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Protein

C-C motif chemokine 7

Gene

CCL7

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Chemotactic factor that attracts monocytes and eosinophils, but not neutrophils. Augments monocyte anti-tumor activity. Also induces the release of gelatinase B. This protein can bind heparin. Binds to CCR1, CCR2 and CCR3.

GO - Molecular functioni

  • CCR1 chemokine receptor binding Source: UniProtKB
  • chemokine activity Source: UniProtKB
  • heparin binding Source: UniProtKB-KW

GO - Biological processi

  • cell-cell signaling Source: ProtInc
  • cellular calcium ion homeostasis Source: ProtInc
  • cellular response to ethanol Source: Ensembl
  • cellular response to interferon-gamma Source: GO_Central
  • cellular response to interleukin-1 Source: GO_Central
  • cellular response to tumor necrosis factor Source: GO_Central
  • chemokine-mediated signaling pathway Source: GO_Central
  • chemotaxis Source: ProtInc
  • cytoskeleton organization Source: UniProtKB
  • eosinophil chemotaxis Source: UniProtKB
  • G-protein coupled receptor signaling pathway Source: GO_Central
  • inflammatory response Source: GO_Central
  • monocyte chemotaxis Source: UniProtKB
  • neutrophil chemotaxis Source: GO_Central
  • positive regulation of cell migration Source: UniProtKB
  • positive regulation of ERK1 and ERK2 cascade Source: GO_Central
  • positive regulation of GTPase activity Source: GO_Central
  • positive regulation of inflammatory response Source: GO_Central
  • positive regulation of natural killer cell chemotaxis Source: UniProtKB
  • regulation of cell shape Source: UniProtKB
  • response to gamma radiation Source: Ensembl
  • signal transduction Source: ProtInc
Complete GO annotation...

Keywords - Molecular functioni

Cytokine

Keywords - Biological processi

Chemotaxis, Inflammatory response

Keywords - Ligandi

Heparin-binding

Enzyme and pathway databases

BioCyciZFISH:ENSG00000108688-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
C-C motif chemokine 7
Alternative name(s):
Monocyte chemoattractant protein 3
Monocyte chemotactic protein 3
Short name:
MCP-3
NC28
Small-inducible cytokine A7
Gene namesi
Name:CCL7
Synonyms:MCP3, SCYA6, SCYA7
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 17

Organism-specific databases

HGNCiHGNC:10634. CCL7.

Subcellular locationi

GO - Cellular componenti

  • cell Source: GOC
  • extracellular region Source: Reactome
  • extracellular space Source: ProtInc
Complete GO annotation...

Keywords - Cellular componenti

Secreted

Pathology & