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P80108

- PHLD_HUMAN

UniProt

P80108 - PHLD_HUMAN

Protein

Phosphatidylinositol-glycan-specific phospholipase D

Gene

GPLD1

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 127 (01 Oct 2014)
      Sequence version 3 (20 Feb 2007)
      Previous versions | rss
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    Functioni

    This protein hydrolyzes the inositol phosphate linkage in proteins anchored by phosphatidylinositol glycans (GPI-anchor) thus releasing these proteins from the membrane.

    Catalytic activityi

    6-(alpha-D-glucosaminyl)-1-phosphatidyl-1D-myo-inositol + H2O = 6-(alpha-D-glucosaminyl)-1D-myo-inositol + phosphatidate.

    GO - Molecular functioni

    1. glycosylphosphatidylinositol phospholipase D activity Source: UniProtKB
    2. phospholipase D activity Source: UniProtKB
    3. sodium channel regulator activity Source: UniProtKB

    GO - Biological processi

    1. cell migration involved in sprouting angiogenesis Source: UniProtKB
    2. cellular response to calcium ion Source: UniProtKB
    3. cellular response to cholesterol Source: UniProtKB
    4. cellular response to drug Source: UniProtKB
    5. cellular response to insulin stimulus Source: UniProtKB
    6. cellular response to pH Source: UniProtKB
    7. cellular response to triglyceride Source: UniProtKB
    8. chondrocyte differentiation Source: UniProtKB
    9. complement receptor mediated signaling pathway Source: UniProtKB
    10. GPI anchor release Source: UniProtKB
    11. hematopoietic stem cell migration Source: UniProtKB
    12. hematopoietic stem cell migration to bone marrow Source: UniProtKB
    13. insulin receptor signaling pathway Source: UniProtKB
    14. negative regulation of cell proliferation Source: UniProtKB
    15. negative regulation of triglyceride catabolic process Source: UniProtKB
    16. ossification Source: UniProtKB
    17. phosphatidylcholine metabolic process Source: UniProtKB
    18. positive regulation of alkaline phosphatase activity Source: UniProtKB
    19. positive regulation of apoptotic process Source: UniProtKB
    20. positive regulation of cytolysis Source: UniProtKB
    21. positive regulation of endothelial cell migration Source: UniProtKB
    22. positive regulation of glucose metabolic process Source: UniProtKB
    23. positive regulation of high-density lipoprotein particle clearance Source: UniProtKB
    24. positive regulation of insulin secretion involved in cellular response to glucose stimulus Source: UniProtKB
    25. positive regulation of membrane protein ectodomain proteolysis Source: UniProtKB
    26. positive regulation of secretion Source: UniProtKB
    27. positive regulation of triglyceride biosynthetic process Source: UniProtKB
    28. regulation of cellular response to insulin stimulus Source: UniProtKB
    29. response to glucose Source: UniProtKB
    30. transepithelial transport Source: UniProtKB

    Keywords - Molecular functioni

    Hydrolase

    Enzyme and pathway databases

    BRENDAi3.1.4.50. 2681.
    SignaLinkiP80108.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Phosphatidylinositol-glycan-specific phospholipase D (EC:3.1.4.50)
    Short name:
    PI-G PLD
    Alternative name(s):
    Glycoprotein phospholipase D
    Glycosyl-phosphatidylinositol-specific phospholipase D
    Short name:
    GPI-PLD
    Short name:
    GPI-specific phospholipase D
    Gene namesi
    Name:GPLD1
    Synonyms:PIGPLD1
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 6

    Organism-specific databases

    HGNCiHGNC:4459. GPLD1.

    Subcellular locationi

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB
    2. extracellular space Source: UniProtKB
    3. intracellular Source: UniProtKB
    4. intracellular membrane-bounded organelle Source: UniProtKB
    5. lysosomal membrane Source: UniProtKB
    6. proteinaceous extracellular matrix Source: UniProtKB

    Keywords - Cellular componenti

    Secreted

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA28842.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 2323Add
    BLAST
    Chaini24 – 840817Phosphatidylinositol-glycan-specific phospholipase DPRO_0000022047Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi94 – 941N-linked (GlcNAc...)1 Publication
    Glycosylationi271 – 2711N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi292 – 2921N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi307 – 3071N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi321 – 3211N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi501 – 5011N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi568 – 5681N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi591 – 5911N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi604 – 6041N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi659 – 6591N-linked (GlcNAc...)1 Publication

    Keywords - PTMi

    Glycoprotein

    Proteomic databases

    PaxDbiP80108.
    PeptideAtlasiP80108.
    PRIDEiP80108.

    PTM databases

    PhosphoSiteiP80108.

    Expressioni

    Gene expression databases

    BgeeiP80108.
    GenevestigatoriP80108.

    Organism-specific databases

    HPAiCAB008625.
    HPA012500.

    Interactioni

    Subunit structurei

    Monomer.Curated

    Protein-protein interaction databases

    BioGridi109083. 2 interactions.

    Structurei

    3D structure databases

    ProteinModelPortaliP80108.
    SMRiP80108. Positions 369-768.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Repeati367 – 42862FG-GAP 1Add
    BLAST
    Repeati436 – 49762FG-GAP 2Add
    BLAST
    Repeati499 – 55961FG-GAP 3Add
    BLAST
    Repeati563 – 62361FG-GAP 4Add
    BLAST
    Repeati633 – 69361FG-GAP 5Add
    BLAST
    Repeati704 – 77067FG-GAP 6Add
    BLAST
    Repeati788 – 84053FG-GAP 7Add
    BLAST

    Sequence similaritiesi

    Belongs to the GPLD1 family.Curated
    Contains 7 FG-GAP repeats.Curated

    Keywords - Domaini

    Repeat, Signal

    Phylogenomic databases

    eggNOGiNOG146018.
    HOVERGENiHBG008185.
    InParanoidiP80108.
    KOiK01127.
    OMAiSYSEAHS.
    OrthoDBiEOG7MD4PC.
    PhylomeDBiP80108.
    TreeFamiTF335726.

    Family and domain databases

    InterProiIPR013517. FG-GAP.
    IPR001028. Gprt_PLipase_D.
    IPR013519. Int_alpha_beta-p.
    IPR029002. PLPC/GPLD1.
    [Graphical view]
    PfamiPF01839. FG-GAP. 3 hits.
    PF00882. Zn_dep_PLPC. 1 hit.
    [Graphical view]
    PRINTSiPR00718. PHPHLIPASED.
    SMARTiSM00191. Int_alpha. 5 hits.
    [Graphical view]
    PROSITEiPS51470. FG_GAP. 7 hits.
    [Graphical view]

    Sequences (2)i

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    This entry describes 2 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: P80108-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MSAFRLWPGL LIMLGSLCHR GSPCGLSTHV EIGHRALEFL QLHNGRVNYR    50
    ELLLEHQDAY QAGIVFPDCF YPSICKGGKF HDVSESTHWT PFLNASVHYI 100
    RENYPLPWEK DTEKLVAFLF GITSHMAADV SWHSLGLEQG FLRTMGAIDF 150
    HGSYSEAHSA GDFGGDVLSQ FEFNFNYLAR RWYVPVKDLL GIYEKLYGRK 200
    VITENVIVDC SHIQFLEMYG EMLAVSKLYP TYSTKSPFLV EQFQEYFLGG 250
    LDDMAFWSTN IYHLTSFMLE NGTSDCNLPE NPLFIACGGQ QNHTQGSKMQ 300
    KNDFHRNLTT SLTESVDRNI NYTERGVFFS VNSWTPDSMS FIYKALERNI 350
    RTMFIGGSQL SQKHVSSPLA SYFLSFPYAR LGWAMTSADL NQDGHGDLVV 400
    GAPGYSRPGH IHIGRVYLIY GNDLGLPPVD LDLDKEAHRI LEGFQPSGRF 450
    GSALAVLDFN VDGVPDLAVG APSVGSEQLT YKGAVYVYFG SKQGGMSSSP 500
    NITISCQDIY CNLGWTLLAA DVNGDSEPDL VIGSPFAPGG GKQKGIVAAF 550
    YSGPSLSDKE KLNVEAANWT VRGEEDFSWF GYSLHGVTVD NRTLLLVGSP 600
    TWKNASRLGH LLHIRDEKKS LGRVYGYFPP NGQSWFTISG DKAMGKLGTS 650
    LSSGHVLMNG TLKQVLLVGA PTYDDVSKVA FLTVTLHQGG ATRMYALTSD 700
    AQPLLLSTFS GDRRFSRFGG VLHLSDLDDD GLDEIIMAAP LRIADVTSGL 750
    IGGEDGRVYV YNGKETTLGD MTGKCKSWIT PCPEEKAQYV LISPEASSRF 800
    GSSLITVRSK AKNQVVIAAG RSSLGARLSG ALHVYSLGSD 840
    Length:840
    Mass (Da):92,336
    Last modified:February 20, 2007 - v3
    Checksum:i11369BAFEC3D6D38
    GO
    Isoform 2 (identifier: P80108-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         165-176: GDVLSQFEFNFN → TVYLHLLNFLVV
         177-840: Missing.

