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P80174 (SODC_CARCR) Reviewed, UniProtKB/Swiss-Prot

Last modified April 3, 2013. Version 80. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Superoxide dismutase [Cu-Zn]
EC=1.15.1.1
OrganismCaretta caretta (Loggerhead sea turtle)
Taxonomic identifier8467 [NCBI]
Taxonomic lineageEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Testudines › Cryptodira › Chelonioidea › Cheloniidae › Caretta

Protein attributes

Sequence length167 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Destroys radicals which are normally produced within the cells and which are toxic to biological systems.

Catalytic activity

2 superoxide + 2 H+ = O2 + H2O2.

Cofactor

Binds 1 copper ion per subunit By similarity.

Binds 1 zinc ion per subunit By similarity.

Subunit structure

Homodimer.

Subcellular location

Cytoplasm.

Sequence similarities

Belongs to the Cu-Zn superoxide dismutase family.

Ontologies

Keywords
   Cellular componentCytoplasm
   DomainRepeat
   LigandCopper
Metal-binding
Zinc
   Molecular functionAntioxidant
Oxidoreductase
   PTMDisulfide bond
   Technical termDirect protein sequencing
Gene Ontology (GO)
   Biological_processsuperoxide metabolic process

Inferred from electronic annotation. Source: InterPro

   Cellular_componentcytoplasm

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular_functionmetal ion binding

Inferred from electronic annotation. Source: UniProtKB-KW

superoxide dismutase activity

Inferred from electronic annotation. Source: EC

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Initiator methionine11Removed Ref.1
Chain2 – 167166Superoxide dismutase [Cu-Zn]
PRO_0000164070

Regions

Repeat15 – 184
Repeat19 – 224
Repeat23 – 264
Repeat27 – 304

Sites

Metal binding591Copper; catalytic By similarity
Metal binding611Copper; catalytic By similarity
Metal binding761Copper; catalytic By similarity
Metal binding761Zinc; structural By similarity
Metal binding841Zinc; structural By similarity
Metal binding931Zinc; structural By similarity
Metal binding961Zinc; structural By similarity
Metal binding1331Copper; catalytic By similarity

Amino acid modifications

Modified residue21Blocked amino end (Ala)
Disulfide bond70 ↔ 159 By similarity

Sequences

Sequence LengthMass (Da)Tools
P80174 [UniParc].

Last modified January 23, 2007. Version 2.
Checksum: F4F46538FAE69E8F

FASTA16717,277
        10         20         30         40         50         60 
MATVKAVCVL KGEDPVKEPV KGPVKEPVKG IIYFEQQGNG PVTLSGSITG LTEGKHGFHV 

        70         80         90        100        110        120 
HEFGDNTNGC TSAGAHFNPP GKNHGGPQDN ERHVGDLGNV IANKEGVAEV CIKDSLISLT 

       130        140        150        160 
GSQSIIGRTM VVHEKEDDLG KGGNDESLKT GNAGSRLACG VVGIAKL

« Hide

References

[1]"The primary structure of turtle Cu,Zn superoxide dismutase. Structural and functional irrelevance of an insert conferring proteolytic susceptibility."
Schinina M.E., Bossa F., Lania A., Capo C.R., Carlini P., Calabrese L.
Eur. J. Biochem. 211:843-849(1993) [PubMed] [Europe PMC] [Abstract]
Cited for: PROTEIN SEQUENCE OF 2-167.
Tissue: Liver.

Cross-references

Sequence databases

PIRS29782.

3D structure databases

ProteinModelPortalP80174.
SMRP80174. Positions 5-166.
ModBaseSearch...

Proteomic databases

PRIDEP80174.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Phylogenomic databases

HOVERGENHBG000062.

Family and domain databases

Gene3D2.60.40.200. 1 hit.
InterProIPR024134. SOD_Cu/Zn_/chaperones.
IPR018152. SOD_Cu/Zn_BS.
IPR001424. SOD_Cu_Zn_dom.
[Graphical view]
PANTHERPTHR10003. PTHR10003. 1 hit.
PfamPF00080. Sod_Cu. 1 hit.
[Graphical view]
PRINTSPR00068. CUZNDISMTASE.
SUPFAMSSF49329. SOD_Cu_Zn. 1 hit.
PROSITEPS00087. SOD_CU_ZN_1. 1 hit.
PS00332. SOD_CU_ZN_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameSODC_CARCR
AccessionPrimary (citable) accession number: P80174
Entry history
Integrated into UniProtKB/Swiss-Prot: April 1, 1993
Last sequence update: January 23, 2007
Last modified: April 3, 2013
This is version 80 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

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