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P80201

- ACVR1_RAT

UniProt

P80201 - ACVR1_RAT

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Protein
Activin receptor type-1
Gene
Acvr1, Acvrlk2
Organism
Rattus norvegicus (Rat)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at transcript leveli

Functioni

On ligand binding, forms a receptor complex consisting of two type II and two type I transmembrane serine/threonine kinases. Type II receptors phosphorylate and activate type I receptors which autophosphorylate, then bind and activate SMAD transcriptional regulators. Receptor for activin. May be involved for left-right pattern formation during embryogenesis By similarity.

Catalytic activityi

ATP + [receptor-protein] = ADP + [receptor-protein] phosphate.

Cofactori

Magnesium or manganese By similarity.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei235 – 2351ATP By similarity
Active sitei336 – 3361Proton acceptor By similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi214 – 2229ATP By similarity

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-KW
  2. SMAD binding Source: RGD
  3. activin receptor activity, type I Source: RGD
  4. metal ion binding Source: UniProtKB-KW
  5. receptor signaling protein serine/threonine kinase activity Source: RGD
  6. transforming growth factor beta receptor activity, type I Source: Ensembl
  7. transmembrane receptor protein serine/threonine kinase activity Source: RGD

GO - Biological processi

  1. BMP signaling pathway Source: Ensembl
  2. G1/S transition of mitotic cell cycle Source: Ensembl
  3. acute inflammatory response Source: Ensembl
  4. atrial septum primum morphogenesis Source: Ensembl
  5. cardiac muscle cell fate commitment Source: Ensembl
  6. cellular response to glucocorticoid stimulus Source: RGD
  7. determination of left/right symmetry Source: Ensembl
  8. embryonic heart tube morphogenesis Source: Ensembl
  9. endocardial cushion cell fate commitment Source: Ensembl
  10. gastrulation with mouth forming second Source: Ensembl
  11. germ cell development Source: Ensembl
  12. in utero embryonic development Source: Ensembl
  13. mesoderm formation Source: Ensembl
  14. mitral valve morphogenesis Source: Ensembl
  15. negative regulation of activin receptor signaling pathway Source: Ensembl
  16. negative regulation of extrinsic apoptotic signaling pathway Source: Ensembl
  17. neural crest cell migration Source: Ensembl
  18. pathway-restricted SMAD protein phosphorylation Source: Ensembl
  19. patterning of blood vessels Source: Ensembl
  20. peptidyl-threonine phosphorylation Source: Ensembl
  21. pharyngeal system development Source: Ensembl
  22. positive regulation of bone mineralization Source: Ensembl
  23. positive regulation of determination of dorsal identity Source: Ensembl
  24. positive regulation of osteoblast differentiation Source: Ensembl
  25. positive regulation of pathway-restricted SMAD protein phosphorylation Source: Ensembl
  26. positive regulation of transcription from RNA polymerase II promoter Source: Ensembl
  27. protein phosphorylation Source: RGD
  28. regulation of skeletal muscle tissue development Source: UniProtKB
  29. signal transduction by phosphorylation Source: GOC
  30. smooth muscle cell differentiation Source: Ensembl
  31. transforming growth factor beta receptor signaling pathway Source: UniProtKB
  32. urogenital system development Source: MGI
Complete GO annotation...

Keywords - Molecular functioni

Kinase, Receptor, Serine/threonine-protein kinase, Transferase

Keywords - Ligandi

ATP-binding, Magnesium, Manganese, Metal-binding, Nucleotide-binding

Enzyme and pathway databases

BRENDAi2.7.10.2. 5301.

