Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Homeobox protein OTX1

Gene

Otx1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at transcript leveli

Functioni

Probably plays a role in the development of the brain and the sense organs. Can bind to the BCD target sequence (BTS): 5'-TCTAATCCC-3'.

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
DNA bindingi38 – 9760HomeoboxPROSITE-ProRule annotationAdd
BLAST

GO - Molecular functioni

GO - Biological processi

  • anterior/posterior pattern specification Source: MGI
  • diencephalon morphogenesis Source: MGI
  • forebrain development Source: MGI
  • inner ear morphogenesis Source: MGI
  • metencephalon development Source: MGI
  • midbrain development Source: MGI
  • positive regulation of transcription from RNA polymerase II promoter Source: MGI
  • regulation of transcription from RNA polymerase II promoter Source: MGI
  • transcription from RNA polymerase II promoter Source: GOC
Complete GO annotation...

Keywords - Molecular functioni

Developmental protein

Keywords - Ligandi

DNA-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Homeobox protein OTX1
Alternative name(s):
Orthodenticle homolog 1
Gene namesi
Name:Otx1
Synonyms:Otx-1
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589 Componenti: Chromosome 11

Organism-specific databases

MGIiMGI:97450. Otx1.

Subcellular locationi

GO - Cellular componenti

  • nucleus Source: MGI
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 355355Homeobox protein OTX1PRO_0000049208Add
BLAST

Proteomic databases

PRIDEiP80205.

PTM databases

PhosphoSiteiP80205.

Expressioni

Tissue specificityi

Brain: restricted regions of the developing rostral brain including the presumptive cerebral cortex and olfactory bulbs; expressed in the developing olfactory, auricolar and ocular systems, including the covering of the optic nerve.

Developmental stagei

Embryo.

Gene expression databases

BgeeiP80205.
CleanExiMM_OTX1.
ExpressionAtlasiP80205. baseline.
GenevisibleiP80205. MM.

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000006071.

Structurei

3D structure databases

ProteinModelPortaliP80205.
SMRiP80205. Positions 39-107.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi275 – 30228His-richAdd
BLAST

Sequence similaritiesi

Contains 1 homeobox DNA-binding domain.PROSITE-ProRule annotation

Keywords - Domaini

Homeobox

Phylogenomic databases

eggNOGiNOG245767.
GeneTreeiENSGT00760000118908.
HOGENOMiHOG000082677.
HOVERGENiHBG004028.
InParanoidiP80205.
KOiK09326.
OMAiTSYPMSY.
OrthoDBiEOG74J98P.
PhylomeDBiP80205.
TreeFamiTF351179.

Family and domain databases

Gene3Di1.10.10.60. 1 hit.
InterProiIPR017970. Homeobox_CS.
IPR001356. Homeobox_dom.
IPR009057. Homeodomain-like.
IPR003026. Otx1_TF.
IPR003025. Otx_TF.
IPR013851. Otx_TF_C.
[Graphical view]
PfamiPF00046. Homeobox. 1 hit.
PF03529. TF_Otx. 1 hit.
[Graphical view]
PRINTSiPR01256. OTX1HOMEOBOX.
PR01255. OTXHOMEOBOX.
SMARTiSM00389. HOX. 1 hit.
[Graphical view]
SUPFAMiSSF46689. SSF46689. 1 hit.
PROSITEiPS00027. HOMEOBOX_1. 1 hit.
PS50071. HOMEOBOX_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P80205-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MMSYLKQPPY GMNGLGLAGP AMDLLHPSVG YPATPRKQRR ERTTFTRSQL
60 70 80 90 100
DVLEALFAKT RYPDIFMREE VALKINLPES RVQVWFKNRR AKCRQQQQSG
110 120 130 140 150
NGTKTRPVKK KSSPVRESSG SESSGQFTPP AVSSSASSSS SASSASANPA
160 170 180 190 200
AAAAAGLGGN PVAAASSLST PTASSIWSPA SISPGSAPTS VSVPEPLAAP
210 220 230 240 250
SNASCMQRSV AAGAATAAAS YPMSYGQGGS YGQGYPAPSS SYFGGVDCSS
260 270 280 290 300
YLAPMHSHHH PHQLSPMAPS SMAGHHHHHP HAHHPLSQSS GHHHHHHHHH
310 320 330 340 350
HHQGYGGSGL AFNSADCLDY KEPAAAAASS AWKLNFNSPD CLDYKDQASW

