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P80098

- CCL7_HUMAN

UniProt

P80098 - CCL7_HUMAN

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Protein

C-C motif chemokine 7

Gene
CCL7, MCP3, SCYA6, SCYA7
Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at protein leveli

Functioni

Chemotactic factor that attracts monocytes and eosinophils, but not neutrophils. Augments monocyte anti-tumor activity. Also induces the release of gelatinase B. This protein can bind heparin. Binds to CCR1, CCR2 and CCR3.

GO - Molecular functioni

  1. CCR1 chemokine receptor binding Source: UniProtKB
  2. chemokine activity Source: UniProtKB
  3. heparin binding Source: UniProtKB-KW

GO - Biological processi

  1. cell-cell signaling Source: ProtInc
  2. cellular calcium ion homeostasis Source: ProtInc
  3. cellular response to ethanol Source: Ensembl
  4. chemotaxis Source: ProtInc
  5. cytoskeleton organization Source: UniProtKB
  6. eosinophil chemotaxis Source: UniProtKB
  7. immune response Source: InterPro
  8. inflammatory response Source: UniProtKB-KW
  9. monocyte chemotaxis Source: UniProtKB
  10. positive regulation of cell migration Source: UniProtKB
  11. positive regulation of natural killer cell chemotaxis Source: UniProtKB
  12. regulation of cell shape Source: UniProtKB
  13. response to gamma radiation Source: Ensembl
  14. signal transduction Source: ProtInc
Complete GO annotation...

Keywords - Molecular functioni

Cytokine

Keywords - Biological processi

Chemotaxis, Inflammatory response

Keywords - Ligandi

Heparin-binding

Enzyme and pathway databases

ReactomeiREACT_15344. Chemokine receptors bind chemokines.

Names & Taxonomyi

Protein namesi
Recommended name:
C-C motif chemokine 7
Alternative name(s):
Monocyte chemoattractant protein 3
Monocyte chemotactic protein 3
Short name:
MCP-3
NC28
Small-inducible cytokine A7
Gene namesi
Name:CCL7
Synonyms:MCP3, SCYA6, SCYA7
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 17

Organism-specific databases

HGNCiHGNC:10634. CCL7.

Subcellular locationi

GO - Cellular componenti

  1. extracellular region Source: Reactome
  2. extracellular space Source: ProtInc
Complete GO annotation...

Keywords - Cellular componenti

Secreted

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA35566.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 23231 PublicationAdd
BLAST
Chaini24 – 9976C-C motif chemokine 7PRO_0000005183Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei24 – 241Pyrrolidone carboxylic acid
Glycosylationi29 – 291N-linked (GlcNAc...) Reviewed prediction
Disulfide bondi34 ↔ 59
Disulfide bondi35 ↔ 75

Post-translational modificationi

O-glycosylated.

Keywords - PTMi

Disulfide bond, Glycoprotein, Pyrrolidone carboxylic acid

Proteomic databases

PaxDbiP80098.
PRIDEiP80098.

Miscellaneous databases

PMAP-CutDBP80098.

Expressioni

Gene expression databases

ArrayExpressiP80098.
BgeeiP80098.
CleanExiHS_CCL7.
GenevestigatoriP80098.

Interactioni

Subunit structurei

Monomer.1 Publication

Protein-protein interaction databases

BioGridi112257. 7 interactions.
DIPiDIP-5847N.
IntActiP80098. 2 interactions.
MINTiMINT-103194.
STRINGi9606.ENSP00000200307.

Structurei

Secondary structure

1
99
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Beta strandi29 – 313
Beta strandi33 – 353
Turni45 – 473
Beta strandi48 – 536
Turni56 – 583
Beta strandi64 – 685
Beta strandi73 – 764
Helixi81 – 9111

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1BO0NMR-A24-99[»]
1NCVNMR-A/B24-99[»]
ProteinModelPortaliP80098.
SMRiP80098. Positions 24-99.

Miscellaneous databases

EvolutionaryTraceiP80098.

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiNOG140372.
HOGENOMiHOG000036686.
HOVERGENiHBG017871.
InParanoidiP80098.
KOiK05509.
OrthoDBiEOG7C5MC2.
PhylomeDBiP80098.
TreeFamiTF334888.

