Skip Header

You are using a version of Internet Explorer that may not display all features of this website. Please upgrade to a modern browser.
Contribute Send feedback
Read comments (?) or add your own

P80190 (LYSCK_SHEEP) Reviewed, UniProtKB/Swiss-Prot

Last modified February 19, 2014. Version 72. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Lysozyme C, kidney isozyme

EC=3.2.1.17
Alternative name(s):
1,4-beta-N-acetylmuramidase C
OrganismOvis aries (Sheep) [Complete proteome]
Taxonomic identifier9940 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeCaprinaeOvis

Protein attributes

Sequence length130 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Lysozymes have primarily a bacteriolytic function; those in tissues and body fluids are associated with the monocyte-macrophage system and enhance the activity of immunoagents.

Catalytic activity

Hydrolysis of (1->4)-beta-linkages between N-acetylmuramic acid and N-acetyl-D-glucosamine residues in a peptidoglycan and between N-acetyl-D-glucosamine residues in chitodextrins.

Subunit structure

Monomer.

Subcellular location

Secreted.

Miscellaneous

The sequence shown here is a non-stomach isozyme.

Sequence similarities

Belongs to the glycosyl hydrolase 22 family.

Ontologies

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 130130Lysozyme C, kidney isozyme
PRO_0000208856

Sites

Active site351 By similarity
Active site531 By similarity

Amino acid modifications

Disulfide bond6 ↔ 128 By similarity
Disulfide bond30 ↔ 116 By similarity
Disulfide bond65 ↔ 81 By similarity
Disulfide bond77 ↔ 95 By similarity

Sequences

Sequence LengthMass (Da)Tools
P80190 [UniParc].

Last modified April 1, 1993. Version 1.
Checksum: C79D70D3B8F70A8E

FASTA13014,611
        10         20         30         40         50         60 
KVFERCELAR TLKRFGMDGF RGISLANWMC LARWESSYNT QATNYNSGDR STDYGIFQIN 

        70         80         90        100        110        120 
SHWWCNDGKT PGAVNACHIP CSALLQDDIT QAVACAKRVV SDPQGIRAWV AWRSHCQNQD 

       130 
LTSYIQGCGV 

« Hide

References

[1]"The primary structures and properties of non-stomach lysozymes of sheep and cow, and implication for functional divergence of lysozyme."
Ito Y., Yamada H., Nakamura M., Yoshikawa A., Ueda T., Imoto T.
Eur. J. Biochem. 213:649-658(1993) [PubMed] [Europe PMC] [Abstract]
Cited for: PROTEIN SEQUENCE.
Tissue: Kidney.
[2]"Evolution of the bovine lysozyme gene family: changes in gene expression and reversion of function."
Irwin D.M.
J. Mol. Evol. 41:299-312(1995) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 34-63.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
U19473 Genomic DNA. Translation: AAA85547.1.
PIRS32465.

3D structure databases

ProteinModelPortalP80190.
SMRP80190. Positions 1-130.
ModBaseSearch...
MobiDBSearch...

Protein family/group databases

CAZyGH22. Glycoside Hydrolase Family 22.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Phylogenomic databases

HOVERGENHBG052297.

Family and domain databases

InterProIPR001916. Glyco_hydro_22.
IPR019799. Glyco_hydro_22_CS.
IPR000974. Glyco_hydro_22_lys.
IPR023346. Lysozyme-like_dom.
[Graphical view]
PfamPF00062. Lys. 1 hit.
[Graphical view]
PRINTSPR00137. LYSOZYME.
PR00135. LYZLACT.
SMARTSM00263. LYZ1. 1 hit.
[Graphical view]
SUPFAMSSF53955. SSF53955. 1 hit.
PROSITEPS00128. LACTALBUMIN_LYSOZYME_1. 1 hit.
PS51348. LACTALBUMIN_LYSOZYME_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameLYSCK_SHEEP
AccessionPrimary (citable) accession number: P80190
Entry history
Integrated into UniProtKB/Swiss-Prot: April 1, 1993
Last sequence update: April 1, 1993
Last modified: February 19, 2014
This is version 72 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

Glycosyl hydrolases

Classification of glycosyl hydrolase families and list of entries