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P80189 (LYSCN_BOVIN) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 104. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Lysozyme C, non-stomach isozyme

EC=3.2.1.17
Alternative name(s):
1,4-beta-N-acetylmuramidase C
Gene names
Name:LYS
Synonyms:LZ
OrganismBos taurus (Bovine) [Reference proteome]
Taxonomic identifier9913 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos

Protein attributes

Sequence length148 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Lysozymes have primarily a bacteriolytic function; those in tissues and body fluids are associated with the monocyte-macrophage system and enhance the activity of immunoagents.

Catalytic activity

Hydrolysis of (1->4)-beta-linkages between N-acetylmuramic acid and N-acetyl-D-glucosamine residues in a peptidoglycan and between N-acetyl-D-glucosamine residues in chitodextrins.

Tissue specificity

Expressed in blood cells.

Sequence similarities

Belongs to the glycosyl hydrolase 22 family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 1818 Potential
Chain19 – 148130Lysozyme C, non-stomach isozyme
PRO_0000018458

Sites

Active site531 By similarity
Active site711 By similarity

Amino acid modifications

Disulfide bond24 ↔ 146 By similarity
Disulfide bond48 ↔ 134 By similarity
Disulfide bond83 ↔ 99 By similarity
Disulfide bond95 ↔ 113 By similarity

Experimental info

Sequence conflict1141A → T Ref.2
Sequence conflict1141A → T Ref.3
Sequence conflict1171V → D Ref.2
Sequence conflict1171V → D Ref.3

Sequences

Sequence LengthMass (Da)Tools
P80189 [UniParc].

Last modified January 4, 2005. Version 4.
Checksum: 707A79AA7FDA4FAC

FASTA14816,476
        10         20         30         40         50         60 
MKALLILGLL LFSVAVQGKV FERCELARSL KRFGMDNFRG ISLANWMCLA RWESNYNTQA 

        70         80         90        100        110        120 
TNYNAGDQST DYGIFQINSH WWCNDGKTPG AVNACHLPCG ALLQDDITQA VACAKRVVSD 

       130        140 
PQGIRAWVAW RSHCQNQDLT SYIQGCGV 

« Hide

References

« Hide 'large scale' references
[1]"Multiple cDNA sequences of bovine tracheal lysozyme."
Takeuchi K., Irwin D.M., Gallup M., Shinbrot E., Kai H., Stewart C.B., Basbaum C.
J. Biol. Chem. 268:27440-27446(1993) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
Tissue: Trachea.
[2]"Structural deviations in a bovine low expression lysozyme-encoding gene active in tissues other than stomach."
Henke M., Hobom G., Senft B., Seyfert H.-M.
Gene 178:131-137(1996) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
Strain: Deutsche Schwarzbunte.
Tissue: Blood.
[3]"The macrophage expressed variant of the bovine lysozyme-encoding gene maps to chromosome 5q23."
Brunner R.M., Henke M., Guerin G., Goldammer T., Seyfert H.M., Schwerin M.
Mamm. Genome 5:834-834(1994) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[4]"The primary structures and properties of non-stomach lysozymes of sheep and cow, and implication for functional divergence of lysozyme."
Ito Y., Yamada H., Nakamura M., Yoshikawa A., Ueda T., Imoto T.
Eur. J. Biochem. 213:649-658(1993) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE.
Tissue: Kidney.
[5]NIH - Mammalian Gene Collection (MGC) project
Submitted (JAN-2006) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Strain: Hereford.
Tissue: Testis.
[6]"Lysozyme-encoding bovine cDNAs from neutrophile granulocytes and mammary gland are derived from a different gene than stomach lysozymes."
Steinhoff U.M., Senft B., Seyfert H.-M.
Gene 143:271-276(1994) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 8-148.
Tissue: Granulocyte and Mammary gland.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
L23757 mRNA. No translation available.
U25810 Genomic DNA. Translation: AAC48683.1.
BC112597 mRNA. Translation: AAI12598.1.
L19980 mRNA. Translation: AAA99863.1.
PIRC49315.
RefSeqNP_001071627.1. NM_001078159.1.
UniGeneBt.64645.

3D structure databases

ProteinModelPortalP80189.
SMRP80189. Positions 19-148.
ModBaseSearch...
MobiDBSearch...

Protein family/group databases

CAZyGH22. Glycoside Hydrolase Family 22.

Proteomic databases

PaxDbP80189.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSBTAT00000038266; ENSBTAP00000038081; ENSBTAG00000026779.
GeneID777776.
KEGGbta:777776.

Organism-specific databases

CTD4069.

Phylogenomic databases

eggNOGNOG85133.
GeneTreeENSGT00550000074398.
HOGENOMHOG000037357.
HOVERGENHBG052297.
InParanoidP80189.
KOK13915.
OMALQDNIAD.
OrthoDBEOG7BW0M5.
TreeFamTF324882.

Family and domain databases

InterProIPR001916. Glyco_hydro_22.
IPR019799. Glyco_hydro_22_CS.
IPR000974. Glyco_hydro_22_lys.
IPR023346. Lysozyme-like_dom.
[Graphical view]
PfamPF00062. Lys. 1 hit.
[Graphical view]
PRINTSPR00137. LYSOZYME.
PR00135. LYZLACT.
SMARTSM00263. LYZ1. 1 hit.
[Graphical view]
SUPFAMSSF53955. SSF53955. 1 hit.
PROSITEPS00128. LACTALBUMIN_LYSOZYME_1. 1 hit.
PS51348. LACTALBUMIN_LYSOZYME_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio20924328.

Entry information

Entry nameLYSCN_BOVIN
AccessionPrimary (citable) accession number: P80189
Secondary accession number(s): Q29447, Q2KIL2
Entry history
Integrated into UniProtKB/Swiss-Prot: April 1, 1993
Last sequence update: January 4, 2005
Last modified: April 16, 2014
This is version 104 of the entry and version 4 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

Glycosyl hydrolases

Classification of glycosyl hydrolase families and list of entries