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Protein

Lysozyme C, non-stomach isozyme

Gene

LYS

Organism
Bos taurus (Bovine)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

Lysozymes have primarily a bacteriolytic function; those in tissues and body fluids are associated with the monocyte-macrophage system and enhance the activity of immunoagents.

Catalytic activityi

Hydrolysis of (1->4)-beta-linkages between N-acetylmuramic acid and N-acetyl-D-glucosamine residues in a peptidoglycan and between N-acetyl-D-glucosamine residues in chitodextrins.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei53PROSITE-ProRule annotation1
Active sitei71PROSITE-ProRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionAntimicrobial, Bacteriolytic enzyme, Glycosidase, Hydrolase

Enzyme and pathway databases

BRENDAi3.2.1.17. 908.
ReactomeiR-BTA-6798695. Neutrophil degranulation.
R-BTA-6803157. Antimicrobial peptides.

Protein family/group databases

CAZyiGH22. Glycoside Hydrolase Family 22.

Names & Taxonomyi

Protein namesi
Recommended name:
Lysozyme C, non-stomach isozyme (EC:3.2.1.17)
Alternative name(s):
1,4-beta-N-acetylmuramidase C
Gene namesi
Name:LYS
Synonyms:LZ
OrganismiBos taurus (Bovine)
Taxonomic identifieri9913 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
Proteomesi
  • UP000009136 Componenti: Chromosome 5

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 18Sequence analysisAdd BLAST18
ChainiPRO_000001845819 – 148Lysozyme C, non-stomach isozymeAdd BLAST130

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi24 ↔ 146PROSITE-ProRule annotation
Disulfide bondi48 ↔ 134PROSITE-ProRule annotation
Disulfide bondi83 ↔ 99PROSITE-ProRule annotation
Disulfide bondi95 ↔ 113PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bond

Proteomic databases

PaxDbiP80189.
PeptideAtlasiP80189.
PRIDEiP80189.

Expressioni

Tissue specificityi

Expressed in blood cells.

Gene expression databases

BgeeiENSBTAG00000026779.
ExpressionAtlasiP80189. baseline and differential.

Interactioni

GO - Molecular functioni

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000038081.

Structurei

3D structure databases

ProteinModelPortaliP80189.
SMRiP80189.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the glycosyl hydrolase 22 family.PROSITE-ProRule annotation

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG410IXGD. Eukaryota.
ENOG4111QHM. LUCA.
GeneTreeiENSGT00550000074398.
HOGENOMiHOG000037357.
HOVERGENiHBG052297.
InParanoidiP80189.
KOiK13915.
OMAiNHCQNRD.
OrthoDBiEOG091G0R9V.
TreeFamiTF324882.

Family and domain databases

CDDicd00119. LYZ1. 1 hit.
InterProiView protein in InterPro
IPR001916. Glyco_hydro_22.
IPR019799. Glyco_hydro_22_CS.
IPR000974. Glyco_hydro_22_lys.
IPR023346. Lysozyme-like_dom_sf.
IPR030056. Lysozyme_C.
PANTHERiPTHR11407:SF28. PTHR11407:SF28. 1 hit.
PfamiView protein in Pfam
PF00062. Lys. 1 hit.
PRINTSiPR00137. LYSOZYME.
PR00135. LYZLACT.
SMARTiView protein in SMART
SM00263. LYZ1. 1 hit.
SUPFAMiSSF53955. SSF53955. 1 hit.
PROSITEiView protein in PROSITE
PS00128. LACTALBUMIN_LYSOZYME_1. 1 hit.
PS51348. LACTALBUMIN_LYSOZYME_2. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P80189-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKALLILGLL LFSVAVQGKV FERCELARSL KRFGMDNFRG ISLANWMCLA
60 70 80 90 100
RWESNYNTQA TNYNAGDQST DYGIFQINSH WWCNDGKTPG AVNACHLPCG
110 120 130 140
ALLQDDITQA VACAKRVVSD PQGIRAWVAW RSHCQNQDLT SYIQGCGV
Length:148
Mass (Da):16,476
Last modified:January 4, 2005 - v4
Checksum:i707A79AA7FDA4FAC
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti114A → T (PubMed:8921904).Curated1
Sequence conflicti114A → T (PubMed:7894180).Curated1
Sequence conflicti117V → D (PubMed:8921904).Curated1
Sequence conflicti117V → D (PubMed:7894180).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L23757 mRNA. No translation available.
U25810 Genomic DNA. Translation: AAC48683.1.
BC112597 mRNA. Translation: AAI12598.1.
L19980 mRNA. Translation: AAA99863.1.
PIRiC49315.
RefSeqiNP_001071627.1. NM_001078159.1.
UniGeneiBt.64645.

Genome annotation databases

EnsembliENSBTAT00000038266; ENSBTAP00000038081; ENSBTAG00000026779.
GeneIDi777776.
KEGGibta:777776.

Similar proteinsi

Entry informationi

Entry nameiLYSCN_BOVIN
AccessioniPrimary (citable) accession number: P80189
Secondary accession number(s): Q29447, Q2KIL2
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 1, 1993
Last sequence update: January 4, 2005
Last modified: November 22, 2017
This is version 131 of the entry and version 4 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Glycosyl hydrolases
    Classification of glycosyl hydrolase families and list of entries
  2. SIMILARITY comments
    Index of protein domains and families