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P80145

- FRIH_ANAPL

UniProt

P80145 - FRIH_ANAPL

Protein

Ferritin heavy chain

Gene

FTH

Organism
Anas platyrhynchos (Domestic duck) (Anas boschas)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at protein leveli
  1. Functioni

    Stores iron in a soluble, non-toxic, readily available form. Important for iron homeostasis. Has ferroxidase activity. Iron is taken up in the ferrous form and deposited as ferric hydroxides after oxidation. Also plays a role in delivery of iron to cells. Mediates iron uptake in capsule cells of the developing kidney By similarity.By similarity
    Inhibits translation of various mRNA species in vitro. Associates with a 35S prosome-like particle that contains non-translated mRNAs in a complex with proteins. May be involved in pre-translational regulation of some mRNA.1 Publication

    Catalytic activityi

    4 Fe2+ + 4 H+ + O2 = 4 Fe3+ + 2 H2O.

    GO - Molecular functioni

    1. ferroxidase activity Source: UniProtKB-EC
    2. metal ion binding Source: UniProtKB-KW
    3. RNA binding Source: UniProtKB-KW

    GO - Biological processi

    1. cellular iron ion homeostasis Source: UniProtKB-KW

    Keywords - Molecular functioni

    Oxidoreductase

    Keywords - Biological processi

    Iron storage

    Keywords - Ligandi

    Iron, Metal-binding, RNA-binding

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Ferritin heavy chain (EC:1.16.3.1)
    Short name:
    Ferritin H subunit
    Alternative name(s):
    Prosome-like particle
    Short name:
    PLP
    RNP particle
    Gene namesi
    Name:FTH
    OrganismiAnas platyrhynchos (Domestic duck) (Anas boschas)
    Taxonomic identifieri8839 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiTestudines + Archosauria groupArchosauriaDinosauriaSaurischiaTheropodaCoelurosauriaAvesNeognathaeAnseriformesAnatidaeAnas
    ProteomesiUP000016666: Unplaced

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini‹1 – 32›32Ferritin heavy chainPRO_0000201056Add
    BLAST

    Interactioni

    Subunit structurei

    Oligomer of 24 subunits. There are two types of subunits: L (light) chain and H (heavy) chain. The major chain can be light or heavy, depending on the species and tissue type. The functional molecule forms a roughly spherical shell with a diameter of 12 nm and contains a central cavity into which the insoluble mineral iron core is deposited By similarity.By similarity

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the ferritin family.Curated

    Sequencei

    Sequence statusi: Fragments.

    P80145-1 [UniParc]FASTAAdd to Basket

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    NVNQSLLELH GAPKYGMAEY LFDKHTLGES DN                      32
    Length:32
    Mass (Da):3,592
    Last modified:April 1, 1993 - v1
    Checksum:iD7274FD4CB175252
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Non-terminal residuei1 – 11
    Non-adjacent residuesi10 – 112Curated

    Sequence databases

    PIRiS24135.

    Cross-referencesi

    Sequence databases

    PIRi S24135.

    3D structure databases

    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Family and domain databases

    ProtoNeti Search...

    Publicationsi

    1. "The protein of M(r) 21,000 constituting the prosome-like particle of duck erythroblasts is homologous to apoferritin."
      Coux O., Camoin L., Nothwang H.-G., Bey F., Silva-Pereira I., Keith G., Strosberg A.-D., Scherrer K.
      Eur. J. Biochem. 207:823-832(1992) [PubMed] [Europe PMC] [Abstract]
      Cited for: PROTEIN SEQUENCE, FUNCTION.
      Tissue: Erythroblast.

    Entry informationi

    Entry nameiFRIH_ANAPL
    AccessioniPrimary (citable) accession number: P80145
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: April 1, 1993
    Last sequence update: April 1, 1993
    Last modified: October 1, 2014
    This is version 59 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Direct protein sequencing, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3