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P80162

- CXCL6_HUMAN

UniProt

P80162 - CXCL6_HUMAN

Protein

C-X-C motif chemokine 6

Gene

CXCL6

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
  1. Functioni

    Chemotactic for neutrophil granulocytes. Signals through binding and activation of its receptors (CXCR1 and CXCR2). In addition to its chemotactic and angiogenic properties, it has strong antibacterial activity against Gram-positive and Gram-negative bacteria (90-fold-higher when compared to CXCL5 and CXCL7).4 Publications

    GO - Molecular functioni

    1. chemokine activity Source: ProtInc
    2. heparin binding Source: UniProtKB-KW

    GO - Biological processi

    1. cell-cell signaling Source: ProtInc
    2. cell chemotaxis Source: GOC
    3. chemotaxis Source: ProtInc
    4. defense response to bacterium Source: UniProtKB-KW
    5. immune response Source: InterPro
    6. inflammatory response Source: ProtInc
    7. signal transduction Source: ProtInc

    Keywords - Molecular functioni

    Antibiotic, Antimicrobial, Cytokine

    Keywords - Biological processi

    Chemotaxis

    Keywords - Ligandi

    Heparin-binding

    Enzyme and pathway databases

    ReactomeiREACT_15344. Chemokine receptors bind chemokines.
    REACT_19231. G alpha (i) signalling events.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    C-X-C motif chemokine 6
    Alternative name(s):
    Chemokine alpha 3
    Short name:
    CKA-3
    Granulocyte chemotactic protein 2
    Short name:
    GCP-2
    Small-inducible cytokine B6
    Cleaved into the following 3 chains:
    Gene namesi
    Name:CXCL6
    Synonyms:GCP2, SCYB6
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 4

    Organism-specific databases

    HGNCiHGNC:10643. CXCL6.

    Subcellular locationi

    GO - Cellular componenti

    1. extracellular region Source: Reactome
    2. extracellular space Source: UniProtKB-KW

    Keywords - Cellular componenti

    Secreted

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA35574.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 37372 PublicationsAdd
    BLAST
    Chaini38 – 11477C-X-C motif chemokine 6PRO_0000005084Add
    BLAST
    Chaini40 – 11475Small-inducible cytokine B6, N-processed variant 1PRO_0000005085Add
    BLAST
    Chaini43 – 11472Small-inducible cytokine B6, N-processed variant 2PRO_0000005086Add
    BLAST
    Chaini46 – 11469Small-inducible cytokine B6, N-processed variant 3PRO_0000005087Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Disulfide bondi49 ↔ 75By similarity
    Disulfide bondi51 ↔ 91By similarity

    Keywords - PTMi

    Disulfide bond

    Proteomic databases

    PaxDbiP80162.
    PRIDEiP80162.

    Miscellaneous databases

    PMAP-CutDBP80162.

    Expressioni

    Gene expression databases

    ArrayExpressiP80162.
    BgeeiP80162.
    CleanExiHS_CXCL6.
    GenevestigatoriP80162.

    Interactioni

    Protein-protein interaction databases

    BioGridi112274. 1 interaction.
    STRINGi9606.ENSP00000226317.

    Structurei

    3D structure databases

    ProteinModelPortaliP80162.
    SMRiP80162. Positions 44-114.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Keywords - Domaini

    Signal

    Phylogenomic databases

    eggNOGiNOG301524.
    HOGENOMiHOG000220915.
    HOVERGENiHBG107789.
    InParanoidiP80162.
    KOiK05506.
    OMAiPAGPQCS.
    OrthoDBiEOG7B5WZS.
    PhylomeDBiP80162.
    TreeFamiTF333433.

    Family and domain databases

    InterProiIPR001089. Chemokine_CXC.
    IPR018048. Chemokine_CXC_CS.
    IPR001811. Chemokine_IL8-like_dom.
    [Graphical view]
    PANTHERiPTHR10179. PTHR10179. 1 hit.
    PfamiPF00048. IL8. 1 hit.
    [Graphical view]
    PRINTSiPR00437. SMALLCYTKCXC.
    SMARTiSM00199. SCY. 1 hit.
    [Graphical view]
    SUPFAMiSSF54117. SSF54117. 1 hit.
    PROSITEiPS00471. SMALL_CYTOKINES_CXC. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    P80162-1 [UniParc]FASTAAdd to Basket

