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Protein

Homeobox protein OTX2

Gene

Otx2

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Probably plays a role in the development of the brain and the sense organs. Can bind to the BCD target sequence (BTS): 5'-TCTAATCCC-3'.

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
DNA bindingi38 – 9760HomeoboxPROSITE-ProRule annotationAdd
BLAST

GO - Molecular functioni

GO - Biological processi

  • anatomical structure development Source: MGI
  • anterior/posterior pattern specification Source: MGI
  • axon guidance Source: MGI
  • cell differentiation Source: MGI
  • cell fate commitment Source: MGI
  • cell fate specification Source: MGI
  • central nervous system development Source: MGI
  • diencephalon morphogenesis Source: MGI
  • dorsal/ventral pattern formation Source: MGI
  • endoderm development Source: MGI
  • eye photoreceptor cell fate commitment Source: MGI
  • forebrain development Source: MGI
  • inner ear morphogenesis Source: MGI
  • metencephalon development Source: MGI
  • midbrain development Source: MGI
  • neuron differentiation Source: MGI
  • neuron fate commitment Source: MGI
  • neuron fate determination Source: MGI
  • organ morphogenesis Source: MGI
  • positive regulation of embryonic development Source: UniProtKB
  • positive regulation of gastrulation Source: UniProtKB
  • positive regulation of transcription, DNA-templated Source: UniProtKB
  • positive regulation of transcription from RNA polymerase II promoter Source: MGI
  • primitive streak formation Source: UniProtKB
  • protein complex assembly Source: MGI
  • regulation of transcription from RNA polymerase II promoter Source: MGI
  • somite rostral/caudal axis specification Source: MGI
Complete GO annotation...

Keywords - Molecular functioni

Developmental protein

Keywords - Ligandi

DNA-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Homeobox protein OTX2
Alternative name(s):
Orthodenticle homolog 2
Gene namesi
Name:Otx2
Synonyms:Otx-2
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589 Componenti: Unplaced

Organism-specific databases

MGIiMGI:97451. Otx2.

Subcellular locationi

GO - Cellular componenti

  • cytoplasm Source: MGI
  • growth cone Source: MGI
  • nucleus Source: MGI
  • protein complex Source: MGI
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Mutagenesisi225 – 2251N → S: Has a dominant negative effect on the proximal promoter region of HESX1 gene; represses reporter expression. 1 Publication

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 289289Homeobox protein OTX2PRO_0000049211Add
BLAST

Proteomic databases

PRIDEiP80206.

PTM databases

PhosphoSiteiP80206.

Expressioni

Tissue specificityi

Brain: restricted regions of the developing rostral brain including the presumptive cerebral cortex and olfactory bulbs; expressed in the developing olfactory, auricolar and ocular systems, including the covering of the optic nerve.

Developmental stagei

Embryo.

Gene expression databases

CleanExiMM_OTX2.
GenevestigatoriP80206.

Interactioni

Protein-protein interaction databases

MINTiMINT-1347226.

Structurei

Secondary structure

1
289
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Helixi47 – 5913
Helixi65 – 7410
Helixi79 – 9012
Helixi92 – 954

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
2DMSNMR-A39-105[»]
ProteinModelPortaliP80206.
SMRiP80206. Positions 39-106.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP80206.

Family & Domainsi

Sequence similaritiesi

Contains 1 homeobox DNA-binding domain.PROSITE-ProRule annotation

Keywords - Domaini

Homeobox

Phylogenomic databases

eggNOGiNOG245767.
HOGENOMiHOG000082677.
HOVERGENiHBG004028.
InParanoidiP80206.
PhylomeDBiP80206.

