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P80163 (SRTXB_ATRBI) Reviewed, UniProtKB/Swiss-Prot

Last modified June 26, 2013. Version 62. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein attributes

Sequence length21 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Vasoconstrictor activity. These toxins cause cardiac arrest probably as a result of coronary vasospasm. May act by displaying agonistic activities towards endothelin-1 and -2 receptors (EDNRA and EDNRB). Ref.1

Subcellular location

Secreted.

Tissue specificity

Expressed by the venom gland.

Sequence similarities

Belongs to the endothelin/sarafotoxin family.

Ontologies

Keywords
   Cellular componentSecreted
   Molecular functionCardiotoxin
G-protein coupled receptor impairing toxin
Toxin
Vasoactive
Vasoconstrictor
   PTMDisulfide bond
   Technical termDirect protein sequencing
Gene Ontology (GO)
   Biological_processregulation of vasoconstriction

Inferred from electronic annotation. Source: InterPro

vasoconstriction

Inferred from electronic annotation. Source: UniProtKB-KW

   Cellular_componentextracellular region

Inferred from electronic annotation. Source: UniProtKB-SubCell

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Peptide1 – 2121Bibrotoxin
PRO_0000043645

Sites

Site211Endothelin-receptor binding site By similarity

Amino acid modifications

Disulfide bond1 ↔ 15 By similarity
Disulfide bond3 ↔ 11 By similarity

Sequences

Sequence LengthMass (Da)Tools
P80163 [UniParc].

Last modified April 1, 1993. Version 1.
Checksum: 83A5DFB81D036AE2

FASTA212,511
        10         20 
CSCADMTDKE CLYFCHQDVI W 

« Hide

References

[1]"Bibrotoxin, a novel member of the endothelin/sarafotoxin peptide family, from the venom of the burrowing asp Atractaspis bibroni."
Becker A., Dowdle E.B., Hechler U., Kauser K., Donner P., Schleuning W.-D.
FEBS Lett. 315:100-103(1993) [PubMed] [Europe PMC] [Abstract]
Cited for: PROTEIN SEQUENCE, FUNCTION.
Tissue: Venom.

Cross-references

Sequence databases

PIRS27039.

3D structure databases

ModBaseSearch...
MobiDBSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Family and domain databases

InterProIPR019764. Endothelin_toxin_CS.
IPR001928. Endothln-like_toxin.
[Graphical view]
PfamPF00322. Endothelin. 1 hit.
[Graphical view]
SMARTSM00272. END. 1 hit.
[Graphical view]
PROSITEPS00270. ENDOTHELIN. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameSRTXB_ATRBI
AccessionPrimary (citable) accession number: P80163
Entry history
Integrated into UniProtKB/Swiss-Prot: April 1, 1993
Last sequence update: April 1, 1993
Last modified: June 26, 2013
This is version 62 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programAnimal Toxin Annotation Program
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families