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Protein

Serine/threonine-protein kinase receptor R3

Gene

Acvrl1

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at transcript leveli

Functioni

Type I receptor for TGF-beta family ligands BMP9/GDF2 and BMP10 and important regulator of normal blood vessel development. On ligand binding, forms a receptor complex consisting of two type II and two type I transmembrane serine/threonine kinases. Type II receptors phosphorylate and activate type I receptors which autophosphorylate, then bind and activate SMAD transcriptional regulators. May bind activin as well.

Catalytic activityi

ATP + [receptor-protein] = ADP + [receptor-protein] phosphate.

Cofactori

Mg2+By similarity, Mn2+By similarity

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei230 – 2301ATPPROSITE-ProRule annotation
Active sitei331 – 3311Proton acceptorPROSITE-ProRule annotation

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi209 – 2179ATPPROSITE-ProRule annotation

GO - Molecular functioni

  • activin receptor activity, type I Source: Ensembl
  • ATP binding Source: UniProtKB-KW
  • metal ion binding Source: UniProtKB-KW
  • receptor signaling protein serine/threonine kinase activity Source: RGD
  • SMAD binding Source: RGD
  • transforming growth factor beta binding Source: RGD
  • transforming growth factor beta receptor activity, type I Source: RGD
  • transmembrane receptor protein serine/threonine kinase activity Source: RGD

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Kinase, Receptor, Serine/threonine-protein kinase, Transferase

Keywords - Biological processi

Angiogenesis

Keywords - Ligandi

ATP-binding, Magnesium, Manganese, Metal-binding, Nucleotide-binding

Enzyme and pathway databases

BRENDAi2.7.10.2. 5301.

Names & Taxonomyi

Protein namesi
Recommended name:
Serine/threonine-protein kinase receptor R3 (EC:2.7.11.30)
Short name:
SKR3
Alternative name(s):
TGF-B superfamily receptor type I
Short name:
TSR-I
Gene namesi
Name:Acvrl1
Synonyms:Acvrlk1
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
ProteomesiUP000002494 Componenti: Chromosome 7

Organism-specific databases

RGDi2029. Acvrl1.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini21 – 121101ExtracellularSequence AnalysisAdd
BLAST
Transmembranei122 – 14221HelicalSequence AnalysisAdd
BLAST
Topological domaini143 – 504362CytoplasmicSequence AnalysisAdd
BLAST

GO - Cellular componenti

  • cell surface Source: Ensembl
  • dendrite Source: RGD
  • integral component of plasma membrane Source: Ensembl
  • neuronal cell body Source: RGD
Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2020Sequence AnalysisAdd
BLAST
Chaini21 – 504484Serine/threonine-protein kinase receptor R3PRO_0000024422Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi34 – 341N-linked (GlcNAc...)Sequence Analysis
Disulfide bondi35 ↔ 52By similarity
Disulfide bondi37 ↔ 42By similarity
Disulfide bondi47 ↔ 70By similarity
Disulfide bondi78 ↔ 90By similarity
Disulfide bondi91 ↔ 96By similarity
Glycosylationi99 – 991N-linked (GlcNAc...)Sequence Analysis
Modified residuei156 – 1561PhosphoserineBy similarity

Keywords - PTMi

Disulfide bond, Glycoprotein, Phosphoprotein

Proteomic databases

PaxDbiP80203.
PRIDEiP80203.

Expressioni

Tissue specificityi

Urogenital ridge, testis, ovary, brain and lung. In lung, found exclusively in pulmonary vessels of all sizes. Also expressed in aorta, vena cava and certain blood vessels of kidney, spleen, heart and intestine. For most blood vessels, a higher level of expression is found in endothelium than in adjacent smooth muscle.1 Publication

Gene expression databases

GenevisibleiP80203. RN.

Interactioni

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000008673.

Structurei

3D structure databases

ProteinModelPortaliP80203.
SMRiP80203. Positions 173-495.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini173 – 20230GSPROSITE-ProRule annotationAdd
BLAST
Domaini203 – 504302Protein kinasePROSITE-ProRule annotationAdd
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni74 – 774Mediates specificity for BMP ligandBy similarity

Sequence similaritiesi

Contains 1 GS domain.PROSITE-ProRule annotation
Contains 1 protein kinase domain.PROSITE-ProRule annotation

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiCOG0515.
GeneTreeiENSGT00760000118876.
HOGENOMiHOG000230587.
HOVERGENiHBG054502.
InParanoidiP80203.
KOiK13594.
OMAiWHVRRRQ.
OrthoDBiEOG7Q8CN3.

