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P80162 (CXCL6_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 132. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Web links·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
C-X-C motif chemokine 6
Alternative name(s):
Chemokine alpha 3
Short name=CKA-3
Granulocyte chemotactic protein 2
Short name=GCP-2
Small-inducible cytokine B6
Gene names
Name:CXCL6
Synonyms:GCP2, SCYB6
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length114 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Chemotactic for neutrophil granulocytes. Signals through binding and activation of its receptors (CXCR1 and CXCR2). In addition to its chemotactic and angiogenic properties, it has strong antibacterial activity against Gram-positive and Gram-negative bacteria (90-fold-higher when compared to CXCL5 and CXCL7). Ref.6 Ref.7 Ref.8 Ref.9

Subcellular location

Secreted.

Sequence similarities

Belongs to the intercrine alpha (chemokine CxC) family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 3737 Ref.7 Ref.8
Chain38 – 11477C-X-C motif chemokine 6
PRO_0000005084
Chain40 – 11475Small-inducible cytokine B6, N-processed variant 1
PRO_0000005085
Chain43 – 11472Small-inducible cytokine B6, N-processed variant 2
PRO_0000005086
Chain46 – 11469Small-inducible cytokine B6, N-processed variant 3
PRO_0000005087

Amino acid modifications

Disulfide bond49 ↔ 75 By similarity
Disulfide bond51 ↔ 91 By similarity

Sequences

Sequence LengthMass (Da)Tools
P80162 [UniParc].

Last modified July 15, 1998. Version 4.
Checksum: 5A58B38C17F25178

FASTA11411,897
        10         20         30         40         50         60 
MSLPSSRAAR VPGPSGSLCA LLALLLLLTP PGPLASAGPV SAVLTELRCT CLRVTLRVNP 

        70         80         90        100        110 
KTIGKLQVFP AGPQCSKVEV VASLKNGKQV CLDPEAPFLK KVIQKILDSG NKKN 

« Hide

References

« Hide 'large scale' references
[1]"Cloning and characterization of the human granulocyte chemotactic protein-2 gene."
Rovai L.E., Herschman H.R., Smith J.B.
J. Immunol. 158:5257-5266(1997) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[2]"Cloning, sequencing and biological characterization of a C-X-C chemokine, CKA-3."
Ni J., Su J., Li H.
Submitted (DEC-1996) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[3]"Complete sequencing and characterization of 21,243 full-length human cDNAs."
Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. expand/collapse author list , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Spleen.
[4]"Generation and annotation of the DNA sequences of human chromosomes 2 and 4."
Hillier L.W., Graves T.A., Fulton R.S., Fulton L.A., Pepin K.H., Minx P., Wagner-McPherson C., Layman D., Wylie K., Sekhon M., Becker M.C., Fewell G.A., Delehaunty K.D., Miner T.L., Nash W.E., Kremitzki C., Oddy L., Du H. expand/collapse author list , Sun H., Bradshaw-Cordum H., Ali J., Carter J., Cordes M., Harris A., Isak A., van Brunt A., Nguyen C., Du F., Courtney L., Kalicki J., Ozersky P., Abbott S., Armstrong J., Belter E.A., Caruso L., Cedroni M., Cotton M., Davidson T., Desai A., Elliott G., Erb T., Fronick C., Gaige T., Haakenson W., Haglund K., Holmes A., Harkins R., Kim K., Kruchowski S.S., Strong C.M., Grewal N., Goyea E., Hou S., Levy A., Martinka S., Mead K., McLellan M.D., Meyer R., Randall-Maher J., Tomlinson C., Dauphin-Kohlberg S., Kozlowicz-Reilly A., Shah N., Swearengen-Shahid S., Snider J., Strong J.T., Thompson J., Yoakum M., Leonard S., Pearman C., Trani L., Radionenko M., Waligorski J.E., Wang C., Rock S.M., Tin-Wollam A.-M., Maupin R., Latreille P., Wendl M.C., Yang S.-P., Pohl C., Wallis J.W., Spieth J., Bieri T.A., Berkowicz N., Nelson J.O., Osborne J., Ding L., Meyer R., Sabo A., Shotland Y., Sinha P., Wohldmann P.E., Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Jones T.A., She X., Ciccarelli F.D., Izaurralde E., Taylor J., Schmutz J., Myers R.M., Cox D.R., Huang X., McPherson J.D., Mardis E.R., Clifton S.W., Warren W.C., Chinwalla A.T., Eddy S.R., Marra M.A., Ovcharenko I., Furey T.S., Miller W., Eichler E.E., Bork P., Suyama M., Torrents D., Waterston R.H., Wilson R.K.
Nature 434:724-731(2005) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[5]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Liver.
[6]"Cloning, bacterial expression and biological characterization of recombinant human granulocyte chemotactic protein-2 and differential expression of granulocyte chemotactic protein-2 and epithelial cell-derived neutrophil activating peptide-78 mRNAs."
Froyen G., Proost P., Ronsse I., Mitera T., Haelens A., Wuyts A., Opdenakker G., van Damme J., Billiau A.
Eur. J. Biochem. 243:762-769(1997) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 38-114, FUNCTION.
[7]"Human and bovine granulocyte chemotactic protein-2: complete amino acid sequence and functional characterization as chemokines."
Proost P., Wuyts A., Conings R., Lenaerts J.-P., Billiau A., Opdenakker G., van Damme J.
Biochemistry 32:10170-10177(1993) [PubMed] [Europe PMC] [Abstract]
Cited for: PROTEIN SEQUENCE OF 38-112, FUNCTION, PROTEOLYTIC PROCESSING OF N-TERMINAL.
Tissue: Osteosarcoma.
[8]"Identification of a novel granulocyte chemotactic protein (GCP-2) from human tumor cells. In vitro and in vivo comparison with natural forms of GRO, IP-10, and IL-8."
Proost P., de Wolf-Peeters C., Conings R., Opdenakker G., Billiau A., van Damme J.
J. Immunol. 150:1000-1010(1993) [PubMed] [Europe PMC] [Abstract]
Cited for: PROTEIN SEQUENCE OF 38-57, FUNCTION.
Tissue: Osteosarcoma.
[9]"The human CXC chemokine granulocyte chemotactic protein 2 (GCP-2)/CXCL6 possesses membrane-disrupting properties and is antibacterial."
Linge H.M., Collin M., Nordenfelt P., Morgelin M., Malmsten M., Egesten A.
Antimicrob. Agents Chemother. 52:2599-2607(2008) [PubMed] [Europe PMC] [Abstract]
Cited for: FUNCTION.
+Additional computationally mapped references.

