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P80205

- OTX1_MOUSE

UniProt

P80205 - OTX1_MOUSE

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Protein

Homeobox protein OTX1

Gene

Otx1

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at transcript leveli

Functioni

Probably plays a role in the development of the brain and the sense organs. Can bind to the BCD target sequence (BTS): 5'-TCTAATCCC-3'.

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
DNA bindingi38 – 9760HomeoboxPROSITE-ProRule annotationAdd
BLAST

GO - Molecular functioni

  1. RNA polymerase II core promoter proximal region sequence-specific DNA binding Source: Ensembl
  2. RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription Source: Ensembl

GO - Biological processi

  1. anterior/posterior pattern specification Source: MGI
  2. diencephalon morphogenesis Source: MGI
  3. forebrain development Source: MGI
  4. inner ear morphogenesis Source: MGI
  5. metencephalon development Source: MGI
  6. midbrain development Source: MGI
  7. regulation of transcription from RNA polymerase II promoter Source: MGI
Complete GO annotation...

Keywords - Molecular functioni

Developmental protein

Keywords - Ligandi

DNA-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Homeobox protein OTX1
Alternative name(s):
Orthodenticle homolog 1
Gene namesi
Name:Otx1
Synonyms:Otx-1
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 11

Organism-specific databases

MGIiMGI:97450. Otx1.

Subcellular locationi

Nucleus Curated

GO - Cellular componenti

  1. nucleus Source: MGI
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 355355Homeobox protein OTX1PRO_0000049208Add
BLAST

Proteomic databases

PRIDEiP80205.

PTM databases

PhosphoSiteiP80205.

Expressioni

Tissue specificityi

Brain: restricted regions of the developing rostral brain including the presumptive cerebral cortex and olfactory bulbs; expressed in the developing olfactory, auricolar and ocular systems, including the covering of the optic nerve.

Developmental stagei

Embryo.

Gene expression databases

BgeeiP80205.
CleanExiMM_OTX1.
ExpressionAtlasiP80205. baseline.
GenevestigatoriP80205.

Structurei

3D structure databases

ProteinModelPortaliP80205.
SMRiP80205. Positions 39-107.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi275 – 30228His-richAdd
BLAST

Sequence similaritiesi

Contains 1 homeobox DNA-binding domain.PROSITE-ProRule annotation

Keywords - Domaini

Homeobox

Phylogenomic databases

eggNOGiNOG245767.
HOGENOMiHOG000082677.
HOVERGENiHBG004028.
InParanoidiP80205.
KOiK09326.
OMAiQTAASSW.
OrthoDBiEOG74J98P.
PhylomeDBiP80205.
TreeFamiTF351179.

Family and domain databases

Gene3Di1.10.10.60. 1 hit.
InterProiIPR017970. Homeobox_CS.
IPR001356. Homeobox_dom.
IPR009057. Homeodomain-like.
IPR003026. Otx1_TF.
IPR003025. Otx_TF.
IPR013851. Otx_TF_C.
[Graphical view]
PfamiPF00046. Homeobox. 1 hit.
PF03529. TF_Otx. 1 hit.
[Graphical view]
PRINTSiPR01256. OTX1HOMEOBOX.
PR01255. OTXHOMEOBOX.
SMARTiSM00389. HOX. 1 hit.
[Graphical view]
SUPFAMiSSF46689. SSF46689. 1 hit.
PROSITEiPS00027. HOMEOBOX_1. 1 hit.
PS50071. HOMEOBOX_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P80205 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MMSYLKQPPY GMNGLGLAGP AMDLLHPSVG YPATPRKQRR ERTTFTRSQL
60 70 80 90 100
DVLEALFAKT RYPDIFMREE VALKINLPES RVQVWFKNRR AKCRQQQQSG
110 120 130 140 150
NGTKTRPVKK KSSPVRESSG SESSGQFTPP AVSSSASSSS SASSASANPA
160 170 180 190 200
AAAAAGLGGN PVAAASSLST PTASSIWSPA SISPGSAPTS VSVPEPLAAP
210 220 230 240 250
SNASCMQRSV AAGAATAAAS YPMSYGQGGS YGQGYPAPSS SYFGGVDCSS
260 270 280 290 300
YLAPMHSHHH PHQLSPMAPS SMAGHHHHHP HAHHPLSQSS GHHHHHHHHH
310 320 330 340 350
HHQGYGGSGL AFNSADCLDY KEPAAAAASS AWKLNFNSPD CLDYKDQASW

