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P80205

- OTX1_MOUSE

UniProt

P80205 - OTX1_MOUSE

Protein

Homeobox protein OTX1

Gene

Otx1

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 116 (01 Oct 2014)
      Sequence version 1 (01 Oct 1993)
      Previous versions | rss
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    Functioni

    Probably plays a role in the development of the brain and the sense organs. Can bind to the BCD target sequence (BTS): 5'-TCTAATCCC-3'.

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    DNA bindingi38 – 9760HomeoboxPROSITE-ProRule annotationAdd
    BLAST

    GO - Molecular functioni

    1. protein binding Source: MGI
    2. sequence-specific DNA binding Source: InterPro
    3. sequence-specific DNA binding transcription factor activity Source: InterPro

    GO - Biological processi

    1. anterior/posterior pattern specification Source: MGI
    2. diencephalon morphogenesis Source: MGI
    3. forebrain development Source: MGI
    4. inner ear morphogenesis Source: MGI
    5. metencephalon development Source: MGI
    6. midbrain development Source: MGI
    7. regulation of transcription from RNA polymerase II promoter Source: MGI

    Keywords - Molecular functioni

    Developmental protein

    Keywords - Ligandi

    DNA-binding

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Homeobox protein OTX1
    Alternative name(s):
    Orthodenticle homolog 1
    Gene namesi
    Name:Otx1
    Synonyms:Otx-1
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 11

    Organism-specific databases

    MGIiMGI:97450. Otx1.

    Subcellular locationi

    Nucleus Curated

    GO - Cellular componenti

    1. nucleus Source: MGI

    Keywords - Cellular componenti

    Nucleus

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 355355Homeobox protein OTX1PRO_0000049208Add
    BLAST

    Proteomic databases

    PRIDEiP80205.

    PTM databases

    PhosphoSiteiP80205.

    Expressioni

    Tissue specificityi

    Brain: restricted regions of the developing rostral brain including the presumptive cerebral cortex and olfactory bulbs; expressed in the developing olfactory, auricolar and ocular systems, including the covering of the optic nerve.

    Developmental stagei

    Embryo.

    Gene expression databases

    BgeeiP80205.
    CleanExiMM_OTX1.
    GenevestigatoriP80205.

    Structurei

    3D structure databases

    ProteinModelPortaliP80205.
    SMRiP80205. Positions 39-107.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Compositional bias

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Compositional biasi275 – 30228His-richAdd
    BLAST

    Sequence similaritiesi

    Contains 1 homeobox DNA-binding domain.PROSITE-ProRule annotation

    Keywords - Domaini

    Homeobox

    Phylogenomic databases

    eggNOGiNOG245767.
    HOGENOMiHOG000082677.
    HOVERGENiHBG004028.
    InParanoidiP80205.
    KOiK09326.
    OMAiQTAASSW.
    OrthoDBiEOG74J98P.
    PhylomeDBiP80205.
    TreeFamiTF351179.

    Family and domain databases

    Gene3Di1.10.10.60. 1 hit.
    InterProiIPR017970. Homeobox_CS.
    IPR001356. Homeobox_dom.
    IPR009057. Homeodomain-like.
    IPR003026. Otx1_TF.
    IPR003025. Otx_TF.
    IPR013851. Otx_TF_C.
    [Graphical view]
    PfamiPF00046. Homeobox. 1 hit.
    PF03529. TF_Otx. 1 hit.
    [Graphical view]
    PRINTSiPR01256. OTX1HOMEOBOX.
    PR01255. OTXHOMEOBOX.
    SMARTiSM00389. HOX. 1 hit.
    [Graphical view]
    SUPFAMiSSF46689. SSF46689. 1 hit.
    PROSITEiPS00027. HOMEOBOX_1. 1 hit.
    PS50071. HOMEOBOX_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    P80205-1 [UniParc]FASTAAdd to Basket