Family and domain databases

Gene3Di1.10.10.60. 1 hit.
InterProiIPR017970. Homeobox_CS.
IPR001356. Homeobox_dom.
IPR009057. Homeodomain-like.
IPR003022. Otx2_TF.
IPR003025. Otx_TF.
IPR013851. Otx_TF_C.
[Graphical view]
PfamiPF00046. Homeobox. 1 hit.
PF03529. TF_Otx. 1 hit.
[Graphical view]
PRINTSiPR01257. OTX2HOMEOBOX.
PR01255. OTXHOMEOBOX.
SMARTiSM00389. HOX. 1 hit.
[Graphical view]
SUPFAMiSSF46689. SSF46689. 1 hit.
PROSITEiPS00027. HOMEOBOX_1. 1 hit.
PS50071. HOMEOBOX_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P80206-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MMSYLKQPPY AVNGLSLTTS GMDLLHPSVG YPATPRKQRR ERTTFTRAQL
60 70 80 90 100
DVLEALFAKT RYPDIFMREE VALKINLPES RVQVWFKNRR AKCRQQQQQQ
110 120 130 140 150
QNGGQNKVRP AKKKSSPARE VSSESGTSGQ FTPPSSTSVP TIASSSAPVS
160 170 180 190 200
IWSPASISPL SDPLSTSSSC MQRSYPMTYT QASGYSQGYA GSTSYFGGMD
210 220 230 240 250
CGSYLTPMHH QLPGPGATLS PMGTNAVTSH LNQSPASLST QGYGASSLGF
260 270 280
NSTTDCLDYK DQTASWKLNF NADCLDYKDQ TSSWKFQVL
Length:289
Mass (Da):31,622
Last modified:October 1, 1993 - v1
Checksum:iB4EA3A5BF83E2D99
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X68884 mRNA. Translation: CAA48755.1.
CCDSiCCDS49473.1.
PIRiS35346.
UniGeneiMm.134516.
Mm.487292.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X68884 mRNA. Translation: CAA48755.1.
CCDSiCCDS49473.1.
PIRiS35346.
UniGeneiMm.134516.
Mm.487292.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
2DMSNMR-A39-105[»]
ProteinModelPortaliP80206.
SMRiP80206. Positions 39-106.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

MINTiMINT-1347226.

PTM databases

PhosphoSiteiP80206.

Proteomic databases

PRIDEiP80206.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Organism-specific databases

MGIiMGI:97451. Otx2.

Phylogenomic databases

eggNOGiNOG245767.
HOGENOMiHOG000082677.
HOVERGENiHBG004028.
InParanoidiP80206.
PhylomeDBiP80206.

Miscellaneous databases

ChiTaRSiOtx2. mouse.
EvolutionaryTraceiP80206.
PROiP80206.
SOURCEiSearch...

Gene expression databases

CleanExiMM_OTX2.
GenevestigatoriP80206.

Family and domain databases

Gene3Di1.10.10.60. 1 hit.
InterProiIPR017970. Homeobox_CS.
IPR001356. Homeobox_dom.
IPR009057. Homeodomain-like.
IPR003022. Otx2_TF.
IPR003025. Otx_TF.
IPR013851. Otx_TF_C.
[Graphical view]
PfamiPF00046. Homeobox. 1 hit.
PF03529. TF_Otx. 1 hit.
[Graphical view]
PRINTSiPR01257. OTX2HOMEOBOX.
PR01255. OTXHOMEOBOX.
SMARTiSM00389. HOX. 1 hit.
[Graphical view]
SUPFAMiSSF46689. SSF46689. 1 hit.
PROSITEiPS00027. HOMEOBOX_1. 1 hit.
PS50071. HOMEOBOX_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "A vertebrate gene related to orthodenticle contains a homeodomain of the bicoid class and demarcates anterior neuroectoderm in the gastrulating mouse embryo."
    Simeone A., Acampora D., Mallamaci A., Stornaiuolo A., D'Apice M.R., Nigro V., Boncinelli E.
    EMBO J. 12:2735-2747(1993) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Strain: C57BL/6.
  2. "Nested expression domains of four homeobox genes in developing rostral brain."
    Simeone A., Acampora D., Gulisano M., Stornaiuolo A., Boncinelli E.
    Nature 358:687-690(1992) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 31-98.
    Tissue: Embryo.
  3. "A novel dominant negative mutation of OTX2 associated with combined pituitary hormone deficiency."
    Diaczok D., Romero C., Zunich J., Marshall I., Radovick S.
    J. Clin. Endocrinol. Metab. 93:4351-4359(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: MUTAGENESIS OF ASN-225.
  4. "Solution structure of the homeobox domain of homeobox protein OTX2."
    RIKEN structural genomics initiative (RSGI)
    Submitted (OCT-2006) to the PDB data bank
    Cited for: STRUCTURE BY NMR OF 39-105.

Entry informationi

Entry nameiOTX2_MOUSE
AccessioniPrimary (citable) accession number: P80206
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 1, 1993
Last sequence update: October 1, 1993
Last modified: February 4, 2015
This is version 119 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.