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P80188

- NGAL_HUMAN

UniProt

P80188 - NGAL_HUMAN

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Protein

Neutrophil gelatinase-associated lipocalin

Gene
LCN2, HNL, NGAL
Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at protein leveli

Functioni

Iron-trafficking protein involved in multiple processes such as apoptosis, innate immunity and renal development. Binds iron through association with 2,5-dihydroxybenzoic acid (2,5-DHBA), a siderophore that shares structural similarities with bacterial enterobactin, and delivers or removes iron from the cell, depending on the context. Iron-bound form (holo-24p3) is internalized following binding to the SLC22A17 (24p3R) receptor, leading to release of iron and subsequent increase of intracellular iron concentration. In contrast, association of the iron-free form (apo-24p3) with the SLC22A17 (24p3R) receptor is followed by association with an intracellular siderophore, iron chelation and iron transfer to the extracellular medium, thereby reducing intracellular iron concentration. Involved in apoptosis due to interleukin-3 (IL3) deprivation: iron-loaded form increases intracellular iron concentration without promoting apoptosis, while iron-free form decreases intracellular iron levels, inducing expression of the proapoptotic protein BCL2L11/BIM, resulting in apoptosis. Involved in innate immunity, possibly by sequestrating iron, leading to limit bacterial growth.1 Publication

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei126 – 1261Catecholate-type ferric siderophore
Binding sitei145 – 1451Catecholate-type ferric siderophore
Binding sitei154 – 1541Catecholate-type ferric siderophore

GO - Molecular functioni

  1. iron ion binding Source: UniProtKB
  2. small molecule binding Source: InterPro
  3. transporter activity Source: InterPro

GO - Biological processi

  1. cellular response to hydrogen peroxide Source: Ensembl
  2. cellular response to interleukin-1 Source: Ensembl
  3. cellular response to lipopolysaccharide Source: Ensembl
  4. cellular response to nutrient levels Source: Ensembl
  5. cellular response to tumor necrosis factor Source: Ensembl
  6. extrinsic apoptotic signaling pathway in absence of ligand Source: Ensembl
  7. innate immune response Source: UniProtKB
  8. ion transport Source: UniProtKB-KW
  9. positive regulation of cell projection organization Source: Ensembl
  10. positive regulation of gene expression Source: Ensembl
  11. protein homotrimerization Source: Ensembl
  12. response to drug Source: Ensembl
  13. response to herbicide Source: Ensembl
  14. response to virus Source: Ensembl
  15. siderophore transport Source: UniProtKB
Complete GO annotation...

Keywords - Biological processi

Apoptosis, Immunity, Innate immunity, Ion transport, Iron transport, Transport

Keywords - Ligandi

Iron

Names & Taxonomyi

Protein namesi
Recommended name:
Neutrophil gelatinase-associated lipocalin
Short name:
NGAL
Alternative name(s):
25 kDa alpha-2-microglobulin-related subunit of MMP-9
Lipocalin-2
Oncogene 24p3
Siderocalin LCN2
p25
Gene namesi
Name:LCN2
Synonyms:HNL, NGAL
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 9

Organism-specific databases

HGNCiHGNC:6526. LCN2.

Subcellular locationi

Secreted
Note: Upon binding to the SLC22A17 (24p3R) receptor, it is internalized.1 Publication

GO - Cellular componenti

  1. cytosol Source: Ensembl
  2. extracellular region Source: UniProtKB
  3. extracellular space Source: UniProt
  4. extracellular vesicular exosome Source: UniProt
Complete GO annotation...

Keywords - Cellular componenti

Secreted

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA30309.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 20201 PublicationAdd
BLAST
Chaini21 – 198178Neutrophil gelatinase-associated lipocalinPRO_0000017933Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei21 – 211Pyrrolidone carboxylic acid1 Publication
Glycosylationi85 – 851N-linked (GlcNAc...)5 Publications
Disulfide bondi96 ↔ 195

Keywords - PTMi

Disulfide bond, Glycoprotein, Pyrrolidone carboxylic acid

Proteomic databases

MaxQBiP80188.
PaxDbiP80188.
PRIDEiP80188.

