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P80203

- ACVL1_RAT

UniProt

P80203 - ACVL1_RAT

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Protein
Serine/threonine-protein kinase receptor R3
Gene
Acvrl1, Acvrlk1
Organism
Rattus norvegicus (Rat)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at transcript leveli

Functioni

Type I receptor for TGF-beta family ligands BMP9/GDF2 and BMP10 and important regulator of normal blood vessel development. On ligand binding, forms a receptor complex consisting of two type II and two type I transmembrane serine/threonine kinases. Type II receptors phosphorylate and activate type I receptors which autophosphorylate, then bind and activate SMAD transcriptional regulators. May bind activin as well.

Catalytic activityi

ATP + [receptor-protein] = ADP + [receptor-protein] phosphate.

Cofactori

Magnesium or manganese By similarity.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei230 – 2301ATP By similarity
Active sitei331 – 3311Proton acceptor By similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi209 – 2179ATP By similarity

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-KW
  2. SMAD binding Source: RGD
  3. activin receptor activity, type I Source: Ensembl
  4. metal ion binding Source: UniProtKB-KW
  5. receptor signaling protein serine/threonine kinase activity Source: RGD
  6. transforming growth factor beta binding Source: RGD
  7. transforming growth factor beta receptor activity, type I Source: RGD
  8. transmembrane receptor protein serine/threonine kinase activity Source: RGD

GO - Biological processi

  1. BMP signaling pathway Source: Ensembl
  2. angiogenesis Source: UniProtKB-KW
  3. artery development Source: Ensembl
  4. blood vessel remodeling Source: Ensembl
  5. cellular response to BMP stimulus Source: Ensembl
  6. endothelial tube morphogenesis Source: Ensembl
  7. in utero embryonic development Source: Ensembl
  8. lymphangiogenesis Source: Ensembl
  9. negative regulation of DNA biosynthetic process Source: Ensembl
  10. negative regulation of blood vessel endothelial cell migration Source: Ensembl
  11. negative regulation of cell growth Source: Ensembl
  12. negative regulation of endothelial cell differentiation Source: Ensembl
  13. negative regulation of endothelial cell proliferation Source: Ensembl
  14. negative regulation of focal adhesion assembly Source: Ensembl
  15. positive regulation of BMP signaling pathway Source: Ensembl
  16. positive regulation of endothelial cell differentiation Source: Ensembl
  17. positive regulation of endothelial cell proliferation Source: Ensembl
  18. positive regulation of pathway-restricted SMAD protein phosphorylation Source: Ensembl
  19. positive regulation of transcription from RNA polymerase II promoter Source: Ensembl
  20. protein heterooligomerization Source: RGD
  21. protein phosphorylation Source: RGD
  22. regulation of blood pressure Source: Ensembl
  23. retina vasculature development in camera-type eye Source: Ensembl
  24. signal transduction by phosphorylation Source: GOC
  25. transforming growth factor beta receptor signaling pathway Source: RGD
  26. venous blood vessel development Source: Ensembl
  27. wound healing, spreading of epidermal cells Source: Ensembl
Complete GO annotation...

Keywords - Molecular functioni

Kinase, Receptor, Serine/threonine-protein kinase, Transferase

Keywords - Biological processi

Angiogenesis

Keywords - Ligandi

ATP-binding, Magnesium, Manganese, Metal-binding, Nucleotide-binding

Enzyme and pathway databases

BRENDAi2.7.10.2. 5301.

Names & Taxonomyi

Protein namesi
Recommended name:
Serine/threonine-protein kinase receptor R3 (EC:2.7.11.30)
Short name:
SKR3
Alternative name(s):
TGF-B superfamily receptor type I
Short name:
TSR-I
Gene namesi
Name:Acvrl1
Synonyms:Acvrlk1
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
ProteomesiUP000002494: Chromosome 7

Organism-specific databases

RGDi2029. Acvrl1.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini21 – 121101Extracellular Reviewed prediction
Add
BLAST
Transmembranei122 – 14221Helical; Reviewed prediction
Add
BLAST
Topological domaini143 – 504362Cytoplasmic Reviewed prediction
Add
BLAST

