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P80195

- GLCM1_BOVIN

UniProt

P80195 - GLCM1_BOVIN

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Protein

Glycosylation-dependent cell adhesion molecule 1

Gene

GLYCAM1

Organism
Bos taurus (Bovine)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

  1. identical protein binding Source: IntAct
  2. sulfate binding Source: Ensembl
Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
Glycosylation-dependent cell adhesion molecule 1
Short name:
GlyCAM-1
Alternative name(s):
28 kDa milk glycoprotein PP3
Lactophorin
Proteose-peptone component 3
Short name:
PP3
Gene namesi
Name:GLYCAM1
OrganismiBos taurus (Bovine)
Taxonomic identifieri9913 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
ProteomesiUP000009136: Chromosome 5

Subcellular locationi

GO - Cellular componenti

  1. extracellular region Source: Ensembl
  2. membrane Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 18182 PublicationsAdd
BLAST
Chaini19 – 153135Glycosylation-dependent cell adhesion molecule 1PRO_0000025408Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi34 – 341O-linked (GalNAc...); partial3 Publications
Modified residuei47 – 471Phosphoserine3 Publications
Modified residuei52 – 521Phosphoserine3 Publications
Modified residuei56 – 561Phosphoserine3 Publications
Modified residuei58 – 581Phosphoserine3 Publications
Modified residuei64 – 641Phosphoserine3 Publications
Glycosylationi78 – 781O-linked (HexNAc...)1 Publication
Glycosylationi95 – 951N-linked (GlcNAc...)3 Publications
Glycosylationi104 – 1041O-linked (GalNAc...)2 PublicationsCAR_000158

Keywords - PTMi

Glycoprotein, Phosphoprotein

Proteomic databases

PaxDbiP80195.
PRIDEiP80195.

PTM databases

UniCarbKBiP80195.

Expressioni

Tissue specificityi

Highly and specifically expressed in the lactating mammary gland.

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
itself4EBI-7562491,EBI-7562491

Protein-protein interaction databases

MINTiMINT-8292696.
STRINGi9913.ENSBTAP00000017854.

Family & Domainsi

Sequence similaritiesi

Belongs to the PP3/GlyCAM-1 family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiNOG86685.
GeneTreeiENSGT00520000060242.
HOGENOMiHOG000290655.
HOVERGENiHBG106667.
InParanoidiP80195.
KOiK06815.
OMAiSEEETHW.
OrthoDBiEOG7H1JNK.
TreeFamiTF339780.

Family and domain databases

InterProiIPR007906. GLYCAM-1.
[Graphical view]
PfamiPF05242. GLYCAM-1. 1 hit.
[Graphical view]
ProDomiPD012695. PD012695. 1 hit.
[Graphical view] [Entries sharing at least one domain]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P80195-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MKFLCVLLLA SLAATSLAIL NKPEDETHLE AQPTDASAQF IRNLQISNED
60 70 80 90 100
LSKEPSISRE DLISKEQIVI RSSRQPQSQN PKLPLSILKE KHLRNATLGS
110 120 130 140 150
EETTEHTPSD ASTTEGKLME LGHKIMRNLE NTVKETIKYL KSLFSHAFEV

VKT
Length:153
Mass (Da):17,152
Last modified:October 1, 1996 - v2
Checksum:i6679E5F1F99CB886
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
D26176 mRNA. Translation: BAA05164.1.
L36854 mRNA. Translation: AAA79330.1.
X79406 mRNA. Translation: CAA55943.1.
X83391 Genomic DNA. Translation: CAA58309.1.
BC108244 mRNA. Translation: AAI08245.1.
PIRiS52083.
RefSeqiNP_777253.1. NM_174828.2.
UniGeneiBt.4665.

Genome annotation databases

EnsembliENSBTAT00000017854; ENSBTAP00000017854; ENSBTAG00000013417.
GeneIDi282430.
KEGGibta:282430.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
D26176 mRNA. Translation: BAA05164.1 .
L36854 mRNA. Translation: AAA79330.1 .
X79406 mRNA. Translation: CAA55943.1 .
X83391 Genomic DNA. Translation: CAA58309.1 .
BC108244 mRNA. Translation: AAI08245.1 .
PIRi S52083.
RefSeqi NP_777253.1. NM_174828.2.
UniGenei Bt.4665.

