Reviewed, UniProtKB/Swiss-Prot P80190 (LYSCK_SHEEP)

Names and origin

Protein names	Recommended name:     Lysozyme C, kidney isozyme     EC=3.2.1.17 Alternative name(s):     1,4-beta-N-acetylmuramidase C
Organism	Ovis aries (Sheep)
Taxonomic identifier	9940 [NCBI]
Taxonomic lineage	Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Laurasiatheria › Cetartiodactyla › Ruminantia › Pecora › Bovidae › Caprinae › Ovis

Protein attributes

Sequence length	130 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Evidence at protein level.

General annotation (Comments)

Function	Lysozymes have primarily a bacteriolytic function; those in tissues and body fluids are associated with the monocyte-macrophage system and enhance the activity of immunoagents.
Catalytic activity	Hydrolysis of (1->4)-beta-linkages between N-acetylmuramic acid and N-acetyl-D-glucosamine residues in a peptidoglycan and between N-acetyl-D-glucosamine residues in chitodextrins.
Subunit structure	Monomer.
Miscellaneous	The sequence shown here is a non-stomach isozyme.
Sequence similarities	Belongs to the glycosyl hydrolase 22 family.

Ontologies

Keywords
Molecular function	Antimicrobial Bacteriolytic enzyme Glycosidase Hydrolase
PTM	Disulfide bond
Technical term	Direct protein sequencing
Gene Ontology (GO)
Biological process	cell wall macromolecule catabolic process Inferred from electronic annotation. Source: InterPro cytolysis Inferred from electronic annotation. Source: UniProtKB-KW defense response to bacterium Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	lysozyme activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 130	130	Lysozyme C, kidney isozyme		PRO_0000208856
Sites
	Active site	35	1	By similarity
	Active site	53	1	By similarity
Amino acid modifications
	Disulfide bond	6 ↔ 128		By similarity
	Disulfide bond	30 ↔ 116		By similarity
	Disulfide bond	65 ↔ 81		By similarity
	Disulfide bond	77 ↔ 95		By similarity

Sequences

	Sequence		Length	Mass (Da)
	P80190-1 [UniParc]. Last modified April 1, 1993. Version 1. Checksum: C79D70D3B8F70A8E	FASTA	130	14,611
	10 20 30 40 50 60 KVFERCELAR TLKRFGMDGF RGISLANWMC LARWESSYNT QATNYNSGDR STDYGIFQIN 70 80 90 100 110 120 SHWWCNDGKT PGAVNACHIP CSALLQDDIT QAVACAKRVV SDPQGIRAWV AWRSHCQNQD 130 LTSYIQGCGV

References

[1]	"The primary structures and properties of non-stomach lysozymes of sheep and cow, and implication for functional divergence of lysozyme." Ito Y., Yamada H., Nakamura M., Yoshikawa A., Ueda T., Imoto T. Eur. J. Biochem. 213:649-658(1993) [PubMed: 8477739] [Abstract] Cited for: PROTEIN SEQUENCE. Tissue: Kidney.
[2]	"Evolution of the bovine lysozyme gene family: changes in gene expression and reversion of function." Irwin D.M. J. Mol. Evol. 41:299-312(1995) [PubMed: 7563116] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 34-63.

Cross-references

Sequence databases
EMBLGenBankDDBJ	U19473 Genomic DNA. Translation: AAA85547.1.
PIR	S32465.
3D structure databases
HSSP	HSSP built from PDB template 1TDY based on UniProtKB P00695.
SMR	P80190. Positions 1-130.
ModBase	Search...
Protein family/group databases
CAZy	GH22. Glycoside Hydrolase Family 22.
Phylogenomic databases
HOVERGEN	P80190.
Enzyme and pathway databases
BRENDA	3.2.1.17. 271.
Family and domain databases
InterPro	IPR001916. Glyco_hydro_22. IPR019799. Glyco_hydro_22_CS. IPR000974. Glyco_hydro_22_lys. [Graphical view]
Pfam	PF00062. Lys. 1 hit. [Graphical view]
PRINTS	PR00137. LYSOZYME. PR00135. LYZLACT.
SMART	SM00263. LYZ1. 1 hit. [Graphical view]
PROSITE	PS00128. LACTALBUMIN_LYSOZYME_1. 1 hit. PS51348. LACTALBUMIN_LYSOZYME_2. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

LYSCK_SHEEP

Accession

Primary (citable) accession number: P80190

Entry history

Integrated into UniProtKB/Swiss-Prot:	April 1, 1993
Last sequence update:	April 1, 1993
Last modified:	June 16, 2009
This is version 63 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HPI (Human Proteome Initiative)