PTM databases

PhosphoSiteiP80188.

Expressioni

Tissue specificityi

Expressed in bone marrow and in tissues that are prone to exposure to microorganism. High expression is found in bone marrow as well as in uterus, prostate, salivary gland, stomach, appendix, colon, trachea and lung. Not found in the small intestine or peripheral blood leukocytes.1 Publication

Inductioni

Expression is activated by the oncoprotein BCR-ABL; BCR-ABL misregulates expression via the JAK/STAT pathway and binding of STAT5A to the promoter.1 Publication

Gene expression databases

BgeeiP80188.
CleanExiHS_LCN2.
GenevestigatoriP80188.

Organism-specific databases

HPAiCAB016549.
CAB016550.
HPA002695.

Interactioni

Subunit structurei

Homodimer; disulfide-linked. Heterodimer; disulfide-linked with MMP9.1 Publication

Protein-protein interaction databases

BioGridi110126. 2 interactions.
DIPiDIP-29952N.
STRINGi9606.ENSP00000277480.

Structurei

Secondary structure

1
198
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Helixi33 – 353
Helixi44 – 474
Beta strandi49 – 6012
Helixi66 – 694
Beta strandi73 – 786
Turni80 – 823
Beta strandi84 – 929
Beta strandi95 – 10511
Beta strandi111 – 1144
Helixi117 – 1193
Beta strandi123 – 13311
Beta strandi135 – 14713
Beta strandi150 – 16213
Helixi166 – 17813
Helixi183 – 1853
Turni194 – 1963

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1DFVX-ray2.60A/B21-197[»]
1L6MX-ray2.40A/B/C21-198[»]
1NGLNMR-A21-198[»]
1QQSX-ray2.40A24-197[»]
1X71X-ray2.10A/B/C21-198[»]
1X89X-ray2.10A/B/C21-198[»]
1X8UX-ray2.20A/B/C21-198[»]
3BY0X-ray2.57A/B/C1-198[»]
3CBCX-ray2.17A/B/C1-198[»]
3CMPX-ray2.80A/B/C1-198[»]
3DSZX-ray2.00A/B21-198[»]
3DTQX-ray2.50A/B/C21-198[»]
3FW4X-ray2.30A/B/C21-198[»]
3FW5X-ray2.30A/B/C21-198[»]
3HWDX-ray2.95A/B/C1-198[»]
3HWEX-ray2.80A/B/C1-198[»]
3HWFX-ray3.20A/B/C1-198[»]
3HWGX-ray2.19A/B/C1-198[»]
3I0AX-ray2.60A/B/C1-198[»]
3K3LX-ray2.62A/B/C21-198[»]
3PECX-ray2.19A/B/C21-198[»]
3PEDX-ray2.30A/B/C21-198[»]
3T1DX-ray2.30A/B/C1-198[»]
3TF6X-ray2.35A/B/C21-198[»]
3TZSX-ray2.45A/B/C21-198[»]
3U03X-ray2.40A/C1-198[»]
3U0DX-ray2.51A/B/C/D1-198[»]
4GH7X-ray2.60A/C21-198[»]
4IAWX-ray2.40A/B/C21-198[»]
4IAXX-ray1.90A21-198[»]
4K19X-ray2.74A/B/C21-198[»]
ProteinModelPortaliP80188.
SMRiP80188. Positions 24-197.

Miscellaneous databases

EvolutionaryTraceiP80188.

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiNOG40148.
HOVERGENiHBG106490.
OrthoDBiEOG78M03G.
PhylomeDBiP80188.
TreeFamiTF336103.

Family and domain databases

Gene3Di2.40.128.20. 1 hit.
InterProiIPR012674. Calycin.
IPR011038. Calycin-like.
IPR002345. Lipocalin.
IPR022272. Lipocalin_CS.
IPR000566. Lipocln_cytosolic_FA-bd_dom.
IPR003087. N_gelatinase.
[Graphical view]
PfamiPF00061. Lipocalin. 1 hit.
[Graphical view]
PRINTSiPR00179. LIPOCALIN.
PR01275. NGELATINASE.
SUPFAMiSSF50814. SSF50814. 1 hit.
PROSITEiPS00213. LIPOCALIN. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by alternative splicing. Align

Isoform 1 (identifier: P80188-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

MPLGLLWLGL ALLGALHAQA QDSTSDLIPA PPLSKVPLQQ NFQDNQFQGK    50
WYVVGLAGNA ILREDKDPQK MYATIYELKE DKSYNVTSVL FRKKKCDYWI 100
RTFVPGCQPG EFTLGNIKSY PGLTSYLVRV VSTNYNQHAM VFFKKVSQNR 150
EYFKITLYGR TKELTSELKE NFIRFSKSLG LPENHIVFPV PIDQCIDG 198
Length:198
Mass (Da):22,588
Last modified:November 1, 1995 - v2
Checksum:iCD761805723FEF1E
GO
Isoform 2 (identifier: P80188-2) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     193-198: DQCIDG → GNGQSG

Show »
Length:198
Mass (Da):22,457
Checksum:iCD691E83A0AD3F1E
GO

Sequence cautioni

The sequence CAI13824.1 differs from that shown. Reason: Erroneous gene model prediction.

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei193 – 1986DQCIDG → GNGQSG in isoform 2. VSP_039780

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti9 – 91G → R in BAG63166. 1 Publication
Sequence conflicti13 – 131L → S in CAG46889. 1 Publication
Sequence conflicti82 – 821K → N AA sequence 1 Publication
Sequence conflicti155 – 1551I → V AA sequence 1 Publication
Sequence conflicti178 – 1781S → Y in CAA67574. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
X83006 mRNA. Translation: CAA58127.1.
X99133 Genomic DNA. Translation: CAA67574.1.
AK301694 mRNA. Translation: BAG63166.1.
AK316217 mRNA. Translation: BAH14588.1.
CR542092 mRNA. Translation: CAG46889.1.
AL590708 Genomic DNA. Translation: CAI13823.1.
AL590708 Genomic DNA. Translation: CAI13824.1. Sequence problems.
CH471090 Genomic DNA. Translation: EAW87750.1.
BC033089 mRNA. Translation: AAH33089.1.
S75256 mRNA. Translation: AAD14168.1.
CCDSiCCDS6892.1. [P80188-1]
PIRiJC2339.
RefSeqiNP_005555.2. NM_005564.3. [P80188-1]
UniGeneiHs.204238.

Genome annotation databases

EnsembliENST00000277480; ENSP00000277480; ENSG00000148346. [P80188-1]
ENST00000373017; ENSP00000362108; ENSG00000148346. [P80188-1]
ENST00000540948; ENSP00000441666; ENSG00000148346. [P80188-2]
GeneIDi3934.
KEGGihsa:3934.
UCSCiuc004bto.1. human. [P80188-1]
uc011map.1. human. [P80188-2]

Polymorphism databases

DMDMi1171700.

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
X83006 mRNA. Translation: CAA58127.1 .
X99133 Genomic DNA. Translation: CAA67574.1 .
AK301694 mRNA. Translation: BAG63166.1 .
AK316217 mRNA. Translation: BAH14588.1 .
CR542092 mRNA. Translation: CAG46889.1 .
AL590708 Genomic DNA. Translation: CAI13823.1 .
AL590708 Genomic DNA. Translation: CAI13824.1 . Sequence problems.
CH471090 Genomic DNA. Translation: EAW87750.1 .
BC033089 mRNA. Translation: AAH33089.1 .
S75256 mRNA. Translation: AAD14168.1 .
CCDSi CCDS6892.1. [P80188-1 ]
PIRi JC2339.
RefSeqi NP_005555.2. NM_005564.3. [P80188-1 ]
UniGenei Hs.204238.

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
Entry Method Resolution (Å) Chain Positions PDBsum
1DFV X-ray 2.60 A/B 21-197 [» ]
1L6M X-ray 2.40 A/B/C 21-198 [» ]
1NGL NMR - A 21-198 [» ]
1QQS X-ray 2.40 A 24-197 [» ]
1X71 X-ray 2.10 A/B/C 21-198 [» ]
1X89 X-ray 2.10 A/B/C 21-198 [» ]
1X8U X-ray 2.20 A/B/C 21-198 [» ]
3BY0 X-ray 2.57 A/B/C 1-198 [» ]
3CBC X-ray 2.17 A/B/C 1-198 [» ]
3CMP X-ray 2.80 A/B/C 1-198 [» ]
3DSZ X-ray 2.00 A/B 21-198 [» ]
3DTQ X-ray 2.50 A/B/C 21-198 [» ]
3FW4 X-ray 2.30 A/B/C 21-198 [» ]
3FW5 X-ray 2.30 A/B/C 21-198 [» ]
3HWD X-ray 2.95 A/B/C 1-198 [» ]
3HWE X-ray 2.80 A/B/C 1-198 [» ]
3HWF X-ray 3.20 A/B/C 1-198 [» ]
3HWG X-ray 2.19 A/B/C 1-198 [» ]
3I0A X-ray 2.60 A/B/C 1-198 [» ]
3K3L X-ray 2.62 A/B/C 21-198 [» ]
3PEC X-ray 2.19 A/B/C 21-198 [» ]
3PED X-ray 2.30 A/B/C 21-198 [» ]
3T1D X-ray 2.30 A/B/C 1-198 [» ]
3TF6 X-ray 2.35 A/B/C 21-198 [» ]
3TZS X-ray 2.45 A/B/C 21-198 [» ]
3U03 X-ray 2.40 A/C 1-198 [» ]
3U0D X-ray 2.51 A/B/C/D 1-198 [» ]
4GH7 X-ray 2.60 A/C 21-198 [» ]
4IAW X-ray 2.40 A/B/C 21-198 [» ]
4IAX X-ray 1.90 A 21-198 [» ]
4K19 X-ray 2.74 A/B/C 21-198 [» ]
ProteinModelPortali P80188.
SMRi P80188. Positions 24-197.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 110126. 2 interactions.
DIPi DIP-29952N.
STRINGi 9606.ENSP00000277480.

PTM databases

PhosphoSitei P80188.

Polymorphism databases

DMDMi 1171700.

Proteomic databases

MaxQBi P80188.
PaxDbi P80188.
PRIDEi P80188.

Protocols and materials databases

DNASUi 3934.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000277480 ; ENSP00000277480 ; ENSG00000148346 . [P80188-1 ]
ENST00000373017 ; ENSP00000362108 ; ENSG00000148346 . [P80188-1 ]
ENST00000540948 ; ENSP00000441666 ; ENSG00000148346 . [P80188-2 ]
GeneIDi 3934.
KEGGi hsa:3934.
UCSCi uc004bto.1. human. [P80188-1 ]
uc011map.1. human. [P80188-2 ]

Organism-specific databases

CTDi 3934.
GeneCardsi GC09P130911.
HGNCi HGNC:6526. LCN2.
HPAi CAB016549.
CAB016550.
HPA002695.
MIMi 600181. gene.
neXtProti NX_P80188.
PharmGKBi PA30309.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG40148.
HOVERGENi HBG106490.
OrthoDBi EOG78M03G.
PhylomeDBi P80188.
TreeFami TF336103.

Miscellaneous databases

ChiTaRSi LCN2. human.
EvolutionaryTracei P80188.
GeneWikii LCN2.
GenomeRNAii 3934.
NextBioi 15451.
PROi P80188.
SOURCEi Search...

Gene expression databases

Bgeei P80188.
CleanExi HS_LCN2.
Genevestigatori P80188.

Family and domain databases

Gene3Di 2.40.128.20. 1 hit.
InterProi IPR012674. Calycin.
IPR011038. Calycin-like.
IPR002345. Lipocalin.
IPR022272. Lipocalin_CS.
IPR000566. Lipocln_cytosolic_FA-bd_dom.
IPR003087. N_gelatinase.
[Graphical view ]
Pfami PF00061. Lipocalin. 1 hit.
[Graphical view ]
PRINTSi PR00179. LIPOCALIN.
PR01275. NGELATINASE.
SUPFAMi SSF50814. SSF50814. 1 hit.
PROSITEi PS00213. LIPOCALIN. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Molecular cloning and expression of a cDNA encoding NGAL: a lipocalin expressed in human neutrophils."
    Bundgaard J.R., Sengelov H., Borregaard N., Kjeldsen L.
    Biochem. Biophys. Res. Commun. 202:1468-1475(1994) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
  2. "Molecular characterization and pattern of tissue expression of the gene for neutrophil gelatinase-associated lipocalin from humans."
    Cowland J.B., Borregaard N.
    Genomics 45:17-23(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], TISSUE SPECIFICITY.
    Tissue: Bone marrow.
  3. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
    Tissue: Esophagus.
  4. "Cloning of human full open reading frames in Gateway(TM) system entry vector (pDONR201)."
    Ebert L., Schick M., Neubert P., Schatten R., Henze S., Korn B.
    Submitted (JUN-2004) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
  5. "DNA sequence and analysis of human chromosome 9."
    Humphray S.J., Oliver K., Hunt A.R., Plumb R.W., Loveland J.E., Howe K.L., Andrews T.D., Searle S., Hunt S.E., Scott C.E., Jones M.C., Ainscough R., Almeida J.P., Ambrose K.D., Ashwell R.I.S., Babbage A.K., Babbage S., Bagguley C.L.
    , Bailey J., Banerjee R., Barker D.J., Barlow K.F., Bates K., Beasley H., Beasley O., Bird C.P., Bray-Allen S., Brown A.J., Brown J.Y., Burford D., Burrill W., Burton J., Carder C., Carter N.P., Chapman J.C., Chen Y., Clarke G., Clark S.Y., Clee C.M., Clegg S., Collier R.E., Corby N., Crosier M., Cummings A.T., Davies J., Dhami P., Dunn M., Dutta I., Dyer L.W., Earthrowl M.E., Faulkner L., Fleming C.J., Frankish A., Frankland J.A., French L., Fricker D.G., Garner P., Garnett J., Ghori J., Gilbert J.G.R., Glison C., Grafham D.V., Gribble S., Griffiths C., Griffiths-Jones S., Grocock R., Guy J., Hall R.E., Hammond S., Harley J.L., Harrison E.S.I., Hart E.A., Heath P.D., Henderson C.D., Hopkins B.L., Howard P.J., Howden P.J., Huckle E., Johnson C., Johnson D., Joy A.A., Kay M., Keenan S., Kershaw J.K., Kimberley A.M., King A., Knights A., Laird G.K., Langford C., Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C., Lloyd D.M., Lovell J., Martin S., Mashreghi-Mohammadi M., Matthews L., McLaren S., McLay K.E., McMurray A., Milne S., Nickerson T., Nisbett J., Nordsiek G., Pearce A.V., Peck A.I., Porter K.M., Pandian R., Pelan S., Phillimore B., Povey S., Ramsey Y., Rand V., Scharfe M., Sehra H.K., Shownkeen R., Sims S.K., Skuce C.D., Smith M., Steward C.A., Swarbreck D., Sycamore N., Tester J., Thorpe A., Tracey A., Tromans A., Thomas D.W., Wall M., Wallis J.M., West A.P., Whitehead S.L., Willey D.L., Williams S.A., Wilming L., Wray P.W., Young L., Ashurst J.L., Coulson A., Blocker H., Durbin R.M., Sulston J.E., Hubbard T., Jackson M.J., Bentley D.R., Beck S., Rogers J., Dunham I.
    Nature 429:369-374(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  6. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  7. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    Tissue: Pancreas.
  8. "Cloning and expression of human neutrophil lipocalin cDNA derived from bone marrow and ovarian cancer cells."
    Bartsch S., Tschesche H.
    FEBS Lett. 357:255-259(1995) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 21-198, PARTIAL PROTEIN SEQUENCE.
