Reviewed,
UniProtKB/Swiss-Prot P80202 (ACV1B_RAT)
Last modified
September 23, 2008.
Version 87.
History...
Clusters with 100%,
90%,
50% identity |
Documents (1) |
Third-party data |
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Names and origin
| Protein names | Recommended name: Activin receptor type-1B EC=2.7.11.30 Alternative name(s): ACTR-IB Serine/threonine-protein kinase receptor R2 Short name=SKR2 | ||||
| Gene names |
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| Organism | Rattus norvegicus (Rat) | ||||
| Taxonomic identifier | 10116 [NCBI] | ||||
| Taxonomic lineage | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Rattus |
Protein attributes
| Sequence length | 505 AA. |
| Sequence status | Complete. |
| Sequence processing | The displayed sequence is further processed into a mature form. |
| Protein existence | Evidence at transcript level. |
General annotation (Comments)
| Function | On ligand binding, forms a receptor complex consisting of two type II and two type I transmembrane serine/threonine kinases. Type II receptors phosphorylate and activate type I receptors which autophosphorylate, then bind and activate SMAD transcriptional regulators. |
| Catalytic activity | ATP + [receptor-protein] = ADP + [receptor-protein] phosphate. |
| Cofactor | Magnesium or manganese By similarity. |
| Subunit structure | Interacts with AIP1. Part of a complex consisting of AIP1, ACVR2A, ACVR1B and SMAD3 By similarity. |
| Subcellular location | |
| Tissue specificity | Urogenital ridge, testis, ovary, brain and lungs. |
| Sequence similarities | Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. Contains 1 GS domain. Contains 1 protein kinase domain. |
Ontologies
Keywords | |
|---|---|
| Cellular component | Membrane |
| Domain | Signal Transmembrane |
| Ligand | ATP-binding Magnesium Manganese Metal-binding Nucleotide-binding |
| Molecular function | Kinase Receptor Serine/threonine-protein kinase Transferase |
| PTM | Glycoprotein Phosphoprotein |
Gene Ontology (GO) | |
| None. [Check GOA] | |
Sequence annotation (Features)
| Feature key | Position(s) | Length | Description | Graphical view | ||||
Molecule processing | ||||||||
|---|---|---|---|---|---|---|---|---|
| Signal peptide | 1 – 23 | 23 | Potential | |||||
| Chain | 24 – 505 | 482 | Activin receptor type-1B | |||||
Regions | ||||||||
| Topological domain | 24 – 126 | 103 | Extracellular Potential | |||||
| Transmembrane | 127 – 149 | 23 | Potential | |||||
| Topological domain | 150 – 505 | 356 | Cytoplasmic Potential | |||||
| Domain | 177 – 206 | 30 | GS | |||||
| Domain | 207 – 497 | 291 | Protein kinase | |||||
| Nucleotide binding | 213 – 221 | 9 | ATP By similarity | |||||
Sites | ||||||||
| Active site | 335 | 1 | Proton acceptor By similarity | |||||
| Binding site | 234 | 1 | ATP By similarity | |||||
Amino acid modifications | ||||||||
| Modified residue | 380 | 1 | Phosphotyrosine By similarity | |||||
| Glycosylation | 43 | 1 | N-linked (GlcNAc...) Potential | |||||
Sequences
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References
| [1] | "Developmental expression of four novel serine/threonine kinase receptors homologous to the activin/transforming growth factor-beta type II receptor family." He W.-W., Gustafson M.L., Hirobe S., Donahoe P.K. Dev. Dyn. 196:133-142(1993) [PubMed: 8395914] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA]. Strain: Sprague-Dawley. Tissue: Urogenital ridge. |
| [2] | "Molecular characterization of a type I serine-threonine kinase receptor for TGF-beta and activin in the rat pituitary tumor cell line GH3." Takumi T., Moustakas A., Lin H.Y., Lodish H.F. Exp. Cell Res. 216:208-214(1995) [PubMed: 7813622] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA]. Tissue: Pituitary. |
Cross-references
Sequence databases | |
|---|---|
| S76466 mRNA. Translation: AAB33045.1. | |
| RefSeq | NP_954700.1. |
| UniGene | Rn.214018 |
3D structure databases | |
| HSSP | HSSP built from PDB template 1B6C based on UniProtKB P36897. |
| SMR | P80202. Positions 173-501. |
| ModBase | Search... |
Genome annotation databases | |
| Ensembl | ENSRNOG00000006934. Rattus norvegicus. [Contig view] |
| GeneID | 29381. |
| KEGG | rno:29381. |
| NMPDR | fig|10116.3.peg.27799. |
Organism-specific databases | |
| RGD | 735207. Acvr1b. |
Phylogenomic databases | |
| HOVERGEN | P80202. |
Gene expression databases | |
| ArrayExpress | P80202. |
| GermOnline | ENSRNOG00000006934. Rattus norvegicus. |
Family and domain databases | |
| InterPro | IPR000472. Activin_rcpt. IPR000719. Prot_kinase_core. IPR017441. Protein_kinase_ATP_bd_CS. IPR017442. Se/Thr_pkinase-rel. IPR008271. Ser_thr_pkin_AS. IPR003605. TGF_beta_rcpt_GS. [Graphical view] |
| Pfam | PF01064. Activin_recp. 1 hit. PF00069. Pkinase. 1 hit. PF08515. TGF_beta_GS. 1 hit. [Graphical view] |
| ProDom | PD000001. Prot_kinase. 1 hit. [Graphical view] [Entries sharing at least one domain] |
| SMART | SM00467. GS. 1 hit. [Graphical view] |
| PROSITE | PS51256. GS. 1 hit. PS00107. PROTEIN_KINASE_ATP. 1 hit. PS50011. PROTEIN_KINASE_DOM. 1 hit. PS00108. PROTEIN_KINASE_ST. 1 hit. [Graphical view] |
| BLOCKS | Search... |
Other Resources | |
| ProtoNet | Search... |
Entry information
| Entry name | ACV1B_RAT | ||||||||
| Accession | Primary (citable) accession number: P80202 | ||||||||
| Entry history |
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| Entry status | Reviewed (UniProtKB/Swiss-Prot) | ||||||||
| Annotation project | HPI (Human Proteome Initiative) | ||||||||

Clusters with


