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Protein

Serine/threonine-protein kinase receptor R3

Gene

Acvrl1

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Type I receptor for TGF-beta family ligands BMP9/GDF2 and BMP10 and important regulator of normal blood vessel development. On ligand binding, forms a receptor complex consisting of two type II and two type I transmembrane serine/threonine kinases. Type II receptors phosphorylate and activate type I receptors which autophosphorylate, then bind and activate SMAD transcriptional regulators. May bind activin as well.By similarity

Catalytic activityi

ATP + [receptor-protein] = ADP + [receptor-protein] phosphate.

Cofactori

Mg2+By similarity, Mn2+By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei230ATPPROSITE-ProRule annotation1
Active sitei331Proton acceptorPROSITE-ProRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi209 – 217ATPPROSITE-ProRule annotation9

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionKinase, Receptor, Serine/threonine-protein kinase, Transferase
Biological processAngiogenesis
LigandATP-binding, Magnesium, Manganese, Metal-binding, Nucleotide-binding

Enzyme and pathway databases

BRENDAi2.7.10.2 5301
ReactomeiR-RNO-201451 Signaling by BMP

Names & Taxonomyi

Protein namesi
Recommended name:
Serine/threonine-protein kinase receptor R3 (EC:2.7.11.30)
Short name:
SKR3
Alternative name(s):
TGF-B superfamily receptor type I
Short name:
TSR-I
Gene namesi
Name:Acvrl1
Synonyms:Acvrlk1
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 7

Organism-specific databases

RGDi2029 Acvrl1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini21 – 121ExtracellularSequence analysisAdd BLAST101
Transmembranei122 – 142HelicalSequence analysisAdd BLAST21
Topological domaini143 – 504CytoplasmicSequence analysisAdd BLAST362

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 20Sequence analysisAdd BLAST20
ChainiPRO_000002442221 – 504Serine/threonine-protein kinase receptor R3Add BLAST484

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi34N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi35 ↔ 52By similarity
Disulfide bondi37 ↔ 42By similarity
Disulfide bondi47 ↔ 70By similarity
Disulfide bondi78 ↔ 90By similarity
Disulfide bondi91 ↔ 96By similarity
Glycosylationi99N-linked (GlcNAc...) asparagineSequence analysis1
Modified residuei156PhosphoserineCombined sources1
Modified residuei161PhosphoserineCombined sources1
Modified residuei162PhosphoserineCombined sources1

Keywords - PTMi

Disulfide bond, Glycoprotein, Phosphoprotein

Proteomic databases

PaxDbiP80203
PRIDEiP80203

PTM databases

iPTMnetiP80203
PhosphoSitePlusiP80203

Expressioni

Tissue specificityi

Urogenital ridge, testis, ovary, brain and lung. In lung, found exclusively in pulmonary vessels of all sizes. Also expressed in aorta, vena cava and certain blood vessels of kidney, spleen, heart and intestine. For most blood vessels, a higher level of expression is found in endothelium than in adjacent smooth muscle.1 Publication

Gene expression databases

BgeeiENSRNOG00000028713
GenevisibleiP80203 RN

Interactioni

GO - Molecular functioni

  • protein kinase binding Source: RGD
  • SMAD binding Source: RGD
  • transforming growth factor beta binding Source: RGD

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000008673

Structurei

3D structure databases

ProteinModelPortaliP80203
SMRiP80203
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini173 – 202GSPROSITE-ProRule annotationAdd BLAST30
Domaini203 – 504Protein kinasePROSITE-ProRule annotationAdd BLAST302

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni74 – 77Mediates specificity for BMP ligandBy similarity4

Sequence similaritiesi

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG2052 Eukaryota
ENOG410XQT0 LUCA
GeneTreeiENSGT00760000118876
HOGENOMiHOG000230587
HOVERGENiHBG054502
InParanoidiP80203
KOiK13594
OMAiWHVRRRQ

Family and domain databases

InterProiView protein in InterPro
IPR003605 GS_dom
IPR011009 Kinase-like_dom_sf
IPR000719 Prot_kinase_dom
IPR017441 Protein_kinase_ATP_BS
IPR001245 Ser-Thr/Tyr_kinase_cat_dom
IPR008271 Ser/Thr_kinase_AS
IPR000333 TGFB_receptor
PANTHERiPTHR23255 PTHR23255, 1 hit
PfamiView protein in Pfam
PF07714 Pkinase_Tyr, 1 hit
PF08515 TGF_beta_GS, 1 hit
SMARTiView protein in SMART
SM00467 GS, 1 hit
SM00220 S_TKc, 1 hit
SUPFAMiSSF56112 SSF56112, 1 hit
PROSITEiView protein in PROSITE
PS51256 GS, 1 hit
PS00107 PROTEIN_KINASE_ATP, 1 hit
PS50011 PROTEIN_KINASE_DOM, 1 hit
PS00108 PROTEIN_KINASE_ST, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P80203-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTLGIFRRVF LMLSVALGLT KGDLVKPSRG QLVNCTCENP HCKRPICQGA
60 70 80 90 100
WCTVVLVREQ GRHPQVYRGC GSLNQELCLG RPTEFVNHHC CYRSFCNHNV
110 120 130 140 150
SLMLEATQTP SEEPEVDAHL PLILGPVLAL LVLVALGTLG LWRVRRRQEK
160 170 180 190 200
QRGLHSDLGE SSLILKASEQ GDSMLGDFLV SDCTTGSGSG LPFLVQRTVA
210 220 230 240 250
RQVALVECVG KGRYGEVWRG SWHGESVAVK IFSSRDEQSW FRETEIYNTV
260 270 280 290 300
LLRHDNILGF IASDMTSRNS STQLWLITHY HEHGSLYDFL QRQTLEPQLA
310 320 330 340 350
LRLAVSAACG LAHLHVEIFG TQGKPAIAHR DLKSRNVLVK SNLQCCIADL
360 370 380 390 400
GLAVMHSQSS DYLDIGNNPR VGTKRYMAPE VLDEQIRTDC FESYKWTDIW
410 420 430 440 450
AFGLVLWEIA RRTIINGIVE DYRPPFYDMV PNDPSFEDMK KVVCVDQQTP
460 470 480 490 500
TIPNRLAADP VLSGLAQMMR ECWYPNPSAR LTALRIKKTL QKLSQNPEKP

KVIH
Length:504
Mass (Da):56,703
Last modified:April 13, 2004 - v2
Checksum:iB40EA30775223C8F
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti309C → CA (PubMed:8395914).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L36088 mRNA Translation: AAC37705.1
BC083173 mRNA Translation: AAH83173.1
RefSeqiNP_071886.1, NM_022441.2
XP_006242365.1, XM_006242303.3
XP_006242366.1, XM_006242304.3
XP_006242367.1, XM_006242305.3
XP_008763895.1, XM_008765673.2
XP_017450156.1, XM_017594667.1
XP_017450157.1, XM_017594668.1
UniGeneiRn.10631

Genome annotation databases

EnsembliENSRNOT00000008673; ENSRNOP00000008673; ENSRNOG00000028713
ENSRNOT00000081047; ENSRNOP00000072526; ENSRNOG00000028713
GeneIDi25237
KEGGirno:25237
UCSCiRGD:2029 rat

Similar proteinsi

Entry informationi

Entry nameiACVL1_RAT
AccessioniPrimary (citable) accession number: P80203
Secondary accession number(s): Q63559
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 1, 1993
Last sequence update: April 13, 2004
Last modified: March 28, 2018
This is version 157 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome