P80203 (ACVL1_RAT) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Serine/threonine-protein kinase receptor R3
Short name=SKR3
EC=2.7.11.30

Alternative name(s):
TGF-B superfamily receptor type I
Short name=TSR-I

Gene names

Name:	Acvrl1
Synonyms:	Acvrlk1

Organism

Rattus norvegicus (Rat) [Reference proteome]

Taxonomic identifier

10116 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Rattus

Protein attributes

Sequence length	504 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at transcript level

General annotation (Comments)

Function	Type I receptor for TGF-beta family ligands BMP9/GDF2 and BMP10 and important regulator of normal blood vessel development. On ligand binding, forms a receptor complex consisting of two type II and two type I transmembrane serine/threonine kinases. Type II receptors phosphorylate and activate type I receptors which autophosphorylate, then bind and activate SMAD transcriptional regulators. May bind activin as well.
Catalytic activity	ATP + [receptor-protein] = ADP + [receptor-protein] phosphate.
Cofactor	Magnesium or manganese By similarity.
Subcellular location	Membrane; Single-pass type I membrane protein.
Tissue specificity	Urogenital ridge, testis, ovary, brain and lung. In lung, found exclusively in pulmonary vessels of all sizes. Also expressed in aorta, vena cava and certain blood vessels of kidney, spleen, heart and intestine. For most blood vessels, a higher level of expression is found in endothelium than in adjacent smooth muscle. Ref.2
Sequence similarities	Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. Contains 1 GS domain. Contains 1 protein kinase domain.

Ontologies

Keywords
Biological process	Angiogenesis
Cellular component	Membrane
Domain	Signal Transmembrane Transmembrane helix
Ligand	ATP-binding Magnesium Manganese Metal-binding Nucleotide-binding
Molecular function	Kinase Receptor Serine/threonine-protein kinase Transferase
PTM	Disulfide bond Glycoprotein Phosphoprotein
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	BMP signaling pathway Inferred from electronic annotation. Source: Compara angiogenesis Inferred from electronic annotation. Source: UniProtKB-KW artery development Inferred from electronic annotation. Source: Compara blood vessel remodeling Inferred from electronic annotation. Source: Compara cellular response to BMP stimulus Inferred from electronic annotation. Source: Compara endothelial tube morphogenesis Inferred from electronic annotation. Source: Compara in utero embryonic development Inferred from electronic annotation. Source: Compara lymphangiogenesis Inferred from electronic annotation. Source: Compara negative regulation of DNA biosynthetic process Inferred from electronic annotation. Source: Compara negative regulation of blood vessel endothelial cell migration Inferred from electronic annotation. Source: Compara negative regulation of cell growth Inferred from electronic annotation. Source: Compara negative regulation of endothelial cell differentiation Inferred from electronic annotation. Source: Compara negative regulation of endothelial cell proliferation Inferred from electronic annotation. Source: Compara negative regulation of focal adhesion assembly Inferred from electronic annotation. Source: Compara positive regulation of BMP signaling pathway Inferred from electronic annotation. Source: Compara positive regulation of endothelial cell differentiation Inferred from electronic annotation. Source: Compara positive regulation of endothelial cell proliferation Inferred from electronic annotation. Source: Compara positive regulation of pathway-restricted SMAD protein phosphorylation Inferred from electronic annotation. Source: Compara positive regulation of transcription from RNA polymerase II promoter Inferred from electronic annotation. Source: Compara protein heterooligomerization Inferred from direct assay PubMed 15781474. Source: RGD regulation of blood pressure Inferred from electronic annotation. Source: Compara retina vasculature development in camera-type eye Inferred from electronic annotation. Source: Compara transforming growth factor beta receptor signaling pathway Inferred from direct assay PubMed 15781474. Source: RGD venous blood vessel development Inferred from electronic annotation. Source: Compara wound healing, spreading of epidermal cells Inferred from electronic annotation. Source: Compara
Cellular_component	cell surface Inferred from electronic annotation. Source: Compara dendrite Inferred from direct assay PubMed 15781474. Source: RGD integral to plasma membrane Inferred from electronic annotation. Source: Compara neuronal cell body Inferred from direct assay PubMed 15781474. Source: RGD
Molecular_function	ATP binding Inferred from electronic annotation. Source: UniProtKB-KW SMAD binding Inferred from direct assay PubMed 15781474. Source: RGD metal ion binding Inferred from electronic annotation. Source: UniProtKB-KW receptor signaling protein serine/threonine kinase activity Inferred from direct assay PubMed 15781474. Source: RGD transforming growth factor beta binding Traceable author statement PubMed 15781474. Source: RGD transforming growth factor beta receptor activity, type I Inferred from direct assay PubMed 15781474. Source: RGD
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Signal peptide	1 – 20	20	Potential
	Chain	21 – 504	484	Serine/threonine-protein kinase receptor R3		PRO_0000024422
Regions
	Topological domain	21 – 121	101	Extracellular Potential
	Transmembrane	122 – 142	21	Helical; Potential
	Topological domain	143 – 504	362	Cytoplasmic Potential
	Domain	173 – 202	30	GS
	Domain	203 – 504	302	Protein kinase
	Nucleotide binding	209 – 217	9	ATP By similarity
	Region	74 – 77	4	Mediates specificity for BMP ligand By similarity
Sites
	Active site	331	1	Proton acceptor By similarity
	Binding site	230	1	ATP By similarity
Amino acid modifications
	Modified residue	156	1	Phosphoserine By similarity
	Glycosylation	34	1	N-linked (GlcNAc...) Potential
	Glycosylation	99	1	N-linked (GlcNAc...) Potential
	Disulfide bond	35 ↔ 52		By similarity
	Disulfide bond	37 ↔ 42		By similarity
	Disulfide bond	47 ↔ 70		By similarity
	Disulfide bond	78 ↔ 90		By similarity
	Disulfide bond	91 ↔ 96		By similarity
Experimental info
	Sequence conflict	309	1	C → CA Ref.1