RFQVL
Length:355
Mass (Da):37,532
Last modified:October 1, 1993 - v1
Checksum:iDA5136D9D4FC948F
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
BC057105 mRNA. Translation: AAH57105.1.
BC058354 mRNA. Translation: AAH58354.1.
X68883 mRNA. Translation: CAA48754.1.
CCDSiCCDS24468.1.
PIRiS35345.
RefSeqiNP_035153.1. NM_011023.3.
UniGeneiMm.129663.

Genome annotation databases

EnsembliENSMUST00000006071; ENSMUSP00000006071; ENSMUSG00000005917.
GeneIDi18423.
KEGGimmu:18423.
UCSCiuc007idy.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
BC057105 mRNA. Translation: AAH57105.1 .
BC058354 mRNA. Translation: AAH58354.1 .
X68883 mRNA. Translation: CAA48754.1 .
CCDSi CCDS24468.1.
PIRi S35345.
RefSeqi NP_035153.1. NM_011023.3.
UniGenei Mm.129663.

3D structure databases

ProteinModelPortali P80205.
SMRi P80205. Positions 39-107.
ModBasei Search...
MobiDBi Search...

PTM databases

PhosphoSitei P80205.

Proteomic databases

PRIDEi P80205.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000006071 ; ENSMUSP00000006071 ; ENSMUSG00000005917 .
GeneIDi 18423.
KEGGi mmu:18423.
UCSCi uc007idy.1. mouse.

Organism-specific databases

CTDi 5013.
MGIi MGI:97450. Otx1.

Phylogenomic databases

eggNOGi NOG245767.
HOGENOMi HOG000082677.
HOVERGENi HBG004028.
InParanoidi P80205.
KOi K09326.
OMAi QTAASSW.
OrthoDBi EOG74J98P.
PhylomeDBi P80205.
TreeFami TF351179.

Miscellaneous databases

NextBioi 294076.
PROi P80205.
SOURCEi Search...

Gene expression databases

Bgeei P80205.
CleanExi MM_OTX1.
ExpressionAtlasi P80205. baseline.
Genevestigatori P80205.

Family and domain databases

Gene3Di 1.10.10.60. 1 hit.
InterProi IPR017970. Homeobox_CS.
IPR001356. Homeobox_dom.
IPR009057. Homeodomain-like.
IPR003026. Otx1_TF.
IPR003025. Otx_TF.
IPR013851. Otx_TF_C.
[Graphical view ]
Pfami PF00046. Homeobox. 1 hit.
PF03529. TF_Otx. 1 hit.
[Graphical view ]
PRINTSi PR01256. OTX1HOMEOBOX.
PR01255. OTXHOMEOBOX.
SMARTi SM00389. HOX. 1 hit.
[Graphical view ]
SUPFAMi SSF46689. SSF46689. 1 hit.
PROSITEi PS00027. HOMEOBOX_1. 1 hit.
PS50071. HOMEOBOX_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "A vertebrate gene related to orthodenticle contains a homeodomain of the bicoid class and demarcates anterior neuroectoderm in the gastrulating mouse embryo."
    Simeone A., Acampora D., Mallamaci A., Stornaiuolo A., D'Apice M.R., Nigro V., Boncinelli E.
    EMBO J. 12:2735-2747(1993) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Strain: C57BL/6.
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6.
    Tissue: Brain.
  3. "Nested expression domains of four homeobox genes in developing rostral brain."
    Simeone A., Acampora D., Gulisano M., Stornaiuolo A., Boncinelli E.
    Nature 358:687-690(1992) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 31-98.

Entry informationi

Entry nameiOTX1_MOUSE
AccessioniPrimary (citable) accession number: P80205
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 1, 1993
Last sequence update: October 1, 1993
Last modified: October 29, 2014
This is version 117 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3