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P80163

- SRTXB_ATRBI

UniProt

P80163 - SRTXB_ATRBI

Protein

Bibrotoxin

Gene
N/A
Organism
Atractaspis bibronii (Bibron's mole viper) (Southern stiletto snake)
Status
Reviewed - Annotation score: 2 out of 5- Experimental evidence at protein leveli
  1. Functioni

    Vasoconstrictor activity. These toxins cause cardiac arrest probably as a result of coronary vasospasm. May act by displaying agonistic activities towards endothelin-1 and -2 receptors (EDNRA and EDNRB).1 Publication

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sitei21 – 211Endothelin-receptor binding siteBy similarity

    GO - Biological processi

    1. regulation of vasoconstriction Source: InterPro
    2. vasoconstriction Source: UniProtKB-KW

    Keywords - Molecular functioni

    Cardiotoxin, G-protein coupled receptor impairing toxin, Toxin, Vasoactive, Vasoconstrictor

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Bibrotoxin
    Short name:
    BTX
    OrganismiAtractaspis bibronii (Bibron's mole viper) (Southern stiletto snake)
    Taxonomic identifieri61304 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiLepidosauriaSquamataBifurcataUnidentataEpisquamataToxicoferaSerpentesColubroideaAtractaspididaeAtractaspis

    Subcellular locationi

    GO - Cellular componenti

    1. extracellular region Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Secreted

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Peptidei1 – 2121BibrotoxinPRO_0000043645Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Disulfide bondi1 ↔ 15By similarity
    Disulfide bondi3 ↔ 11By similarity

    Keywords - PTMi

    Disulfide bond

    Expressioni

    Tissue specificityi

    Expressed by the venom gland.

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the endothelin/sarafotoxin family.Curated

    Family and domain databases

    InterProiIPR019764. Endothelin_toxin_CS.
    IPR001928. Endothln-like_toxin.
    [Graphical view]
    PfamiPF00322. Endothelin. 1 hit.
    [Graphical view]
    SMARTiSM00272. END. 1 hit.
    [Graphical view]
    PROSITEiPS00270. ENDOTHELIN. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    P80163-1 [UniParc]FASTAAdd to Basket

    « Hide

    CSCADMTDKE CLYFCHQDVI W                                  21
    Length:21
    Mass (Da):2,511
    Last modified:April 1, 1993 - v1
    Checksum:i83A5DFB81D036AE2
    GO

    Sequence databases

    PIRiS27039.

    Cross-referencesi

    Sequence databases

    PIRi S27039.

    3D structure databases

    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Family and domain databases

    InterProi IPR019764. Endothelin_toxin_CS.
    IPR001928. Endothln-like_toxin.
    [Graphical view ]
    Pfami PF00322. Endothelin. 1 hit.
    [Graphical view ]
    SMARTi SM00272. END. 1 hit.
    [Graphical view ]
    PROSITEi PS00270. ENDOTHELIN. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Bibrotoxin, a novel member of the endothelin/sarafotoxin peptide family, from the venom of the burrowing asp Atractaspis bibroni."
      Becker A., Dowdle E.B., Hechler U., Kauser K., Donner P., Schleuning W.-D.
      FEBS Lett. 315:100-103(1993) [PubMed] [Europe PMC] [Abstract]
      Cited for: PROTEIN SEQUENCE, FUNCTION.
      Tissue: Venom.

    Entry informationi

    Entry nameiSRTXB_ATRBI
    AccessioniPrimary (citable) accession number: P80163
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: April 1, 1993
    Last sequence update: April 1, 1993
    Last modified: October 1, 2014
    This is version 63 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programAnimal Toxin Annotation Program
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Direct protein sequencing

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3