Reviewed,
UniProtKB/Swiss-Prot P80108 (PHLD_HUMAN)
Last modified
November 25, 2008.
Version 69.
History...
Clusters with 100%,
90%,
50% identity |
Documents (5) |
Third-party data |
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Names and origin
| Protein names | Recommended name: Phosphatidylinositol-glycan-specific phospholipase D Short name=PI-G PLD EC=3.1.4.50 Alternative name(s): Glycoprotein phospholipase D Glycosyl-phosphatidylinositol-specific phospholipase D | ||||
| Gene names |
| ||||
| Organism | Homo sapiens (Human) | ||||
| Taxonomic identifier | 9606 [NCBI] | ||||
| Taxonomic lineage | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Protein attributes
| Sequence length | 840 AA. |
| Sequence status | Complete. |
| Sequence processing | The displayed sequence is further processed into a mature form. |
| Protein existence | Evidence at protein level. |
General annotation (Comments)
| Function | This protein hydrolyzes the inositol phosphate linkage in proteins anchored by phosphatidylinositol glycans (GPI-anchor) thus releasing these proteins from the membrane. |
| Catalytic activity | 6-(alpha-D-glucosaminyl)-1-phosphatidyl-1D-myo-inositol + H(2)O = 6-(alpha-D-glucosaminyl)-1D-myo-inositol + phosphatidate. |
| Subcellular location | |
| Sequence similarities | Contains 4 FG-GAP repeats. |
| Sequence caution | The sequence AAA36444.1 differs from that shown. Reason: Miscellaneous discrepancy. This sequence has numerous of conflicts with the human genome. |
Ontologies
Keywords | |
|---|---|
| Cellular component | Secreted |
| Coding sequence diversity | Alternative splicing Polymorphism |
| Domain | Repeat Signal |
| Molecular function | Hydrolase |
| PTM | Glycoprotein |
| Technical term | Direct protein sequencing |
Gene Ontology (GO) | |
| Molecular function | glycosylphosphatidylinositol phospholipase D activity Inferred from electronic annotation. Source: InterPro |
| Complete GO annotation... | |
Alternative products
| This entry describes 2 isoforms produced by alternative splicing. [Align] [Select] | ||||||
| Isoform 1 (identifier: P80108-1) This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. | ||||||
| Isoform 2 (identifier: P80108-2) The sequence of this isoform differs from the canonical sequence as follows: 165-176: GDVLSQFEFNFN → TVYLHLLNFLVV 177-840: Missing. |
Sequence annotation (Features)
| Feature key | Position(s) | Length | Description | Graphical view | Feature identifier | ||||
Molecule processing | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Signal peptide | 1 – 23 | 23 | |||||||
| Chain | 24 – 840 | 817 | Phosphatidylinositol-glycan-specific phospholipase D | PRO_0000022047 | |||||
Regions | |||||||||
| Repeat | 381 – 419 | 39 | FG-GAP 1 | ||||||
| Repeat | 450 – 488 | 39 | FG-GAP 2 | ||||||
| Repeat | 513 – 550 | 38 | FG-GAP 3 | ||||||
| Repeat | 718 – 750 | 33 | FG-GAP 4 | ||||||
Amino acid modifications | |||||||||
| Glycosylation | 94 | 1 | N-linked (GlcNAc...) | ||||||
| Glycosylation | 271 | 1 | N-linked (GlcNAc...) Potential | ||||||
| Glycosylation | 292 | 1 | N-linked (GlcNAc...) Potential | ||||||
| Glycosylation | 307 | 1 | N-linked (GlcNAc...) Potential | ||||||
| Glycosylation | 321 | 1 | N-linked (GlcNAc...) Potential | ||||||
| Glycosylation | 501 | 1 | N-linked (GlcNAc...) Potential | ||||||
| Glycosylation | 568 | 1 | N-linked (GlcNAc...) Potential | ||||||
| Glycosylation | 591 | 1 | N-linked (GlcNAc...) Potential | ||||||
| Glycosylation | 604 | 1 | N-linked (GlcNAc...) Potential | ||||||
| Glycosylation | 659 | 1 | N-linked (GlcNAc...) Probable | ||||||
Natural variations | |||||||||
| Alternative sequence | 165 – 176 | 12 | GDVLS…EFNFN → TVYLHLLNFLVV in isoform 2. | VSP_023261 | |||||
| Alternative sequence | 177 – 840 | 664 | Missing in isoform 2. | VSP_023262 | |||||
| Natural variant | 17 | 1 | L → V: dbSNP rs2235501. | VAR_030743 | |||||
| Natural variant | 30 | 1 | V → I: dbSNP rs1126617. | VAR_030744 | |||||
| Natural variant | 275 | 1 | D → E: dbSNP rs17300770. | VAR_030745 | |||||
| Natural variant | 396 | 1 | G → S: dbSNP rs6924628. | VAR_030746 | |||||
| Natural variant | 461 | 1 | V → M: dbSNP rs1062505. | VAR_030747 | |||||
| Natural variant | 694 | 1 | M → V: dbSNP rs1042303. | VAR_030748 | |||||
