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P80176

- HIP_THETI

UniProt

P80176 - HIP_THETI

Protein

High-potential iron-sulfur protein

Gene

hip

Organism
Thermochromatium tepidum (Chromatium tepidum)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at protein leveli
  1. Functioni

    Specific class of high-redox-potential 4Fe-4S ferredoxins. Functions in anaerobic electron transport in most purple and in some other photosynthetic bacteria and in at least one genus (Paracoccus) of halophilic, denitrifying bacteria.

    Redox potential

    E0 is +323 mV.

    Temperature dependencei

    Thermostable.

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Metal bindingi43 – 431Iron-sulfur (4Fe-4S)
    Metal bindingi46 – 461Iron-sulfur (4Fe-4S)
    Metal bindingi61 – 611Iron-sulfur (4Fe-4S)
    Metal bindingi75 – 751Iron-sulfur (4Fe-4S)

    GO - Molecular functioni

    1. 4 iron, 4 sulfur cluster binding Source: UniProtKB-KW
    2. electron carrier activity Source: InterPro
    3. metal ion binding Source: UniProtKB-KW

    GO - Biological processi

    1. aerobic electron transport chain Source: InterPro

    Keywords - Biological processi

    Electron transport, Transport

    Keywords - Ligandi

    4Fe-4S, Iron, Iron-sulfur, Metal-binding

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    High-potential iron-sulfur protein
    Short name:
    HiPIP
    Gene namesi
    Name:hip
    OrganismiThermochromatium tepidum (Chromatium tepidum)
    Taxonomic identifieri1050 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaChromatialesChromatiaceaeThermochromatium

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 8383High-potential iron-sulfur proteinPRO_0000220429Add
    BLAST

    Interactioni

    Subunit structurei

    Homodimer.Curated

    Structurei

    Secondary structure

    1
    83
    Legend: HelixTurnBeta strand
    Show more details
    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Helixi12 – 176
    Beta strandi20 – 223
    Helixi23 – 253
    Helixi28 – 314
    Helixi38 – 403
    Helixi43 – 453
    Beta strandi49 – 557
    Beta strandi58 – 614
    Beta strandi68 – 703

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    EntryMethodResolution (Å)ChainPositionsPDBsum
    1EYTX-ray1.50A1-83[»]
    1IUAX-ray0.80A1-83[»]
    2AMSX-ray1.40A1-83[»]
    2FLAX-ray0.95A1-83[»]
    3A38X-ray0.70A1-83[»]
    3A39X-ray0.72A1-83[»]
    ProteinModelPortaliP80176.
    SMRiP80176. Positions 1-83.
    ModBaseiSearch...
    MobiDBiSearch...

    Miscellaneous databases

    EvolutionaryTraceiP80176.

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the high-potential iron-sulfur protein (HiPIP) family.PROSITE-ProRule annotation

    Family and domain databases

    Gene3Di4.10.490.10. 1 hit.
    InterProiIPR000170. High_potential_FeS_prot.
    [Graphical view]
    PfamiPF01355. HIPIP. 1 hit.
    [Graphical view]
    SUPFAMiSSF57652. SSF57652. 1 hit.
    PROSITEiPS51373. HIPIP. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    P80176-1 [UniParc]FASTAAdd to Basket

    « Hide

    AAPANAVTAD DPTAIALKYN QDATKSERVA AARPGLPPEE QHCANCQFMQ   50
    ANVGEGDWKG CQLFPGKLIN VNGWCASWTL KAG 83
    Length:83
    Mass (Da):8,786
    Last modified:October 1, 1993 - v1
    Checksum:i92116E4FD2C44E0A
    GO

    Sequence databases

    PIRiS35586.

    Cross-referencesi

    Sequence databases

    PIRi S35586.

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    Entry Method Resolution (Å) Chain Positions PDBsum
    1EYT X-ray 1.50 A 1-83 [» ]
    1IUA X-ray 0.80 A 1-83 [» ]
    2AMS X-ray 1.40 A 1-83 [» ]
    2FLA X-ray 0.95 A 1-83 [» ]
    3A38 X-ray 0.70 A 1-83 [» ]
    3A39 X-ray 0.72 A 1-83 [» ]
    ProteinModelPortali P80176.
    SMRi P80176. Positions 1-83.
    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Miscellaneous databases

    EvolutionaryTracei P80176.

    Family and domain databases

    Gene3Di 4.10.490.10. 1 hit.
    InterProi IPR000170. High_potential_FeS_prot.
    [Graphical view ]
    Pfami PF01355. HIPIP. 1 hit.
    [Graphical view ]
    SUPFAMi SSF57652. SSF57652. 1 hit.
    PROSITEi PS51373. HIPIP. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Primary structure of Chromatium tepidum high-potential iron-sulfur protein in relation to thermal denaturation."
      Moulis J.-M., Scherrer N., Gagnon J., Forest E., Petillot Y., Garcia D.
      Arch. Biochem. Biophys. 305:186-192(1993) [PubMed] [Europe PMC] [Abstract]
      Cited for: PROTEIN SEQUENCE.
      Strain: ATCC 43061 / DSM 3771 / MC.
    2. "Crystal structures of photosynthetic reaction center and high-potential iron-sulfur protein from Thermochromatium tepidum: thermostability and electron transfer."
      Nogi T., Fathir I., Kobayashi M., Nozawa T., Miki K.
      Proc. Natl. Acad. Sci. U.S.A. 97:13561-13566(2000) [PubMed] [Europe PMC] [Abstract]
      Cited for: X-RAY CRYSTALLOGRAPHY (1.5 ANGSTROMS).
    3. "Ultrahigh-resolution structure of high-potential iron-sulfur protein from Thermochromatium tepidum."
      Liu L., Nogi T., Kobayashi M., Nozawa T., Miki K.
      Acta Crystallogr. D 58:1085-1091(2002) [PubMed] [Europe PMC] [Abstract]
      Cited for: X-RAY CRYSTALLOGRAPHY (0.8 ANGSTROMS).

    Entry informationi

    Entry nameiHIP_THETI
    AccessioniPrimary (citable) accession number: P80176
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: October 1, 1993
    Last sequence update: October 1, 1993
    Last modified: October 1, 2014
    This is version 77 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    3D-structure, Direct protein sequencing

    Documents

    1. PDB cross-references
      Index of Protein Data Bank (PDB) cross-references
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3