GO - Cellular componenti

  1. cell surface Source: Ensembl
  2. dendrite Source: RGD
  3. integral component of plasma membrane Source: Ensembl
  4. neuronal cell body Source: RGD
Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2020 Reviewed prediction
Add
BLAST
Chaini21 – 504484Serine/threonine-protein kinase receptor R3
PRO_0000024422Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi34 – 341N-linked (GlcNAc...) Reviewed prediction
Disulfide bondi35 ↔ 52 By similarity
Disulfide bondi37 ↔ 42 By similarity
Disulfide bondi47 ↔ 70 By similarity
Disulfide bondi78 ↔ 90 By similarity
Disulfide bondi91 ↔ 96 By similarity
Glycosylationi99 – 991N-linked (GlcNAc...) Reviewed prediction
Modified residuei156 – 1561Phosphoserine By similarity

Keywords - PTMi

Disulfide bond, Glycoprotein, Phosphoprotein

Proteomic databases

PaxDbiP80203.
PRIDEiP80203.

Expressioni

Tissue specificityi

Urogenital ridge, testis, ovary, brain and lung. In lung, found exclusively in pulmonary vessels of all sizes. Also expressed in aorta, vena cava and certain blood vessels of kidney, spleen, heart and intestine. For most blood vessels, a higher level of expression is found in endothelium than in adjacent smooth muscle.1 Publication

Gene expression databases

GenevestigatoriP80203.

Interactioni

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000062675.

Structurei

3D structure databases

ProteinModelPortaliP80203.
SMRiP80203. Positions 173-495.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini173 – 20230GS
Add
BLAST
Domaini203 – 504302Protein kinase
Add
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni74 – 774Mediates specificity for BMP ligand By similarity

Sequence similaritiesi

Contains 1 GS domain.

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiCOG0515.
GeneTreeiENSGT00730000110868.
HOGENOMiHOG000230587.
HOVERGENiHBG054502.
InParanoidiP80203.
KOiK13594.
OMAiWHVRRRQ.
OrthoDBiEOG7Q8CN3.

Family and domain databases

InterProiIPR000472. Activin_rcpt.
IPR011009. Kinase-like_dom.
IPR000719. Prot_kinase_dom.
IPR017441. Protein_kinase_ATP_BS.
IPR008271. Ser/Thr_kinase_AS.
IPR003605. TGF_beta_rcpt_GS.
IPR000333. TGFB_receptor.
[Graphical view]
PANTHERiPTHR23255. PTHR23255. 1 hit.
PfamiPF01064. Activin_recp. 1 hit.
PF00069. Pkinase. 1 hit.
PF08515. TGF_beta_GS. 1 hit.
[Graphical view]
SMARTiSM00467. GS. 1 hit.
[Graphical view]
SUPFAMiSSF56112. SSF56112. 1 hit.
PROSITEiPS51256. GS. 1 hit.
PS00107. PROTEIN_KINASE_ATP. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00108. PROTEIN_KINASE_ST. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P80203-1 [UniParc]FASTAAdd to Basket

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MTLGIFRRVF LMLSVALGLT KGDLVKPSRG QLVNCTCENP HCKRPICQGA    50
WCTVVLVREQ GRHPQVYRGC GSLNQELCLG RPTEFVNHHC CYRSFCNHNV 100
SLMLEATQTP SEEPEVDAHL PLILGPVLAL LVLVALGTLG LWRVRRRQEK 150
QRGLHSDLGE SSLILKASEQ GDSMLGDFLV SDCTTGSGSG LPFLVQRTVA 200
RQVALVECVG KGRYGEVWRG SWHGESVAVK IFSSRDEQSW FRETEIYNTV 250
LLRHDNILGF IASDMTSRNS STQLWLITHY HEHGSLYDFL QRQTLEPQLA 300
LRLAVSAACG LAHLHVEIFG TQGKPAIAHR DLKSRNVLVK SNLQCCIADL 350
GLAVMHSQSS DYLDIGNNPR VGTKRYMAPE VLDEQIRTDC FESYKWTDIW 400
AFGLVLWEIA RRTIINGIVE DYRPPFYDMV PNDPSFEDMK KVVCVDQQTP 450
TIPNRLAADP VLSGLAQMMR ECWYPNPSAR LTALRIKKTL QKLSQNPEKP 500
KVIH 504
Length:504
Mass (Da):56,703
Last modified:April 13, 2004 - v2
Checksum:iB40EA30775223C8F
GO

