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P80203

- ACVL1_RAT

UniProt

P80203 - ACVL1_RAT

Protein

Serine/threonine-protein kinase receptor R3

Gene

Acvrl1

Organism
Rattus norvegicus (Rat)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 130 (01 Oct 2014)
      Sequence version 2 (13 Apr 2004)
      Previous versions | rss
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    Functioni

    Type I receptor for TGF-beta family ligands BMP9/GDF2 and BMP10 and important regulator of normal blood vessel development. On ligand binding, forms a receptor complex consisting of two type II and two type I transmembrane serine/threonine kinases. Type II receptors phosphorylate and activate type I receptors which autophosphorylate, then bind and activate SMAD transcriptional regulators. May bind activin as well.

    Catalytic activityi

    ATP + [receptor-protein] = ADP + [receptor-protein] phosphate.

    Cofactori

    Magnesium or manganese.By similarity

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei230 – 2301ATPPROSITE-ProRule annotation
    Active sitei331 – 3311Proton acceptorPROSITE-ProRule annotation

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi209 – 2179ATPPROSITE-ProRule annotation

    GO - Molecular functioni

    1. activin receptor activity, type I Source: Ensembl
    2. ATP binding Source: UniProtKB-KW
    3. metal ion binding Source: UniProtKB-KW
    4. receptor signaling protein serine/threonine kinase activity Source: RGD
    5. SMAD binding Source: RGD
    6. transforming growth factor beta binding Source: RGD
    7. transforming growth factor beta receptor activity, type I Source: RGD
    8. transmembrane receptor protein serine/threonine kinase activity Source: RGD

    GO - Biological processi

    1. angiogenesis Source: UniProtKB-KW
    2. artery development Source: Ensembl
    3. blood vessel remodeling Source: Ensembl
    4. BMP signaling pathway Source: Ensembl
    5. cellular response to BMP stimulus Source: Ensembl
    6. endothelial tube morphogenesis Source: Ensembl
    7. in utero embryonic development Source: Ensembl
    8. lymphangiogenesis Source: Ensembl
    9. negative regulation of blood vessel endothelial cell migration Source: Ensembl
    10. negative regulation of cell growth Source: Ensembl
    11. negative regulation of DNA biosynthetic process Source: Ensembl
    12. negative regulation of endothelial cell differentiation Source: Ensembl
    13. negative regulation of endothelial cell proliferation Source: Ensembl
    14. negative regulation of focal adhesion assembly Source: Ensembl
    15. positive regulation of BMP signaling pathway Source: Ensembl
    16. positive regulation of endothelial cell differentiation Source: Ensembl
    17. positive regulation of endothelial cell proliferation Source: Ensembl
    18. positive regulation of pathway-restricted SMAD protein phosphorylation Source: Ensembl
    19. positive regulation of transcription from RNA polymerase II promoter Source: Ensembl
    20. protein heterooligomerization Source: RGD
    21. protein phosphorylation Source: RGD
    22. regulation of blood pressure Source: Ensembl
    23. retina vasculature development in camera-type eye Source: Ensembl
    24. signal transduction by phosphorylation Source: GOC
    25. transforming growth factor beta receptor signaling pathway Source: RGD
    26. venous blood vessel development Source: Ensembl
    27. wound healing, spreading of epidermal cells Source: Ensembl

    Keywords - Molecular functioni

    Kinase, Receptor, Serine/threonine-protein kinase, Transferase

    Keywords - Biological processi

    Angiogenesis

    Keywords - Ligandi

    ATP-binding, Magnesium, Manganese, Metal-binding, Nucleotide-binding

    Enzyme and pathway databases

    BRENDAi2.7.10.2. 5301.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Serine/threonine-protein kinase receptor R3 (EC:2.7.11.30)
    Short name:
    SKR3
    Alternative name(s):
    TGF-B superfamily receptor type I
    Short name:
    TSR-I
    Gene namesi
    Name:Acvrl1
    Synonyms:Acvrlk1
    OrganismiRattus norvegicus (Rat)
    Taxonomic identifieri10116 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
    ProteomesiUP000002494: Chromosome 7

    Organism-specific databases

    RGDi2029. Acvrl1.