Family and domain databases

InterProiIPR011009. Kinase-like_dom.
IPR000719. Prot_kinase_dom.
IPR017441. Protein_kinase_ATP_BS.
IPR008271. Ser/Thr_kinase_AS.
IPR000472. TFB_recept_I/II_C.
IPR003605. TGF_beta_rcpt_GS.
IPR000333. TGFB_receptor.
[Graphical view]
PANTHERiPTHR23255. PTHR23255. 1 hit.
PfamiPF01064. Activin_recp. 1 hit.
PF00069. Pkinase. 1 hit.
PF08515. TGF_beta_GS. 1 hit.
[Graphical view]
SMARTiSM00467. GS. 1 hit.
[Graphical view]
SUPFAMiSSF56112. SSF56112. 1 hit.
PROSITEiPS51256. GS. 1 hit.
PS00107. PROTEIN_KINASE_ATP. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00108. PROTEIN_KINASE_ST. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P80203-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTLGIFRRVF LMLSVALGLT KGDLVKPSRG QLVNCTCENP HCKRPICQGA
60 70 80 90 100
WCTVVLVREQ GRHPQVYRGC GSLNQELCLG RPTEFVNHHC CYRSFCNHNV
110 120 130 140 150
SLMLEATQTP SEEPEVDAHL PLILGPVLAL LVLVALGTLG LWRVRRRQEK
160 170 180 190 200
QRGLHSDLGE SSLILKASEQ GDSMLGDFLV SDCTTGSGSG LPFLVQRTVA
210 220 230 240 250
RQVALVECVG KGRYGEVWRG SWHGESVAVK IFSSRDEQSW FRETEIYNTV
260 270 280 290 300
LLRHDNILGF IASDMTSRNS STQLWLITHY HEHGSLYDFL QRQTLEPQLA
310 320 330 340 350
LRLAVSAACG LAHLHVEIFG TQGKPAIAHR DLKSRNVLVK SNLQCCIADL
360 370 380 390 400
GLAVMHSQSS DYLDIGNNPR VGTKRYMAPE VLDEQIRTDC FESYKWTDIW
410 420 430 440 450
AFGLVLWEIA RRTIINGIVE DYRPPFYDMV PNDPSFEDMK KVVCVDQQTP
460 470 480 490 500
TIPNRLAADP VLSGLAQMMR ECWYPNPSAR LTALRIKKTL QKLSQNPEKP

KVIH
Length:504
Mass (Da):56,703
Last modified:April 13, 2004 - v2
Checksum:iB40EA30775223C8F
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti309 – 3091C → CA (PubMed:8395914).Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L36088 mRNA. Translation: AAC37705.1.
BC083173 mRNA. Translation: AAH83173.1.
RefSeqiNP_071886.1. NM_022441.2.
XP_006242365.1. XM_006242303.2.
XP_006242366.1. XM_006242304.2.
XP_006242367.1. XM_006242305.2.
XP_006242369.1. XM_006242307.2.
XP_008763895.1. XM_008765673.1.
UniGeneiRn.10631.

Genome annotation databases

EnsembliENSRNOT00000008673; ENSRNOP00000008673; ENSRNOG00000028713.
GeneIDi25237.
KEGGirno:25237.
UCSCiRGD:2029. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L36088 mRNA. Translation: AAC37705.1.
BC083173 mRNA. Translation: AAH83173.1.
RefSeqiNP_071886.1. NM_022441.2.
XP_006242365.1. XM_006242303.2.
XP_006242366.1. XM_006242304.2.
XP_006242367.1. XM_006242305.2.
XP_006242369.1. XM_006242307.2.
XP_008763895.1. XM_008765673.1.
UniGeneiRn.10631.

3D structure databases

ProteinModelPortaliP80203.
SMRiP80203. Positions 173-495.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000008673.

Proteomic databases

PaxDbiP80203.
PRIDEiP80203.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSRNOT00000008673; ENSRNOP00000008673; ENSRNOG00000028713.
GeneIDi25237.
KEGGirno:25237.
UCSCiRGD:2029. rat.

Organism-specific databases

CTDi94.
RGDi2029. Acvrl1.

Phylogenomic databases

eggNOGiCOG0515.
GeneTreeiENSGT00760000118876.
HOGENOMiHOG000230587.
HOVERGENiHBG054502.
InParanoidiP80203.
KOiK13594.
OMAiWHVRRRQ.
OrthoDBiEOG7Q8CN3.

Enzyme and pathway databases

BRENDAi2.7.10.2. 5301.

Miscellaneous databases

NextBioi605811.
PROiP80203.

Gene expression databases

GenevisibleiP80203. RN.

Family and domain databases

InterProiIPR011009. Kinase-like_dom.
IPR000719. Prot_kinase_dom.
IPR017441. Protein_kinase_ATP_BS.
IPR008271. Ser/Thr_kinase_AS.
IPR000472. TFB_recept_I/II_C.
IPR003605. TGF_beta_rcpt_GS.
IPR000333. TGFB_receptor.
[Graphical view]
PANTHERiPTHR23255. PTHR23255. 1 hit.
PfamiPF01064. Activin_recp. 1 hit.
PF00069. Pkinase. 1 hit.
PF08515. TGF_beta_GS. 1 hit.
[Graphical view]
SMARTiSM00467. GS. 1 hit.
[Graphical view]
SUPFAMiSSF56112. SSF56112. 1 hit.
PROSITEiPS51256. GS. 1 hit.
PS00107. PROTEIN_KINASE_ATP. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00108. PROTEIN_KINASE_ST. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Developmental expression of four novel serine/threonine kinase receptors homologous to the activin/transforming growth factor-beta type II receptor family."
    He W.-W., Gustafson M.L., Hirobe S., Donahoe P.K.
    Dev. Dyn. 196:133-142(1993) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Strain: Sprague-Dawley.
    Tissue: Urogenital ridge.
  2. "Type I receptor serine-threonine kinase preferentially expressed in pulmonary blood vessels."
    Panchenko M.P., Williams M.C., Brody J.S., Yu Q.
    Am. J. Physiol. 270:L547-L558(1996) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY.
    Strain: Sprague-Dawley.
    Tissue: Lung.
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Lung.

Entry informationi

Entry nameiACVL1_RAT
AccessioniPrimary (citable) accession number: P80203
Secondary accession number(s): Q63559
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 1, 1993
Last sequence update: April 13, 2004
Last modified: June 24, 2015
This is version 136 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.