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P80195

- GLCM1_BOVIN

UniProt

P80195 - GLCM1_BOVIN

Protein

Glycosylation-dependent cell adhesion molecule 1

Gene

GLYCAM1

Organism
Bos taurus (Bovine)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 95 (01 Oct 2014)
      Sequence version 2 (01 Oct 1996)
      Previous versions | rss
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    Functioni

    GO - Molecular functioni

    1. identical protein binding Source: IntAct
    2. sulfate binding Source: Ensembl

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Glycosylation-dependent cell adhesion molecule 1
    Short name:
    GlyCAM-1
    Alternative name(s):
    28 kDa milk glycoprotein PP3
    Lactophorin
    Proteose-peptone component 3
    Short name:
    PP3
    Gene namesi
    Name:GLYCAM1
    OrganismiBos taurus (Bovine)
    Taxonomic identifieri9913 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
    ProteomesiUP000009136: Chromosome 5

    Subcellular locationi

    GO - Cellular componenti

    1. extracellular region Source: Ensembl
    2. membrane Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 18182 PublicationsAdd
    BLAST
    Chaini19 – 153135Glycosylation-dependent cell adhesion molecule 1PRO_0000025408Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi34 – 341O-linked (GalNAc...); partial3 Publications
    Modified residuei47 – 471Phosphoserine3 Publications
    Modified residuei52 – 521Phosphoserine3 Publications
    Modified residuei56 – 561Phosphoserine3 Publications
    Modified residuei58 – 581Phosphoserine3 Publications
    Modified residuei64 – 641Phosphoserine3 Publications
    Glycosylationi78 – 781O-linked (HexNAc...)1 Publication
    Glycosylationi95 – 951N-linked (GlcNAc...)3 Publications
    Glycosylationi104 – 1041O-linked (GalNAc...)2 PublicationsCAR_000158

    Keywords - PTMi

    Glycoprotein, Phosphoprotein

    Proteomic databases

    PaxDbiP80195.
    PRIDEiP80195.

    PTM databases

    UniCarbKBiP80195.

    Expressioni

    Tissue specificityi

    Highly and specifically expressed in the lactating mammary gland.

    Interactioni

    Binary interactionsi

    WithEntry#Exp.IntActNotes
    itself4EBI-7562491,EBI-7562491

    Protein-protein interaction databases

    MINTiMINT-8292696.
    STRINGi9913.ENSBTAP00000017854.

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the PP3/GlyCAM-1 family.Curated

    Keywords - Domaini

    Signal

    Phylogenomic databases

    eggNOGiNOG86685.
    GeneTreeiENSGT00520000060242.
    HOGENOMiHOG000290655.
    HOVERGENiHBG106667.
    InParanoidiP80195.
    KOiK06815.
    OMAiSEEETHW.
    OrthoDBiEOG7H1JNK.
    TreeFamiTF339780.

    Family and domain databases

    InterProiIPR007906. GLYCAM-1.
    [Graphical view]
    PfamiPF05242. GLYCAM-1. 1 hit.
    [Graphical view]
    ProDomiPD012695. PD012695. 1 hit.
    [Graphical view] [Entries sharing at least one domain]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    P80195-1 [UniParc]FASTAAdd to Basket

    « Hide

    MKFLCVLLLA SLAATSLAIL NKPEDETHLE AQPTDASAQF IRNLQISNED    50
    LSKEPSISRE DLISKEQIVI RSSRQPQSQN PKLPLSILKE KHLRNATLGS 100
    EETTEHTPSD ASTTEGKLME LGHKIMRNLE NTVKETIKYL KSLFSHAFEV 150
    VKT 153
    Length:153
    Mass (Da):17,152
    Last modified:October 1, 1996 - v2
    Checksum:i6679E5F1F99CB886
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    D26176 mRNA. Translation: BAA05164.1.
    L36854 mRNA. Translation: AAA79330.1.
    X79406 mRNA. Translation: CAA55943.1.
    X83391 Genomic DNA. Translation: CAA58309.1.
    BC108244 mRNA. Translation: AAI08245.1.
    PIRiS52083.
    RefSeqiNP_777253.1. NM_174828.2.
    UniGeneiBt.4665.

