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P80108

- PHLD_HUMAN

UniProt

P80108 - PHLD_HUMAN

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Protein

Phosphatidylinositol-glycan-specific phospholipase D

Gene

GPLD1

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli

Functioni

This protein hydrolyzes the inositol phosphate linkage in proteins anchored by phosphatidylinositol glycans (GPI-anchor) thus releasing these proteins from the membrane.

Catalytic activityi

6-(alpha-D-glucosaminyl)-1-phosphatidyl-1D-myo-inositol + H2O = 6-(alpha-D-glucosaminyl)-1D-myo-inositol + phosphatidate.

GO - Molecular functioni

  1. glycosylphosphatidylinositol phospholipase D activity Source: UniProtKB
  2. phospholipase D activity Source: UniProtKB
  3. sodium channel regulator activity Source: UniProtKB

GO - Biological processi

  1. cell migration involved in sprouting angiogenesis Source: UniProtKB
  2. cellular response to calcium ion Source: UniProtKB
  3. cellular response to cholesterol Source: UniProtKB
  4. cellular response to drug Source: UniProtKB
  5. cellular response to insulin stimulus Source: UniProtKB
  6. cellular response to pH Source: UniProtKB
  7. cellular response to triglyceride Source: UniProtKB
  8. chondrocyte differentiation Source: UniProtKB
  9. complement receptor mediated signaling pathway Source: UniProtKB
  10. GPI anchor release Source: UniProtKB
  11. hematopoietic stem cell migration Source: UniProtKB
  12. hematopoietic stem cell migration to bone marrow Source: UniProtKB
  13. insulin receptor signaling pathway Source: UniProtKB
  14. negative regulation of cell proliferation Source: UniProtKB
  15. negative regulation of triglyceride catabolic process Source: UniProtKB
  16. ossification Source: UniProtKB
  17. phosphatidylcholine metabolic process Source: UniProtKB
  18. positive regulation of alkaline phosphatase activity Source: UniProtKB
  19. positive regulation of apoptotic process Source: UniProtKB
  20. positive regulation of cytolysis Source: UniProtKB
  21. positive regulation of endothelial cell migration Source: UniProtKB
  22. positive regulation of glucose metabolic process Source: UniProtKB
  23. positive regulation of high-density lipoprotein particle clearance Source: UniProtKB
  24. positive regulation of insulin secretion involved in cellular response to glucose stimulus Source: UniProtKB
  25. positive regulation of membrane protein ectodomain proteolysis Source: UniProtKB
  26. positive regulation of secretion Source: UniProtKB
  27. positive regulation of triglyceride biosynthetic process Source: UniProtKB
  28. regulation of cellular response to insulin stimulus Source: UniProtKB
  29. response to glucose Source: UniProtKB
  30. transepithelial transport Source: UniProtKB
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Enzyme and pathway databases

BRENDAi3.1.4.50. 2681.
SignaLinkiP80108.

Names & Taxonomyi

Protein namesi
Recommended name:
Phosphatidylinositol-glycan-specific phospholipase D (EC:3.1.4.50)
Short name:
PI-G PLD
Alternative name(s):
Glycoprotein phospholipase D
Glycosyl-phosphatidylinositol-specific phospholipase D
Short name:
GPI-PLD
Short name:
GPI-specific phospholipase D
Gene namesi
Name:GPLD1
Synonyms:PIGPLD1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 6

Organism-specific databases

HGNCiHGNC:4459. GPLD1.

Subcellular locationi

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB
  2. extracellular space Source: UniProtKB
  3. extracellular vesicular exosome Source: UniProtKB
  4. intracellular Source: UniProtKB
  5. intracellular membrane-bounded organelle Source: UniProtKB
  6. lysosomal membrane Source: UniProtKB
  7. proteinaceous extracellular matrix Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Secreted

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA28842.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2323Add
BLAST
Chaini24 – 840817Phosphatidylinositol-glycan-specific phospholipase DPRO_0000022047Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi94 – 941N-linked (GlcNAc...)1 Publication
Glycosylationi271 – 2711N-linked (GlcNAc...)Sequence Analysis
Glycosylationi292 – 2921N-linked (GlcNAc...)Sequence Analysis
Glycosylationi307 – 3071N-linked (GlcNAc...)Sequence Analysis
Glycosylationi321 – 3211N-linked (GlcNAc...)Sequence Analysis
Glycosylationi501 – 5011N-linked (GlcNAc...)Sequence Analysis
Glycosylationi568 – 5681N-linked (GlcNAc...)Sequence Analysis
Glycosylationi591 – 5911N-linked (GlcNAc...)Sequence Analysis
Glycosylationi604 – 6041N-linked (GlcNAc...)Sequence Analysis
Glycosylationi659 – 6591N-linked (GlcNAc...)1 Publication

Keywords - PTMi

Glycoprotein

Proteomic databases

PaxDbiP80108.
PeptideAtlasiP80108.
PRIDEiP80108.

