P80111 (ANTR_RANCA) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Gastrin/cholecystokinin-like peptide

Alternative name(s):
Antral peptide

Gene names

Name:

GAST

Organism

Rana catesbeiana (American bullfrog) (Lithobates catesbeiana)

Taxonomic identifier

8400 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Amphibia › Batrachia › Anura › Neobatrachia › Ranoidea › Ranidae › Raninae › Rana › Aquarana

Protein attributes

Sequence length	102 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	May control digestion processes.
Subcellular location	Secreted.
Tissue specificity	Expressed in antrum, duodenum, colon, pancreas, brain and testis. No expression found in kidney, lung, liver, skin or distal two-thirds of small intestine. In the brain, strongly expressed in the pituitary gland with moderate expression in the neural lobe, brain stem and hypothalamus.
Sequence similarities	Belongs to the gastrin/cholecystokinin family.

Ontologies

Keywords
Biological process	Digestion
Cellular component	Secreted
Domain	Signal
Molecular function	Hormone
PTM	Amidation Cleavage on pair of basic residues Sulfation
Technical term	Direct protein sequencing
Gene Ontology (GO)
Biological process	digestion Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	extracellular region Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	hormone activity Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Signal peptide	1 – 20	20	Potential
	Propeptide	21 – 45	25			PRO_0000010659
	Peptide	46 – 92	47	Gastrin/cholecystokinin-like peptide Ref.2		PRO_0000010660
	Propeptide	96 – 102	7			PRO_0000010661
Amino acid modifications
	Modified residue	86	1	Sulfotyrosine
	Modified residue	92	1	Phenylalanine amide

Sequences

	Sequence		Length	Mass (Da)
	P80111 [UniParc]. Last modified July 15, 1999. Version 2. Checksum: 6FCBEB01538A0C93	FASTA	102	11,551
	10 20 30 40 50 60 MDKKVCVSIL LAMLAIAALC RPMTELESAR HGAQRKNSIS DVSRRDLLAS LTHEQKQLIM 70 80 90 100 SQLLPELLSE LSNAEDHLHP MRDRDYAGWM DFGRRSSEVT ES

References

[1]	"Characterization of the cholecystokinin and gastrin genes from the bullfrog, Rana catesbeiana: evolutionary conservation of primary and secondary sites of gene expression." Rourke I.J., Rehfeld J.F., Moeller M., Johnson A.H. Endocrinology 138:1719-1727(1997) [PubMed: 9075736] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA].
[2]	"Identification of cholecystokinin/gastrin peptides in frog and turtle. Evidence that cholecystokinin is phylogenetically older than gastrin." Johnsen A.H., Rehfeld J.F. Eur. J. Biochem. 207:419-428(1992) [PubMed: 1633800] [Abstract] Cited for: PROTEIN SEQUENCE OF 46-92. Tissue: Gastric mucosa.

Cross-references

Sequence databases
EMBL GenBank DDBJ	Y08399, Y08400 Genomic DNA. Translation: CAA69676.1. Y08397 mRNA. Translation: CAA69675.1.
PIR	S24142.
3D structure databases
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Phylogenomic databases
HOVERGEN	HBG098151.
Family and domain databases
InterPro	IPR001651. Gastrin. IPR013152. Gastrin/cholecystokinin_CS. [Graphical view]
Pfam	PF00918. Gastrin. 1 hit. [Graphical view]
SMART	SM00029. GASTRIN. 1 hit. [Graphical view]
PROSITE	PS00259. GASTRIN. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

ANTR_RANCA

Accession

Primary (citable) accession number: P80111

Entry history

Integrated into UniProtKB/Swiss-Prot:	August 1, 1992
Last sequence update:	July 15, 1999
Last modified:	March 8, 2011
This is version 54 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program