPR013851. Otx_TF_C.
    [Graphical view ]
    Pfami PF00046. Homeobox. 1 hit.
    PF03529. TF_Otx. 1 hit.
    [Graphical view ]
    PRINTSi PR01257. OTX2HOMEOBOX.
    PR01255. OTXHOMEOBOX.
    SMARTi SM00389. HOX. 1 hit.
    [Graphical view ]
    SUPFAMi SSF46689. SSF46689. 1 hit.
    PROSITEi PS00027. HOMEOBOX_1. 1 hit.
    PS50071. HOMEOBOX_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "A vertebrate gene related to orthodenticle contains a homeodomain of the bicoid class and demarcates anterior neuroectoderm in the gastrulating mouse embryo."
      Simeone A., Acampora D., Mallamaci A., Stornaiuolo A., D'Apice M.R., Nigro V., Boncinelli E.
      EMBO J. 12:2735-2747(1993) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Strain: C57BL/6.
    2. "Nested expression domains of four homeobox genes in developing rostral brain."
      Simeone A., Acampora D., Gulisano M., Stornaiuolo A., Boncinelli E.
      Nature 358:687-690(1992) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 31-98.
      Tissue: Embryo.
    3. "A novel dominant negative mutation of OTX2 associated with combined pituitary hormone deficiency."
      Diaczok D., Romero C., Zunich J., Marshall I., Radovick S.
      J. Clin. Endocrinol. Metab. 93:4351-4359(2008) [PubMed] [Europe PMC] [Abstract]
      Cited for: MUTAGENESIS OF ASN-225.
    4. "Solution structure of the homeobox domain of homeobox protein OTX2."
      RIKEN structural genomics initiative (RSGI)
      Submitted (OCT-2006) to the PDB data bank
      Cited for: STRUCTURE BY NMR OF 39-105.

    Entry informationi

    Entry nameiOTX2_MOUSE
    AccessioniPrimary (citable) accession number: P80206
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: October 1, 1993
    Last sequence update: October 1, 1993
    Last modified: October 1, 2014
    This is version 115 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    3D-structure, Complete proteome, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. PDB cross-references
      Index of Protein Data Bank (PDB) cross-references
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3