PTM databases

PhosphoSiteiP80108.

Expressioni

Gene expression databases

BgeeiP80108.
GenevestigatoriP80108.

Organism-specific databases

HPAiCAB008625.
HPA012500.

Interactioni

Subunit structurei

Monomer.Curated

Protein-protein interaction databases

BioGridi109083. 2 interactions.

Structurei

3D structure databases

ProteinModelPortaliP80108.
SMRiP80108. Positions 369-768.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Repeati367 – 42862FG-GAP 1Add
BLAST
Repeati436 – 49762FG-GAP 2Add
BLAST
Repeati499 – 55961FG-GAP 3Add
BLAST
Repeati563 – 62361FG-GAP 4Add
BLAST
Repeati633 – 69361FG-GAP 5Add
BLAST
Repeati704 – 77067FG-GAP 6Add
BLAST
Repeati788 – 84053FG-GAP 7Add
BLAST

Sequence similaritiesi

Belongs to the GPLD1 family.Curated
Contains 7 FG-GAP repeats.Curated

Keywords - Domaini

Repeat, Signal

Phylogenomic databases

eggNOGiNOG146018.
GeneTreeiENSGT00390000013522.
HOVERGENiHBG008185.
InParanoidiP80108.
KOiK01127.
OMAiSYSEAHS.
OrthoDBiEOG7MD4PC.
PhylomeDBiP80108.
TreeFamiTF335726.

Family and domain databases

InterProiIPR013517. FG-GAP.
IPR001028. Gprt_PLipase_D.
IPR013519. Int_alpha_beta-p.
IPR029002. PLPC/GPLD1.
[Graphical view]
PfamiPF01839. FG-GAP. 3 hits.
PF00882. Zn_dep_PLPC. 1 hit.
[Graphical view]
PRINTSiPR00718. PHPHLIPASED.
SMARTiSM00191. Int_alpha. 5 hits.
[Graphical view]
PROSITEiPS51470. FG_GAP. 7 hits.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by alternative splicing. Align

Isoform 1 (identifier: P80108-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MSAFRLWPGL LIMLGSLCHR GSPCGLSTHV EIGHRALEFL QLHNGRVNYR
60 70 80 90 100
ELLLEHQDAY QAGIVFPDCF YPSICKGGKF HDVSESTHWT PFLNASVHYI
110 120 130 140 150
RENYPLPWEK DTEKLVAFLF GITSHMAADV SWHSLGLEQG FLRTMGAIDF
160 170 180 190 200
HGSYSEAHSA GDFGGDVLSQ FEFNFNYLAR RWYVPVKDLL GIYEKLYGRK
210 220 230 240 250
VITENVIVDC SHIQFLEMYG EMLAVSKLYP TYSTKSPFLV EQFQEYFLGG
260 270 280 290 300
LDDMAFWSTN IYHLTSFMLE NGTSDCNLPE NPLFIACGGQ QNHTQGSKMQ
310 320 330 340 350
KNDFHRNLTT SLTESVDRNI NYTERGVFFS VNSWTPDSMS FIYKALERNI
360 370 380 390 400
RTMFIGGSQL SQKHVSSPLA SYFLSFPYAR LGWAMTSADL NQDGHGDLVV
410 420 430 440 450
GAPGYSRPGH IHIGRVYLIY GNDLGLPPVD LDLDKEAHRI LEGFQPSGRF
460 470 480 490 500
GSALAVLDFN VDGVPDLAVG APSVGSEQLT YKGAVYVYFG SKQGGMSSSP
510 520 530 540 550
NITISCQDIY CNLGWTLLAA DVNGDSEPDL VIGSPFAPGG GKQKGIVAAF
560 570 580 590 600
YSGPSLSDKE KLNVEAANWT VRGEEDFSWF GYSLHGVTVD NRTLLLVGSP
610 620 630 640 650
TWKNASRLGH LLHIRDEKKS LGRVYGYFPP NGQSWFTISG DKAMGKLGTS
660 670 680 690 700
LSSGHVLMNG TLKQVLLVGA PTYDDVSKVA FLTVTLHQGG ATRMYALTSD
710 720 730 740 750
AQPLLLSTFS GDRRFSRFGG VLHLSDLDDD GLDEIIMAAP LRIADVTSGL
760 770 780 790 800
IGGEDGRVYV YNGKETTLGD MTGKCKSWIT PCPEEKAQYV LISPEASSRF
810 820 830 840
GSSLITVRSK AKNQVVIAAG RSSLGARLSG ALHVYSLGSD
Length:840
Mass (Da):92,336
Last modified:February 20, 2007 - v3
Checksum:i11369BAFEC3D6D38
GO
Isoform 2 (identifier: P80108-2) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     165-176: GDVLSQFEFNFN → TVYLHLLNFLVV
     177-840: Missing.

Show »
Length:176
Mass (Da):19,865
Checksum:iB71070D7DD58234B
GO

Sequence cautioni

The sequence AAA36444.1 differs from that shown. Reason: This sequence has numerous of conflicts with the human genome.

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti531 – 5344VIGS → MLGT AA sequence (PubMed:1606959)Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti17 – 171L → V.1 Publication
Corresponds to variant rs2235501 [ dbSNP | Ensembl ].
VAR_030743
Natural varianti30 – 301V → I.3 Publications
Corresponds to variant rs1126617 [ dbSNP | Ensembl ].
VAR_030744
Natural varianti275 – 2751D → E.
Corresponds to variant rs17300770 [ dbSNP | Ensembl ].
VAR_030745
Natural varianti350 – 3501I → V.1 Publication
Corresponds to variant rs1062496 [ dbSNP | Ensembl ].
VAR_051278
Natural varianti396 – 3961G → S.
Corresponds to variant rs6924628 [ dbSNP | Ensembl ].
VAR_030746
Natural varianti461 – 4611V → M.1 Publication
Corresponds to variant rs1062505 [ dbSNP | Ensembl ].
VAR_030747
Natural varianti694 – 6941M → V.1 Publication
Corresponds to variant rs1042303 [ dbSNP | Ensembl ].
VAR_030748
Natural varianti698 – 6981T → I.4 Publications
Corresponds to variant rs1772256 [ dbSNP | Ensembl ].
VAR_030749

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei165 – 17612GDVLS…EFNFN → TVYLHLLNFLVV in isoform 2. 1 PublicationVSP_023261Add
BLAST
Alternative sequencei177 – 840664Missing in isoform 2. 1 PublicationVSP_023262Add
BLAST

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
L11701 mRNA. Translation: AAA36444.1. Sequence problems.
L11702 mRNA. Translation: AAA36445.1.
AJ308108 mRNA. Translation: CAC87068.1.
AJ400872
, AJ400873, AJ400874, AJ400875, AJ400876 Genomic DNA. Translation: CAC14844.1.
AY007546 mRNA. Translation: AAG16627.2.
AL359713, AL031230 Genomic DNA. Translation: CAI17103.1.
AL031230, AL359713 Genomic DNA. Translation: CAI22602.1.
AL031230 Genomic DNA. Translation: CAD92520.1.
BC007614 mRNA. Translation: AAH07614.1.
BC020748 mRNA. Translation: AAH20748.1.
BC093645 mRNA. Translation: AAH93645.1.
BC112001 mRNA. Translation: AAI12002.1.
CCDSiCCDS4553.1. [P80108-1]
RefSeqiNP_001494.2. NM_001503.3. [P80108-1]
UniGeneiHs.533291.

Genome annotation databases

EnsembliENST00000230036; ENSP00000230036; ENSG00000112293. [P80108-1]
GeneIDi2822.
KEGGihsa:2822.
UCSCiuc003ned.2. human. [P80108-1]
uc003nee.4. human. [P80108-2]

Polymorphism databases

DMDMi126302583.

