Skip Header

 
Contribute Send feedback
Read comments (0) or add your own

Reviewed, UniProtKB/Swiss-Prot P80201 (ACVR1_RAT)

Last modified November 3, 2009. Version 92. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data | Customize display text xml rdf/xml gff fasta
Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents

Hide | Top

Names and origin

Protein namesRecommended name:
    Activin receptor type-1
    EC=2.7.11.30
Alternative name(s):
    Activin receptor type I
      Short name=ACTR-I
    Serine/threonine-protein kinase receptor R1
      Short name=SKR1
    TGF-B superfamily receptor type I
      Short name=TSR-I
Gene names
Name: Acvr1
Synonyms: Acvrlk2
OrganismRattus norvegicus (Rat)
Taxonomic identifier10116 [NCBI]
Taxonomic lineageEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Rattus

Hide | Top

Protein attributes

Sequence length509 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at transcript level.

Hide | Top

General annotation (Comments)

Function

On ligand binding, forms a receptor complex consisting of two type II and two type I transmembrane serine/threonine kinases. Type II receptors phosphorylate and activate type I receptors which autophosphorylate, then bind and activate SMAD transcriptional regulators. Receptor for activin. May be involved for left-right pattern formation during embryogenesis By similarity.

Catalytic activity

ATP + [receptor-protein] = ADP + [receptor-protein] phosphate.

Cofactor

Magnesium or manganese By similarity.

Subcellular location

Membrane; Single-pass type I membrane protein.

Tissue specificity

Urogenital ridge, testis, ovary, brain and lungs.

Sequence similarities

Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily.

Contains 1 GS domain.

Contains 1 protein kinase domain.

Hide | Top

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 2020 Potential
Chain21 – 509489Activin receptor type-1
PRO_0000024396

Regions

Topological domain21 – 123103Extracellular Potential
Transmembrane124 – 14623 Potential
Topological domain147 – 509363Cytoplasmic Potential
Domain178 – 20730GS
Domain208 – 502295Protein kinase
Nucleotide binding214 – 2229ATP By similarity

Sites

Active site3361Proton acceptor By similarity
Binding site2351ATP By similarity

Amino acid modifications

Modified residue5011Phosphoserine By similarity
Glycosylation1021N-linked (GlcNAc...) Potential

Hide | Top

Sequences

Sequence LengthMass (Da)Tools
P80201-1 [UniParc].

Last modified October 1, 1993. Version 1.
Checksum: 7A70A477784DCF87

FASTA50957,195
        10         20         30         40         50         60 
MVDGAMILSV LMMMALPSPS MEDEEPKVNP KLYMCVCEGL SCGNEDHCEG QQCFSSLSVN 

        70         80         90        100        110        120 
DGFRVYQKGC FQVYEQGKMT CKTPPSPGQA VECCQGDWCN RNVTARLPTK GKSFPGSQNF 

       130        140        150        160        170        180 
HLEVGLIILS VVFAVCLFAC ILGVALRKFK RRNQERLNPR DVEYGTIEGL ITTNVGDSTL 

       190        200        210        220        230        240 
AELLDHSCTS GSGSGLPFLV QRTVARQITL LECVGKGRYG EVWRGSWQGE NVAVKIFSSR 

       250        260        270        280        290        300 
DEKSWFRETE LYNTVMLRHE NILGFIASDM TSRHSSTQLW LITHYHEMGS LYDYLQLTTL 

       310        320        330        340        350        360 
DTVSCLRIVL SIASGLAHLH IEIFGTQGKS AIAHRDLKSK NILVKKNGQC CIADLGLAVM 

       370        380        390        400        410        420 
HSQSTNQLDV GNNPRVGTKR YMAPEVLDET IQVDCFDSYK RVDIWAFGLV LWEVARRMVS 

       430        440        450        460        470        480 
NGIVEDYKPP FYDVVPNDPS FEDMRKVVCV DQQRPNIPNR WFSDPTLTSL AKLMKECWYQ 

       490        500 
NPSARLTALR IKKTLTKIDN SLDKLKTDC

« Hide

Hide | Top

References

[1]"Developmental expression of four novel serine/threonine kinase receptors homologous to the activin/transforming growth factor-beta type II receptor family."
He W.-W., Gustafson M.L., Hirobe S., Donahoe P.K.
Dev. Dyn. 196:133-142(1993) [PubMed: 8395914] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
Strain: Sprague-Dawley.
Tissue: Urogenital ridge.
[2]"Cloning and characterization of a transmembrane serine kinase that acts as an activin type I receptor."
Tsuchida K.K.T., Vale W.W.
Proc. Natl. Acad. Sci. U.S.A. 90:11242-11246(1993) [PubMed: 8248234] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
Strain: Sprague-Dawley.
+Additional computationally mapped references.

Hide | Top

Cross-references

Sequence databases

L19341 mRNA. Translation: AAA40673.1.
IPIIPI00195453.
PIRA49664.
RefSeqNP_077812.1.
UniGeneRn.87899

3D structure databases

HSSPHSSP built from PDB template 1IAS based on UniProtKB P36897.
ModBaseSearch...

Protein-protein interaction databases

STRINGP80201.

PTM databases

PhosphoSiteP80201.

Genome annotation databases

EnsemblENSRNOT00000006963; ENSRNOP00000006963; ENSRNOG00000005033; Rattus norvegicus. [Genome view]
GeneID79558.
KEGGrno:79558.
UCSCNM_024486. rat.

Organism-specific databases

CTD79558.
RGD620200. Acvr1.

Phylogenomic databases

HOVERGENP80201.
OMAGSEDHCE.

Enzyme and pathway databases

BRENDA2.7.10.2. 248.
2.7.11.30. 248.

Gene expression databases

ArrayExpressP80201.
GenevestigatorP80201.
GermOnlineENSRNOG00000005033. Rattus norvegicus.

Family and domain databases

InterProIPR000333. Activin_II_recpt.
IPR000472. Activin_rcpt.
IPR000719. Prot_kinase_core.
IPR017441. Protein_kinase_ATP_BS.
IPR017442. Se/Thr_pkinase-rel.
IPR008271. Ser_thr_pkin_AS.
IPR003605. TGF_beta_rcpt_GS.
[Graphical view]
PfamPF01064. Activin_recp. 1 hit.
PF00069. Pkinase. 1 hit.
PF08515. TGF_beta_GS. 1 hit.
[Graphical view]
PRINTSPR00653. ACTIVIN2R.
ProDomPD000001. Prot_kinase. 1 hit.
[Graphical view] [Entries sharing at least one domain]
SMARTSM00467. GS. 1 hit.
[Graphical view]
PROSITEPS51256. GS. 1 hit.
PS00107. PROTEIN_KINASE_ATP. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00108. PROTEIN_KINASE_ST. 1 hit.
[Graphical view]
ProtoNetSearch...

Other Resources

NextBio614838.

Hide | Top

Entry information

Entry nameACVR1_RAT
AccessionPrimary (citable) accession number: P80201
Entry history
Integrated into UniProtKB/Swiss-Prot: October 1, 1993
Last sequence update: October 1, 1993
Last modified: November 3, 2009
This is version 92 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation projectHPI (Human Proteome Initiative)

Hide | Top

Relevant documents

SIMILARITY comments

Index of protein domains and families

Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents