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Protein

Lysozyme C, non-stomach isozyme

Gene

LYS

Organism
Bos taurus (Bovine)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Lysozymes have primarily a bacteriolytic function; those in tissues and body fluids are associated with the monocyte-macrophage system and enhance the activity of immunoagents.

Catalytic activityi

Hydrolysis of (1->4)-beta-linkages between N-acetylmuramic acid and N-acetyl-D-glucosamine residues in a peptidoglycan and between N-acetyl-D-glucosamine residues in chitodextrins.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei53PROSITE-ProRule annotation1
Active sitei71PROSITE-ProRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionAntimicrobial, Bacteriolytic enzyme, Glycosidase, Hydrolase

Enzyme and pathway databases

BRENDAi3.2.1.17 908
ReactomeiR-BTA-6798695 Neutrophil degranulation
R-BTA-6803157 Antimicrobial peptides

Protein family/group databases

CAZyiGH22 Glycoside Hydrolase Family 22

Names & Taxonomyi

Protein namesi
Recommended name:
Lysozyme C, non-stomach isozyme (EC:3.2.1.17)
Alternative name(s):
1,4-beta-N-acetylmuramidase C
Gene namesi
Name:LYS
Synonyms:LZ
OrganismiBos taurus (Bovine)
Taxonomic identifieri9913 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
Proteomesi
  • UP000009136 Componenti: Chromosome 5

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 18Sequence analysisAdd BLAST18
ChainiPRO_000001845819 – 148Lysozyme C, non-stomach isozymeAdd BLAST130

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi24 ↔ 146PROSITE-ProRule annotation
Disulfide bondi48 ↔ 134PROSITE-ProRule annotation
Disulfide bondi83 ↔ 99PROSITE-ProRule annotation
Disulfide bondi95 ↔ 113PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bond

Proteomic databases

PaxDbiP80189
PeptideAtlasiP80189
PRIDEiP80189

Expressioni

Tissue specificityi

Expressed in blood cells.

Gene expression databases

BgeeiENSBTAG00000026779
ExpressionAtlasiP80189 baseline and differential

Interactioni

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000038081

Structurei

3D structure databases

ProteinModelPortaliP80189
SMRiP80189
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the glycosyl hydrolase 22 family.PROSITE-ProRule annotation

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG410IXGD Eukaryota
ENOG4111QHM LUCA
GeneTreeiENSGT00550000074398
HOGENOMiHOG000037357
HOVERGENiHBG052297
InParanoidiP80189
KOiK13915
OMAiKWESNYN
OrthoDBiEOG091G0R9V
TreeFamiTF324882

Family and domain databases

CDDicd00119 LYZ1, 1 hit
InterProiView protein in InterPro
IPR001916 Glyco_hydro_22
IPR019799 Glyco_hydro_22_CS
IPR000974 Glyco_hydro_22_lys
IPR023346 Lysozyme-like_dom_sf
IPR030056 Lysozyme_C
PANTHERiPTHR11407:SF28 PTHR11407:SF28, 1 hit
PfamiView protein in Pfam
PF00062 Lys, 1 hit
PRINTSiPR00137 LYSOZYME
PR00135 LYZLACT
SMARTiView protein in SMART
SM00263 LYZ1, 1 hit
SUPFAMiSSF53955 SSF53955, 1 hit
PROSITEiView protein in PROSITE
PS00128 LACTALBUMIN_LYSOZYME_1, 1 hit
PS51348 LACTALBUMIN_LYSOZYME_2, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P80189-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKALLILGLL LFSVAVQGKV FERCELARSL KRFGMDNFRG ISLANWMCLA
60 70 80 90 100
RWESNYNTQA TNYNAGDQST DYGIFQINSH WWCNDGKTPG AVNACHLPCG
110 120 130 140
ALLQDDITQA VACAKRVVSD PQGIRAWVAW RSHCQNQDLT SYIQGCGV
Length:148
Mass (Da):16,476
Last modified:January 4, 2005 - v4
Checksum:i707A79AA7FDA4FAC
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti114A → T (PubMed:8921904).Curated1
Sequence conflicti114A → T (PubMed:7894180).Curated1
Sequence conflicti117V → D (PubMed:8921904).Curated1
Sequence conflicti117V → D (PubMed:7894180).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L23757 mRNA No translation available.
U25810 Genomic DNA Translation: AAC48683.1
BC112597 mRNA Translation: AAI12598.1
L19980 mRNA Translation: AAA99863.1
PIRiC49315
RefSeqiNP_001071627.1, NM_001078159.1
UniGeneiBt.64645

Genome annotation databases

EnsembliENSBTAT00000038266; ENSBTAP00000038081; ENSBTAG00000026779
GeneIDi777776
KEGGibta:777776

Similar proteinsi

Entry informationi

Entry nameiLYSCN_BOVIN
AccessioniPrimary (citable) accession number: P80189
Secondary accession number(s): Q29447, Q2KIL2
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 1, 1993
Last sequence update: January 4, 2005
Last modified: March 28, 2018
This is version 133 of the entry and version 4 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
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Main funding by: National Institutes of Health