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P80205 (OTX1_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 115. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Homeobox protein OTX1
Alternative name(s):
Orthodenticle homolog 1
Gene names
Name:Otx1
Synonyms:Otx-1
OrganismMus musculus (Mouse) [Reference proteome]
Taxonomic identifier10090 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus

Protein attributes

Sequence length355 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Probably plays a role in the development of the brain and the sense organs. Can bind to the BCD target sequence (BTS): 5'-TCTAATCCC-3'.

Subcellular location

Nucleus Probable.

Tissue specificity

Brain: restricted regions of the developing rostral brain including the presumptive cerebral cortex and olfactory bulbs; expressed in the developing olfactory, auricolar and ocular systems, including the covering of the optic nerve.

Developmental stage

Embryo.

Sequence similarities

Belongs to the paired homeobox family. Bicoid subfamily.

Contains 1 homeobox DNA-binding domain.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 355355Homeobox protein OTX1
PRO_0000049208

Regions

DNA binding38 – 9760Homeobox
Compositional bias275 – 30228His-rich

Sequences

Sequence LengthMass (Da)Tools
P80205 [UniParc].

Last modified October 1, 1993. Version 1.
Checksum: DA5136D9D4FC948F

FASTA35537,532
        10         20         30         40         50         60 
MMSYLKQPPY GMNGLGLAGP AMDLLHPSVG YPATPRKQRR ERTTFTRSQL DVLEALFAKT 

        70         80         90        100        110        120 
RYPDIFMREE VALKINLPES RVQVWFKNRR AKCRQQQQSG NGTKTRPVKK KSSPVRESSG 

       130        140        150        160        170        180 
SESSGQFTPP AVSSSASSSS SASSASANPA AAAAAGLGGN PVAAASSLST PTASSIWSPA 

       190        200        210        220        230        240 
SISPGSAPTS VSVPEPLAAP SNASCMQRSV AAGAATAAAS YPMSYGQGGS YGQGYPAPSS 

       250        260        270        280        290        300 
SYFGGVDCSS YLAPMHSHHH PHQLSPMAPS SMAGHHHHHP HAHHPLSQSS GHHHHHHHHH 

       310        320        330        340        350 
HHQGYGGSGL AFNSADCLDY KEPAAAAASS AWKLNFNSPD CLDYKDQASW RFQVL 

« Hide

References

« Hide 'large scale' references
[1]"A vertebrate gene related to orthodenticle contains a homeodomain of the bicoid class and demarcates anterior neuroectoderm in the gastrulating mouse embryo."
Simeone A., Acampora D., Mallamaci A., Stornaiuolo A., D'Apice M.R., Nigro V., Boncinelli E.
EMBO J. 12:2735-2747(1993) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
Strain: C57BL/6.
[2]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Strain: C57BL/6.
Tissue: Brain.
[3]"Nested expression domains of four homeobox genes in developing rostral brain."
Simeone A., Acampora D., Gulisano M., Stornaiuolo A., Boncinelli E.
Nature 358:687-690(1992) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 31-98.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
BC057105 mRNA. Translation: AAH57105.1.
BC058354 mRNA. Translation: AAH58354.1.
X68883 mRNA. Translation: CAA48754.1.
CCDSCCDS24468.1.
PIRS35345.
RefSeqNP_035153.1. NM_011023.3.
UniGeneMm.129663.

3D structure databases

ProteinModelPortalP80205.
SMRP80205. Positions 39-107.
ModBaseSearch...
MobiDBSearch...

PTM databases

PhosphoSiteP80205.

Proteomic databases

PRIDEP80205.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSMUST00000006071; ENSMUSP00000006071; ENSMUSG00000005917.
GeneID18423.
KEGGmmu:18423.
UCSCuc007idy.1. mouse.

Organism-specific databases

CTD5013.
MGIMGI:97450. Otx1.

Phylogenomic databases

eggNOGNOG245767.
HOGENOMHOG000082677.
HOVERGENHBG004028.
InParanoidP80205.
KOK09326.
OMAQTAASSW.
OrthoDBEOG74J98P.
PhylomeDBP80205.
TreeFamTF351179.

Gene expression databases

BgeeP80205.
CleanExMM_OTX1.
GenevestigatorP80205.

Family and domain databases

Gene3D1.10.10.60. 1 hit.
InterProIPR017970. Homeobox_CS.
IPR001356. Homeobox_dom.
IPR009057. Homeodomain-like.
IPR003026. Otx1_TF.
IPR003025. Otx_TF.
IPR013851. Otx_TF_C.
[Graphical view]
PfamPF00046. Homeobox. 1 hit.
PF03529. TF_Otx. 1 hit.
[Graphical view]
PRINTSPR01256. OTX1HOMEOBOX.
PR01255. OTXHOMEOBOX.
SMARTSM00389. HOX. 1 hit.
[Graphical view]
SUPFAMSSF46689. SSF46689. 1 hit.
PROSITEPS00027. HOMEOBOX_1. 1 hit.
PS50071. HOMEOBOX_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio294076.
PROP80205.
SOURCESearch...

Entry information

Entry nameOTX1_MOUSE
AccessionPrimary (citable) accession number: P80205
Entry history
Integrated into UniProtKB/Swiss-Prot: October 1, 1993
Last sequence update: October 1, 1993
Last modified: July 9, 2014
This is version 115 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

MGD cross-references

Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot