P80162 (CXCL6_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
C-X-C motif chemokine 6

Alternative name(s):
Chemokine alpha 3
Short name=CKA-3
Granulocyte chemotactic protein 2
Short name=GCP-2
Small-inducible cytokine B6

Cleaved into the following 3 chains:

1. Small-inducible cytokine B6, N-processed variant 1
2. Small-inducible cytokine B6, N-processed variant 2
3. Small-inducible cytokine B6, N-processed variant 3

Gene names

Name:	CXCL6
Synonyms:	GCP2, SCYB6

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	114 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	Chemotactic for neutrophil granulocytes. Ref.6 Ref.7 Ref.8
Subcellular location	Secreted.
Sequence similarities	Belongs to the intercrine alpha (chemokine CxC) family.

Ontologies

Keywords
Biological process	Chemotaxis
Cellular component	Secreted
Domain	Signal
Ligand	Heparin-binding
Molecular function	Cytokine
PTM	Disulfide bond
Technical term	Complete proteome Direct protein sequencing Reference proteome
Gene Ontology (GO)
Biological_process	cell-cell signaling Traceable author statement Ref.1. Source: ProtInc chemotaxis Traceable author statement Ref.1. Source: ProtInc immune response Inferred from electronic annotation. Source: InterPro inflammatory response Traceable author statement Ref.7. Source: ProtInc signal transduction Traceable author statement Ref.1. Source: ProtInc
Cellular_component	extracellular region Traceable author statement. Source: Reactome extracellular space Inferred from electronic annotation. Source: UniProtKB-KW
Molecular_function	chemokine activity Traceable author statement Ref.7. Source: ProtInc heparin binding Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Signal peptide	1 – 37	37	Ref.7 Ref.8
	Chain	38 – 114	77	C-X-C motif chemokine 6		PRO_0000005084
	Chain	40 – 114	75	Small-inducible cytokine B6, N-processed variant 1		PRO_0000005085
	Chain	43 – 114	72	Small-inducible cytokine B6, N-processed variant 2		PRO_0000005086
	Chain	46 – 114	69	Small-inducible cytokine B6, N-processed variant 3		PRO_0000005087
Amino acid modifications
	Disulfide bond	49 ↔ 75		By similarity
	Disulfide bond	51 ↔ 91		By similarity

Sequences

	Sequence		Length	Mass (Da)
	P80162 [UniParc]. Last modified July 15, 1998. Version 4. Checksum: 5A58B38C17F25178	FASTA	114	11,897
	10 20 30 40 50 60 MSLPSSRAAR VPGPSGSLCA LLALLLLLTP PGPLASAGPV SAVLTELRCT CLRVTLRVNP 70 80 90 100 110 KTIGKLQVFP AGPQCSKVEV VASLKNGKQV CLDPEAPFLK KVIQKILDSG NKKN

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Cloning and characterization of the human granulocyte chemotactic protein-2 gene." Rovai L.E., Herschman H.R., Smith J.B. J. Immunol. 158:5257-5266(1997) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[2]	"Cloning, sequencing and biological characterization of a C-X-C chemokine, CKA-3." Ni J., Su J., Li H. Submitted (DEC-1996) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[3]	"Complete sequencing and characterization of 21,243 full-length human cDNAs." Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S. Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Spleen.
[4]	"Generation and annotation of the DNA sequences of human chromosomes 2 and 4." Hillier L.W., Graves T.A., Fulton R.S., Fulton L.A., Pepin K.H., Minx P., Wagner-McPherson C., Layman D., Wylie K., Sekhon M., Becker M.C., Fewell G.A., Delehaunty K.D., Miner T.L., Nash W.E., Kremitzki C., Oddy L., Du H. , Sun H., Bradshaw-Cordum H., Ali J., Carter J., Cordes M., Harris A., Isak A., van Brunt A., Nguyen C., Du F., Courtney L., Kalicki J., Ozersky P., Abbott S., Armstrong J., Belter E.A., Caruso L., Cedroni M., Cotton M., Davidson T., Desai A., Elliott G., Erb T., Fronick C., Gaige T., Haakenson W., Haglund K., Holmes A., Harkins R., Kim K., Kruchowski S.S., Strong C.M., Grewal N., Goyea E., Hou S., Levy A., Martinka S., Mead K., McLellan M.D., Meyer R., Randall-Maher J., Tomlinson C., Dauphin-Kohlberg S., Kozlowicz-Reilly A., Shah N., Swearengen-Shahid S., Snider J., Strong J.T., Thompson J., Yoakum M., Leonard S., Pearman C., Trani L., Radionenko M., Waligorski J.E., Wang C., Rock S.M., Tin-Wollam A.-M., Maupin R., Latreille P., Wendl M.C., Yang S.-P., Pohl C., Wallis J.W., Spieth J., Bieri T.A., Berkowicz N., Nelson J.O., Osborne J., Ding L., Meyer R., Sabo A., Shotland Y., Sinha P., Wohldmann P.E., Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Jones T.A., She X., Ciccarelli F.D., Izaurralde E., Taylor J., Schmutz J., Myers R.M., Cox D.R., Huang X., McPherson J.D., Mardis E.R., Clifton S.W., Warren W.C., Chinwalla A.T., Eddy S.R., Marra M.A., Ovcharenko I., Furey T.S., Miller W., Eichler E.E., Bork P., Suyama M., Torrents D., Waterston R.H., Wilson R.K. Nature 434:724-731(2005) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[5]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Liver.
[6]	"Cloning, bacterial expression and biological characterization of recombinant human granulocyte chemotactic protein-2 and differential expression of granulocyte chemotactic protein-2 and epithelial cell-derived neutrophil activating peptide-78 mRNAs." Froyen G., Proost P., Ronsse I., Mitera T., Haelens A., Wuyts A., Opdenakker G., van Damme J., Billiau A. Eur. J. Biochem. 243:762-769(1997) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 38-114, FUNCTION.
[7]	"Human and bovine granulocyte chemotactic protein-2: complete amino acid sequence and functional characterization as chemokines." Proost P., Wuyts A., Conings R., Lenaerts J.-P., Billiau A., Opdenakker G., van Damme J. Biochemistry 32:10170-10177(1993) [PubMed] [Europe PMC] [Abstract] Cited for: PROTEIN SEQUENCE OF 38-112, FUNCTION, PROTEOLYTIC PROCESSING OF N-TERMINAL. Tissue: Osteosarcoma.
[8]	"Identification of a novel granulocyte chemotactic protein (GCP-2) from human tumor cells. In vitro and in vivo comparison with natural forms of GRO, IP-10, and IL-8." Proost P., de Wolf-Peeters C., Conings R., Opdenakker G., Billiau A., van Damme J. J. Immunol. 150:1000-1010(1993) [PubMed] [Europe PMC] [Abstract] Cited for: PROTEIN SEQUENCE OF 38-57, FUNCTION. Tissue: Osteosarcoma.
+	Additional computationally mapped references.