3D structure databases

ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

MINTi MINT-8292696.
STRINGi 9913.ENSBTAP00000017854.

PTM databases

UniCarbKBi P80195.

Proteomic databases

PaxDbi P80195.
PRIDEi P80195.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSBTAT00000017854 ; ENSBTAP00000017854 ; ENSBTAG00000013417 .
GeneIDi 282430.
KEGGi bta:282430.

Organism-specific databases

CTDi 644076.

Phylogenomic databases

eggNOGi NOG86685.
GeneTreei ENSGT00520000060242.
HOGENOMi HOG000290655.
HOVERGENi HBG106667.
InParanoidi P80195.
KOi K06815.
OMAi SEEETHW.
OrthoDBi EOG7H1JNK.
TreeFami TF339780.

Miscellaneous databases

NextBioi 20806206.

Family and domain databases

InterProi IPR007906. GLYCAM-1.
[Graphical view ]
Pfami PF05242. GLYCAM-1. 1 hit.
[Graphical view ]
ProDomi PD012695. PD012695. 1 hit.
[Graphical view ] [Entries sharing at least one domain ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "cDNA cloning of lactophorin from bovine milk."
    Kuriki H., Motoshima H., Minagawa E., Tsukasaki F., Kanno C.
    Submitted (DEC-1993) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Milk.
  2. "Characterization of a bovine mammary gland PP3 cDNA reveals homology with mouse and rat adhesion molecule GlyCAM-1."
    Johnsen L.B., Soerensen E.S., Petersen T.E., Berglund L.
    Biochim. Biophys. Acta 1260:116-118(1995) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Strain: Black and white Danish dairy cattle.
  3. "Characterization of a GlyCAM1-like gene (glycosylation-dependent cell adhesion molecule 1) which is highly and specifically expressed in the lactating bovine mammary gland."
    Groenen M.A., Dijkhof R.J., der Poel J.J.
    Gene 158:189-195(1995) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Tissue: Lactating mammary gland.
  4. NIH - Mammalian Gene Collection (MGC) project
    Submitted (OCT-2005) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: Crossbred X Angus.
    Tissue: Liver.
  5. "Phosphorylation, glycosylation and amino acid sequence of component PP3 from the proteose peptone fraction of bovine milk."
    Soerensen E.S., Petersen T.E.
    J. Dairy Res. 60:535-542(1993) [PubMed] [Europe PMC] [Abstract]
    Cited for: PROTEIN SEQUENCE OF 19-153, PHOSPHORYLATION AT SER-47; SER-52; SER-56; SER-58 AND SER-64, GLYCOSYLATION AT THR-34; ASN-95 AND THR-104.
    Tissue: Milk.
  6. "Purification and characterization of three proteins isolated from the proteose peptone fraction of bovine milk."
    Soerensen E.S., Petersen T.E.
    J. Dairy Res. 60:189-197(1993) [PubMed] [Europe PMC] [Abstract]
    Cited for: PROTEIN SEQUENCE OF 19-48 AND 72-91.
    Tissue: Milk.
  7. "Complete characterization of posttranslational modification sites in the bovine milk protein PP3 by tandem mass spectrometry with electron capture dissociation as the last stage."
    Kjeldsen F., Haselmann K.F., Budnik B.A., Sorensen E.S., Zubarev R.A.
    Anal. Chem. 75:2355-2361(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION AT SER-47; SER-52; SER-56; SER-58 AND SER-64, GLYCOSYLATION AT THR-34; SER-78; ASN-95 AND THR-104.
    Tissue: Milk.

Entry informationi

Entry nameiGLCM1_BOVIN
AccessioniPrimary (citable) accession number: P80195
Secondary accession number(s): P35451, Q32P62
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 1, 1994
Last sequence update: October 1, 1996
Last modified: October 29, 2014
This is version 96 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3