    Show »
    Length:176
    Mass (Da):19,865
    Checksum:iB71070D7DD58234B
    GO

    Sequence cautioni

    The sequence AAA36444.1 differs from that shown. Reason: This sequence has numerous of conflicts with the human genome.

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti531 – 5344VIGS → MLGT AA sequence (PubMed:1606959)Curated

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti17 – 171L → V.1 Publication
    Corresponds to variant rs2235501 [ dbSNP | Ensembl ].
    VAR_030743
    Natural varianti30 – 301V → I.3 Publications
    Corresponds to variant rs1126617 [ dbSNP | Ensembl ].
    VAR_030744
    Natural varianti275 – 2751D → E.
    Corresponds to variant rs17300770 [ dbSNP | Ensembl ].
    VAR_030745
    Natural varianti350 – 3501I → V.1 Publication
    Corresponds to variant rs1062496 [ dbSNP | Ensembl ].
    VAR_051278
    Natural varianti396 – 3961G → S.
    Corresponds to variant rs6924628 [ dbSNP | Ensembl ].
    VAR_030746
    Natural varianti461 – 4611V → M.1 Publication
    Corresponds to variant rs1062505 [ dbSNP | Ensembl ].
    VAR_030747
    Natural varianti694 – 6941M → V.1 Publication
    Corresponds to variant rs1042303 [ dbSNP | Ensembl ].
    VAR_030748
    Natural varianti698 – 6981T → I.4 Publications
    Corresponds to variant rs1772256 [ dbSNP | Ensembl ].
    VAR_030749

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei165 – 17612GDVLS…EFNFN → TVYLHLLNFLVV in isoform 2. 1 PublicationVSP_023261Add
    BLAST
    Alternative sequencei177 – 840664Missing in isoform 2. 1 PublicationVSP_023262Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    L11701 mRNA. Translation: AAA36444.1. Sequence problems.
    L11702 mRNA. Translation: AAA36445.1.
    AJ308108 mRNA. Translation: CAC87068.1.
    AJ400872
    , AJ400873, AJ400874, AJ400875, AJ400876 Genomic DNA. Translation: CAC14844.1.
    AY007546 mRNA. Translation: AAG16627.2.
    AL359713, AL031230 Genomic DNA. Translation: CAI17103.1.
    AL031230, AL359713 Genomic DNA. Translation: CAI22602.1.
    AL031230 Genomic DNA. Translation: CAD92520.1.
    BC007614 mRNA. Translation: AAH07614.1.
    BC020748 mRNA. Translation: AAH20748.1.
    BC093645 mRNA. Translation: AAH93645.1.
    BC112001 mRNA. Translation: AAI12002.1.
    CCDSiCCDS4553.1. [P80108-1]
    RefSeqiNP_001494.2. NM_001503.3. [P80108-1]
    UniGeneiHs.533291.

    Genome annotation databases

    EnsembliENST00000230036; ENSP00000230036; ENSG00000112293. [P80108-1]
    GeneIDi2822.
    KEGGihsa:2822.
    UCSCiuc003ned.2. human. [P80108-1]
    uc003nee.4. human. [P80108-2]

    Polymorphism databases

    DMDMi126302583.

    Keywords - Coding sequence diversityi

    Alternative splicing, Polymorphism

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    L11701 mRNA. Translation: AAA36444.1 . Sequence problems.
    L11702 mRNA. Translation: AAA36445.1 .
    AJ308108 mRNA. Translation: CAC87068.1 .
    AJ400872
    , AJ400873 , AJ400874 , AJ400875 , AJ400876 Genomic DNA. Translation: CAC14844.1 .
    AY007546 mRNA. Translation: AAG16627.2 .
    AL359713 , AL031230 Genomic DNA. Translation: CAI17103.1 .
    AL031230 , AL359713 Genomic DNA. Translation: CAI22602.1 .
    AL031230 Genomic DNA. Translation: CAD92520.1 .
    BC007614 mRNA. Translation: AAH07614.1 .
    BC020748 mRNA. Translation: AAH20748.1 .
    BC093645 mRNA. Translation: AAH93645.1 .
    BC112001 mRNA. Translation: AAI12002.1 .
    CCDSi CCDS4553.1. [P80108-1 ]
    RefSeqi NP_001494.2. NM_001503.3. [P80108-1 ]
    UniGenei Hs.533291.