Web resources

Wikipedia

CXCL6 entry

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
U83303 Genomic DNA. Translation: AAC51338.1.
U81234 mRNA. Translation: AAD00506.1.
AK311981 mRNA. Translation: BAG34920.1.
AC108029 Genomic DNA. Translation: AAY40939.1.
BC013744 mRNA. Translation: AAH13744.1.
Y08770 mRNA. Translation: CAA70023.1.
CCDSCCDS3560.1.
PIRA54188.
RefSeqNP_002984.1. NM_002993.3.
UniGeneHs.164021.

3D structure databases

ProteinModelPortalP80162.
SMRP80162. Positions 44-114.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid112274. 1 interaction.
STRING9606.ENSP00000226317.

Polymorphism databases

DMDM2851486.

Proteomic databases

PaxDbP80162.
PRIDEP80162.

Protocols and materials databases

DNASU6372.
StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000226317; ENSP00000226317; ENSG00000124875.
GeneID6372.
KEGGhsa:6372.
UCSCuc003hhf.3. human.

Organism-specific databases

CTD6372.
GeneCardsGC04P074691.
HGNCHGNC:10643. CXCL6.
MIM138965. gene.
neXtProtNX_P80162.
PharmGKBPA35574.
GenAtlasSearch...

Phylogenomic databases

eggNOGNOG301524.
HOGENOMHOG000220915.
HOVERGENHBG107789.
InParanoidP80162.
KOK05506.
OMAPAGPQCS.
OrthoDBEOG7B5WZS.
PhylomeDBP80162.
TreeFamTF333433.

Enzyme and pathway databases

ReactomeREACT_111102. Signal Transduction.

Gene expression databases

ArrayExpressP80162.
BgeeP80162.
CleanExHS_CXCL6.
GenevestigatorP80162.

Family and domain databases

InterProIPR001089. Chemokine_CXC.
IPR018048. Chemokine_CXC_CS.
IPR001811. Chemokine_IL8-like_dom.
[Graphical view]
PANTHERPTHR10179. PTHR10179. 1 hit.
PfamPF00048. IL8. 1 hit.
[Graphical view]
PRINTSPR00437. SMALLCYTKCXC.
SMARTSM00199. SCY. 1 hit.
[Graphical view]
SUPFAMSSF54117. SSF54117. 1 hit.
PROSITEPS00471. SMALL_CYTOKINES_CXC. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

GenomeRNAi6372.
NextBio24756.
PMAP-CutDBP80162.
PROP80162.
SOURCESearch...

Entry information

Entry nameCXCL6_HUMAN
AccessionPrimary (citable) accession number: P80162
Secondary accession number(s): B2R4X3, Q4W5D4
Entry history
Integrated into UniProtKB/Swiss-Prot: April 1, 1993
Last sequence update: July 15, 1998
Last modified: July 9, 2014
This is version 132 of the entry and version 4 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Human chromosome 4

Human chromosome 4: entries, gene names and cross-references to MIM