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Protein

Lysozyme C, non-stomach isozyme

Gene

LYS

Organism
Bos taurus (Bovine)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Lysozymes have primarily a bacteriolytic function; those in tissues and body fluids are associated with the monocyte-macrophage system and enhance the activity of immunoagents.

Catalytic activityi

Hydrolysis of (1->4)-beta-linkages between N-acetylmuramic acid and N-acetyl-D-glucosamine residues in a peptidoglycan and between N-acetyl-D-glucosamine residues in chitodextrins.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei53 – 531PROSITE-ProRule annotation
Active sitei71 – 711PROSITE-ProRule annotation

GO - Molecular functioni

  1. lysozyme activity Source: UniProtKB-EC

GO - Biological processi

  1. cytolysis Source: UniProtKB-KW
  2. defense response to bacterium Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Antimicrobial, Bacteriolytic enzyme, Glycosidase, Hydrolase

Enzyme and pathway databases

BRENDAi3.2.1.17. 908.
ReactomeiREACT_325565. Amyloids.

Protein family/group databases

CAZyiGH22. Glycoside Hydrolase Family 22.

Names & Taxonomyi

Protein namesi
Recommended name:
Lysozyme C, non-stomach isozyme (EC:3.2.1.17)
Alternative name(s):
1,4-beta-N-acetylmuramidase C
Gene namesi
Name:LYS
Synonyms:LZ
OrganismiBos taurus (Bovine)
Taxonomic identifieri9913 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
ProteomesiUP000009136 Componenti: Chromosome 5

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 1818Sequence AnalysisAdd
BLAST
Chaini19 – 148130Lysozyme C, non-stomach isozymePRO_0000018458Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi24 ↔ 146PROSITE-ProRule annotation
Disulfide bondi48 ↔ 134PROSITE-ProRule annotation
Disulfide bondi83 ↔ 99PROSITE-ProRule annotation
Disulfide bondi95 ↔ 113PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bond

Proteomic databases

PaxDbiP80189.

Expressioni

Tissue specificityi

Expressed in blood cells.

Gene expression databases

ExpressionAtlasiP80189. baseline.

Structurei

3D structure databases

SMRiP80189. Positions 19-148.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the glycosyl hydrolase 22 family.PROSITE-ProRule annotation

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiNOG85133.
GeneTreeiENSGT00550000074398.
HOGENOMiHOG000037357.
HOVERGENiHBG052297.
InParanoidiP80189.
KOiK13915.
OMAiLQDNIAD.
OrthoDBiEOG7BW0M5.
TreeFamiTF324882.

Family and domain databases

InterProiIPR001916. Glyco_hydro_22.
IPR019799. Glyco_hydro_22_CS.
IPR000974. Glyco_hydro_22_lys.
IPR023346. Lysozyme-like_dom.
IPR030056. Lysozyme_C.
[Graphical view]
PANTHERiPTHR11407:SF22. PTHR11407:SF22. 1 hit.
PfamiPF00062. Lys. 1 hit.
[Graphical view]
PRINTSiPR00137. LYSOZYME.
PR00135. LYZLACT.
SMARTiSM00263. LYZ1. 1 hit.
[Graphical view]
SUPFAMiSSF53955. SSF53955. 1 hit.
PROSITEiPS00128. LACTALBUMIN_LYSOZYME_1. 1 hit.
PS51348. LACTALBUMIN_LYSOZYME_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P80189-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKALLILGLL LFSVAVQGKV FERCELARSL KRFGMDNFRG ISLANWMCLA
60 70 80 90 100
RWESNYNTQA TNYNAGDQST DYGIFQINSH WWCNDGKTPG AVNACHLPCG
110 120 130 140
ALLQDDITQA VACAKRVVSD PQGIRAWVAW RSHCQNQDLT SYIQGCGV
Length:148
Mass (Da):16,476
Last modified:January 4, 2005 - v4
Checksum:i707A79AA7FDA4FAC
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti114 – 1141A → T (PubMed:8921904).Curated
Sequence conflicti114 – 1141A → T (PubMed:7894180).Curated
Sequence conflicti117 – 1171V → D (PubMed:8921904).Curated
Sequence conflicti117 – 1171V → D (PubMed:7894180).Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L23757 mRNA. No translation available.
U25810 Genomic DNA. Translation: AAC48683.1.
BC112597 mRNA. Translation: AAI12598.1.
L19980 mRNA. Translation: AAA99863.1.
PIRiC49315.
RefSeqiNP_001071627.1. NM_001078159.1.
UniGeneiBt.64645.

