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P80189

- LYSCN_BOVIN

UniProt

P80189 - LYSCN_BOVIN

Protein

Lysozyme C, non-stomach isozyme

Gene

LYS

Organism
Bos taurus (Bovine)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli
  1. Functioni

    Lysozymes have primarily a bacteriolytic function; those in tissues and body fluids are associated with the monocyte-macrophage system and enhance the activity of immunoagents.

    Catalytic activityi

    Hydrolysis of (1->4)-beta-linkages between N-acetylmuramic acid and N-acetyl-D-glucosamine residues in a peptidoglycan and between N-acetyl-D-glucosamine residues in chitodextrins.

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei53 – 531PROSITE-ProRule annotation
    Active sitei71 – 711PROSITE-ProRule annotation

    GO - Molecular functioni

    1. lysozyme activity Source: UniProtKB-EC

    GO - Biological processi

    1. cell wall macromolecule catabolic process Source: InterPro
    2. cytolysis Source: UniProtKB-KW
    3. defense response to bacterium Source: UniProtKB-KW

    Keywords - Molecular functioni

    Antimicrobial, Bacteriolytic enzyme, Glycosidase, Hydrolase

    Enzyme and pathway databases

    ReactomeiREACT_206540. Amyloids.

    Protein family/group databases

    CAZyiGH22. Glycoside Hydrolase Family 22.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Lysozyme C, non-stomach isozyme (EC:3.2.1.17)
    Alternative name(s):
    1,4-beta-N-acetylmuramidase C
    Gene namesi
    Name:LYS
    Synonyms:LZ
    OrganismiBos taurus (Bovine)
    Taxonomic identifieri9913 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
    ProteomesiUP000009136: Chromosome 5

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 1818Sequence AnalysisAdd
    BLAST
    Chaini19 – 148130Lysozyme C, non-stomach isozymePRO_0000018458Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Disulfide bondi24 ↔ 146PROSITE-ProRule annotation
    Disulfide bondi48 ↔ 134PROSITE-ProRule annotation
    Disulfide bondi83 ↔ 99PROSITE-ProRule annotation
    Disulfide bondi95 ↔ 113PROSITE-ProRule annotation

    Keywords - PTMi

    Disulfide bond

    Proteomic databases

    PaxDbiP80189.

    Expressioni

    Tissue specificityi

    Expressed in blood cells.

    Structurei

    3D structure databases

    ProteinModelPortaliP80189.
    SMRiP80189. Positions 19-148.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the glycosyl hydrolase 22 family.PROSITE-ProRule annotation

    Keywords - Domaini

    Signal

    Phylogenomic databases

    eggNOGiNOG85133.
    GeneTreeiENSGT00550000074398.
    HOGENOMiHOG000037357.
    HOVERGENiHBG052297.
    InParanoidiP80189.
    KOiK13915.
    OMAiLQDNIAD.
    OrthoDBiEOG7BW0M5.
    TreeFamiTF324882.

    Family and domain databases

    InterProiIPR001916. Glyco_hydro_22.
    IPR019799. Glyco_hydro_22_CS.
    IPR000974. Glyco_hydro_22_lys.
    IPR023346. Lysozyme-like_dom.
    [Graphical view]
    PfamiPF00062. Lys. 1 hit.
    [Graphical view]
    PRINTSiPR00137. LYSOZYME.
    PR00135. LYZLACT.
    SMARTiSM00263. LYZ1. 1 hit.
    [Graphical view]
    SUPFAMiSSF53955. SSF53955. 1 hit.
    PROSITEiPS00128. LACTALBUMIN_LYSOZYME_1. 1 hit.
    PS51348. LACTALBUMIN_LYSOZYME_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    P80189-1 [UniParc]FASTAAdd to Basket

    « Hide

    MKALLILGLL LFSVAVQGKV FERCELARSL KRFGMDNFRG ISLANWMCLA    50
    RWESNYNTQA TNYNAGDQST DYGIFQINSH WWCNDGKTPG AVNACHLPCG 100
    ALLQDDITQA VACAKRVVSD PQGIRAWVAW RSHCQNQDLT SYIQGCGV 148
    Length:148
    Mass (Da):16,476
    Last modified:January 4, 2005 - v4
    Checksum:i707A79AA7FDA4FAC
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti114 – 1141A → T(PubMed:8921904)Curated
    Sequence conflicti114 – 1141A → T(PubMed:7894180)Curated
    Sequence conflicti117 – 1171V → D(PubMed:8921904)Curated
    Sequence conflicti117 – 1171V → D(PubMed:7894180)Curated

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    L23757 mRNA. No translation available.
    U25810 Genomic DNA. Translation: AAC48683.1.
    BC112597 mRNA. Translation: AAI12598.1.
    L19980 mRNA. Translation: AAA99863.1.
    PIRiC49315.
    RefSeqiNP_001071627.1. NM_001078159.1.
    UniGeneiBt.64645.