Names & Taxonomyi

Protein namesi
Recommended name:
Activin receptor type-1 (EC:2.7.11.30)
Alternative name(s):
Activin receptor type I
Short name:
ACTR-I
Serine/threonine-protein kinase receptor R1
Short name:
SKR1
TGF-B superfamily receptor type I
Short name:
TSR-I
Gene namesi
Name:Acvr1
Synonyms:Acvrlk2
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
ProteomesiUP000002494: Chromosome 3

Organism-specific databases

RGDi620200. Acvr1.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini21 – 123103Extracellular Reviewed prediction
Add
BLAST
Transmembranei124 – 14623Helical; Reviewed prediction
Add
BLAST
Topological domaini147 – 509363Cytoplasmic Reviewed prediction
Add
BLAST

GO - Cellular componenti

  1. activin receptor complex Source: RGD
  2. apical part of cell Source: Ensembl
Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2020 Reviewed prediction
Add
BLAST
Chaini21 – 509489Activin receptor type-1
PRO_0000024396Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi102 – 1021N-linked (GlcNAc...) Reviewed prediction
Modified residuei501 – 5011Phosphoserine By similarity

Keywords - PTMi

Glycoprotein, Phosphoprotein

PTM databases

PhosphoSiteiP80201.

Expressioni

Tissue specificityi

Urogenital ridge, testis, ovary, brain and lungs.

Gene expression databases

GenevestigatoriP80201.

Interactioni

Subunit structurei

Interacts with FKBP1A. Interacts with FCHO1 By similarity.

Protein-protein interaction databases

BioGridi249474. 1 interaction.

Structurei

3D structure databases

ProteinModelPortaliP80201.
SMRiP80201. Positions 178-498.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini178 – 20730GS
Add
BLAST
Domaini208 – 502295Protein kinase
Add
BLAST

Sequence similaritiesi

Contains 1 GS domain.

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiCOG0515.
GeneTreeiENSGT00730000110868.
HOGENOMiHOG000230587.
HOVERGENiHBG054502.
InParanoidiP80201.
KOiK04675.
OMAiVCEGMSC.
OrthoDBiEOG7Q8CN3.
PhylomeDBiP80201.
TreeFamiTF314724.

Family and domain databases

InterProiIPR000472. Activin_rcpt.
IPR011009. Kinase-like_dom.
IPR000719. Prot_kinase_dom.
IPR017441. Protein_kinase_ATP_BS.
IPR008271. Ser/Thr_kinase_AS.
IPR003605. TGF_beta_rcpt_GS.
IPR000333. TGFB_receptor.
[Graphical view]
PANTHERiPTHR23255. PTHR23255. 1 hit.
PfamiPF01064. Activin_recp. 1 hit.
PF00069. Pkinase. 1 hit.
PF08515. TGF_beta_GS. 1 hit.
[Graphical view]
PRINTSiPR00653. ACTIVIN2R.
SMARTiSM00467. GS. 1 hit.
[Graphical view]
SUPFAMiSSF56112. SSF56112. 1 hit.
PROSITEiPS51256. GS. 1 hit.
PS00107. PROTEIN_KINASE_ATP. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00108. PROTEIN_KINASE_ST. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P80201-1 [UniParc]FASTAAdd to Basket

« Hide

MVDGAMILSV LMMMALPSPS MEDEEPKVNP KLYMCVCEGL SCGNEDHCEG    50
QQCFSSLSVN DGFRVYQKGC FQVYEQGKMT CKTPPSPGQA VECCQGDWCN 100
RNVTARLPTK GKSFPGSQNF HLEVGLIILS VVFAVCLFAC ILGVALRKFK 150
RRNQERLNPR DVEYGTIEGL ITTNVGDSTL AELLDHSCTS GSGSGLPFLV 200
QRTVARQITL LECVGKGRYG EVWRGSWQGE NVAVKIFSSR DEKSWFRETE 250
LYNTVMLRHE NILGFIASDM TSRHSSTQLW LITHYHEMGS LYDYLQLTTL 300
DTVSCLRIVL SIASGLAHLH IEIFGTQGKS AIAHRDLKSK NILVKKNGQC 350
CIADLGLAVM HSQSTNQLDV GNNPRVGTKR YMAPEVLDET IQVDCFDSYK 400
RVDIWAFGLV LWEVARRMVS NGIVEDYKPP FYDVVPNDPS FEDMRKVVCV 450
DQQRPNIPNR WFSDPTLTSL AKLMKECWYQ NPSARLTALR IKKTLTKIDN 500
SLDKLKTDC 509
Length:509
Mass (Da):57,195
Last modified:October 1, 1993 - v1
Checksum:i7A70A477784DCF87
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
L19341 mRNA. Translation: AAA40673.1.
PIRiA49664.
RefSeqiNP_077812.1. NM_024486.1.
XP_006234276.1. XM_006234214.1.
UniGeneiRn.87899.