Genome annotation databases

EnsembliENSBTAT00000038266; ENSBTAP00000038081; ENSBTAG00000026779.
GeneIDi777776.
KEGGibta:777776.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L23757 mRNA. No translation available.
U25810 Genomic DNA. Translation: AAC48683.1.
BC112597 mRNA. Translation: AAI12598.1.
L19980 mRNA. Translation: AAA99863.1.
PIRiC49315.
RefSeqiNP_001071627.1. NM_001078159.1.
UniGeneiBt.64645.

3D structure databases

SMRiP80189. Positions 19-148.
ModBaseiSearch...
MobiDBiSearch...

Protein family/group databases

CAZyiGH22. Glycoside Hydrolase Family 22.

Proteomic databases

PaxDbiP80189.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSBTAT00000038266; ENSBTAP00000038081; ENSBTAG00000026779.
GeneIDi777776.
KEGGibta:777776.

Organism-specific databases

CTDi4069.

Phylogenomic databases

eggNOGiNOG85133.
GeneTreeiENSGT00550000074398.
HOGENOMiHOG000037357.
HOVERGENiHBG052297.
InParanoidiP80189.
KOiK13915.
OMAiLQDNIAD.
OrthoDBiEOG7BW0M5.
TreeFamiTF324882.

Enzyme and pathway databases

BRENDAi3.2.1.17. 908.
ReactomeiREACT_325565. Amyloids.

Miscellaneous databases

NextBioi20924328.

Gene expression databases

ExpressionAtlasiP80189. baseline.

Family and domain databases

InterProiIPR001916. Glyco_hydro_22.
IPR019799. Glyco_hydro_22_CS.
IPR000974. Glyco_hydro_22_lys.
IPR023346. Lysozyme-like_dom.
IPR030056. Lysozyme_C.
[Graphical view]
PANTHERiPTHR11407:SF22. PTHR11407:SF22. 1 hit.
PfamiPF00062. Lys. 1 hit.
[Graphical view]
PRINTSiPR00137. LYSOZYME.
PR00135. LYZLACT.
SMARTiSM00263. LYZ1. 1 hit.
[Graphical view]
SUPFAMiSSF53955. SSF53955. 1 hit.
PROSITEiPS00128. LACTALBUMIN_LYSOZYME_1. 1 hit.
PS51348. LACTALBUMIN_LYSOZYME_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Multiple cDNA sequences of bovine tracheal lysozyme."
    Takeuchi K., Irwin D.M., Gallup M., Shinbrot E., Kai H., Stewart C.B., Basbaum C.
    J. Biol. Chem. 268:27440-27446(1993) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Trachea.
  2. "Structural deviations in a bovine low expression lysozyme-encoding gene active in tissues other than stomach."
    Henke M., Hobom G., Senft B., Seyfert H.-M.
    Gene 178:131-137(1996) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: Deutsche Schwarzbunte.
    Tissue: Blood.
  3. "The macrophage expressed variant of the bovine lysozyme-encoding gene maps to chromosome 5q23."
    Brunner R.M., Henke M., Guerin G., Goldammer T., Seyfert H.M., Schwerin M.
    Mamm. Genome 5:834-834(1994) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  4. "The primary structures and properties of non-stomach lysozymes of sheep and cow, and implication for functional divergence of lysozyme."
    Ito Y., Yamada H., Nakamura M., Yoshikawa A., Ueda T., Imoto T.
    Eur. J. Biochem. 213:649-658(1993) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE.
    Tissue: Kidney.
  5. NIH - Mammalian Gene Collection (MGC) project
    Submitted (JAN-2006) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: Hereford.
    Tissue: Testis.
  6. "Lysozyme-encoding bovine cDNAs from neutrophile granulocytes and mammary gland are derived from a different gene than stomach lysozymes."
    Steinhoff U.M., Senft B., Seyfert H.-M.
    Gene 143:271-276(1994) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 8-148.
    Tissue: Granulocyte and Mammary gland.

Entry informationi

Entry nameiLYSCN_BOVIN
AccessioniPrimary (citable) accession number: P80189
Secondary accession number(s): Q29447, Q2KIL2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 1, 1993
Last sequence update: January 4, 2005
Last modified: April 1, 2015
This is version 110 of the entry and version 4 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Glycosyl hydrolases
    Classification of glycosyl hydrolase families and list of entries
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.