Web resources

Wikipedia

CXCL6 entry

Cross-references

Sequence databases
EMBL GenBank DDBJ	U83303 Genomic DNA. Translation: AAC51338.1. U81234 mRNA. Translation: AAD00506.1. AK311981 mRNA. Translation: BAG34920.1. AC108029 Genomic DNA. Translation: AAY40939.1. BC013744 mRNA. Translation: AAH13744.1. Y08770 mRNA. Translation: CAA70023.1.
IPI	IPI00008079.
PIR	A54188.
RefSeq	NP_002984.1. NM_002993.3.
UniGene	Hs.164021.
3D structure databases
ProteinModelPortal	P80162.
ModBase	Search...
Protein-protein interaction databases
STRING	9606.ENSP00000226317.
Polymorphism databases
DMDM	2851486.
Proteomic databases
PaxDb	P80162.
PRIDE	P80162.
Protocols and materials databases
DNASU	6372.
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000226317; ENSP00000226317; ENSG00000124875.
GeneID	6372.
KEGG	hsa:6372.
UCSC	uc003hhf.3. human.
Organism-specific databases
CTD	6372.
GeneCards	GC04P074691.
HGNC	HGNC:10643. CXCL6.
MIM	138965. gene.
neXtProt	NX_P80162.
PharmGKB	PA35574.
GenAtlas	Search...
Phylogenomic databases
eggNOG	NOG301524.
HOGENOM	HOG000220915.
HOVERGEN	HBG107789.
InParanoid	P80162.
KO	K05506.
OMA	TELRCTC.
OrthoDB	EOG4NKBX5.
PhylomeDB	P80162.
Enzyme and pathway databases
Reactome	REACT_111102. Signal Transduction.
Gene expression databases
ArrayExpress	P80162.
Bgee	P80162.
CleanEx	HS_CXCL6.
Genevestigator	P80162.
GermOnline	ENSG00000124875. Homo sapiens.
Family and domain databases
InterPro	IPR001089. Chemokine_CXC. IPR018048. Chemokine_CXC_CS. IPR001811. Chemokine_IL8-like_dom. [Graphical view]
PANTHER	PTHR10179. PTHR10179. 1 hit.
Pfam	PF00048. IL8. 1 hit. [Graphical view]
PRINTS	PR00437. SMALLCYTKCXC.
SMART	SM00199. SCY. 1 hit. [Graphical view]
SUPFAM	SSF54117. Chemokine_IL8. 1 hit.
PROSITE	PS00471. SMALL_CYTOKINES_CXC. 1 hit. [Graphical view]
ProtoNet	Search...
Other
GenomeRNAi	6372.
NextBio	24756.
PMAP-CutDB	P80162.
SOURCE	Search...

Entry information

Entry name

CXCL6_HUMAN

Accession

Primary (citable) accession number: P80162
Secondary accession number(s): B2R4X3, Q4W5D4

Entry history

Integrated into UniProtKB/Swiss-Prot:	April 1, 1993
Last sequence update:	July 15, 1998
Last modified:	May 1, 2013
This is version 122 of the entry and version 4 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.