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Protein

C-X-C motif chemokine 6

Gene

CXCL6

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Chemotactic for neutrophil granulocytes. Signals through binding and activation of its receptors (CXCR1 and CXCR2). In addition to its chemotactic and angiogenic properties, it has strong antibacterial activity against Gram-positive and Gram-negative bacteria (90-fold-higher when compared to CXCL5 and CXCL7).4 Publications

GO - Molecular functioni

  • chemokine activity Source: ProtInc
  • CXCR chemokine receptor binding Source: GO_Central
  • heparin binding Source: UniProtKB-KW

GO - Biological processi

  • cell-cell signaling Source: ProtInc
  • cell chemotaxis Source: GOC
  • chemokine-mediated signaling pathway Source: GO_Central
  • chemotaxis Source: ProtInc
  • defense response to bacterium Source: UniProtKB-KW
  • G-protein coupled receptor signaling pathway Source: GO_Central
  • immune response Source: GO_Central
  • inflammatory response Source: ProtInc
  • neutrophil mediated immunity Source: GO_Central
  • positive regulation of leukocyte chemotaxis Source: GO_Central
  • regulation of cell proliferation Source: GO_Central
  • response to lipopolysaccharide Source: GO_Central
  • signal transduction Source: ProtInc
Complete GO annotation...

Keywords - Molecular functioni

Antibiotic, Antimicrobial, Cytokine

Keywords - Biological processi

Chemotaxis

Keywords - Ligandi

Heparin-binding

Enzyme and pathway databases

ReactomeiREACT_15344. Chemokine receptors bind chemokines.
REACT_19231. G alpha (i) signalling events.

Names & Taxonomyi

Protein namesi
Recommended name:
C-X-C motif chemokine 6
Alternative name(s):
Chemokine alpha 3
Short name:
CKA-3
Granulocyte chemotactic protein 2
Short name:
GCP-2
Small-inducible cytokine B6
Cleaved into the following 3 chains:
Gene namesi
Name:CXCL6
Synonyms:GCP2, SCYB6
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640 Componenti: Chromosome 4

Organism-specific databases

HGNCiHGNC:10643. CXCL6.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Secreted

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA35574.

Polymorphism and mutation databases

BioMutaiCXCL6.
DMDMi2851486.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 37372 PublicationsAdd
BLAST
Chaini38 – 11477C-X-C motif chemokine 6PRO_0000005084Add
BLAST
Chaini40 – 11475Small-inducible cytokine B6, N-processed variant 1PRO_0000005085Add
BLAST
Chaini43 – 11472Small-inducible cytokine B6, N-processed variant 2PRO_0000005086Add
BLAST
Chaini46 – 11469Small-inducible cytokine B6, N-processed variant 3PRO_0000005087Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi49 ↔ 75By similarity
Disulfide bondi51 ↔ 91By similarity

Keywords - PTMi

Disulfide bond

Proteomic databases

PaxDbiP80162.
PRIDEiP80162.

Miscellaneous databases

PMAP-CutDBP80162.

Expressioni

Gene expression databases

BgeeiP80162.
CleanExiHS_CXCL6.
ExpressionAtlasiP80162. baseline and differential.
GenevestigatoriP80162.

Interactioni

Protein-protein interaction databases

BioGridi112274. 1 interaction.
IntActiP80162. 1 interaction.
STRINGi9606.ENSP00000226317.

Structurei

3D structure databases

ProteinModelPortaliP80162.
SMRiP80162. Positions 44-114.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiNOG301524.
GeneTreeiENSGT00530000062901.
HOGENOMiHOG000220915.
HOVERGENiHBG107789.
InParanoidiP80162.
KOiK05506.
OMAiTELRCTC.
OrthoDBiEOG7B5WZS.
PhylomeDBiP80162.
TreeFamiTF333433.