    « Hide

    MSLPSSRAAR VPGPSGSLCA LLALLLLLTP PGPLASAGPV SAVLTELRCT    50
    CLRVTLRVNP KTIGKLQVFP AGPQCSKVEV VASLKNGKQV CLDPEAPFLK 100
    KVIQKILDSG NKKN 114
    Length:114
    Mass (Da):11,897
    Last modified:July 15, 1998 - v4
    Checksum:i5A58B38C17F25178
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U83303 Genomic DNA. Translation: AAC51338.1.
    U81234 mRNA. Translation: AAD00506.1.
    AK311981 mRNA. Translation: BAG34920.1.
    AC108029 Genomic DNA. Translation: AAY40939.1.
    BC013744 mRNA. Translation: AAH13744.1.
    Y08770 mRNA. Translation: CAA70023.1.
    CCDSiCCDS3560.1.
    PIRiA54188.
    RefSeqiNP_002984.1. NM_002993.3.
    UniGeneiHs.164021.

    Genome annotation databases

    EnsembliENST00000226317; ENSP00000226317; ENSG00000124875.
    GeneIDi6372.
    KEGGihsa:6372.
    UCSCiuc003hhf.3. human.

    Polymorphism databases

    DMDMi2851486.

    Cross-referencesi

    Web resourcesi

    Wikipedia

    CXCL6 entry

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U83303 Genomic DNA. Translation: AAC51338.1 .
    U81234 mRNA. Translation: AAD00506.1 .
    AK311981 mRNA. Translation: BAG34920.1 .
    AC108029 Genomic DNA. Translation: AAY40939.1 .
    BC013744 mRNA. Translation: AAH13744.1 .
    Y08770 mRNA. Translation: CAA70023.1 .
    CCDSi CCDS3560.1.
    PIRi A54188.
    RefSeqi NP_002984.1. NM_002993.3.
    UniGenei Hs.164021.

    3D structure databases

    ProteinModelPortali P80162.
    SMRi P80162. Positions 44-114.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 112274. 1 interaction.
    STRINGi 9606.ENSP00000226317.

    Polymorphism databases

    DMDMi 2851486.

    Proteomic databases

    PaxDbi P80162.
    PRIDEi P80162.

    Protocols and materials databases

    DNASUi 6372.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000226317 ; ENSP00000226317 ; ENSG00000124875 .
    GeneIDi 6372.
    KEGGi hsa:6372.
    UCSCi uc003hhf.3. human.

    Organism-specific databases

    CTDi 6372.
    GeneCardsi GC04P074691.
    HGNCi HGNC:10643. CXCL6.
    MIMi 138965. gene.
    neXtProti NX_P80162.
    PharmGKBi PA35574.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG301524.
    HOGENOMi HOG000220915.
    HOVERGENi HBG107789.
    InParanoidi P80162.
    KOi K05506.
    OMAi PAGPQCS.
    OrthoDBi EOG7B5WZS.
    PhylomeDBi P80162.
    TreeFami TF333433.

    Enzyme and pathway databases

    Reactomei REACT_15344. Chemokine receptors bind chemokines.
    REACT_19231. G alpha (i) signalling events.

    Miscellaneous databases

    GenomeRNAii 6372.
    NextBioi 24756.
    PMAP-CutDB P80162.
    PROi P80162.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi P80162.
    Bgeei P80162.
    CleanExi HS_CXCL6.
    Genevestigatori P80162.

    Family and domain databases

    InterProi IPR001089. Chemokine_CXC.
    IPR018048. Chemokine_CXC_CS.
    IPR001811. Chemokine_IL8-like_dom.
    [Graphical view ]
    PANTHERi PTHR10179. PTHR10179. 1 hit.
    Pfami PF00048. IL8. 1 hit.
    [Graphical view ]
    PRINTSi PR00437. SMALLCYTKCXC.
    SMARTi SM00199. SCY. 1 hit.
    [Graphical view ]
    SUPFAMi SSF54117. SSF54117. 1 hit.
    PROSITEi PS00471. SMALL_CYTOKINES_CXC. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Cloning and characterization of the human granulocyte chemotactic protein-2 gene."
      Rovai L.E., Herschman H.R., Smith J.B.
      J. Immunol. 158:5257-5266(1997) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    2. "Cloning, sequencing and biological characterization of a C-X-C chemokine, CKA-3."
      Ni J., Su J., Li H.
      Submitted (DEC-1996) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    3. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
      , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
      Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Spleen.
    4. "Generation and annotation of the DNA sequences of human chromosomes 2 and 4."
      Hillier L.W., Graves T.A., Fulton R.S., Fulton L.A., Pepin K.H., Minx P., Wagner-McPherson C., Layman D., Wylie K., Sekhon M., Becker M.C., Fewell G.A., Delehaunty K.D., Miner T.L., Nash W.E., Kremitzki C., Oddy L., Du H.
      , Sun H., Bradshaw-Cordum H., Ali J., Carter J., Cordes M., Harris A., Isak A., van Brunt A., Nguyen C., Du F., Courtney L., Kalicki J., Ozersky P., Abbott S., Armstrong J., Belter E.A., Caruso L., Cedroni M., Cotton M., Davidson T., Desai A., Elliott G., Erb T., Fronick C., Gaige T., Haakenson W., Haglund K., Holmes A., Harkins R., Kim K., Kruchowski S.S., Strong C.M., Grewal N., Goyea E., Hou S., Levy A., Martinka S., Mead K., McLellan M.D., Meyer R., Randall-Maher J., Tomlinson C., Dauphin-Kohlberg S., Kozlowicz-Reilly A., Shah N., Swearengen-Shahid S., Snider J., Strong J.T., Thompson J., Yoakum M., Leonard S., Pearman C., Trani L., Radionenko M., Waligorski J.E., Wang C., Rock S.M., Tin-Wollam A.-M., Maupin R., Latreille P., Wendl M.C., Yang S.-P., Pohl C., Wallis J.W., Spieth J., Bieri T.A., Berkowicz N., Nelson J.O., Osborne J., Ding L., Meyer R., Sabo A., Shotland Y., Sinha P., Wohldmann P.E., Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Jones T.A., She X., Ciccarelli F.D., Izaurralde E., Taylor J., Schmutz J., Myers R.M., Cox D.R., Huang X., McPherson J.D., Mardis E.R., Clifton S.W., Warren W.C., Chinwalla A.T., Eddy S.R., Marra M.A., Ovcharenko I., Furey T.S., Miller W., Eichler E.E., Bork P., Suyama M., Torrents D., Waterston R.H., Wilson R.K.
      Nature 434:724-731(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Liver.
    6. "Cloning, bacterial expression and biological characterization of recombinant human granulocyte chemotactic protein-2 and differential expression of granulocyte chemotactic protein-2 and epithelial cell-derived neutrophil activating peptide-78 mRNAs."
      Froyen G., Proost P., Ronsse I., Mitera T., Haelens A., Wuyts A., Opdenakker G., van Damme J., Billiau A.
      Eur. J. Biochem. 243:762-769(1997) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 38-114, FUNCTION.
    7. "Human and bovine granulocyte chemotactic protein-2: complete amino acid sequence and functional characterization as chemokines."
      Proost P., Wuyts A., Conings R., Lenaerts J.-P., Billiau A., Opdenakker G., van Damme J.
      Biochemistry 32:10170-10177(1993) [PubMed] [Europe PMC] [Abstract]
      Cited for: PROTEIN SEQUENCE OF 38-112, FUNCTION, PROTEOLYTIC PROCESSING OF N-TERMINAL.
      Tissue: Osteosarcoma.
    8. "Identification of a novel granulocyte chemotactic protein (GCP-2) from human tumor cells. In vitro and in vivo comparison with natural forms of GRO, IP-10, and IL-8."
      Proost P., de Wolf-Peeters C., Conings R., Opdenakker G., Billiau A., van Damme J.
      J. Immunol. 150:1000-1010(1993) [PubMed] [Europe PMC] [Abstract]
      Cited for: PROTEIN SEQUENCE OF 38-57, FUNCTION.
      Tissue: Osteosarcoma.
    9. "The human CXC chemokine granulocyte chemotactic protein 2 (GCP-2)/CXCL6 possesses membrane-disrupting properties and is antibacterial."
      Linge H.M., Collin M., Nordenfelt P., Morgelin M., Malmsten M., Egesten A.
      Antimicrob. Agents Chemother. 52:2599-2607(2008) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION.

    Entry informationi

    Entry nameiCXCL6_HUMAN
    AccessioniPrimary (citable) accession number: P80162
    Secondary accession number(s): B2R4X3, Q4W5D4
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: April 1, 1993
    Last sequence update: July 15, 1998
    Last modified: October 1, 2014
    This is version 134 of the entry and version 4 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Direct protein sequencing, Reference proteome

    Documents

    1. Human chromosome 4
      Human chromosome 4: entries, gene names and cross-references to MIM
    2. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3