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    MMSYLKQPPY GMNGLGLAGP AMDLLHPSVG YPATPRKQRR ERTTFTRSQL    50
    DVLEALFAKT RYPDIFMREE VALKINLPES RVQVWFKNRR AKCRQQQQSG 100
    NGTKTRPVKK KSSPVRESSG SESSGQFTPP AVSSSASSSS SASSASANPA 150
    AAAAAGLGGN PVAAASSLST PTASSIWSPA SISPGSAPTS VSVPEPLAAP 200
    SNASCMQRSV AAGAATAAAS YPMSYGQGGS YGQGYPAPSS SYFGGVDCSS 250
    YLAPMHSHHH PHQLSPMAPS SMAGHHHHHP HAHHPLSQSS GHHHHHHHHH 300
    HHQGYGGSGL AFNSADCLDY KEPAAAAASS AWKLNFNSPD CLDYKDQASW 350
    RFQVL 355
    Length:355
    Mass (Da):37,532
    Last modified:October 1, 1993 - v1
    Checksum:iDA5136D9D4FC948F
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BC057105 mRNA. Translation: AAH57105.1.
    BC058354 mRNA. Translation: AAH58354.1.
    X68883 mRNA. Translation: CAA48754.1.
    CCDSiCCDS24468.1.
    PIRiS35345.
    RefSeqiNP_035153.1. NM_011023.3.
    UniGeneiMm.129663.

    Genome annotation databases

    EnsembliENSMUST00000006071; ENSMUSP00000006071; ENSMUSG00000005917.
    GeneIDi18423.
    KEGGimmu:18423.
    UCSCiuc007idy.1. mouse.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BC057105 mRNA. Translation: AAH57105.1 .
    BC058354 mRNA. Translation: AAH58354.1 .
    X68883 mRNA. Translation: CAA48754.1 .
    CCDSi CCDS24468.1.
    PIRi S35345.
    RefSeqi NP_035153.1. NM_011023.3.
    UniGenei Mm.129663.

    3D structure databases

    ProteinModelPortali P80205.
    SMRi P80205. Positions 39-107.
    ModBasei Search...
    MobiDBi Search...

    PTM databases

    PhosphoSitei P80205.

    Proteomic databases

    PRIDEi P80205.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000006071 ; ENSMUSP00000006071 ; ENSMUSG00000005917 .
    GeneIDi 18423.
    KEGGi mmu:18423.
    UCSCi uc007idy.1. mouse.

    Organism-specific databases

    CTDi 5013.
    MGIi MGI:97450. Otx1.

    Phylogenomic databases

    eggNOGi NOG245767.
    HOGENOMi HOG000082677.
    HOVERGENi HBG004028.
    InParanoidi P80205.
    KOi K09326.
    OMAi QTAASSW.
    OrthoDBi EOG74J98P.
    PhylomeDBi P80205.
    TreeFami TF351179.

    Miscellaneous databases

    NextBioi 294076.
    PROi P80205.
    SOURCEi Search...

    Gene expression databases

    Bgeei P80205.
    CleanExi MM_OTX1.
    Genevestigatori P80205.

    Family and domain databases

    Gene3Di 1.10.10.60. 1 hit.
    InterProi IPR017970. Homeobox_CS.
    IPR001356. Homeobox_dom.
    IPR009057. Homeodomain-like.
    IPR003026. Otx1_TF.
    IPR003025. Otx_TF.
    IPR013851. Otx_TF_C.
    [Graphical view ]
    Pfami PF00046. Homeobox. 1 hit.
    PF03529. TF_Otx. 1 hit.
    [Graphical view ]
    PRINTSi PR01256. OTX1HOMEOBOX.
    PR01255. OTXHOMEOBOX.
    SMARTi SM00389. HOX. 1 hit.
    [Graphical view ]
    SUPFAMi SSF46689. SSF46689. 1 hit.
    PROSITEi PS00027. HOMEOBOX_1. 1 hit.
    PS50071. HOMEOBOX_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "A vertebrate gene related to orthodenticle contains a homeodomain of the bicoid class and demarcates anterior neuroectoderm in the gastrulating mouse embryo."
      Simeone A., Acampora D., Mallamaci A., Stornaiuolo A., D'Apice M.R., Nigro V., Boncinelli E.
      EMBO J. 12:2735-2747(1993) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Strain: C57BL/6.
    2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Strain: C57BL/6.
      Tissue: Brain.
    3. "Nested expression domains of four homeobox genes in developing rostral brain."
      Simeone A., Acampora D., Gulisano M., Stornaiuolo A., Boncinelli E.
      Nature 358:687-690(1992) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 31-98.

    Entry informationi

    Entry nameiOTX1_MOUSE
    AccessioniPrimary (citable) accession number: P80205
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: October 1, 1993
    Last sequence update: October 1, 1993
    Last modified: October 1, 2014
    This is version 116 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3