Skip Header

You are using a version of Internet Explorer that may not display all features of this website. Please upgrade to a modern browser.
Contribute Send feedback
Read comments (?) or add your own

P80201 (ACVR1_RAT) Reviewed, UniProtKB/Swiss-Prot

Last modified June 11, 2014. Version 131. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Activin receptor type-1

EC=2.7.11.30
Alternative name(s):
Activin receptor type I
Short name=ACTR-I
Serine/threonine-protein kinase receptor R1
Short name=SKR1
TGF-B superfamily receptor type I
Short name=TSR-I
Gene names
Name:Acvr1
Synonyms:Acvrlk2
OrganismRattus norvegicus (Rat) [Reference proteome]
Taxonomic identifier10116 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus

Protein attributes

Sequence length509 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

On ligand binding, forms a receptor complex consisting of two type II and two type I transmembrane serine/threonine kinases. Type II receptors phosphorylate and activate type I receptors which autophosphorylate, then bind and activate SMAD transcriptional regulators. Receptor for activin. May be involved for left-right pattern formation during embryogenesis By similarity.

Catalytic activity

ATP + [receptor-protein] = ADP + [receptor-protein] phosphate.

Cofactor

Magnesium or manganese By similarity.

Subunit structure

Interacts with FKBP1A. Interacts with FCHO1 By similarity.

Subcellular location

Membrane; Single-pass type I membrane protein.

Tissue specificity

Urogenital ridge, testis, ovary, brain and lungs.

Sequence similarities

Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily.

Contains 1 GS domain.

Contains 1 protein kinase domain.

Ontologies

Keywords
   Cellular componentMembrane
   DomainSignal
Transmembrane
Transmembrane helix
   LigandATP-binding
Magnesium
Manganese
Metal-binding
Nucleotide-binding
   Molecular functionKinase
Receptor
Serine/threonine-protein kinase
Transferase
   PTMGlycoprotein
Phosphoprotein
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processBMP signaling pathway

Inferred from electronic annotation. Source: Ensembl

G1/S transition of mitotic cell cycle

Inferred from electronic annotation. Source: Ensembl

acute inflammatory response

Inferred from electronic annotation. Source: Ensembl

atrial septum primum morphogenesis

Inferred from electronic annotation. Source: Ensembl

cardiac muscle cell fate commitment

Inferred from electronic annotation. Source: Ensembl

cellular response to glucocorticoid stimulus

Inferred from expression pattern PubMed 16150914. Source: RGD

determination of left/right symmetry

Inferred from electronic annotation. Source: Ensembl

embryonic heart tube morphogenesis

Inferred from electronic annotation. Source: Ensembl

endocardial cushion cell fate commitment

Inferred from electronic annotation. Source: Ensembl

gastrulation with mouth forming second

Inferred from electronic annotation. Source: Ensembl

germ cell development

Inferred from electronic annotation. Source: Ensembl

in utero embryonic development

Inferred from electronic annotation. Source: Ensembl

mesoderm formation

Inferred from electronic annotation. Source: Ensembl

mitral valve morphogenesis

Inferred from electronic annotation. Source: Ensembl

negative regulation of activin receptor signaling pathway

Inferred from electronic annotation. Source: Ensembl

negative regulation of extrinsic apoptotic signaling pathway

Inferred from electronic annotation. Source: Ensembl

neural crest cell migration

Inferred from electronic annotation. Source: Ensembl

pathway-restricted SMAD protein phosphorylation

Inferred from electronic annotation. Source: Ensembl

patterning of blood vessels

Inferred from electronic annotation. Source: Ensembl

peptidyl-threonine phosphorylation

Inferred from electronic annotation. Source: Ensembl

pharyngeal system development

Inferred from electronic annotation. Source: Ensembl

positive regulation of bone mineralization

Inferred from electronic annotation. Source: Ensembl

positive regulation of determination of dorsal identity

Inferred from electronic annotation. Source: Ensembl

positive regulation of osteoblast differentiation

Inferred from electronic annotation. Source: Ensembl

positive regulation of pathway-restricted SMAD protein phosphorylation

Inferred from electronic annotation. Source: Ensembl

positive regulation of transcription from RNA polymerase II promoter

Inferred from electronic annotation. Source: Ensembl

protein phosphorylation

Inferred from mutant phenotype PubMed 12844345. Source: RGD

regulation of skeletal muscle tissue development

Inferred from expression pattern PubMed 12968668. Source: UniProtKB

signal transduction by phosphorylation

Inferred from mutant phenotype PubMed 12844345. Source: GOC

smooth muscle cell differentiation

Inferred from electronic annotation. Source: Ensembl

transforming growth factor beta receptor signaling pathway

Inferred from mutant phenotype PubMed 12968668. Source: UniProtKB

urogenital system development

Inferred from mutant phenotype PubMed 11376112. Source: MGI

   Cellular_componentactivin receptor complex

Inferred from direct assay Ref.2. Source: RGD

apical part of cell

Inferred from electronic annotation. Source: Ensembl

   Molecular_functionATP binding

Inferred from electronic annotation. Source: UniProtKB-KW

SMAD binding

Inferred from mutant phenotype PubMed 12844345. Source: RGD

activin receptor activity, type I

Inferred from direct assay Ref.2. Source: RGD

metal ion binding

Inferred from electronic annotation. Source: UniProtKB-KW

receptor signaling protein serine/threonine kinase activity

Inferred from mutant phenotype PubMed 12844345. Source: RGD

transforming growth factor beta receptor activity, type I

Inferred from electronic annotation. Source: Ensembl

transmembrane receptor protein serine/threonine kinase activity

Traceable author statement PubMed 12770730. Source: RGD

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 2020 Potential
Chain21 – 509489Activin receptor type-1
PRO_0000024396