    3D structure databases

    ProteinModelPortali P80108.
    SMRi P80108. Positions 369-768.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 109083. 2 interactions.

    PTM databases

    PhosphoSitei P80108.

    Polymorphism databases

    DMDMi 126302583.

    Proteomic databases

    PaxDbi P80108.
    PeptideAtlasi P80108.
    PRIDEi P80108.

    Protocols and materials databases

    DNASUi 2822.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000230036 ; ENSP00000230036 ; ENSG00000112293 . [P80108-1 ]
    GeneIDi 2822.
    KEGGi hsa:2822.
    UCSCi uc003ned.2. human. [P80108-1 ]
    uc003nee.4. human. [P80108-2 ]

    Organism-specific databases

    CTDi 2822.
    GeneCardsi GC06M024377.
    H-InvDB HIX0032817.
    HGNCi HGNC:4459. GPLD1.
    HPAi CAB008625.
    HPA012500.
    MIMi 602515. gene.
    neXtProti NX_P80108.
    PharmGKBi PA28842.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG146018.
    HOVERGENi HBG008185.
    InParanoidi P80108.
    KOi K01127.
    OMAi SYSEAHS.
    OrthoDBi EOG7MD4PC.
    PhylomeDBi P80108.
    TreeFami TF335726.

    Enzyme and pathway databases

    BRENDAi 3.1.4.50. 2681.
    SignaLinki P80108.

    Miscellaneous databases

    GeneWikii GPLD1.
    GenomeRNAii 2822.
    NextBioi 11121.
    PROi P80108.
    SOURCEi Search...

    Gene expression databases

    Bgeei P80108.
    Genevestigatori P80108.