Family and domain databases

InterProiIPR000827. Chemokine_CC_CS.
IPR001811. Chemokine_IL8-like_dom.
[Graphical view]
PfamiPF00048. IL8. 1 hit.
[Graphical view]
SMARTiSM00199. SCY. 1 hit.
[Graphical view]
SUPFAMiSSF54117. SSF54117. 1 hit.
PROSITEiPS00472. SMALL_CYTOKINES_CC. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P80098-1 [UniParc]FASTAAdd to Basket

« Hide

MKASAALLCL LLTAAAFSPQ GLAQPVGINT STTCCYRFIN KKIPKQRLES   50
YRRTTSSHCP REAVIFKTKL DKEICADPTQ KWVQDFMKHL DKKTQTPKL 99
Length:99
Mass (Da):11,200
Last modified:November 1, 1995 - v3
Checksum:i96048B371C25D00E
GO

Sequence cautioni

The sequence CAA50405.1 differs from that shown. Reason: Erroneous initiation.
The sequence CAA50406.1 differs from that shown. Reason: Erroneous initiation.
The sequence CAA51055.1 differs from that shown. Reason: Erroneous initiation.

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti30 – 301T → K AA sequence 1 Publication
Sequence conflicti68 – 703Missing AA sequence 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
X72308 mRNA. Translation: CAA51055.1. Different initiation.
X72309 Genomic DNA. No translation available.
X71087 mRNA. Translation: CAA50407.1.
X71087 mRNA. Translation: CAA50406.1. Different initiation.
X71087 mRNA. Translation: CAA50405.1. Different initiation.
BC092436 mRNA. Translation: AAH92436.1.
BC112258 mRNA. Translation: AAI12259.1.
BC112260 mRNA. Translation: AAI12261.1.
AF043338 mRNA. Translation: AAC03538.1.
CCDSiCCDS11278.1.
RefSeqiNP_006264.2. NM_006273.3.
UniGeneiHs.251526.

Genome annotation databases

EnsembliENST00000378569; ENSP00000367832; ENSG00000108688.
GeneIDi6354.
KEGGihsa:6354.
UCSCiuc002hhz.4. human.

Polymorphism databases

DMDMi1170890.

Cross-referencesi

Web resourcesi

Wikipedia

CCL7 entry

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
X72308 mRNA. Translation: CAA51055.1 . Different initiation.
X72309 Genomic DNA. No translation available.
X71087 mRNA. Translation: CAA50407.1 .
X71087 mRNA. Translation: CAA50406.1 . Different initiation.
X71087 mRNA. Translation: CAA50405.1 . Different initiation.
BC092436 mRNA. Translation: AAH92436.1 .
BC112258 mRNA. Translation: AAI12259.1 .
BC112260 mRNA. Translation: AAI12261.1 .
AF043338 mRNA. Translation: AAC03538.1 .
CCDSi CCDS11278.1.
RefSeqi NP_006264.2. NM_006273.3.
UniGenei Hs.251526.

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
Entry Method Resolution (Å) Chain Positions PDBsum
1BO0 NMR - A 24-99 [» ]
1NCV NMR - A/B 24-99 [» ]
ProteinModelPortali P80098.
SMRi P80098. Positions 24-99.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 112257. 7 interactions.
DIPi DIP-5847N.
IntActi P80098. 2 interactions.
MINTi MINT-103194.
STRINGi 9606.ENSP00000200307.

Polymorphism databases

DMDMi 1170890.

Proteomic databases

PaxDbi P80098.
PRIDEi P80098.

Protocols and materials databases

DNASUi 6354.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000378569 ; ENSP00000367832 ; ENSG00000108688 .
GeneIDi 6354.
KEGGi hsa:6354.
UCSCi uc002hhz.4. human.

Organism-specific databases

CTDi 6354.
GeneCardsi GC17P032597.
HGNCi HGNC:10634. CCL7.
MIMi 158106. gene.
neXtProti NX_P80098.
PharmGKBi PA35566.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG140372.
HOGENOMi HOG000036686.
HOVERGENi HBG017871.
InParanoidi P80098.
KOi K05509.
OrthoDBi EOG7C5MC2.
PhylomeDBi P80098.
TreeFami TF334888.

