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P80201

- ACVR1_RAT

UniProt

P80201 - ACVR1_RAT

Protein

Activin receptor type-1

Gene

Acvr1

Organism
Rattus norvegicus (Rat)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 132 (01 Oct 2014)
      Sequence version 1 (01 Oct 1993)
      Previous versions | rss
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    Functioni

    On ligand binding, forms a receptor complex consisting of two type II and two type I transmembrane serine/threonine kinases. Type II receptors phosphorylate and activate type I receptors which autophosphorylate, then bind and activate SMAD transcriptional regulators. Receptor for activin. May be involved for left-right pattern formation during embryogenesis By similarity.By similarity

    Catalytic activityi

    ATP + [receptor-protein] = ADP + [receptor-protein] phosphate.

    Cofactori

    Magnesium or manganese.By similarity

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei235 – 2351ATPPROSITE-ProRule annotation
    Active sitei336 – 3361Proton acceptorPROSITE-ProRule annotation

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi214 – 2229ATPPROSITE-ProRule annotation

    GO - Molecular functioni

    1. activin receptor activity, type I Source: RGD
    2. ATP binding Source: UniProtKB-KW
    3. metal ion binding Source: UniProtKB-KW
    4. receptor signaling protein serine/threonine kinase activity Source: RGD
    5. SMAD binding Source: RGD
    6. transforming growth factor beta receptor activity, type I Source: Ensembl
    7. transmembrane receptor protein serine/threonine kinase activity Source: RGD

    GO - Biological processi

    1. acute inflammatory response Source: Ensembl
    2. atrial septum primum morphogenesis Source: Ensembl
    3. BMP signaling pathway Source: Ensembl
    4. cardiac muscle cell fate commitment Source: Ensembl
    5. cellular response to glucocorticoid stimulus Source: RGD
    6. determination of left/right symmetry Source: Ensembl
    7. embryonic heart tube morphogenesis Source: Ensembl
    8. endocardial cushion cell fate commitment Source: Ensembl
    9. G1/S transition of mitotic cell cycle Source: Ensembl
    10. gastrulation with mouth forming second Source: Ensembl
    11. germ cell development Source: Ensembl
    12. in utero embryonic development Source: Ensembl
    13. mesoderm formation Source: Ensembl
    14. mitral valve morphogenesis Source: Ensembl
    15. negative regulation of activin receptor signaling pathway Source: Ensembl
    16. negative regulation of extrinsic apoptotic signaling pathway Source: Ensembl
    17. neural crest cell migration Source: Ensembl
    18. pathway-restricted SMAD protein phosphorylation Source: Ensembl
    19. patterning of blood vessels Source: Ensembl
    20. peptidyl-threonine phosphorylation Source: Ensembl
    21. pharyngeal system development Source: Ensembl
    22. positive regulation of bone mineralization Source: Ensembl
    23. positive regulation of determination of dorsal identity Source: Ensembl
    24. positive regulation of osteoblast differentiation Source: Ensembl
    25. positive regulation of pathway-restricted SMAD protein phosphorylation Source: Ensembl
    26. positive regulation of transcription from RNA polymerase II promoter Source: Ensembl
    27. protein phosphorylation Source: RGD
    28. regulation of skeletal muscle tissue development Source: UniProtKB
    29. signal transduction by phosphorylation Source: GOC
    30. smooth muscle cell differentiation Source: Ensembl
    31. transforming growth factor beta receptor signaling pathway Source: UniProtKB
    32. urogenital system development Source: MGI

    Keywords - Molecular functioni

    Kinase, Receptor, Serine/threonine-protein kinase, Transferase

    Keywords - Ligandi

    ATP-binding, Magnesium, Manganese, Metal-binding, Nucleotide-binding

    Enzyme and pathway databases

    BRENDAi2.7.10.2. 5301.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Activin receptor type-1 (EC:2.7.11.30)
    Alternative name(s):
    Activin receptor type I
    Short name:
    ACTR-I
    Serine/threonine-protein kinase receptor R1
    Short name:
    SKR1
    TGF-B superfamily receptor type I
    Short name:
    TSR-I
    Gene namesi
    Name:Acvr1
    Synonyms:Acvrlk2
    OrganismiRattus norvegicus (Rat)
    Taxonomic identifieri10116 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
    ProteomesiUP000002494: Chromosome 3

    Organism-specific databases

    RGDi620200. Acvr1.

    Subcellular locationi

    GO - Cellular componenti

    1. activin receptor complex Source: RGD
    2. apical part of cell Source: Ensembl

    Keywords - Cellular componenti

    Membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 2020Sequence AnalysisAdd
    BLAST
    Chaini21 – 509489Activin receptor type-1PRO_0000024396Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi102 – 1021N-linked (GlcNAc...)Sequence Analysis
    Modified residuei501 – 5011PhosphoserineBy similarity

    Keywords - PTMi

    Glycoprotein, Phosphoprotein

    PTM databases

    PhosphoSiteiP80201.

    Expressioni

    Tissue specificityi

    Urogenital ridge, testis, ovary, brain and lungs.

    Gene expression databases

    GenevestigatoriP80201.

    Interactioni

    Subunit structurei

    Interacts with FKBP1A. Interacts with FCHO1 By similarity.By similarity

    Protein-protein interaction databases

    BioGridi249474. 1 interaction.

    Structurei

    3D structure databases

    ProteinModelPortaliP80201.
    SMRiP80201. Positions 178-498.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini21 – 123103ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini147 – 509363CytoplasmicSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei124 – 14623HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini178 – 20730GSPROSITE-ProRule annotationAdd
    BLAST
    Domaini208 – 502295Protein kinasePROSITE-ProRule annotationAdd
    BLAST

    Sequence similaritiesi

    Contains 1 GS domain.PROSITE-ProRule annotation
    Contains 1 protein kinase domain.PROSITE-ProRule annotation

    Keywords - Domaini

    Signal, Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiCOG0515.
    GeneTreeiENSGT00730000110868.
    HOGENOMiHOG000230587.
    HOVERGENiHBG054502.
    InParanoidiP80201.
    KOiK04675.
    OMAiVCEGMSC.
    OrthoDBiEOG7Q8CN3.
    PhylomeDBiP80201.
    TreeFamiTF314724.

    Family and domain databases

    InterProiIPR000472. Activin_rcpt.
    IPR011009. Kinase-like_dom.
    IPR000719. Prot_kinase_dom.
    IPR017441. Protein_kinase_ATP_BS.
    IPR008271. Ser/Thr_kinase_AS.
    IPR003605. TGF_beta_rcpt_GS.
    IPR000333. TGFB_receptor.
    [Graphical view]
    PANTHERiPTHR23255. PTHR23255. 1 hit.
    PfamiPF01064. Activin_recp. 1 hit.
    PF00069. Pkinase. 1 hit.
    PF08515. TGF_beta_GS. 1 hit.
    [Graphical view]
    PRINTSiPR00653. ACTIVIN2R.
    SMARTiSM00467. GS. 1 hit.
    [Graphical view]
    SUPFAMiSSF56112. SSF56112. 1 hit.
    PROSITEiPS51256. GS. 1 hit.
    PS00107. PROTEIN_KINASE_ATP. 1 hit.
    PS50011. PROTEIN_KINASE_DOM. 1 hit.
    PS00108. PROTEIN_KINASE_ST. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    P80201-1 [UniParc]FASTAAdd to Basket

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    MVDGAMILSV LMMMALPSPS MEDEEPKVNP KLYMCVCEGL SCGNEDHCEG    50
    QQCFSSLSVN DGFRVYQKGC FQVYEQGKMT CKTPPSPGQA VECCQGDWCN 100
    RNVTARLPTK GKSFPGSQNF HLEVGLIILS VVFAVCLFAC ILGVALRKFK 150
    RRNQERLNPR DVEYGTIEGL ITTNVGDSTL AELLDHSCTS GSGSGLPFLV 200
    QRTVARQITL LECVGKGRYG EVWRGSWQGE NVAVKIFSSR DEKSWFRETE 250
    LYNTVMLRHE NILGFIASDM TSRHSSTQLW LITHYHEMGS LYDYLQLTTL 300
    DTVSCLRIVL SIASGLAHLH IEIFGTQGKS AIAHRDLKSK NILVKKNGQC 350
    CIADLGLAVM HSQSTNQLDV GNNPRVGTKR YMAPEVLDET IQVDCFDSYK 400
    RVDIWAFGLV LWEVARRMVS NGIVEDYKPP FYDVVPNDPS FEDMRKVVCV 450
    DQQRPNIPNR WFSDPTLTSL AKLMKECWYQ NPSARLTALR IKKTLTKIDN 500
    SLDKLKTDC 509
    Length:509
    Mass (Da):57,195
    Last modified:October 1, 1993 - v1
    Checksum:i7A70A477784DCF87
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    L19341 mRNA. Translation: AAA40673.1.
    PIRiA49664.
    RefSeqiNP_077812.1. NM_024486.1.
    XP_006234276.1. XM_006234214.1.
    UniGeneiRn.87899.

