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P80203 (ACVL1_RAT) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 128. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Serine/threonine-protein kinase receptor R3

Short name=SKR3
EC=2.7.11.30
Alternative name(s):
TGF-B superfamily receptor type I
Short name=TSR-I
Gene names
Name:Acvrl1
Synonyms:Acvrlk1
OrganismRattus norvegicus (Rat) [Reference proteome]
Taxonomic identifier10116 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus

Protein attributes

Sequence length504 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Type I receptor for TGF-beta family ligands BMP9/GDF2 and BMP10 and important regulator of normal blood vessel development. On ligand binding, forms a receptor complex consisting of two type II and two type I transmembrane serine/threonine kinases. Type II receptors phosphorylate and activate type I receptors which autophosphorylate, then bind and activate SMAD transcriptional regulators. May bind activin as well.

Catalytic activity

ATP + [receptor-protein] = ADP + [receptor-protein] phosphate.

Cofactor

Magnesium or manganese By similarity.

Subcellular location

Membrane; Single-pass type I membrane protein.

Tissue specificity

Urogenital ridge, testis, ovary, brain and lung. In lung, found exclusively in pulmonary vessels of all sizes. Also expressed in aorta, vena cava and certain blood vessels of kidney, spleen, heart and intestine. For most blood vessels, a higher level of expression is found in endothelium than in adjacent smooth muscle. Ref.2

Sequence similarities

Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily.

Contains 1 GS domain.

Contains 1 protein kinase domain.

Ontologies

Keywords
   Biological processAngiogenesis
   Cellular componentMembrane
   DomainSignal
Transmembrane
Transmembrane helix
   LigandATP-binding
Magnesium
Manganese
Metal-binding
Nucleotide-binding
   Molecular functionKinase
Receptor
Serine/threonine-protein kinase
Transferase
   PTMDisulfide bond
Glycoprotein
Phosphoprotein
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processBMP signaling pathway

Inferred from electronic annotation. Source: Ensembl

angiogenesis

Inferred from electronic annotation. Source: UniProtKB-KW

artery development

Inferred from electronic annotation. Source: Ensembl

blood vessel remodeling

Inferred from electronic annotation. Source: Ensembl

cellular response to BMP stimulus

Inferred from electronic annotation. Source: Ensembl

endothelial tube morphogenesis

Inferred from electronic annotation. Source: Ensembl

in utero embryonic development

Inferred from electronic annotation. Source: Ensembl

lymphangiogenesis

Inferred from electronic annotation. Source: Ensembl

negative regulation of DNA biosynthetic process

Inferred from electronic annotation. Source: Ensembl

negative regulation of blood vessel endothelial cell migration

Inferred from electronic annotation. Source: Ensembl

negative regulation of cell growth

Inferred from electronic annotation. Source: Ensembl

negative regulation of endothelial cell differentiation

Inferred from electronic annotation. Source: Ensembl

negative regulation of endothelial cell proliferation

Inferred from electronic annotation. Source: Ensembl

negative regulation of focal adhesion assembly

Inferred from electronic annotation. Source: Ensembl

positive regulation of BMP signaling pathway

Inferred from electronic annotation. Source: Ensembl

positive regulation of endothelial cell differentiation

Inferred from electronic annotation. Source: Ensembl

positive regulation of endothelial cell proliferation

Inferred from electronic annotation. Source: Ensembl

positive regulation of pathway-restricted SMAD protein phosphorylation

Inferred from electronic annotation. Source: Ensembl

positive regulation of transcription from RNA polymerase II promoter

Inferred from electronic annotation. Source: Ensembl

protein heterooligomerization

Inferred from direct assay PubMed 15781474. Source: RGD

protein phosphorylation

Inferred from direct assay PubMed 15781474. Source: RGD

regulation of blood pressure

Inferred from electronic annotation. Source: Ensembl

retina vasculature development in camera-type eye

Inferred from electronic annotation. Source: Ensembl

signal transduction by phosphorylation

Inferred from direct assay PubMed 15781474. Source: GOC

transforming growth factor beta receptor signaling pathway

Inferred from direct assay PubMed 15781474. Source: RGD

venous blood vessel development

Inferred from electronic annotation. Source: Ensembl

wound healing, spreading of epidermal cells

Inferred from electronic annotation. Source: Ensembl

   Cellular_componentcell surface

Inferred from electronic annotation. Source: Ensembl

dendrite

Inferred from direct assay PubMed 15781474. Source: RGD

integral component of plasma membrane

Inferred from electronic annotation. Source: Ensembl

neuronal cell body

Inferred from direct assay PubMed 15781474. Source: RGD

   Molecular_functionATP binding

Inferred from electronic annotation. Source: UniProtKB-KW

SMAD binding

Inferred from direct assay PubMed 15781474. Source: RGD

activin receptor activity, type I

Inferred from electronic annotation. Source: Ensembl

metal ion binding

Inferred from electronic annotation. Source: UniProtKB-KW

receptor signaling protein serine/threonine kinase activity

Inferred from direct assay PubMed 15781474. Source: RGD

transforming growth factor beta binding

Traceable author statement PubMed 15781474. Source: RGD

transforming growth factor beta receptor activity, type I

Inferred from direct assay PubMed 15781474. Source: RGD

transmembrane receptor protein serine/threonine kinase activity

Traceable author statement PubMed 12770730. Source: RGD

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 2020 Potential
Chain21 – 504484Serine/threonine-protein kinase receptor R3
PRO_0000024422

Regions

Topological domain21 – 121101Extracellular Potential
Transmembrane122 – 14221Helical; Potential
Topological domain143 – 504362Cytoplasmic Potential
Domain173 – 20230GS
Domain203 – 504302Protein kinase
Nucleotide binding209 – 2179ATP By similarity
Region74 – 774Mediates specificity for BMP ligand By similarity