Family and domain databases

InterProiIPR001089. Chemokine_CXC.
IPR018048. Chemokine_CXC_CS.
IPR001811. Chemokine_IL8-like_dom.
[Graphical view]
PANTHERiPTHR10179. PTHR10179. 1 hit.
PfamiPF00048. IL8. 1 hit.
[Graphical view]
PRINTSiPR00437. SMALLCYTKCXC.
SMARTiSM00199. SCY. 1 hit.
[Graphical view]
SUPFAMiSSF54117. SSF54117. 1 hit.
PROSITEiPS00471. SMALL_CYTOKINES_CXC. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P80162-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSLPSSRAAR VPGPSGSLCA LLALLLLLTP PGPLASAGPV SAVLTELRCT
60 70 80 90 100
CLRVTLRVNP KTIGKLQVFP AGPQCSKVEV VASLKNGKQV CLDPEAPFLK
110
KVIQKILDSG NKKN
Length:114
Mass (Da):11,897
Last modified:July 15, 1998 - v4
Checksum:i5A58B38C17F25178
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U83303 Genomic DNA. Translation: AAC51338.1.
U81234 mRNA. Translation: AAD00506.1.
AK311981 mRNA. Translation: BAG34920.1.
AC108029 Genomic DNA. Translation: AAY40939.1.
BC013744 mRNA. Translation: AAH13744.1.
Y08770 mRNA. Translation: CAA70023.1.
CCDSiCCDS3560.1.
PIRiA54188.
RefSeqiNP_002984.1. NM_002993.3.
UniGeneiHs.164021.

Genome annotation databases

EnsembliENST00000226317; ENSP00000226317; ENSG00000124875.
GeneIDi6372.
KEGGihsa:6372.
UCSCiuc003hhf.3. human.

Cross-referencesi

Web resourcesi

Wikipedia

CXCL6 entry

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U83303 Genomic DNA. Translation: AAC51338.1.
U81234 mRNA. Translation: AAD00506.1.
AK311981 mRNA. Translation: BAG34920.1.
AC108029 Genomic DNA. Translation: AAY40939.1.
BC013744 mRNA. Translation: AAH13744.1.
Y08770 mRNA. Translation: CAA70023.1.
CCDSiCCDS3560.1.
PIRiA54188.
RefSeqiNP_002984.1. NM_002993.3.
UniGeneiHs.164021.

3D structure databases

ProteinModelPortaliP80162.
SMRiP80162. Positions 44-114.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi112274. 1 interaction.
IntActiP80162. 1 interaction.
STRINGi9606.ENSP00000226317.

Polymorphism and mutation databases

BioMutaiCXCL6.
DMDMi2851486.

Proteomic databases

PaxDbiP80162.
PRIDEiP80162.

Protocols and materials databases

DNASUi6372.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000226317; ENSP00000226317; ENSG00000124875.
GeneIDi6372.
KEGGihsa:6372.
UCSCiuc003hhf.3. human.

Organism-specific databases

CTDi6372.
GeneCardsiGC04P074691.
HGNCiHGNC:10643. CXCL6.
MIMi138965. gene.
neXtProtiNX_P80162.
PharmGKBiPA35574.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiNOG301524.
GeneTreeiENSGT00530000062901.
HOGENOMiHOG000220915.
HOVERGENiHBG107789.
InParanoidiP80162.
KOiK05506.
OMAiTELRCTC.
OrthoDBiEOG7B5WZS.
PhylomeDBiP80162.
TreeFamiTF333433.

Enzyme and pathway databases

ReactomeiREACT_15344. Chemokine receptors bind chemokines.
REACT_19231. G alpha (i) signalling events.

Miscellaneous databases

GenomeRNAii6372.
NextBioi24756.
PMAP-CutDBP80162.
PROiP80162.
SOURCEiSearch...

Gene expression databases

BgeeiP80162.
CleanExiHS_CXCL6.
ExpressionAtlasiP80162. baseline and differential.
GenevestigatoriP80162.