    Genome annotation databases

    EnsembliENSRNOT00000006963; ENSRNOP00000006963; ENSRNOG00000005033.
    GeneIDi79558.
    KEGGirno:79558.
    UCSCiRGD:620200. rat.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    L19341 mRNA. Translation: AAA40673.1 .
    PIRi A49664.
    RefSeqi NP_077812.1. NM_024486.1.
    XP_006234276.1. XM_006234214.1.
    UniGenei Rn.87899.

    3D structure databases

    ProteinModelPortali P80201.
    SMRi P80201. Positions 178-498.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 249474. 1 interaction.

    PTM databases

    PhosphoSitei P80201.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSRNOT00000006963 ; ENSRNOP00000006963 ; ENSRNOG00000005033 .
    GeneIDi 79558.
    KEGGi rno:79558.
    UCSCi RGD:620200. rat.

    Organism-specific databases

    CTDi 90.
    RGDi 620200. Acvr1.

    Phylogenomic databases

    eggNOGi COG0515.
    GeneTreei ENSGT00730000110868.
    HOGENOMi HOG000230587.
    HOVERGENi HBG054502.
    InParanoidi P80201.
    KOi K04675.
    OMAi VCEGMSC.
    OrthoDBi EOG7Q8CN3.
    PhylomeDBi P80201.
    TreeFami TF314724.

    Enzyme and pathway databases

    BRENDAi 2.7.10.2. 5301.

    Miscellaneous databases

    NextBioi 614838.
    PROi P80201.

    Gene expression databases

    Genevestigatori P80201.

    Family and domain databases

    InterProi IPR000472. Activin_rcpt.
    IPR011009. Kinase-like_dom.
    IPR000719. Prot_kinase_dom.
    IPR017441. Protein_kinase_ATP_BS.
    IPR008271. Ser/Thr_kinase_AS.
    IPR003605. TGF_beta_rcpt_GS.
    IPR000333. TGFB_receptor.
    [Graphical view ]
    PANTHERi PTHR23255. PTHR23255. 1 hit.
    Pfami PF01064. Activin_recp. 1 hit.
    PF00069. Pkinase. 1 hit.
    PF08515. TGF_beta_GS. 1 hit.
    [Graphical view ]
    PRINTSi PR00653. ACTIVIN2R.
    SMARTi SM00467. GS. 1 hit.
    [Graphical view ]
    SUPFAMi SSF56112. SSF56112. 1 hit.
    PROSITEi PS51256. GS. 1 hit.
    PS00107. PROTEIN_KINASE_ATP. 1 hit.
    PS50011. PROTEIN_KINASE_DOM. 1 hit.
    PS00108. PROTEIN_KINASE_ST. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Developmental expression of four novel serine/threonine kinase receptors homologous to the activin/transforming growth factor-beta type II receptor family."
      He W.-W., Gustafson M.L., Hirobe S., Donahoe P.K.
      Dev. Dyn. 196:133-142(1993) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Strain: Sprague-Dawley.
      Tissue: Urogenital ridge.
    2. "Cloning and characterization of a transmembrane serine kinase that acts as an activin type I receptor."
      Tsuchida K.K.T., Vale W.W.
      Proc. Natl. Acad. Sci. U.S.A. 90:11242-11246(1993) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Strain: Sprague-Dawley.

    Entry informationi

    Entry nameiACVR1_RAT
    AccessioniPrimary (citable) accession number: P80201
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: October 1, 1993
    Last sequence update: October 1, 1993
    Last modified: October 1, 2014
    This is version 132 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3