Sites

Active site3311Proton acceptor By similarity
Binding site2301ATP By similarity

Amino acid modifications

Modified residue1561Phosphoserine By similarity
Glycosylation341N-linked (GlcNAc...) Potential
Glycosylation991N-linked (GlcNAc...) Potential
Disulfide bond35 ↔ 52 By similarity
Disulfide bond37 ↔ 42 By similarity
Disulfide bond47 ↔ 70 By similarity
Disulfide bond78 ↔ 90 By similarity
Disulfide bond91 ↔ 96 By similarity

Experimental info

Sequence conflict3091C → CA Ref.1

Sequences

Sequence LengthMass (Da)Tools
P80203 [UniParc].

Last modified April 13, 2004. Version 2.
Checksum: B40EA30775223C8F

FASTA50456,703
        10         20         30         40         50         60 
MTLGIFRRVF LMLSVALGLT KGDLVKPSRG QLVNCTCENP HCKRPICQGA WCTVVLVREQ 

        70         80         90        100        110        120 
GRHPQVYRGC GSLNQELCLG RPTEFVNHHC CYRSFCNHNV SLMLEATQTP SEEPEVDAHL 

       130        140        150        160        170        180 
PLILGPVLAL LVLVALGTLG LWRVRRRQEK QRGLHSDLGE SSLILKASEQ GDSMLGDFLV 

       190        200        210        220        230        240 
SDCTTGSGSG LPFLVQRTVA RQVALVECVG KGRYGEVWRG SWHGESVAVK IFSSRDEQSW 

       250        260        270        280        290        300 
FRETEIYNTV LLRHDNILGF IASDMTSRNS STQLWLITHY HEHGSLYDFL QRQTLEPQLA 

       310        320        330        340        350        360 
LRLAVSAACG LAHLHVEIFG TQGKPAIAHR DLKSRNVLVK SNLQCCIADL GLAVMHSQSS 

       370        380        390        400        410        420 
DYLDIGNNPR VGTKRYMAPE VLDEQIRTDC FESYKWTDIW AFGLVLWEIA RRTIINGIVE 

       430        440        450        460        470        480 
DYRPPFYDMV PNDPSFEDMK KVVCVDQQTP TIPNRLAADP VLSGLAQMMR ECWYPNPSAR 

       490        500 
LTALRIKKTL QKLSQNPEKP KVIH 

« Hide

References

« Hide 'large scale' references
[1]"Developmental expression of four novel serine/threonine kinase receptors homologous to the activin/transforming growth factor-beta type II receptor family."
He W.-W., Gustafson M.L., Hirobe S., Donahoe P.K.
Dev. Dyn. 196:133-142(1993) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
Strain: Sprague-Dawley.
Tissue: Urogenital ridge.
[2]"Type I receptor serine-threonine kinase preferentially expressed in pulmonary blood vessels."
Panchenko M.P., Williams M.C., Brody J.S., Yu Q.
Am. J. Physiol. 270:L547-L558(1996) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY.
Strain: Sprague-Dawley.
Tissue: Lung.
[3]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Lung.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
L36088 mRNA. Translation: AAC37705.1.
BC083173 mRNA. Translation: AAH83173.1.
RefSeqNP_071886.1. NM_022441.2.
XP_006242365.1. XM_006242303.1.
XP_006242366.1. XM_006242304.1.
XP_006242367.1. XM_006242305.1.
XP_006242368.1. XM_006242306.1.
XP_006242369.1. XM_006242307.1.
UniGeneRn.10631.

3D structure databases

ProteinModelPortalP80203.
SMRP80203. Positions 173-495.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING10116.ENSRNOP00000062675.

Proteomic databases

PaxDbP80203.
PRIDEP80203.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSRNOT00000008673; ENSRNOP00000008673; ENSRNOG00000028713.
GeneID25237.
KEGGrno:25237.
UCSCRGD:2029. rat.

Organism-specific databases

CTD94.
RGD2029. Acvrl1.

Phylogenomic databases

eggNOGCOG0515.
GeneTreeENSGT00730000110868.
HOGENOMHOG000230587.
HOVERGENHBG054502.
InParanoidP80203.
KOK13594.
OMAWHVRRRQ.
OrthoDBEOG7Q8CN3.

Enzyme and pathway databases

BRENDA2.7.10.2. 5301.

Gene expression databases

GenevestigatorP80203.

Family and domain databases

InterProIPR000472. Activin_rcpt.
IPR011009. Kinase-like_dom.
IPR000719. Prot_kinase_dom.
IPR017441. Protein_kinase_ATP_BS.
IPR008271. Ser/Thr_kinase_AS.
IPR003605. TGF_beta_rcpt_GS.
[Graphical view]
PfamPF01064. Activin_recp. 1 hit.
PF00069. Pkinase. 1 hit.
PF08515. TGF_beta_GS. 1 hit.
[Graphical view]
SMARTSM00467. GS. 1 hit.
[Graphical view]
SUPFAMSSF56112. SSF56112. 1 hit.
PROSITEPS51256. GS. 1 hit.
PS00107. PROTEIN_KINASE_ATP. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00108. PROTEIN_KINASE_ST. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio605811.
PROP80203.

Entry information

Entry nameACVL1_RAT
AccessionPrimary (citable) accession number: P80203
Secondary accession number(s): Q63559
Entry history
Integrated into UniProtKB/Swiss-Prot: October 1, 1993
Last sequence update: April 13, 2004
Last modified: April 16, 2014
This is version 128 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families