Sequences

	Sequence		Length	Mass (Da)
	P80203 [UniParc]. Last modified April 13, 2004. Version 2. Checksum: B40EA30775223C8F	FASTA	504	56,703
	10 20 30 40 50 60 MTLGIFRRVF LMLSVALGLT KGDLVKPSRG QLVNCTCENP HCKRPICQGA WCTVVLVREQ 70 80 90 100 110 120 GRHPQVYRGC GSLNQELCLG RPTEFVNHHC CYRSFCNHNV SLMLEATQTP SEEPEVDAHL 130 140 150 160 170 180 PLILGPVLAL LVLVALGTLG LWRVRRRQEK QRGLHSDLGE SSLILKASEQ GDSMLGDFLV 190 200 210 220 230 240 SDCTTGSGSG LPFLVQRTVA RQVALVECVG KGRYGEVWRG SWHGESVAVK IFSSRDEQSW 250 260 270 280 290 300 FRETEIYNTV LLRHDNILGF IASDMTSRNS STQLWLITHY HEHGSLYDFL QRQTLEPQLA 310 320 330 340 350 360 LRLAVSAACG LAHLHVEIFG TQGKPAIAHR DLKSRNVLVK SNLQCCIADL GLAVMHSQSS 370 380 390 400 410 420 DYLDIGNNPR VGTKRYMAPE VLDEQIRTDC FESYKWTDIW AFGLVLWEIA RRTIINGIVE 430 440 450 460 470 480 DYRPPFYDMV PNDPSFEDMK KVVCVDQQTP TIPNRLAADP VLSGLAQMMR ECWYPNPSAR 490 500 LTALRIKKTL QKLSQNPEKP KVIH

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Developmental expression of four novel serine/threonine kinase receptors homologous to the activin/transforming growth factor-beta type II receptor family." He W.-W., Gustafson M.L., Hirobe S., Donahoe P.K. Dev. Dyn. 196:133-142(1993) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA]. Strain: Sprague-Dawley. Tissue: Urogenital ridge.
[2]	"Type I receptor serine-threonine kinase preferentially expressed in pulmonary blood vessels." Panchenko M.P., Williams M.C., Brody J.S., Yu Q. Am. J. Physiol. 270:L547-L558(1996) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY. Strain: Sprague-Dawley. Tissue: Lung.
[3]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Lung.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	L36088 mRNA. Translation: AAC37705.1. BC083173 mRNA. Translation: AAH83173.1.
IPI	IPI00323983.
RefSeq	NP_071886.1. NM_022441.2.
UniGene	Rn.10631.
3D structure databases
ProteinModelPortal	P80203.
SMR	P80203. Positions 173-495.
ModBase	Search...
Protein-protein interaction databases
STRING	10116.ENSRNOP00000062675.
Proteomic databases
PaxDb	P80203.
PRIDE	P80203.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENSRNOT00000008673; ENSRNOP00000008673; ENSRNOG00000028713.
GeneID	25237.
KEGG	rno:25237.
UCSC	RGD:2029. rat.
Organism-specific databases
CTD	94.
RGD	2029. Acvrl1.
Phylogenomic databases
eggNOG	COG0515.
GeneTree	ENSGT00670000098005.
HOGENOM	HOG000230587.
HOVERGEN	HBG054502.
InParanoid	P80203.
KO	K13594.
OMA	WHVRRRQ.
OrthoDB	EOG4HDSTB.
Enzyme and pathway databases
BRENDA	2.7.10.2. 5301.
Gene expression databases
ArrayExpress	P80203.
Genevestigator	P80203.
GermOnline	ENSRNOG00000028713. Rattus norvegicus.
Family and domain databases
InterPro	IPR000472. Activin_rcpt. IPR011009. Kinase-like_dom. IPR000719. Prot_kinase_cat_dom. IPR017441. Protein_kinase_ATP_BS. IPR008271. Ser/Thr_kinase_AS. IPR003605. TGF_beta_rcpt_GS. [Graphical view]
Pfam	PF01064. Activin_recp. 1 hit. PF00069. Pkinase. 1 hit. PF08515. TGF_beta_GS. 1 hit. [Graphical view]
SMART	SM00467. GS. 1 hit. [Graphical view]
SUPFAM	SSF56112. Kinase_like. 1 hit.
PROSITE	PS51256. GS. 1 hit. PS00107. PROTEIN_KINASE_ATP. 1 hit. PS50011. PROTEIN_KINASE_DOM. 1 hit. PS00108. PROTEIN_KINASE_ST. 1 hit. [Graphical view]
ProtoNet	Search...
Other
NextBio	605811.

Entry information

Entry name

ACVL1_RAT

Accession

Primary (citable) accession number: P80203
Secondary accession number(s): Q63559

Entry history

Integrated into UniProtKB/Swiss-Prot:	October 1, 1993
Last sequence update:	April 13, 2004
Last modified:	April 3, 2013
This is version 119 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program