Reviewed,
UniProtKB/Swiss-Prot P80203 (ACVL1_RAT)
Last modified
July 22, 2008.
Version 78.
History...
Clusters with 100%,
90%,
50% identity |
Documents (2) |
Third-party data |
Customize display | text xml rdf/xml gff fasta |
Names and origin
| Protein names | Recommended name: Serine/threonine-protein kinase receptor R3 Short name(s)=SKR3 EC=2.7.11.30 Alternative name(s): TGF-B superfamily receptor type I Short name(s)=TSR-I | ||||
| Gene names |
| ||||
| Organism | Rattus norvegicus (Rat) | ||||
| Taxonomic identifier | 10116 [NCBI] | ||||
| Taxonomic lineage | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Rattus |
Protein attributes
| Sequence length | 504 AA. |
| Sequence status | Complete. |
| Sequence processing | The displayed sequence is further processed into a mature form. |
| Protein existence | Evidence at transcript level. |
General annotation (Comments)
| Function | On ligand binding, forms a receptor complex consisting of two type II and two type I transmembrane serine/threonine kinases. Type II receptors phosphorylate and activate type I receptors which autophosphorylate, then bind and activate SMAD transcriptional regulators. Receptor for TGF-beta. May bind activin as well. |
| Catalytic activity | ATP + [receptor-protein] = ADP + [receptor-protein] phosphate. |
| Cofactor | Magnesium or manganese By similarity. |
| Subcellular location | |
| Tissue specificity | Urogenital ridge, testis, ovary, brain and lung. In lung, found exclusively in pulmonary vessels of all sizes. Also expressed in aorta, vena cava and certain blood vessels of kidney, spleen, heart and intestine. For most blood vessels, a higher level of expression is found in endothelium than in adjacent smooth muscle. |
| Sequence similarities | Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. Contains 1 GS domain. Contains 1 protein kinase domain. |
Ontologies
Keywords | |
|---|---|
| Cellular component | Membrane |
| Domain | Signal Transmembrane |
| Ligand | ATP-binding Magnesium Manganese Metal-binding Nucleotide-binding |
| Molecular function | Kinase Receptor Serine/threonine-protein kinase Transferase |
| PTM | Glycoprotein |
Gene Ontology (GO) | |
| None. [Check GOA] | |
Sequence annotation (Features)
| Feature key | Position(s) | Length | Description | Graphical view | ||||
Molecule processing | ||||||||
|---|---|---|---|---|---|---|---|---|
| Signal peptide | 1 – 20 | 20 | Potential | |||||
| Chain | 21 – 504 | 484 | Serine/threonine-protein kinase receptor R3 | |||||
Regions | ||||||||
| Topological domain | 21 – 121 | 101 | Extracellular Potential | |||||
| Transmembrane | 122 – 142 | 21 | Potential | |||||
| Topological domain | 143 – 504 | 362 | Cytoplasmic Potential | |||||
| Domain | 173 – 202 | 30 | GS | |||||
| Domain | 203 – 504 | 302 | Protein kinase | |||||
| Nucleotide binding | 209 – 217 | 9 | ATP By similarity | |||||
Sites | ||||||||
| Active site | 331 | 1 | Proton acceptor By similarity | |||||
| Binding site | 230 | 1 | ATP By similarity | |||||
Amino acid modifications | ||||||||
| Glycosylation | 34 | 1 | N-linked (GlcNAc...) Potential | |||||
| Glycosylation | 99 | 1 | N-linked (GlcNAc...) Potential | |||||
Experimental info | ||||||||
| Sequence conflict | 309 | 1 | C → CA Ref.1 | |||||
Sequences
| ||||||||||||||||||
References
| « Hide 'large scale' references | |
| [1] | "Developmental expression of four novel serine/threonine kinase receptors homologous to the activin/transforming growth factor-beta type II receptor family." He W.-W., Gustafson M.L., Hirobe S., Donahoe P.K. Dev. Dyn. 196:133-142(1993) [PubMed: 8395914] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA]. Strain: Sprague-Dawley. Tissue: Urogenital ridge. |
| [2] | "Type I receptor serine-threonine kinase preferentially expressed in pulmonary blood vessels." Panchenko M.P., Williams M.C., Brody J.S., Yu Q. Am. J. Physiol. 270:L547-L558(1996) [PubMed: 8928814] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY. Strain: Sprague-Dawley. Tissue: Lung. |
| [3] | "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Lung. |
Cross-references
Sequence databases | |
|---|---|
| L36088 mRNA. Translation: AAC37705.1. BC083173 mRNA. Translation: AAH83173.1. | |
| RefSeq | NP_071886.1. |
| UniGene | Rn.10631 |
3D structure databases | |
| HSSP | HSSP built from PDB template 1IAS based on UniProtKB P36897. |
| ModBase | Search... |
Genome annotation databases | |
| Ensembl | ENSRNOG00000028713. Rattus norvegicus. [Contig view] |
| GeneID | 25237. |
| KEGG | rno:25237. |
Organism-specific databases | |
| RGD | 2029. Acvrl1. |
| GeneLynx | Search... |
Phylogenomic databases | |
| HOVERGEN | P80203. |
Gene expression databases | |
| ArrayExpress | P80203. |
| GermOnline | ENSRNOG00000028713. Rattus norvegicus. |
Family and domain databases | |
| InterPro | IPR000472. Activin_rcpt. IPR000719. Prot_kinase_core. IPR017441. Protein_kinase_ATP_bd_CS. IPR017442. Se/Thr_pkinase-rel. IPR008271. Ser_thr_pkin_AS. IPR003605. TGF_beta_rcpt_GS. [Graphical view] |
| Pfam | PF01064. Activin_recp. 1 hit. PF00069. Pkinase. 1 hit. PF08515. TGF_beta_GS. 1 hit. [Graphical view] |
| ProDom | PD000001. Prot_kinase. 1 hit. [Graphical view] [Entries sharing at least one domain] |
| SMART | SM00467. GS. 1 hit. [Graphical view] |
| PROSITE | PS51256. GS. 1 hit. PS00107. PROTEIN_KINASE_ATP. 1 hit. PS50011. PROTEIN_KINASE_DOM. 1 hit. PS00108. PROTEIN_KINASE_ST. 1 hit. [Graphical view] |
| BLOCKS | Search... |
Other Resources | |
| ProtoNet | Search... |
Entry information
| Entry name | ACVL1_RAT | ||||||||
| Accession | Primary (citable) accession number: P80203 Secondary accession number(s): Q63559 | ||||||||
| Entry history |
| ||||||||
| Entry status | Reviewed (UniProtKB/Swiss-Prot) | ||||||||
| Annotation project | HPI (Human Proteome Initiative) | ||||||||
Relevant documents
| UniProtKB secondary accession numbers Index of UniProtKB secondary accession numbers |
| SIMILARITY comments Index of protein domains and families |

Clusters with