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
L11701 mRNA. Translation: AAA36444.1 . Sequence problems.
L11702 mRNA. Translation: AAA36445.1 .
AJ308108 mRNA. Translation: CAC87068.1 .
AJ400872
, AJ400873 , AJ400874 , AJ400875 , AJ400876 Genomic DNA. Translation: CAC14844.1 .
AY007546 mRNA. Translation: AAG16627.2 .
AL359713 , AL031230 Genomic DNA. Translation: CAI17103.1 .
AL031230 , AL359713 Genomic DNA. Translation: CAI22602.1 .
AL031230 Genomic DNA. Translation: CAD92520.1 .
BC007614 mRNA. Translation: AAH07614.1 .
BC020748 mRNA. Translation: AAH20748.1 .
BC093645 mRNA. Translation: AAH93645.1 .
BC112001 mRNA. Translation: AAI12002.1 .
CCDSi CCDS4553.1. [P80108-1 ]
RefSeqi NP_001494.2. NM_001503.3. [P80108-1 ]
UniGenei Hs.533291.

3D structure databases

ProteinModelPortali P80108.
SMRi P80108. Positions 369-768.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 109083. 2 interactions.

PTM databases

PhosphoSitei P80108.

Polymorphism databases

DMDMi 126302583.

Proteomic databases

PaxDbi P80108.
PeptideAtlasi P80108.
PRIDEi P80108.

Protocols and materials databases

DNASUi 2822.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000230036 ; ENSP00000230036 ; ENSG00000112293 . [P80108-1 ]
GeneIDi 2822.
KEGGi hsa:2822.
UCSCi uc003ned.2. human. [P80108-1 ]
uc003nee.4. human. [P80108-2 ]

Organism-specific databases

CTDi 2822.
GeneCardsi GC06M024425.
H-InvDB HIX0032817.
HGNCi HGNC:4459. GPLD1.
HPAi CAB008625.
HPA012500.
MIMi 602515. gene.
neXtProti NX_P80108.
PharmGKBi PA28842.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG146018.
GeneTreei ENSGT00390000013522.
HOVERGENi HBG008185.
InParanoidi P80108.
KOi K01127.
OMAi SYSEAHS.
OrthoDBi EOG7MD4PC.
PhylomeDBi P80108.
TreeFami TF335726.

Enzyme and pathway databases

BRENDAi 3.1.4.50. 2681.
SignaLinki P80108.

Miscellaneous databases

GeneWikii GPLD1.
GenomeRNAii 2822.
NextBioi 11121.
PROi P80108.
SOURCEi Search...

Gene expression databases

Bgeei P80108.
Genevestigatori P80108.

