P80189 (LYSCN_BOVIN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Lysozyme C, non-stomach isozyme
EC=3.2.1.17

Alternative name(s):
1,4-beta-N-acetylmuramidase C

Gene names

Name:	LYS
Synonyms:	LZ

Organism

Bos taurus (Bovine) [Reference proteome]

Taxonomic identifier

9913 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Laurasiatheria › Cetartiodactyla › Ruminantia › Pecora › Bovidae › Bovinae › Bos

Protein attributes

Sequence length	148 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at transcript level

General annotation (Comments)

Function	Lysozymes have primarily a bacteriolytic function; those in tissues and body fluids are associated with the monocyte-macrophage system and enhance the activity of immunoagents.
Catalytic activity	Hydrolysis of (1->4)-beta-linkages between N-acetylmuramic acid and N-acetyl-D-glucosamine residues in a peptidoglycan and between N-acetyl-D-glucosamine residues in chitodextrins.
Tissue specificity	Expressed in blood cells.
Sequence similarities	Belongs to the glycosyl hydrolase 22 family.

Ontologies

Keywords
Domain	Signal
Molecular function	Antimicrobial Bacteriolytic enzyme Glycosidase Hydrolase
PTM	Disulfide bond
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	cell wall macromolecule catabolic process Inferred from electronic annotation. Source: InterPro cytolysis Inferred from electronic annotation. Source: UniProtKB-KW defense response to bacterium Inferred from electronic annotation. Source: UniProtKB-KW
Molecular_function	lysozyme activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Signal peptide	1 – 18	18	Potential
	Chain	19 – 148	130	Lysozyme C, non-stomach isozyme		PRO_0000018458
Sites
	Active site	53	1	By similarity
	Active site	71	1	By similarity
Amino acid modifications
	Disulfide bond	24 ↔ 146		By similarity
	Disulfide bond	48 ↔ 134		By similarity
	Disulfide bond	83 ↔ 99		By similarity
	Disulfide bond	95 ↔ 113		By similarity
Experimental info
	Sequence conflict	114	1	A → T Ref.2
	Sequence conflict	114	1	A → T Ref.3
	Sequence conflict	117	1	V → D Ref.2
	Sequence conflict	117	1	V → D Ref.3

Sequences

	Sequence		Length	Mass (Da)
	P80189 [UniParc]. Last modified January 4, 2005. Version 4. Checksum: 707A79AA7FDA4FAC	FASTA	148	16,476
	10 20 30 40 50 60 MKALLILGLL LFSVAVQGKV FERCELARSL KRFGMDNFRG ISLANWMCLA RWESNYNTQA 70 80 90 100 110 120 TNYNAGDQST DYGIFQINSH WWCNDGKTPG AVNACHLPCG ALLQDDITQA VACAKRVVSD 130 140 PQGIRAWVAW RSHCQNQDLT SYIQGCGV

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Multiple cDNA sequences of bovine tracheal lysozyme." Takeuchi K., Irwin D.M., Gallup M., Shinbrot E., Kai H., Stewart C.B., Basbaum C. J. Biol. Chem. 268:27440-27446(1993) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA]. Tissue: Trachea.
[2]	"Structural deviations in a bovine low expression lysozyme-encoding gene active in tissues other than stomach." Henke M., Hobom G., Senft B., Seyfert H.-M. Gene 178:131-137(1996) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]. Strain: Deutsche Schwarzbunte. Tissue: Blood.
[3]	"The macrophage expressed variant of the bovine lysozyme-encoding gene maps to chromosome 5q23." Brunner R.M., Henke M., Guerin G., Goldammer T., Seyfert H.M., Schwerin M. Mamm. Genome 5:834-834(1994) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[4]	"The primary structures and properties of non-stomach lysozymes of sheep and cow, and implication for functional divergence of lysozyme." Ito Y., Yamada H., Nakamura M., Yoshikawa A., Ueda T., Imoto T. Eur. J. Biochem. 213:649-658(1993) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE. Tissue: Kidney.
[5]	NIH - Mammalian Gene Collection (MGC) project Submitted (JAN-2006) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Strain: Hereford. Tissue: Testis.
[6]	"Lysozyme-encoding bovine cDNAs from neutrophile granulocytes and mammary gland are derived from a different gene than stomach lysozymes." Steinhoff U.M., Senft B., Seyfert H.-M. Gene 143:271-276(1994) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 8-148. Tissue: Granulocyte and Mammary gland.

Cross-references

Sequence databases
EMBL GenBank DDBJ	L23757 mRNA. No translation available. U25810 Genomic DNA. Translation: AAC48683.1. BC112597 mRNA. Translation: AAI12598.1. L19980 mRNA. Translation: AAA99863.1.
IPI	IPI00718034.
PIR	C49315.
RefSeq	NP_001071627.1. NM_001078159.1.
UniGene	Bt.64645.
3D structure databases
ProteinModelPortal	P80189.
SMR	P80189. Positions 19-148.
ModBase	Search...
Protein family/group databases
CAZy	GH22. Glycoside Hydrolase Family 22.
Proteomic databases
PaxDb	P80189.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENSBTAT00000038266; ENSBTAP00000038081; ENSBTAG00000026779.
GeneID	777776.
KEGG	bta:777776.
Organism-specific databases
CTD	4069.
Phylogenomic databases
eggNOG	NOG85133.
GeneTree	ENSGT00550000074398.
HOGENOM	HOG000037357.
HOVERGEN	HBG052297.
InParanoid	P80189.
KO	K13915.
OMA	CNALLQD.
OrthoDB	EOG48KRCP.
Gene expression databases
ArrayExpress	P80189.
Family and domain databases
InterPro	IPR001916. Glyco_hydro_22. IPR019799. Glyco_hydro_22_CS. IPR000974. Glyco_hydro_22_lys. IPR023346. Lysozyme-like_dom. [Graphical view]
Pfam	PF00062. Lys. 1 hit. [Graphical view]
PRINTS	PR00137. LYSOZYME. PR00135. LYZLACT.
SMART	SM00263. LYZ1. 1 hit. [Graphical view]
SUPFAM	SSF53955. SSF53955. 1 hit.
PROSITE	PS00128. LACTALBUMIN_LYSOZYME_1. 1 hit. PS51348. LACTALBUMIN_LYSOZYME_2. 1 hit. [Graphical view]
ProtoNet	Search...
Other
NextBio	20924328.

Entry information

Entry name

LYSCN_BOVIN

Accession

Primary (citable) accession number: P80189
Secondary accession number(s): Q29447, Q2KIL2

Entry history

Integrated into UniProtKB/Swiss-Prot:	April 1, 1993
Last sequence update:	January 4, 2005
Last modified:	April 3, 2013
This is version 97 of the entry and version 4 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program