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti309 – 3091C → CA1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
L36088 mRNA. Translation: AAC37705.1.
BC083173 mRNA. Translation: AAH83173.1.
RefSeqiNP_071886.1. NM_022441.2.
XP_006242365.1. XM_006242303.1.
XP_006242366.1. XM_006242304.1.
XP_006242367.1. XM_006242305.1.
XP_006242368.1. XM_006242306.1.
XP_006242369.1. XM_006242307.1.
UniGeneiRn.10631.

Genome annotation databases

EnsembliENSRNOT00000008673; ENSRNOP00000008673; ENSRNOG00000028713.
GeneIDi25237.
KEGGirno:25237.
UCSCiRGD:2029. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
L36088 mRNA. Translation: AAC37705.1 .
BC083173 mRNA. Translation: AAH83173.1 .
RefSeqi NP_071886.1. NM_022441.2.
XP_006242365.1. XM_006242303.1.
XP_006242366.1. XM_006242304.1.
XP_006242367.1. XM_006242305.1.
XP_006242368.1. XM_006242306.1.
XP_006242369.1. XM_006242307.1.
UniGenei Rn.10631.

3D structure databases

ProteinModelPortali P80203.
SMRi P80203. Positions 173-495.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 10116.ENSRNOP00000062675.

Proteomic databases

PaxDbi P80203.
PRIDEi P80203.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSRNOT00000008673 ; ENSRNOP00000008673 ; ENSRNOG00000028713 .
GeneIDi 25237.
KEGGi rno:25237.
UCSCi RGD:2029. rat.

Organism-specific databases

CTDi 94.
RGDi 2029. Acvrl1.

Phylogenomic databases

eggNOGi COG0515.
GeneTreei ENSGT00730000110868.
HOGENOMi HOG000230587.
HOVERGENi HBG054502.
InParanoidi P80203.
KOi K13594.
OMAi WHVRRRQ.
OrthoDBi EOG7Q8CN3.

Enzyme and pathway databases

BRENDAi 2.7.10.2. 5301.

Miscellaneous databases

NextBioi 605811.
PROi P80203.

Gene expression databases

Genevestigatori P80203.

Family and domain databases

InterProi IPR000472. Activin_rcpt.
IPR011009. Kinase-like_dom.
IPR000719. Prot_kinase_dom.
IPR017441. Protein_kinase_ATP_BS.
IPR008271. Ser/Thr_kinase_AS.
IPR003605. TGF_beta_rcpt_GS.
IPR000333. TGFB_receptor.
[Graphical view ]
PANTHERi PTHR23255. PTHR23255. 1 hit.
Pfami PF01064. Activin_recp. 1 hit.
PF00069. Pkinase. 1 hit.
PF08515. TGF_beta_GS. 1 hit.
[Graphical view ]
SMARTi SM00467. GS. 1 hit.
[Graphical view ]
SUPFAMi SSF56112. SSF56112. 1 hit.
PROSITEi PS51256. GS. 1 hit.
PS00107. PROTEIN_KINASE_ATP. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00108. PROTEIN_KINASE_ST. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Developmental expression of four novel serine/threonine kinase receptors homologous to the activin/transforming growth factor-beta type II receptor family."
    He W.-W., Gustafson M.L., Hirobe S., Donahoe P.K.
    Dev. Dyn. 196:133-142(1993) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Strain: Sprague-Dawley.
    Tissue: Urogenital ridge.
  2. "Type I receptor serine-threonine kinase preferentially expressed in pulmonary blood vessels."
    Panchenko M.P., Williams M.C., Brody J.S., Yu Q.
    Am. J. Physiol. 270:L547-L558(1996) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY.
    Strain: Sprague-Dawley.
    Tissue: Lung.
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Lung.

Entry informationi

Entry nameiACVL1_RAT
AccessioniPrimary (citable) accession number: P80203
Secondary accession number(s): Q63559
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 1, 1993
Last sequence update: April 13, 2004
Last modified: June 11, 2014
This is version 129 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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