Enzyme and pathway databases

Reactomei REACT_15344. Chemokine receptors bind chemokines.

Miscellaneous databases

EvolutionaryTracei P80098.
GeneWikii CCL7.
GenomeRNAii 6354.
NextBioi 24680.
PMAP-CutDB P80098.
PROi P80098.
SOURCEi Search...

Gene expression databases

ArrayExpressi P80098.
Bgeei P80098.
CleanExi HS_CCL7.
Genevestigatori P80098.

Family and domain databases

InterProi IPR000827. Chemokine_CC_CS.
IPR001811. Chemokine_IL8-like_dom.
[Graphical view ]
Pfami PF00048. IL8. 1 hit.
[Graphical view ]
SMARTi SM00199. SCY. 1 hit.
[Graphical view ]
SUPFAMi SSF54117. SSF54117. 1 hit.
PROSITEi PS00472. SMALL_CYTOKINES_CC. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Human monocyte chemotactic protein-3 (MCP-3): molecular cloning of the cDNA and comparison with other chemokines."
    Opdenakker G., Froyen G., Fiten P., Proost P., van Damme J.
    Biochem. Biophys. Res. Commun. 191:535-542(1993) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], PROTEIN SEQUENCE OF 31-67 AND 71-99.
  2. "The human MCP-3 gene (SCYA7): cloning, sequence analysis, and assignment to the C-C chemokine gene cluster on chromosome 17q11.2-q12."
    Opdenakker G., Fiten P., Nys G., Froyen G., van Roy N., Speleman F., Laureys G., van Damme J.
    Genomics 21:403-408(1994) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA].
  3. "Molecular cloning of the MCP-3 chemokine gene and regulation of its expression."
    Minty A., Chalon P., Guillemot J.-C., Kaghad M., Liauzun P., Magazin M., Miloux B., Minty C., Ramond P., Vita N., Lupker J., Shire D., Ferrara P., Caput D.
    Eur. Cytokine Netw. 4:99-110(1993) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Blood and Colon.
  5. Jang J.S., Kim B.E.
    Submitted (JAN-1998) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 24-99.
  6. "Structural and functional identification of two human, tumor-derived monocyte chemotactic proteins (MCP-2 and MCP-3) belonging to the chemokine family."
    van Damme J., Proost P., Lenaerts J.-P., Opdenakker G.
    J. Exp. Med. 176:59-65(1992) [PubMed] [Europe PMC] [Abstract]
    Cited for: PROTEIN SEQUENCE OF 30-99.
    Tissue: Osteosarcoma.
  7. "Signal peptide prediction based on analysis of experimentally verified cleavage sites."
    Zhang Z., Henzel W.J.
    Protein Sci. 13:2819-2824(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: PROTEIN SEQUENCE OF 24-38, PYROGLUTAMATE FORMATION AT GLN-24.
  8. "Structural characterization of a monomeric chemokine: monocyte chemoattractant protein-3."
    Kim K.-S., Rajarathnam K., Clark-Lewis I., Sykes B.D.
    FEBS Lett. 395:277-282(1996) [PubMed] [Europe PMC] [Abstract]
    Cited for: STRUCTURE BY NMR, SUBUNIT.
  9. "Determination of the three-dimensional structure of CC chemokine monocyte chemoattractant protein 3 by 1H two-dimensional NMR spectroscopy."
    Meunier S., Bernassau J.-M., Guillemot J.-C., Ferrara P., Darbon H.
    Biochemistry 36:4412-4422(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: STRUCTURE BY NMR.
  10. Kwon D., Lee D., Sykes B.D., Kim K.-S.
    Submitted (AUG-1998) to the PDB data bank
    Cited for: STRUCTURE BY NMR.

Entry informationi

Entry nameiCCL7_HUMAN
AccessioniPrimary (citable) accession number: P80098
Secondary accession number(s): Q569J6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 1, 1992
Last sequence update: November 1, 1995
Last modified: September 3, 2014
This is version 137 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Human chromosome 17
    Human chromosome 17: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  4. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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