RFQVL
Length:355
Mass (Da):37,532
Last modified:October 1, 1993 - v1
Checksum:iDA5136D9D4FC948F
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC057105 mRNA. Translation: AAH57105.1.
BC058354 mRNA. Translation: AAH58354.1.
X68883 mRNA. Translation: CAA48754.1.
CCDSiCCDS24468.1.
PIRiS35345.
RefSeqiNP_035153.1. NM_011023.3.
UniGeneiMm.129663.

Genome annotation databases

EnsembliENSMUST00000006071; ENSMUSP00000006071; ENSMUSG00000005917.
GeneIDi18423.
KEGGimmu:18423.
UCSCiuc007idy.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC057105 mRNA. Translation: AAH57105.1.
BC058354 mRNA. Translation: AAH58354.1.
X68883 mRNA. Translation: CAA48754.1.
CCDSiCCDS24468.1.
PIRiS35345.
RefSeqiNP_035153.1. NM_011023.3.
UniGeneiMm.129663.

3D structure databases

ProteinModelPortaliP80205.
SMRiP80205. Positions 39-107.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000006071.

PTM databases

PhosphoSiteiP80205.

Proteomic databases

PRIDEiP80205.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000006071; ENSMUSP00000006071; ENSMUSG00000005917.
GeneIDi18423.
KEGGimmu:18423.
UCSCiuc007idy.1. mouse.

Organism-specific databases

CTDi5013.
MGIiMGI:97450. Otx1.

Phylogenomic databases

eggNOGiNOG245767.
GeneTreeiENSGT00760000118908.
HOGENOMiHOG000082677.
HOVERGENiHBG004028.
InParanoidiP80205.
KOiK09326.
OMAiTSYPMSY.
OrthoDBiEOG74J98P.
PhylomeDBiP80205.
TreeFamiTF351179.

Miscellaneous databases

NextBioi294076.
PROiP80205.
SOURCEiSearch...

Gene expression databases

BgeeiP80205.
CleanExiMM_OTX1.
ExpressionAtlasiP80205. baseline.
GenevisibleiP80205. MM.

Family and domain databases

Gene3Di1.10.10.60. 1 hit.
InterProiIPR017970. Homeobox_CS.
IPR001356. Homeobox_dom.
IPR009057. Homeodomain-like.
IPR003026. Otx1_TF.
IPR003025. Otx_TF.
IPR013851. Otx_TF_C.
[Graphical view]
PfamiPF00046. Homeobox. 1 hit.
PF03529. TF_Otx. 1 hit.
[Graphical view]
PRINTSiPR01256. OTX1HOMEOBOX.
PR01255. OTXHOMEOBOX.
SMARTiSM00389. HOX. 1 hit.
[Graphical view]
SUPFAMiSSF46689. SSF46689. 1 hit.
PROSITEiPS00027. HOMEOBOX_1. 1 hit.
PS50071. HOMEOBOX_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "A vertebrate gene related to orthodenticle contains a homeodomain of the bicoid class and demarcates anterior neuroectoderm in the gastrulating mouse embryo."
    Simeone A., Acampora D., Mallamaci A., Stornaiuolo A., D'Apice M.R., Nigro V., Boncinelli E.
    EMBO J. 12:2735-2747(1993) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Strain: C57BL/6.
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6.
    Tissue: Brain.
  3. "Nested expression domains of four homeobox genes in developing rostral brain."
    Simeone A., Acampora D., Gulisano M., Stornaiuolo A., Boncinelli E.
    Nature 358:687-690(1992) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 31-98.

Entry informationi

Entry nameiOTX1_MOUSE
AccessioniPrimary (citable) accession number: P80205
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 1, 1993
Last sequence update: October 1, 1993
Last modified: July 22, 2015
This is version 121 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.