Reviewed, UniProtKB/Swiss-Prot P80202 (ACV1B_RAT)

Names and origin

Protein names

Recommended name:
    Activin receptor type-1B
    EC=2.7.11.30
Alternative name(s):
    ACTR-IB
    Serine/threonine-protein kinase receptor R2
      Short name=SKR2

Gene names

Name:	Acvr1b
Synonyms:	Acvrlk4

Organism

Rattus norvegicus (Rat)

Taxonomic identifier

10116 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Rattus

Protein attributes

Sequence length	505 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at transcript level.

General annotation (Comments)

Function	On ligand binding, forms a receptor complex consisting of two type II and two type I transmembrane serine/threonine kinases. Type II receptors phosphorylate and activate type I receptors which autophosphorylate, then bind and activate SMAD transcriptional regulators.
Catalytic activity	ATP + [receptor-protein] = ADP + [receptor-protein] phosphate.
Cofactor	Magnesium or manganese By similarity.
Subunit structure	Interacts with AIP1. Part of a complex consisting of AIP1, ACVR2A, ACVR1B and SMAD3 By similarity.
Subcellular location	Membrane; Single-pass type I membrane protein.
Tissue specificity	Urogenital ridge, testis, ovary, brain and lungs.
Sequence similarities	Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. Contains 1 GS domain. Contains 1 protein kinase domain.

Ontologies

Keywords
Cellular component	Membrane
Domain	Signal Transmembrane
Ligand	ATP-binding Magnesium Manganese Metal-binding Nucleotide-binding
Molecular function	Kinase Receptor Serine/threonine-protein kinase Transferase
PTM	Glycoprotein Phosphoprotein
Gene Ontology (GO)
None. [Check GOA]

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view
Molecule processing
	Signal peptide	1 – 23	23	Potential
	Chain	24 – 505	482	Activin receptor type-1B
Regions
	Topological domain	24 – 126	103	Extracellular Potential
	Transmembrane	127 – 149	23	Potential
	Topological domain	150 – 505	356	Cytoplasmic Potential
	Domain	177 – 206	30	GS
	Domain	207 – 497	291	Protein kinase
	Nucleotide binding	213 – 221	9	ATP By similarity
Sites
	Active site	335	1	Proton acceptor By similarity
	Binding site	234	1	ATP By similarity
Amino acid modifications
	Modified residue	380	1	Phosphotyrosine By similarity
	Glycosylation	43	1	N-linked (GlcNAc...) Potential

Sequences

	Sequence		Length	Mass (Da)
	P80202-1 [UniParc]. Last modified October 1, 1993. Version 1. Checksum: 377F4A5C867B3860	FASTA	505	56,805
	10 20 30 40 50 60 MAESAGASSF FPLVVLLLAG SGGSGPRGIQ ALLCACTSCL QTNYTCETDG ACMVSIFNLD 70 80 90 100 110 120 GMEHHVRTCI PKVELVPAGK PFYCLSSEDL RNTHCCYIDF CNKIDLRVPS GHLKEPEHPS 130 140 150 160 170 180 MWGPVELVGI IAGPVFLLFL IIIIVFLVIN YHQRVYHNRQ RLDMEDPSCE MCLSKDKTLQ 190 200 210 220 230 240 DLVYDLSTSG SGSGLPLFVQ RTVARTIVLQ EIIGKGRFGE VWRGRWRGGD VAVKIFSSRE 250 260 270 280 290 300 ERSWFREAEI YQTVMLRHEN ILGFIAADNK DNGTWTQLWL VSDYHEHGSL FDYLNRYTVT 310 320 330 340 350 360 IEGMIKLALS AASGLAHLHM EIVGTQGKPG IAHRDLKSKN ILVKKNGMCA IADLGLAVRH 370 380 390 400 410 420 DAVTDTIDIA PNQRVGTKRY MAPEVLDETI NMKHFDSFKC ADIYALGLVY WEIARRCNSG 430 440 450 460 470 480 GVHEEYQLPY YDLVPSDPSI EEMRKVVCDQ KLRPNVPNWW QSYEALRVMG KMMRECWYAN 490 500 GAARLTALRI KKTLSQLSVQ EDVKI

References

[1]	"Developmental expression of four novel serine/threonine kinase receptors homologous to the activin/transforming growth factor-beta type II receptor family." He W.-W., Gustafson M.L., Hirobe S., Donahoe P.K. Dev. Dyn. 196:133-142(1993) [PubMed: 8395914] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA]. Strain: Sprague-Dawley. Tissue: Urogenital ridge.
[2]	"Molecular characterization of a type I serine-threonine kinase receptor for TGF-beta and activin in the rat pituitary tumor cell line GH3." Takumi T., Moustakas A., Lin H.Y., Lodish H.F. Exp. Cell Res. 216:208-214(1995) [PubMed: 7813622] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA]. Tissue: Pituitary.

Cross-references

Sequence databases
EMBLGenBankDDBJ	S76466 mRNA. Translation: AAB33045.1.
RefSeq	NP_954700.1.
UniGene	Rn.214018
3D structure databases
HSSP	HSSP built from PDB template 1B6C based on UniProtKB P36897.
SMR	P80202. Positions 173-501.
ModBase	Search...
Genome annotation databases
Ensembl	ENSRNOG00000006934. Rattus norvegicus. [Contig view]
GeneID	29381.
KEGG	rno:29381.
NMPDR	fig|10116.3.peg.27799.
Organism-specific databases
RGD	735207. Acvr1b.
Phylogenomic databases
HOVERGEN	P80202.
Gene expression databases
ArrayExpress	P80202.
GermOnline	ENSRNOG00000006934. Rattus norvegicus.
Family and domain databases
InterPro	IPR000472. Activin_rcpt. IPR000719. Prot_kinase_core. IPR017441. Protein_kinase_ATP_bd_CS. IPR017442. Se/Thr_pkinase-rel. IPR008271. Ser_thr_pkin_AS. IPR003605. TGF_beta_rcpt_GS. [Graphical view]
Pfam	PF01064. Activin_recp. 1 hit. PF00069. Pkinase. 1 hit. PF08515. TGF_beta_GS. 1 hit. [Graphical view]
ProDom	PD000001. Prot_kinase. 1 hit. [Graphical view] [Entries sharing at least one domain]
SMART	SM00467. GS. 1 hit. [Graphical view]
PROSITE	PS51256. GS. 1 hit. PS00107. PROTEIN_KINASE_ATP. 1 hit. PS50011. PROTEIN_KINASE_DOM. 1 hit. PS00108. PROTEIN_KINASE_ST. 1 hit. [Graphical view]
BLOCKS	Search...
Other Resources
ProtoNet	Search...

Entry information

Entry name

ACV1B_RAT

Accession

Primary (citable) accession number: P80202

Entry history

Integrated into UniProtKB/Swiss-Prot:	October 1, 1993
Last sequence update:	October 1, 1993
Last modified:	September 23, 2008
This is version 87 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HPI (Human Proteome Initiative)