| Natural variant | 698 | 1 | T → I: dbSNP rs1772256. | VAR_030749 | |||||
Experimental info | |||||||||
| Sequence conflict | 12 – 15 | 4 | IMLG → MIVMA in AAA36444. Ref.1 | ||||||
| Sequence conflict | 23 | 1 | P → S in AAA36444. Ref.1 | ||||||
| Sequence conflict | 41 | 1 | Q → H in AAA36444. Ref.1 | ||||||
| Sequence conflict | 46 | 1 | R → H in AAA36444. Ref.1 | ||||||
| Sequence conflict | 50 | 1 | R → K in AAA36444. Ref.1 | ||||||
| Sequence conflict | 64 | 1 | I → T in AAA36444. Ref.1 | ||||||
| Sequence conflict | 74 | 1 | I → L in AAA36444. Ref.1 | ||||||
| Sequence conflict | 127 | 1 | A → V in AAA36444. Ref.1 | ||||||
| Sequence conflict | 137 | 1 | L → I in AAA36444. Ref.1 | ||||||
| Sequence conflict | 200 | 1 | K → E in AAA36444. Ref.1 | ||||||
| Sequence conflict | 231 | 1 | T → S in AAA36444. Ref.1 | ||||||
| Sequence conflict | 266 | 1 | S → I in AAA36445. Ref.1 | ||||||
| Sequence conflict | 277 | 1 | N → S in AAA36444. Ref.1 | ||||||
| Sequence conflict | 310 | 1 | T → S in AAA36444. Ref.1 | ||||||
| Sequence conflict | 315 – 316 | 2 | SV → NI in AAA36444. Ref.1 | ||||||
| Sequence conflict | 350 | 1 | I → V in AAA36444. Ref.1 | ||||||
| Sequence conflict | 365 | 1 | V → I in AAA36444. Ref.1 | ||||||
| Sequence conflict | 395 | 1 | H → Y in AAA36444. Ref.1 | ||||||
| Sequence conflict | 410 | 1 | H → R in AAA36444. Ref.1 | ||||||
| Sequence conflict | 423 | 1 | D → E in AAA36444. Ref.1 | ||||||
| Sequence conflict | 439 | 1 | R → G in AAA36444. Ref.1 | ||||||
| Sequence conflict | 456 | 1 | V → M in AAA36444. Ref.1 | ||||||
| Sequence conflict | 495 | 1 | G → R in AAA36444. Ref.1 | ||||||
| Sequence conflict | 531 – 534 | 4 | VIGS → MLGT AA sequence Ref.6 | ||||||
| Sequence conflict | 558 | 1 | D → N in AAA36444. Ref.1 | ||||||
| Sequence conflict | 578 | 1 | S → A in AAA36444. Ref.1 | ||||||
| Sequence conflict | 610 | 1 | H → R in AAA36444. Ref.1 | ||||||
| Sequence conflict | 632 | 1 | G → S in AAA36444. Ref.1 | ||||||
| Sequence conflict | 639 | 1 | S → V in AAA36444. Ref.1 | ||||||
| Sequence conflict | 663 | 1 | K → T in AAA36444. Ref.1 | ||||||
| Sequence conflict | 673 | 1 | Y → R in AAA36444. Ref.1 | ||||||
| Sequence conflict | 679 | 1 | V → M in AAA36444. Ref.1 | ||||||
| Sequence conflict | 684 | 1 | V → M in AAA36444. Ref.1 | ||||||
| Sequence conflict | 701 | 1 | A → L in AAA36444. Ref.1 | ||||||
| Sequence conflict | 704 | 1 | L → P in AAA36444. Ref.1 | ||||||
| Sequence conflict | 732 | 1 | L → V in AAA36444. Ref.1 | ||||||
| Sequence conflict | 737 | 1 | M → V in AAA36444. Ref.1 | ||||||
| Sequence conflict | 779 | 1 | I → M in AAA36444. Ref.1 | ||||||
| Sequence conflict | 837 | 1 | L → F in AAA36444. Ref.1 | ||||||
Sequences
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References
| « Hide 'large scale' references | |
| [1] | "Isolation and expression of two human glycosylphosphatidylinositol phospholipase D (GPI-PLD) cDNAs." Tsang T.C., Fung W.-J.C., Levine J., Metz C.N., Davitz M.A., Burns D.K., Huang K.-S., Kochan J.P. FASEB J. 6:A1922-A1922(1992) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), VARIANTS ILE-30; MET-461 AND ILE-698. Tissue: Liver and Pancreas. |
| [2] | "Structure and expression of the human glycosylphosphatidylinositol phospholipase D1 (GPLD1) gene." Schofield J.N., Rademacher T.W. Biochim. Biophys. Acta 1494:189-194(2000) [PubMed: 11072085] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 384-840, VARIANTS ILE-30; VAL-694 AND ILE-698. Tissue: Liver. |
| [3] | "Preliminary study of the gene structure of human glycosylphosphatidylinositol specific phospholipase D." Tang J.H., Gu S.L., Zhang X.J. Hunan Yi Ke Da Xue Xue Bao 26:96-97(2001) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), VARIANT ILE-698. Tissue: Bone marrow. |
| [4] | "The DNA sequence and analysis of human chromosome 6." Mungall A.J., Palmer S.A., Sims S.K., Edwards C.A., Ashurst J.L., Wilming L., Jones M.C., Horton R., Hunt S.E., Scott C.E., Gilbert J.G.R., Clamp M.E., Bethel G., Milne S., Ainscough R., Almeida J.P., Ambrose K.D., Andrews T.D. Beck S.Nature 425:805-811(2003) [PubMed: 14574404] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. |
| [5] | "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [ |

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