Family and domain databases

InterProiIPR001089. Chemokine_CXC.
IPR018048. Chemokine_CXC_CS.
IPR001811. Chemokine_IL8-like_dom.
[Graphical view]
PANTHERiPTHR10179. PTHR10179. 1 hit.
PfamiPF00048. IL8. 1 hit.
[Graphical view]
PRINTSiPR00437. SMALLCYTKCXC.
SMARTiSM00199. SCY. 1 hit.
[Graphical view]
SUPFAMiSSF54117. SSF54117. 1 hit.
PROSITEiPS00471. SMALL_CYTOKINES_CXC. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Cloning and characterization of the human granulocyte chemotactic protein-2 gene."
    Rovai L.E., Herschman H.R., Smith J.B.
    J. Immunol. 158:5257-5266(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  2. "Cloning, sequencing and biological characterization of a C-X-C chemokine, CKA-3."
    Ni J., Su J., Li H.
    Submitted (DEC-1996) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  3. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Spleen.
  4. "Generation and annotation of the DNA sequences of human chromosomes 2 and 4."
    Hillier L.W., Graves T.A., Fulton R.S., Fulton L.A., Pepin K.H., Minx P., Wagner-McPherson C., Layman D., Wylie K., Sekhon M., Becker M.C., Fewell G.A., Delehaunty K.D., Miner T.L., Nash W.E., Kremitzki C., Oddy L., Du H.
    , Sun H., Bradshaw-Cordum H., Ali J., Carter J., Cordes M., Harris A., Isak A., van Brunt A., Nguyen C., Du F., Courtney L., Kalicki J., Ozersky P., Abbott S., Armstrong J., Belter E.A., Caruso L., Cedroni M., Cotton M., Davidson T., Desai A., Elliott G., Erb T., Fronick C., Gaige T., Haakenson W., Haglund K., Holmes A., Harkins R., Kim K., Kruchowski S.S., Strong C.M., Grewal N., Goyea E., Hou S., Levy A., Martinka S., Mead K., McLellan M.D., Meyer R., Randall-Maher J., Tomlinson C., Dauphin-Kohlberg S., Kozlowicz-Reilly A., Shah N., Swearengen-Shahid S., Snider J., Strong J.T., Thompson J., Yoakum M., Leonard S., Pearman C., Trani L., Radionenko M., Waligorski J.E., Wang C., Rock S.M., Tin-Wollam A.-M., Maupin R., Latreille P., Wendl M.C., Yang S.-P., Pohl C., Wallis J.W., Spieth J., Bieri T.A., Berkowicz N., Nelson J.O., Osborne J., Ding L., Meyer R., Sabo A., Shotland Y., Sinha P., Wohldmann P.E., Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Jones T.A., She X., Ciccarelli F.D., Izaurralde E., Taylor J., Schmutz J., Myers R.M., Cox D.R., Huang X., McPherson J.D., Mardis E.R., Clifton S.W., Warren W.C., Chinwalla A.T., Eddy S.R., Marra M.A., Ovcharenko I., Furey T.S., Miller W., Eichler E.E., Bork P., Suyama M., Torrents D., Waterston R.H., Wilson R.K.
    Nature 434:724-731(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Liver.
  6. "Cloning, bacterial expression and biological characterization of recombinant human granulocyte chemotactic protein-2 and differential expression of granulocyte chemotactic protein-2 and epithelial cell-derived neutrophil activating peptide-78 mRNAs."
    Froyen G., Proost P., Ronsse I., Mitera T., Haelens A., Wuyts A., Opdenakker G., van Damme J., Billiau A.
    Eur. J. Biochem. 243:762-769(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 38-114, FUNCTION.
  7. "Human and bovine granulocyte chemotactic protein-2: complete amino acid sequence and functional characterization as chemokines."
    Proost P., Wuyts A., Conings R., Lenaerts J.-P., Billiau A., Opdenakker G., van Damme J.
    Biochemistry 32:10170-10177(1993) [PubMed] [Europe PMC] [Abstract]
    Cited for: PROTEIN SEQUENCE OF 38-112, FUNCTION, PROTEOLYTIC PROCESSING OF N-TERMINAL.
    Tissue: Osteosarcoma.
  8. "Identification of a novel granulocyte chemotactic protein (GCP-2) from human tumor cells. In vitro and in vivo comparison with natural forms of GRO, IP-10, and IL-8."
    Proost P., de Wolf-Peeters C., Conings R., Opdenakker G., Billiau A., van Damme J.
    J. Immunol. 150:1000-1010(1993) [PubMed] [Europe PMC] [Abstract]
    Cited for: PROTEIN SEQUENCE OF 38-57, FUNCTION.
    Tissue: Osteosarcoma.
  9. "The human CXC chemokine granulocyte chemotactic protein 2 (GCP-2)/CXCL6 possesses membrane-disrupting properties and is antibacterial."
    Linge H.M., Collin M., Nordenfelt P., Morgelin M., Malmsten M., Egesten A.
    Antimicrob. Agents Chemother. 52:2599-2607(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION.

Entry informationi

Entry nameiCXCL6_HUMAN
AccessioniPrimary (citable) accession number: P80162
Secondary accession number(s): B2R4X3, Q4W5D4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 1, 1993
Last sequence update: July 15, 1998
Last modified: May 27, 2015
This is version 140 of the entry and version 4 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Human chromosome 4
    Human chromosome 4: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.