Genome annotation databases

EnsembliENSRNOT00000006963; ENSRNOP00000006963; ENSRNOG00000005033.
GeneIDi79558.
KEGGirno:79558.
UCSCiRGD:620200. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
L19341 mRNA. Translation: AAA40673.1 .
PIRi A49664.
RefSeqi NP_077812.1. NM_024486.1.
XP_006234276.1. XM_006234214.1.
UniGenei Rn.87899.

3D structure databases

ProteinModelPortali P80201.
SMRi P80201. Positions 178-498.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 249474. 1 interaction.

PTM databases

PhosphoSitei P80201.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSRNOT00000006963 ; ENSRNOP00000006963 ; ENSRNOG00000005033 .
GeneIDi 79558.
KEGGi rno:79558.
UCSCi RGD:620200. rat.

Organism-specific databases

CTDi 90.
RGDi 620200. Acvr1.

Phylogenomic databases

eggNOGi COG0515.
GeneTreei ENSGT00730000110868.
HOGENOMi HOG000230587.
HOVERGENi HBG054502.
InParanoidi P80201.
KOi K04675.
OMAi VCEGMSC.
OrthoDBi EOG7Q8CN3.
PhylomeDBi P80201.
TreeFami TF314724.

Enzyme and pathway databases

BRENDAi 2.7.10.2. 5301.

Miscellaneous databases

NextBioi 614838.
PROi P80201.

Gene expression databases

Genevestigatori P80201.

Family and domain databases

InterProi IPR000472. Activin_rcpt.
IPR011009. Kinase-like_dom.
IPR000719. Prot_kinase_dom.
IPR017441. Protein_kinase_ATP_BS.
IPR008271. Ser/Thr_kinase_AS.
IPR003605. TGF_beta_rcpt_GS.
IPR000333. TGFB_receptor.
[Graphical view ]
PANTHERi PTHR23255. PTHR23255. 1 hit.
Pfami PF01064. Activin_recp. 1 hit.
PF00069. Pkinase. 1 hit.
PF08515. TGF_beta_GS. 1 hit.
[Graphical view ]
PRINTSi PR00653. ACTIVIN2R.
SMARTi SM00467. GS. 1 hit.
[Graphical view ]
SUPFAMi SSF56112. SSF56112. 1 hit.
PROSITEi PS51256. GS. 1 hit.
PS00107. PROTEIN_KINASE_ATP. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00108. PROTEIN_KINASE_ST. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Developmental expression of four novel serine/threonine kinase receptors homologous to the activin/transforming growth factor-beta type II receptor family."
    He W.-W., Gustafson M.L., Hirobe S., Donahoe P.K.
    Dev. Dyn. 196:133-142(1993) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Strain: Sprague-Dawley.
    Tissue: Urogenital ridge.
  2. "Cloning and characterization of a transmembrane serine kinase that acts as an activin type I receptor."
    Tsuchida K.K.T., Vale W.W.
    Proc. Natl. Acad. Sci. U.S.A. 90:11242-11246(1993) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Strain: Sprague-Dawley.

Entry informationi

Entry nameiACVR1_RAT
AccessioniPrimary (citable) accession number: P80201
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 1, 1993
Last sequence update: October 1, 1993
Last modified: June 11, 2014
This is version 131 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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