    Genome annotation databases

    EnsembliENSBTAT00000017854; ENSBTAP00000017854; ENSBTAG00000013417.
    GeneIDi282430.
    KEGGibta:282430.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    D26176 mRNA. Translation: BAA05164.1 .
    L36854 mRNA. Translation: AAA79330.1 .
    X79406 mRNA. Translation: CAA55943.1 .
    X83391 Genomic DNA. Translation: CAA58309.1 .
    BC108244 mRNA. Translation: AAI08245.1 .
    PIRi S52083.
    RefSeqi NP_777253.1. NM_174828.2.
    UniGenei Bt.4665.

    3D structure databases

    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    MINTi MINT-8292696.
    STRINGi 9913.ENSBTAP00000017854.

    PTM databases

    UniCarbKBi P80195.

    Proteomic databases

    PaxDbi P80195.
    PRIDEi P80195.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSBTAT00000017854 ; ENSBTAP00000017854 ; ENSBTAG00000013417 .
    GeneIDi 282430.
    KEGGi bta:282430.

    Organism-specific databases

    CTDi 644076.

    Phylogenomic databases

    eggNOGi NOG86685.
    GeneTreei ENSGT00520000060242.
    HOGENOMi HOG000290655.
    HOVERGENi HBG106667.
    InParanoidi P80195.
    KOi K06815.
    OMAi SEEETHW.
    OrthoDBi EOG7H1JNK.
    TreeFami TF339780.

    Miscellaneous databases

    NextBioi 20806206.

    Family and domain databases

    InterProi IPR007906. GLYCAM-1.
    [Graphical view ]
    Pfami PF05242. GLYCAM-1. 1 hit.
    [Graphical view ]
    ProDomi PD012695. PD012695. 1 hit.
    [Graphical view ] [Entries sharing at least one domain ]
    ProtoNeti Search...

    Publicationsi

    1. "cDNA cloning of lactophorin from bovine milk."
      Kuriki H., Motoshima H., Minagawa E., Tsukasaki F., Kanno C.
      Submitted (DEC-1993) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Tissue: Milk.
    2. "Characterization of a bovine mammary gland PP3 cDNA reveals homology with mouse and rat adhesion molecule GlyCAM-1."
      Johnsen L.B., Soerensen E.S., Petersen T.E., Berglund L.
      Biochim. Biophys. Acta 1260:116-118(1995) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Strain: Black and white Danish dairy cattle.
    3. "Characterization of a GlyCAM1-like gene (glycosylation-dependent cell adhesion molecule 1) which is highly and specifically expressed in the lactating bovine mammary gland."
      Groenen M.A., Dijkhof R.J., der Poel J.J.
      Gene 158:189-195(1995) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
      Tissue: Lactating mammary gland.
    4. NIH - Mammalian Gene Collection (MGC) project
      Submitted (OCT-2005) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Strain: Crossbred X Angus.
      Tissue: Liver.
    5. "Phosphorylation, glycosylation and amino acid sequence of component PP3 from the proteose peptone fraction of bovine milk."
      Soerensen E.S., Petersen T.E.
      J. Dairy Res. 60:535-542(1993) [PubMed] [Europe PMC] [Abstract]
      Cited for: PROTEIN SEQUENCE OF 19-153, PHOSPHORYLATION AT SER-47; SER-52; SER-56; SER-58 AND SER-64, GLYCOSYLATION AT THR-34; ASN-95 AND THR-104.
      Tissue: Milk.
    6. "Purification and characterization of three proteins isolated from the proteose peptone fraction of bovine milk."
      Soerensen E.S., Petersen T.E.
      J. Dairy Res. 60:189-197(1993) [PubMed] [Europe PMC] [Abstract]
      Cited for: PROTEIN SEQUENCE OF 19-48 AND 72-91.
      Tissue: Milk.
    7. "Complete characterization of posttranslational modification sites in the bovine milk protein PP3 by tandem mass spectrometry with electron capture dissociation as the last stage."
      Kjeldsen F., Haselmann K.F., Budnik B.A., Sorensen E.S., Zubarev R.A.
      Anal. Chem. 75:2355-2361(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: PHOSPHORYLATION AT SER-47; SER-52; SER-56; SER-58 AND SER-64, GLYCOSYLATION AT THR-34; SER-78; ASN-95 AND THR-104.
      Tissue: Milk.

    Entry informationi

    Entry nameiGLCM1_BOVIN
    AccessioniPrimary (citable) accession number: P80195
    Secondary accession number(s): P35451, Q32P62
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: February 1, 1994
    Last sequence update: October 1, 1996
    Last modified: October 1, 2014
    This is version 95 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Direct protein sequencing, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3