    Subcellular locationi

    GO - Cellular componenti

    1. cell surface Source: Ensembl
    2. dendrite Source: RGD
    3. integral component of plasma membrane Source: Ensembl
    4. neuronal cell body Source: RGD

    Keywords - Cellular componenti

    Membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 2020Sequence AnalysisAdd
    BLAST
    Chaini21 – 504484Serine/threonine-protein kinase receptor R3PRO_0000024422Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi34 – 341N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi35 ↔ 52By similarity
    Disulfide bondi37 ↔ 42By similarity
    Disulfide bondi47 ↔ 70By similarity
    Disulfide bondi78 ↔ 90By similarity
    Disulfide bondi91 ↔ 96By similarity
    Glycosylationi99 – 991N-linked (GlcNAc...)Sequence Analysis
    Modified residuei156 – 1561PhosphoserineBy similarity

    Keywords - PTMi

    Disulfide bond, Glycoprotein, Phosphoprotein

    Proteomic databases

    PaxDbiP80203.
    PRIDEiP80203.

    Expressioni

    Tissue specificityi

    Urogenital ridge, testis, ovary, brain and lung. In lung, found exclusively in pulmonary vessels of all sizes. Also expressed in aorta, vena cava and certain blood vessels of kidney, spleen, heart and intestine. For most blood vessels, a higher level of expression is found in endothelium than in adjacent smooth muscle.1 Publication

    Gene expression databases

    GenevestigatoriP80203.

    Interactioni

    Protein-protein interaction databases

    STRINGi10116.ENSRNOP00000062675.

    Structurei

    3D structure databases

    ProteinModelPortaliP80203.
    SMRiP80203. Positions 173-495.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini21 – 121101ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini143 – 504362CytoplasmicSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei122 – 14221HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini173 – 20230GSPROSITE-ProRule annotationAdd
    BLAST
    Domaini203 – 504302Protein kinasePROSITE-ProRule annotationAdd
    BLAST

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni74 – 774Mediates specificity for BMP ligandBy similarity

    Sequence similaritiesi

    Contains 1 GS domain.PROSITE-ProRule annotation
    Contains 1 protein kinase domain.PROSITE-ProRule annotation

    Keywords - Domaini

    Signal, Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiCOG0515.
    GeneTreeiENSGT00730000110868.
    HOGENOMiHOG000230587.
    HOVERGENiHBG054502.
    InParanoidiP80203.
    KOiK13594.
    OMAiWHVRRRQ.
    OrthoDBiEOG7Q8CN3.

    Family and domain databases

    InterProiIPR000472. Activin_rcpt.
    IPR011009. Kinase-like_dom.
    IPR000719. Prot_kinase_dom.
    IPR017441. Protein_kinase_ATP_BS.
    IPR008271. Ser/Thr_kinase_AS.
    IPR003605. TGF_beta_rcpt_GS.
    IPR000333. TGFB_receptor.
    [Graphical view]
    PANTHERiPTHR23255. PTHR23255. 1 hit.
    PfamiPF01064. Activin_recp. 1 hit.
    PF00069. Pkinase. 1 hit.
    PF08515. TGF_beta_GS. 1 hit.
    [Graphical view]
    SMARTiSM00467. GS. 1 hit.
    [Graphical view]
    SUPFAMiSSF56112. SSF56112. 1 hit.
    PROSITEiPS51256. GS. 1 hit.
    PS00107. PROTEIN_KINASE_ATP. 1 hit.
    PS50011. PROTEIN_KINASE_DOM. 1 hit.
    PS00108. PROTEIN_KINASE_ST. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    P80203-1 [UniParc]FASTAAdd to Basket

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    MTLGIFRRVF LMLSVALGLT KGDLVKPSRG QLVNCTCENP HCKRPICQGA    50
    WCTVVLVREQ GRHPQVYRGC GSLNQELCLG RPTEFVNHHC CYRSFCNHNV 100
    SLMLEATQTP SEEPEVDAHL PLILGPVLAL LVLVALGTLG LWRVRRRQEK 150
    QRGLHSDLGE SSLILKASEQ GDSMLGDFLV SDCTTGSGSG LPFLVQRTVA 200
    RQVALVECVG KGRYGEVWRG SWHGESVAVK IFSSRDEQSW FRETEIYNTV 250
    LLRHDNILGF IASDMTSRNS STQLWLITHY HEHGSLYDFL QRQTLEPQLA 300
    LRLAVSAACG LAHLHVEIFG TQGKPAIAHR DLKSRNVLVK SNLQCCIADL 350
    GLAVMHSQSS DYLDIGNNPR VGTKRYMAPE VLDEQIRTDC FESYKWTDIW 400
    AFGLVLWEIA RRTIINGIVE DYRPPFYDMV PNDPSFEDMK KVVCVDQQTP 450
    TIPNRLAADP VLSGLAQMMR ECWYPNPSAR LTALRIKKTL QKLSQNPEKP 500
    KVIH 504
    Length:504
    Mass (Da):56,703
    Last modified:April 13, 2004 - v2
    Checksum:iB40EA30775223C8F
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti309 – 3091C → CA(PubMed:8395914)Curated