  9. "Isolation and primary structure of NGAL, a novel protein associated with human neutrophil gelatinase."
    Kjeldsen L., Johnsen A.H., Sengelov H., Borregaard N.
    J. Biol. Chem. 268:10425-10432(1993) [PubMed] [Europe PMC] [Abstract]
    Cited for: PROTEIN SEQUENCE OF 21-198, PYROGLUTAMATE FORMATION AT GLN-21.
    Tissue: Neutrophil.
  10. "A 25 kDa alpha 2-microglobulin-related protein is a component of the 125 kDa form of human gelatinase."
    Triebel S., Blaeser J., Reinke H., Tschesche H.
    FEBS Lett. 314:386-388(1992) [PubMed] [Europe PMC] [Abstract]
    Cited for: PROTEIN SEQUENCE OF 51-61; 71-90; 132-136; 152-160 AND 178-192.
    Tissue: Neutrophil.
  11. Cited for: FUNCTION, IRON-BINDING, SIDEROPHORE-BINDING, SUBCELLULAR LOCATION.
  12. Cited for: GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-85.
    Tissue: Bile.
  13. "Human plasma N-glycoproteome analysis by immunoaffinity subtraction, hydrazide chemistry, and mass spectrometry."
    Liu T., Qian W.-J., Gritsenko M.A., Camp D.G. II, Monroe M.E., Moore R.J., Smith R.D.
    J. Proteome Res. 4:2070-2080(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-85.
    Tissue: Plasma.
  14. "Identification of N-linked glycoproteins in human saliva by glycoprotein capture and mass spectrometry."
    Ramachandran P., Boontheung P., Xie Y., Sondej M., Wong D.T., Loo J.A.
    J. Proteome Res. 5:1493-1503(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-85.
    Tissue: Saliva.
  15. "Transcription and signalling pathways involved in BCR-ABL-mediated misregulation of 24p3 and 24p3R."
    Sheng Z., Wang S.Z., Green M.R.
    EMBO J. 28:866-876(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: INDUCTION.
  16. "Glycoproteomics analysis of human liver tissue by combination of multiple enzyme digestion and hydrazide chemistry."
    Chen R., Jiang X., Sun D., Han G., Wang F., Ye M., Wang L., Zou H.
    J. Proteome Res. 8:651-661(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-85.
    Tissue: Liver.
  17. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  18. "Ligand preference inferred from the structure of neutrophil gelatinase associated lipocalin."
    Goetz D.H., Willie S.T., Armen R.S., Bratt T., Borregaard N., Strong R.K.
    Biochemistry 39:1935-1941(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (2.6 ANGSTROMS) OF 21-298.
  19. "The solution structure and dynamics of human neutrophil gelatinase-associated lipocalin."
    Coles M., Diercks T., Muehlenweg B., Bartsch S., Zolzer V., Tschesche H., Kessler H.
    J. Mol. Biol. 289:139-157(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: STRUCTURE BY NMR OF 21-198.
  20. "The neutrophil lipocalin NGAL is a bacteriostatic agent that interferes with siderophore-mediated iron acquisition."
    Goetz D.H., Holmes M.A., Borregaard N., Bluhm M.E., Raymond K.N., Strong R.K.
    Mol. Cell 10:1033-1043(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (2.4 ANGSTROMS) OF 21-198 IN COMPLEX WITH SIDEROPHORE AND IRON, SUBUNIT.

Entry informationi

Entry nameiNGAL_HUMAN
AccessioniPrimary (citable) accession number: P80188
Secondary accession number(s): A6NII8
, B4DWV4, B7ZAA2, P30150, Q5SYV9, Q5SYW0, Q6FGL5, Q92683
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 1, 1993
Last sequence update: November 1, 1995
Last modified: July 9, 2014
This is version 152 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Human chromosome 9
    Human chromosome 9: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  4. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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