    Family and domain databases

    InterProi IPR013517. FG-GAP.
    IPR001028. Gprt_PLipase_D.
    IPR013519. Int_alpha_beta-p.
    IPR029002. PLPC/GPLD1.
    [Graphical view ]
    Pfami PF01839. FG-GAP. 3 hits.
    PF00882. Zn_dep_PLPC. 1 hit.
    [Graphical view ]
    PRINTSi PR00718. PHPHLIPASED.
    SMARTi SM00191. Int_alpha. 5 hits.
    [Graphical view ]
    PROSITEi PS51470. FG_GAP. 7 hits.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Isolation and expression of two human glycosylphosphatidylinositol phospholipase D (GPI-PLD) cDNAs."
      Tsang T.C., Fung W.-J.C., Levine J., Metz C.N., Davitz M.A., Burns D.K., Huang K.-S., Kochan J.P.
      FASEB J. 6:A1922-A1922(1992)
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), VARIANTS ILE-30; VAL-350; MET-461 AND ILE-698.
      Tissue: Liver and Pancreas.
    2. "Structure and expression of the human glycosylphosphatidylinositol phospholipase D1 (GPLD1) gene."
      Schofield J.N., Rademacher T.W.
      Biochim. Biophys. Acta 1494:189-194(2000) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 384-840, VARIANTS ILE-30; VAL-694 AND ILE-698.
      Tissue: Liver.
    3. "Preliminary study of the gene structure of human glycosylphosphatidylinositol specific phospholipase D."
      Tang J.H., Gu S.L., Zhang X.J.
      Hunan Yi Ke Da Xue Xue Bao 26:96-97(2001)
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), VARIANT ILE-698.
      Tissue: Bone marrow.
    4. "The DNA sequence and analysis of human chromosome 6."
      Mungall A.J., Palmer S.A., Sims S.K., Edwards C.A., Ashurst J.L., Wilming L., Jones M.C., Horton R., Hunt S.E., Scott C.E., Gilbert J.G.R., Clamp M.E., Bethel G., Milne S., Ainscough R., Almeida J.P., Ambrose K.D., Andrews T.D.
      , Ashwell R.I.S., Babbage A.K., Bagguley C.L., Bailey J., Banerjee R., Barker D.J., Barlow K.F., Bates K., Beare D.M., Beasley H., Beasley O., Bird C.P., Blakey S.E., Bray-Allen S., Brook J., Brown A.J., Brown J.Y., Burford D.C., Burrill W., Burton J., Carder C., Carter N.P., Chapman J.C., Clark S.Y., Clark G., Clee C.M., Clegg S., Cobley V., Collier R.E., Collins J.E., Colman L.K., Corby N.R., Coville G.J., Culley K.M., Dhami P., Davies J., Dunn M., Earthrowl M.E., Ellington A.E., Evans K.A., Faulkner L., Francis M.D., Frankish A., Frankland J., French L., Garner P., Garnett J., Ghori M.J., Gilby L.M., Gillson C.J., Glithero R.J., Grafham D.V., Grant M., Gribble S., Griffiths C., Griffiths M.N.D., Hall R., Halls K.S., Hammond S., Harley J.L., Hart E.A., Heath P.D., Heathcott R., Holmes S.J., Howden P.J., Howe K.L., Howell G.R., Huckle E., Humphray S.J., Humphries M.D., Hunt A.R., Johnson C.M., Joy A.A., Kay M., Keenan S.J., Kimberley A.M., King A., Laird G.K., Langford C., Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C.R., Lloyd D.M., Loveland J.E., Lovell J., Martin S., Mashreghi-Mohammadi M., Maslen G.L., Matthews L., McCann O.T., McLaren S.J., McLay K., McMurray A., Moore M.J.F., Mullikin J.C., Niblett D., Nickerson T., Novik K.L., Oliver K., Overton-Larty E.K., Parker A., Patel R., Pearce A.V., Peck A.I., Phillimore B.J.C.T., Phillips S., Plumb R.W., Porter K.M., Ramsey Y., Ranby S.A., Rice C.M., Ross M.T., Searle S.M., Sehra H.K., Sheridan E., Skuce C.D., Smith S., Smith M., Spraggon L., Squares S.L., Steward C.A., Sycamore N., Tamlyn-Hall G., Tester J., Theaker A.J., Thomas D.W., Thorpe A., Tracey A., Tromans A., Tubby B., Wall M., Wallis J.M., West A.P., White S.S., Whitehead S.L., Whittaker H., Wild A., Willey D.J., Wilmer T.E., Wood J.M., Wray P.W., Wyatt J.C., Young L., Younger R.M., Bentley D.R., Coulson A., Durbin R.M., Hubbard T., Sulston J.E., Dunham I., Rogers J., Beck S.
      Nature 425:805-811(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2), NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 266-840 (ISOFORM 1), VARIANTS VAL-17; ILE-30 AND ILE-698.
      Tissue: Eye and Liver.
    6. "Phosphatidylinositol-glycan-specific phospholipase D is an amphiphilic glycoprotein that in serum is associated with high-density lipoproteins."
      Hoener M.C., Brodbeck U.
      Eur. J. Biochem. 206:747-757(1992) [PubMed] [Europe PMC] [Abstract]
      Cited for: PARTIAL PROTEIN SEQUENCE.
      Tissue: Serum.
    7. "Human plasma N-glycoproteome analysis by immunoaffinity subtraction, hydrazide chemistry, and mass spectrometry."
      Liu T., Qian W.-J., Gritsenko M.A., Camp D.G. II, Monroe M.E., Moore R.J., Smith R.D.
      J. Proteome Res. 4:2070-2080(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-94.
      Tissue: Plasma.
    8. "Glycoproteomics analysis of human liver tissue by combination of multiple enzyme digestion and hydrazide chemistry."
      Chen R., Jiang X., Sun D., Han G., Wang F., Ye M., Wang L., Zou H.
      J. Proteome Res. 8:651-661(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-659.
      Tissue: Liver.

    Entry informationi

    Entry nameiPHLD_HUMAN
    AccessioniPrimary (citable) accession number: P80108
    Secondary accession number(s): Q15127
    , Q15128, Q2M2F2, Q5T3Y0, Q7Z6T8, Q8TCV0, Q8WW82, Q96ID6, Q9H167, Q9H4M1, Q9UJC9
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: July 1, 1993
    Last sequence update: February 20, 2007
    Last modified: October 1, 2014
    This is version 127 of the entry and version 3 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Direct protein sequencing, Reference proteome

    Documents

    1. Human chromosome 6
      Human chromosome 6: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    5. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3