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P80195 (GLCM1_BOVIN) Reviewed, UniProtKB/Swiss-Prot

Last modified May 14, 2014. Version 94. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Interactions·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Glycosylation-dependent cell adhesion molecule 1

Short name=GlyCAM-1
Alternative name(s):
28 kDa milk glycoprotein PP3
Lactophorin
Proteose-peptone component 3
Short name=PP3
Gene names
Name:GLYCAM1
OrganismBos taurus (Bovine) [Reference proteome]
Taxonomic identifier9913 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos

Protein attributes

Sequence length153 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at protein level

General annotation (Comments)

Subcellular location

Membrane; Peripheral membrane protein.

Tissue specificity

Highly and specifically expressed in the lactating mammary gland.

Sequence similarities

Belongs to the PP3/GlyCAM-1 family.

Binary interactions

With

Entry

#Exp.

IntAct

Notes

itself4EBI-7562491,EBI-7562491

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 1818 Ref.5 Ref.6
Chain19 – 153135Glycosylation-dependent cell adhesion molecule 1
PRO_0000025408

Amino acid modifications

Modified residue471Phosphoserine Ref.2 Ref.5 Ref.7
Modified residue521Phosphoserine Ref.2 Ref.5 Ref.7
Modified residue561Phosphoserine Ref.2 Ref.5 Ref.7
Modified residue581Phosphoserine Ref.2 Ref.5 Ref.7
Modified residue641Phosphoserine Ref.2 Ref.5 Ref.7
Glycosylation341O-linked (GalNAc...); partial Ref.2 Ref.5 Ref.7
Glycosylation781O-linked (HexNAc...) Ref.7
Glycosylation951N-linked (GlcNAc...) Ref.2 Ref.5 Ref.7
Glycosylation1041O-linked (GalNAc...) Ref.5 Ref.7
CAR_000158

Sequences

Sequence LengthMass (Da)Tools
P80195 [UniParc].

Last modified October 1, 1996. Version 2.
Checksum: 6679E5F1F99CB886

FASTA15317,152
        10         20         30         40         50         60 
MKFLCVLLLA SLAATSLAIL NKPEDETHLE AQPTDASAQF IRNLQISNED LSKEPSISRE 

        70         80         90        100        110        120 
DLISKEQIVI RSSRQPQSQN PKLPLSILKE KHLRNATLGS EETTEHTPSD ASTTEGKLME 

       130        140        150 
LGHKIMRNLE NTVKETIKYL KSLFSHAFEV VKT 

« Hide

References

« Hide 'large scale' references
[1]"cDNA cloning of lactophorin from bovine milk."
Kuriki H., Motoshima H., Minagawa E., Tsukasaki F., Kanno C.
Submitted (DEC-1993) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
Tissue: Milk.
[2]"Characterization of a bovine mammary gland PP3 cDNA reveals homology with mouse and rat adhesion molecule GlyCAM-1."
Johnsen L.B., Soerensen E.S., Petersen T.E., Berglund L.
Biochim. Biophys. Acta 1260:116-118(1995) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
Strain: Black and white Danish dairy cattle.
[3]"Characterization of a GlyCAM1-like gene (glycosylation-dependent cell adhesion molecule 1) which is highly and specifically expressed in the lactating bovine mammary gland."
Groenen M.A., Dijkhof R.J., der Poel J.J.
Gene 158:189-195(1995) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
Tissue: Lactating mammary gland.
[4]NIH - Mammalian Gene Collection (MGC) project
Submitted (OCT-2005) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Strain: Crossbred X Angus.
Tissue: Liver.
[5]"Phosphorylation, glycosylation and amino acid sequence of component PP3 from the proteose peptone fraction of bovine milk."
Soerensen E.S., Petersen T.E.
J. Dairy Res. 60:535-542(1993) [PubMed] [Europe PMC] [Abstract]
Cited for: PROTEIN SEQUENCE OF 19-153, PHOSPHORYLATION AT SER-47; SER-52; SER-56; SER-58 AND SER-64, GLYCOSYLATION AT THR-34; ASN-95 AND THR-104.
Tissue: Milk.
[6]"Purification and characterization of three proteins isolated from the proteose peptone fraction of bovine milk."
Soerensen E.S., Petersen T.E.
J. Dairy Res. 60:189-197(1993) [PubMed] [Europe PMC] [Abstract]
Cited for: PROTEIN SEQUENCE OF 19-48 AND 72-91.
Tissue: Milk.
[7]"Complete characterization of posttranslational modification sites in the bovine milk protein PP3 by tandem mass spectrometry with electron capture dissociation as the last stage."
Kjeldsen F., Haselmann K.F., Budnik B.A., Sorensen E.S., Zubarev R.A.
Anal. Chem. 75:2355-2361(2003) [PubMed] [Europe PMC] [Abstract]
Cited for: PHOSPHORYLATION AT SER-47; SER-52; SER-56; SER-58 AND SER-64, GLYCOSYLATION AT THR-34; SER-78; ASN-95 AND THR-104.
Tissue: Milk.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
D26176 mRNA. Translation: BAA05164.1.
L36854 mRNA. Translation: AAA79330.1.
X79406 mRNA. Translation: CAA55943.1.
X83391 Genomic DNA. Translation: CAA58309.1.
BC108244 mRNA. Translation: AAI08245.1.
PIRS52083.
RefSeqNP_777253.1. NM_174828.2.
UniGeneBt.4665.

3D structure databases

ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

MINTMINT-8292696.
STRING9913.ENSBTAP00000017854.

PTM databases

UniCarbKBP80195.

Proteomic databases

PaxDbP80195.
PRIDEP80195.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSBTAT00000017854; ENSBTAP00000017854; ENSBTAG00000013417.
GeneID282430.
KEGGbta:282430.

Organism-specific databases

CTD644076.

Phylogenomic databases

eggNOGNOG86685.
GeneTreeENSGT00520000060242.
HOGENOMHOG000290655.
HOVERGENHBG106667.
InParanoidP80195.
KOK06815.
OMASEEETHW.
OrthoDBEOG7H1JNK.
TreeFamTF339780.

Family and domain databases

InterProIPR007906. GLYCAM-1.
[Graphical view]
PfamPF05242. GLYCAM-1. 1 hit.
[Graphical view]
ProDomPD012695. PD012695. 1 hit.
[Graphical view] [Entries sharing at least one domain]
ProtoNetSearch...

Other

NextBio20806206.

Entry information

Entry nameGLCM1_BOVIN
AccessionPrimary (citable) accession number: P80195
Secondary accession number(s): P35451, Q32P62
Entry history
Integrated into UniProtKB/Swiss-Prot: February 1, 1994
Last sequence update: October 1, 1996
Last modified: May 14, 2014
This is version 94 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families