Reviewed, UniProtKB/Swiss-Prot P80203 (ACVL1_RAT)

Names and origin

Protein names

Recommended name:
    Serine/threonine-protein kinase receptor R3
      Short name(s)=SKR3
    EC=2.7.11.30
Alternative name(s):
    TGF-B superfamily receptor type I
      Short name(s)=TSR-I

Gene names

Name:	Acvrl1
Synonyms:	Acvrlk1

Organism

Rattus norvegicus (Rat)

Taxonomic identifier

10116 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Rattus

Protein attributes

Sequence length	504 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at transcript level.

General annotation (Comments)

Function	On ligand binding, forms a receptor complex consisting of two type II and two type I transmembrane serine/threonine kinases. Type II receptors phosphorylate and activate type I receptors which autophosphorylate, then bind and activate SMAD transcriptional regulators. Receptor for TGF-beta. May bind activin as well.
Catalytic activity	ATP + [receptor-protein] = ADP + [receptor-protein] phosphate.
Cofactor	Magnesium or manganese By similarity.
Subcellular location	Membrane; Single-pass type I membrane protein.
Tissue specificity	Urogenital ridge, testis, ovary, brain and lung. In lung, found exclusively in pulmonary vessels of all sizes. Also expressed in aorta, vena cava and certain blood vessels of kidney, spleen, heart and intestine. For most blood vessels, a higher level of expression is found in endothelium than in adjacent smooth muscle.
Sequence similarities	Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. Contains 1 GS domain. Contains 1 protein kinase domain.

Ontologies

Keywords
Cellular component	Membrane
Domain	Signal Transmembrane
Ligand	ATP-binding Magnesium Manganese Metal-binding Nucleotide-binding
Molecular function	Kinase Receptor Serine/threonine-protein kinase Transferase
PTM	Glycoprotein
Gene Ontology (GO)
None. [Check GOA]

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view
Molecule processing
	Signal peptide	1 – 20	20	Potential
	Chain	21 – 504	484	Serine/threonine-protein kinase receptor R3
Regions
	Topological domain	21 – 121	101	Extracellular Potential
	Transmembrane	122 – 142	21	Potential
	Topological domain	143 – 504	362	Cytoplasmic Potential
	Domain	173 – 202	30	GS
	Domain	203 – 504	302	Protein kinase
	Nucleotide binding	209 – 217	9	ATP By similarity
Sites
	Active site	331	1	Proton acceptor By similarity
	Binding site	230	1	ATP By similarity
Amino acid modifications
	Glycosylation	34	1	N-linked (GlcNAc...) Potential
	Glycosylation	99	1	N-linked (GlcNAc...) Potential
Experimental info
	Sequence conflict	309	1	C → CA Ref.1

Sequences

	Sequence		Length	Mass (Da)
	P80203-1 [UniParc]. Last modified April 13, 2004. Version 2. Checksum: B40EA30775223C8F	FASTA	504	56,703
	10 20 30 40 50 60 MTLGIFRRVF LMLSVALGLT KGDLVKPSRG QLVNCTCENP HCKRPICQGA WCTVVLVREQ 70 80 90 100 110 120 GRHPQVYRGC GSLNQELCLG RPTEFVNHHC CYRSFCNHNV SLMLEATQTP SEEPEVDAHL 130 140 150 160 170 180 PLILGPVLAL LVLVALGTLG LWRVRRRQEK QRGLHSDLGE SSLILKASEQ GDSMLGDFLV 190 200 210 220 230 240 SDCTTGSGSG LPFLVQRTVA RQVALVECVG KGRYGEVWRG SWHGESVAVK IFSSRDEQSW 250 260 270 280 290 300 FRETEIYNTV LLRHDNILGF IASDMTSRNS STQLWLITHY HEHGSLYDFL QRQTLEPQLA 310 320 330 340 350 360 LRLAVSAACG LAHLHVEIFG TQGKPAIAHR DLKSRNVLVK SNLQCCIADL GLAVMHSQSS 370 380 390 400 410 420 DYLDIGNNPR VGTKRYMAPE VLDEQIRTDC FESYKWTDIW AFGLVLWEIA RRTIINGIVE 430 440 450 460 470 480 DYRPPFYDMV PNDPSFEDMK KVVCVDQQTP TIPNRLAADP VLSGLAQMMR ECWYPNPSAR 490 500 LTALRIKKTL QKLSQNPEKP KVIH

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Developmental expression of four novel serine/threonine kinase receptors homologous to the activin/transforming growth factor-beta type II receptor family." He W.-W., Gustafson M.L., Hirobe S., Donahoe P.K. Dev. Dyn. 196:133-142(1993) [PubMed: 8395914] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA]. Strain: Sprague-Dawley. Tissue: Urogenital ridge.
[2]	"Type I receptor serine-threonine kinase preferentially expressed in pulmonary blood vessels." Panchenko M.P., Williams M.C., Brody J.S., Yu Q. Am. J. Physiol. 270:L547-L558(1996) [PubMed: 8928814] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY. Strain: Sprague-Dawley. Tissue: Lung.
[3]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Lung.

Cross-references

Sequence databases
EMBLGenBankDDBJ	L36088 mRNA. Translation: AAC37705.1. BC083173 mRNA. Translation: AAH83173.1.
RefSeq	NP_071886.1.
UniGene	Rn.10631
3D structure databases
HSSP	HSSP built from PDB template 1IAS based on UniProtKB P36897.
ModBase	Search...
Genome annotation databases
Ensembl	ENSRNOG00000028713. Rattus norvegicus. [Contig view]
GeneID	25237.
KEGG	rno:25237.
Organism-specific databases
RGD	2029. Acvrl1.
GeneLynx	Search...
Phylogenomic databases
HOVERGEN	P80203.
Gene expression databases
ArrayExpress	P80203.
GermOnline	ENSRNOG00000028713. Rattus norvegicus.
Family and domain databases
InterPro	IPR000472. Activin_rcpt. IPR000719. Prot_kinase_core. IPR017441. Protein_kinase_ATP_bd_CS. IPR017442. Se/Thr_pkinase-rel. IPR008271. Ser_thr_pkin_AS. IPR003605. TGF_beta_rcpt_GS. [Graphical view]
Pfam	PF01064. Activin_recp. 1 hit. PF00069. Pkinase. 1 hit. PF08515. TGF_beta_GS. 1 hit. [Graphical view]
ProDom	PD000001. Prot_kinase. 1 hit. [Graphical view] [Entries sharing at least one domain]
SMART	SM00467. GS. 1 hit. [Graphical view]
PROSITE	PS51256. GS. 1 hit. PS00107. PROTEIN_KINASE_ATP. 1 hit. PS50011. PROTEIN_KINASE_DOM. 1 hit. PS00108. PROTEIN_KINASE_ST. 1 hit. [Graphical view]
BLOCKS	Search...
Other Resources
ProtoNet	Search...

Entry information

Entry name

ACVL1_RAT

Accession

Primary (citable) accession number: P80203
Secondary accession number(s): Q63559

Entry history

Integrated into UniProtKB/Swiss-Prot:	October 1, 1993
Last sequence update:	April 13, 2004
Last modified:	July 22, 2008
This is version 78 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HPI (Human Proteome Initiative)