    Genome annotation databases

    EnsembliENSBTAT00000038266; ENSBTAP00000038081; ENSBTAG00000026779.
    GeneIDi777776.
    KEGGibta:777776.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    L23757 mRNA. No translation available.
    U25810 Genomic DNA. Translation: AAC48683.1 .
    BC112597 mRNA. Translation: AAI12598.1 .
    L19980 mRNA. Translation: AAA99863.1 .
    PIRi C49315.
    RefSeqi NP_001071627.1. NM_001078159.1.
    UniGenei Bt.64645.

    3D structure databases

    ProteinModelPortali P80189.
    SMRi P80189. Positions 19-148.
    ModBasei Search...
    MobiDBi Search...

    Protein family/group databases

    CAZyi GH22. Glycoside Hydrolase Family 22.

    Proteomic databases

    PaxDbi P80189.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSBTAT00000038266 ; ENSBTAP00000038081 ; ENSBTAG00000026779 .
    GeneIDi 777776.
    KEGGi bta:777776.

    Organism-specific databases

    CTDi 4069.

    Phylogenomic databases

    eggNOGi NOG85133.
    GeneTreei ENSGT00550000074398.
    HOGENOMi HOG000037357.
    HOVERGENi HBG052297.
    InParanoidi P80189.
    KOi K13915.
    OMAi LQDNIAD.
    OrthoDBi EOG7BW0M5.
    TreeFami TF324882.

    Enzyme and pathway databases

    Reactomei REACT_206540. Amyloids.

    Miscellaneous databases

    NextBioi 20924328.

    Family and domain databases

    InterProi IPR001916. Glyco_hydro_22.
    IPR019799. Glyco_hydro_22_CS.
    IPR000974. Glyco_hydro_22_lys.
    IPR023346. Lysozyme-like_dom.
    [Graphical view ]
    Pfami PF00062. Lys. 1 hit.
    [Graphical view ]
    PRINTSi PR00137. LYSOZYME.
    PR00135. LYZLACT.
    SMARTi SM00263. LYZ1. 1 hit.
    [Graphical view ]
    SUPFAMi SSF53955. SSF53955. 1 hit.
    PROSITEi PS00128. LACTALBUMIN_LYSOZYME_1. 1 hit.
    PS51348. LACTALBUMIN_LYSOZYME_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Multiple cDNA sequences of bovine tracheal lysozyme."
      Takeuchi K., Irwin D.M., Gallup M., Shinbrot E., Kai H., Stewart C.B., Basbaum C.
      J. Biol. Chem. 268:27440-27446(1993) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Tissue: Trachea.
    2. "Structural deviations in a bovine low expression lysozyme-encoding gene active in tissues other than stomach."
      Henke M., Hobom G., Senft B., Seyfert H.-M.
      Gene 178:131-137(1996) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
      Strain: Deutsche Schwarzbunte.
      Tissue: Blood.
    3. "The macrophage expressed variant of the bovine lysozyme-encoding gene maps to chromosome 5q23."
      Brunner R.M., Henke M., Guerin G., Goldammer T., Seyfert H.M., Schwerin M.
      Mamm. Genome 5:834-834(1994) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    4. "The primary structures and properties of non-stomach lysozymes of sheep and cow, and implication for functional divergence of lysozyme."
      Ito Y., Yamada H., Nakamura M., Yoshikawa A., Ueda T., Imoto T.
      Eur. J. Biochem. 213:649-658(1993) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE.
      Tissue: Kidney.
    5. NIH - Mammalian Gene Collection (MGC) project
      Submitted (JAN-2006) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Strain: Hereford.
      Tissue: Testis.
    6. "Lysozyme-encoding bovine cDNAs from neutrophile granulocytes and mammary gland are derived from a different gene than stomach lysozymes."
      Steinhoff U.M., Senft B., Seyfert H.-M.
      Gene 143:271-276(1994) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 8-148.
      Tissue: Granulocyte and Mammary gland.

    Entry informationi

    Entry nameiLYSCN_BOVIN
    AccessioniPrimary (citable) accession number: P80189
    Secondary accession number(s): Q29447, Q2KIL2
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: April 1, 1993
    Last sequence update: January 4, 2005
    Last modified: October 1, 2014
    This is version 106 of the entry and version 4 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Glycosyl hydrolases
      Classification of glycosyl hydrolase families and list of entries
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3