Family and domain databases

InterProi IPR013517. FG-GAP.
IPR001028. Gprt_PLipase_D.
IPR013519. Int_alpha_beta-p.
IPR029002. PLPC/GPLD1.
[Graphical view ]
Pfami PF01839. FG-GAP. 3 hits.
PF00882. Zn_dep_PLPC. 1 hit.
[Graphical view ]
PRINTSi PR00718. PHPHLIPASED.
SMARTi SM00191. Int_alpha. 5 hits.
[Graphical view ]
PROSITEi PS51470. FG_GAP. 7 hits.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Isolation and expression of two human glycosylphosphatidylinositol phospholipase D (GPI-PLD) cDNAs."
    Tsang T.C., Fung W.-J.C., Levine J., Metz C.N., Davitz M.A., Burns D.K., Huang K.-S., Kochan J.P.
    FASEB J. 6:A1922-A1922(1992)
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), VARIANTS ILE-30; VAL-350; MET-461 AND ILE-698.
    Tissue: Liver and Pancreas.
  2. "Structure and expression of the human glycosylphosphatidylinositol phospholipase D1 (GPLD1) gene."
    Schofield J.N., Rademacher T.W.
    Biochim. Biophys. Acta 1494:189-194(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 384-840, VARIANTS ILE-30; VAL-694 AND ILE-698.
    Tissue: Liver.
  3. "Preliminary study of the gene structure of human glycosylphosphatidylinositol specific phospholipase D."
    Tang J.H., Gu S.L., Zhang X.J.
    Hunan Yi Ke Da Xue Xue Bao 26:96-97(2001)
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), VARIANT ILE-698.
    Tissue: Bone marrow.
  4. "The DNA sequence and analysis of human chromosome 6."
    Mungall A.J., Palmer S.A., Sims S.K., Edwards C.A., Ashurst J.L., Wilming L., Jones M.C., Horton R., Hunt S.E., Scott C.E., Gilbert J.G.R., Clamp M.E., Bethel G., Milne S., Ainscough R., Almeida J.P., Ambrose K.D., Andrews T.D.
    , Ashwell R.I.S., Babbage A.K., Bagguley C.L., Bailey J., Banerjee R., Barker D.J., Barlow K.F., Bates K., Beare D.M., Beasley H., Beasley O., Bird C.P., Blakey S.E., Bray-Allen S., Brook J., Brown A.J., Brown J.Y., Burford D.C., Burrill W., Burton J., Carder C., Carter N.P., Chapman J.C., Clark S.Y., Clark G., Clee C.M., Clegg S., Cobley V., Collier R.E., Collins J.E., Colman L.K., Corby N.R., Coville G.J., Culley K.M., Dhami P., Davies J., Dunn M., Earthrowl M.E., Ellington A.E., Evans K.A., Faulkner L., Francis M.D., Frankish A., Frankland J., French L., Garner P., Garnett J., Ghori M.J., Gilby L.M., Gillson C.J., Glithero R.J., Grafham D.V., Grant M., Gribble S., Griffiths C., Griffiths M.N.D., Hall R., Halls K.S., Hammond S., Harley J.L., Hart E.A., Heath P.D., Heathcott R., Holmes S.J., Howden P.J., Howe K.L., Howell G.R., Huckle E., Humphray S.J., Humphries M.D., Hunt A.R., Johnson C.M., Joy A.A., Kay M., Keenan S.J., Kimberley A.M., King A., Laird G.K., Langford C., Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C.R., Lloyd D.M., Loveland J.E., Lovell J., Martin S., Mashreghi-Mohammadi M., Maslen G.L., Matthews L., McCann O.T., McLaren S.J., McLay K., McMurray A., Moore M.J.F., Mullikin J.C., Niblett D., Nickerson T., Novik K.L., Oliver K., Overton-Larty E.K., Parker A., Patel R., Pearce A.V., Peck A.I., Phillimore B.J.C.T., Phillips S., Plumb R.W., Porter K.M., Ramsey Y., Ranby S.A., Rice C.M., Ross M.T., Searle S.M., Sehra H.K., Sheridan E., Skuce C.D., Smith S., Smith M., Spraggon L., Squares S.L., Steward C.A., Sycamore N., Tamlyn-Hall G., Tester J., Theaker A.J., Thomas D.W., Thorpe A., Tracey A., Tromans A., Tubby B., Wall M., Wallis J.M., West A.P., White S.S., Whitehead S.L., Whittaker H., Wild A., Willey D.J., Wilmer T.E., Wood J.M., Wray P.W., Wyatt J.C., Young L., Younger R.M., Bentley D.R., Coulson A., Durbin R.M., Hubbard T., Sulston J.E., Dunham I., Rogers J., Beck S.
    Nature 425:805-811(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2), NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 266-840 (ISOFORM 1), VARIANTS VAL-17; ILE-30 AND ILE-698.
    Tissue: Eye and Liver.
  6. "Phosphatidylinositol-glycan-specific phospholipase D is an amphiphilic glycoprotein that in serum is associated with high-density lipoproteins."
    Hoener M.C., Brodbeck U.
    Eur. J. Biochem. 206:747-757(1992) [PubMed] [Europe PMC] [Abstract]
    Cited for: PARTIAL PROTEIN SEQUENCE.
    Tissue: Serum.
  7. "Human plasma N-glycoproteome analysis by immunoaffinity subtraction, hydrazide chemistry, and mass spectrometry."
    Liu T., Qian W.-J., Gritsenko M.A., Camp D.G. II, Monroe M.E., Moore R.J., Smith R.D.
    J. Proteome Res. 4:2070-2080(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-94.
    Tissue: Plasma.
  8. "Glycoproteomics analysis of human liver tissue by combination of multiple enzyme digestion and hydrazide chemistry."
    Chen R., Jiang X., Sun D., Han G., Wang F., Ye M., Wang L., Zou H.
    J. Proteome Res. 8:651-661(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-659.
    Tissue: Liver.

Entry informationi

Entry nameiPHLD_HUMAN
AccessioniPrimary (citable) accession number: P80108
Secondary accession number(s): Q15127
, Q15128, Q2M2F2, Q5T3Y0, Q7Z6T8, Q8TCV0, Q8WW82, Q96ID6, Q9H167, Q9H4M1, Q9UJC9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 1, 1993
Last sequence update: February 20, 2007
Last modified: October 29, 2014
This is version 128 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Human chromosome 6
    Human chromosome 6: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3