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    L36088 mRNA. Translation: AAC37705.1.
    BC083173 mRNA. Translation: AAH83173.1.
    RefSeqiNP_071886.1. NM_022441.2.
    XP_006242365.1. XM_006242303.1.
    XP_006242366.1. XM_006242304.1.
    XP_006242367.1. XM_006242305.1.
    XP_006242368.1. XM_006242306.1.
    XP_006242369.1. XM_006242307.1.
    UniGeneiRn.10631.

    Genome annotation databases

    EnsembliENSRNOT00000008673; ENSRNOP00000008673; ENSRNOG00000028713.
    GeneIDi25237.
    KEGGirno:25237.
    UCSCiRGD:2029. rat.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    L36088 mRNA. Translation: AAC37705.1 .
    BC083173 mRNA. Translation: AAH83173.1 .
    RefSeqi NP_071886.1. NM_022441.2.
    XP_006242365.1. XM_006242303.1.
    XP_006242366.1. XM_006242304.1.
    XP_006242367.1. XM_006242305.1.
    XP_006242368.1. XM_006242306.1.
    XP_006242369.1. XM_006242307.1.
    UniGenei Rn.10631.

    3D structure databases

    ProteinModelPortali P80203.
    SMRi P80203. Positions 173-495.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 10116.ENSRNOP00000062675.

    Proteomic databases

    PaxDbi P80203.
    PRIDEi P80203.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSRNOT00000008673 ; ENSRNOP00000008673 ; ENSRNOG00000028713 .
    GeneIDi 25237.
    KEGGi rno:25237.
    UCSCi RGD:2029. rat.

    Organism-specific databases

    CTDi 94.
    RGDi 2029. Acvrl1.

    Phylogenomic databases

    eggNOGi COG0515.
    GeneTreei ENSGT00730000110868.
    HOGENOMi HOG000230587.
    HOVERGENi HBG054502.
    InParanoidi P80203.
    KOi K13594.
    OMAi WHVRRRQ.
    OrthoDBi EOG7Q8CN3.

    Enzyme and pathway databases

    BRENDAi 2.7.10.2. 5301.

    Miscellaneous databases

    NextBioi 605811.
    PROi P80203.

    Gene expression databases

    Genevestigatori P80203.

    Family and domain databases

    InterProi IPR000472. Activin_rcpt.
    IPR011009. Kinase-like_dom.
    IPR000719. Prot_kinase_dom.
    IPR017441. Protein_kinase_ATP_BS.
    IPR008271. Ser/Thr_kinase_AS.
    IPR003605. TGF_beta_rcpt_GS.
    IPR000333. TGFB_receptor.
    [Graphical view ]
    PANTHERi PTHR23255. PTHR23255. 1 hit.
    Pfami PF01064. Activin_recp. 1 hit.
    PF00069. Pkinase. 1 hit.
    PF08515. TGF_beta_GS. 1 hit.
    [Graphical view ]
    SMARTi SM00467. GS. 1 hit.
    [Graphical view ]
    SUPFAMi SSF56112. SSF56112. 1 hit.
    PROSITEi PS51256. GS. 1 hit.
    PS00107. PROTEIN_KINASE_ATP. 1 hit.
    PS50011. PROTEIN_KINASE_DOM. 1 hit.
    PS00108. PROTEIN_KINASE_ST. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Developmental expression of four novel serine/threonine kinase receptors homologous to the activin/transforming growth factor-beta type II receptor family."
      He W.-W., Gustafson M.L., Hirobe S., Donahoe P.K.
      Dev. Dyn. 196:133-142(1993) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Strain: Sprague-Dawley.
      Tissue: Urogenital ridge.
    2. "Type I receptor serine-threonine kinase preferentially expressed in pulmonary blood vessels."
      Panchenko M.P., Williams M.C., Brody J.S., Yu Q.
      Am. J. Physiol. 270:L547-L558(1996) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY.
      Strain: Sprague-Dawley.
      Tissue: Lung.
    3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Lung.

    Entry informationi

    Entry nameiACVL1_RAT
    AccessioniPrimary (citable) accession number: P80203
    Secondary accession number(s): Q63559
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: October 1, 1993
    Last sequence update: April 13, 2004
    Last modified: October 1, 2014
    This is version 130 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3