Regions

Topological domain21 – 123103Extracellular Potential
Transmembrane124 – 14623Helical; Potential
Topological domain147 – 509363Cytoplasmic Potential
Domain178 – 20730GS
Domain208 – 502295Protein kinase
Nucleotide binding214 – 2229ATP By similarity

Sites

Active site3361Proton acceptor By similarity
Binding site2351ATP By similarity

Amino acid modifications

Modified residue5011Phosphoserine By similarity
Glycosylation1021N-linked (GlcNAc...) Potential

Sequences

Sequence LengthMass (Da)Tools
P80201 [UniParc].

Last modified October 1, 1993. Version 1.
Checksum: 7A70A477784DCF87

FASTA50957,195
        10         20         30         40         50         60 
MVDGAMILSV LMMMALPSPS MEDEEPKVNP KLYMCVCEGL SCGNEDHCEG QQCFSSLSVN 

        70         80         90        100        110        120 
DGFRVYQKGC FQVYEQGKMT CKTPPSPGQA VECCQGDWCN RNVTARLPTK GKSFPGSQNF 

       130        140        150        160        170        180 
HLEVGLIILS VVFAVCLFAC ILGVALRKFK RRNQERLNPR DVEYGTIEGL ITTNVGDSTL 

       190        200        210        220        230        240 
AELLDHSCTS GSGSGLPFLV QRTVARQITL LECVGKGRYG EVWRGSWQGE NVAVKIFSSR 

       250        260        270        280        290        300 
DEKSWFRETE LYNTVMLRHE NILGFIASDM TSRHSSTQLW LITHYHEMGS LYDYLQLTTL 

       310        320        330        340        350        360 
DTVSCLRIVL SIASGLAHLH IEIFGTQGKS AIAHRDLKSK NILVKKNGQC CIADLGLAVM 

       370        380        390        400        410        420 
HSQSTNQLDV GNNPRVGTKR YMAPEVLDET IQVDCFDSYK RVDIWAFGLV LWEVARRMVS 

       430        440        450        460        470        480 
NGIVEDYKPP FYDVVPNDPS FEDMRKVVCV DQQRPNIPNR WFSDPTLTSL AKLMKECWYQ 

       490        500 
NPSARLTALR IKKTLTKIDN SLDKLKTDC 

« Hide

References

[1]"Developmental expression of four novel serine/threonine kinase receptors homologous to the activin/transforming growth factor-beta type II receptor family."
He W.-W., Gustafson M.L., Hirobe S., Donahoe P.K.
Dev. Dyn. 196:133-142(1993) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
Strain: Sprague-Dawley.
Tissue: Urogenital ridge.
[2]"Cloning and characterization of a transmembrane serine kinase that acts as an activin type I receptor."
Tsuchida K.K.T., Vale W.W.
Proc. Natl. Acad. Sci. U.S.A. 90:11242-11246(1993) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
Strain: Sprague-Dawley.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
L19341 mRNA. Translation: AAA40673.1.
PIRA49664.
RefSeqNP_077812.1. NM_024486.1.
XP_006234276.1. XM_006234214.1.
UniGeneRn.87899.

3D structure databases

ProteinModelPortalP80201.
SMRP80201. Positions 178-498.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid249474. 1 interaction.

PTM databases

PhosphoSiteP80201.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSRNOT00000006963; ENSRNOP00000006963; ENSRNOG00000005033.
GeneID79558.
KEGGrno:79558.
UCSCRGD:620200. rat.

Organism-specific databases

CTD90.
RGD620200. Acvr1.

Phylogenomic databases

eggNOGCOG0515.
GeneTreeENSGT00730000110868.
HOGENOMHOG000230587.
HOVERGENHBG054502.
InParanoidP80201.
KOK04675.
OMAVCEGMSC.
OrthoDBEOG7Q8CN3.
PhylomeDBP80201.
TreeFamTF314724.

Enzyme and pathway databases

BRENDA2.7.10.2. 5301.

Gene expression databases

GenevestigatorP80201.

Family and domain databases

InterProIPR000472. Activin_rcpt.
IPR011009. Kinase-like_dom.
IPR000719. Prot_kinase_dom.
IPR017441. Protein_kinase_ATP_BS.
IPR008271. Ser/Thr_kinase_AS.
IPR003605. TGF_beta_rcpt_GS.
IPR000333. TGFB_receptor.
[Graphical view]
PANTHERPTHR23255. PTHR23255. 1 hit.
PfamPF01064. Activin_recp. 1 hit.
PF00069. Pkinase. 1 hit.
PF08515. TGF_beta_GS. 1 hit.
[Graphical view]
PRINTSPR00653. ACTIVIN2R.
SMARTSM00467. GS. 1 hit.
[Graphical view]
SUPFAMSSF56112. SSF56112. 1 hit.
PROSITEPS51256. GS. 1 hit.
PS00107. PROTEIN_KINASE_ATP. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00108. PROTEIN_KINASE_ST. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio614838.
PROP80201.

Entry information

Entry nameACVR1_RAT
AccessionPrimary (citable) accession number: P80201
Entry history
Integrated into UniProtKB/Swiss-Prot: October 1, 1993
Last sequence update: October 1, 1993
Last modified: June 11, 2014
This is version 131 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families