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Protein

Glycosylation-dependent cell adhesion molecule 1

Gene

GLYCAM1

Organism
Bos taurus (Bovine)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

  • identical protein binding Source: IntAct
  • sulfate binding Source: Ensembl
Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
Glycosylation-dependent cell adhesion molecule 1
Short name:
GlyCAM-1
Alternative name(s):
28 kDa milk glycoprotein PP3
Lactophorin
Proteose-peptone component 3
Short name:
PP3
Gene namesi
Name:GLYCAM1
OrganismiBos taurus (Bovine)
Taxonomic identifieri9913 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
Proteomesi
  • UP000009136 Componenti: Chromosome 5

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 182 PublicationsAdd BLAST18
ChainiPRO_000002540819 – 153Glycosylation-dependent cell adhesion molecule 1Add BLAST135

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi34O-linked (GalNAc...); partial3 Publications1
Modified residuei47Phosphoserine3 Publications1
Modified residuei52Phosphoserine3 Publications1
Modified residuei56Phosphoserine3 Publications1
Modified residuei58Phosphoserine3 Publications1
Modified residuei64Phosphoserine3 Publications1
Glycosylationi78O-linked (HexNAc...)1 Publication1
Glycosylationi95N-linked (GlcNAc...)3 Publications1
GlycosylationiCAR_000158104O-linked (GalNAc...)2 Publications1

Keywords - PTMi

Glycoprotein, Phosphoprotein

Proteomic databases

PaxDbiP80195.
PeptideAtlasiP80195.
PRIDEiP80195.

PTM databases

iPTMnetiP80195.
UniCarbKBiP80195.

Expressioni

Tissue specificityi

Highly and specifically expressed in the lactating mammary gland.

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
itself4EBI-7562491,EBI-7562491

GO - Molecular functioni

  • identical protein binding Source: IntAct

Protein-protein interaction databases

MINTiMINT-8292696.
STRINGi9913.ENSBTAP00000017854.

Family & Domainsi

Sequence similaritiesi

Belongs to the PP3/GlyCAM-1 family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG410JFZZ. Eukaryota.
ENOG41117RE. LUCA.
GeneTreeiENSGT00520000060242.
HOGENOMiHOG000290655.
HOVERGENiHBG106667.
InParanoidiP80195.
KOiK06815.
OMAiSKGIMNY.
OrthoDBiEOG091G180P.
TreeFamiTF339780.

Family and domain databases

InterProiIPR007906. GLYCAM-1.
[Graphical view]
PfamiPF05242. GLYCAM-1. 1 hit.
[Graphical view]
ProDomiPD012695. PD012695. 1 hit.
[Graphical view] [Entries sharing at least one domain]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P80195-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKFLCVLLLA SLAATSLAIL NKPEDETHLE AQPTDASAQF IRNLQISNED
60 70 80 90 100
LSKEPSISRE DLISKEQIVI RSSRQPQSQN PKLPLSILKE KHLRNATLGS
110 120 130 140 150
EETTEHTPSD ASTTEGKLME LGHKIMRNLE NTVKETIKYL KSLFSHAFEV

VKT
Length:153
Mass (Da):17,152
Last modified:October 1, 1996 - v2
Checksum:i6679E5F1F99CB886
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D26176 mRNA. Translation: BAA05164.1.
L36854 mRNA. Translation: AAA79330.1.
X79406 mRNA. Translation: CAA55943.1.
X83391 Genomic DNA. Translation: CAA58309.1.
BC108244 mRNA. Translation: AAI08245.1.
PIRiS52083.
RefSeqiNP_777253.1. NM_174828.2.
UniGeneiBt.4665.

Genome annotation databases

EnsembliENSBTAT00000017854; ENSBTAP00000017854; ENSBTAG00000013417.
GeneIDi282430.
KEGGibta:282430.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D26176 mRNA. Translation: BAA05164.1.
L36854 mRNA. Translation: AAA79330.1.
X79406 mRNA. Translation: CAA55943.1.
X83391 Genomic DNA. Translation: CAA58309.1.
BC108244 mRNA. Translation: AAI08245.1.
PIRiS52083.
RefSeqiNP_777253.1. NM_174828.2.
UniGeneiBt.4665.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

MINTiMINT-8292696.
STRINGi9913.ENSBTAP00000017854.

PTM databases

iPTMnetiP80195.
UniCarbKBiP80195.

Proteomic databases

PaxDbiP80195.
PeptideAtlasiP80195.
PRIDEiP80195.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSBTAT00000017854; ENSBTAP00000017854; ENSBTAG00000013417.
GeneIDi282430.
KEGGibta:282430.

Organism-specific databases

CTDi644076.

Phylogenomic databases

eggNOGiENOG410JFZZ. Eukaryota.
ENOG41117RE. LUCA.
GeneTreeiENSGT00520000060242.
HOGENOMiHOG000290655.
HOVERGENiHBG106667.
InParanoidiP80195.
KOiK06815.
OMAiSKGIMNY.
OrthoDBiEOG091G180P.
TreeFamiTF339780.

Family and domain databases

InterProiIPR007906. GLYCAM-1.
[Graphical view]
PfamiPF05242. GLYCAM-1. 1 hit.
[Graphical view]
ProDomiPD012695. PD012695. 1 hit.
[Graphical view] [Entries sharing at least one domain]
ProtoNetiSearch...

Entry informationi

Entry nameiGLCM1_BOVIN
AccessioniPrimary (citable) accession number: P80195
Secondary accession number(s): P35451, Q32P62
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 1, 1994
Last sequence update: October 1, 1996
Last modified: September 7, 2016
This is version 103 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.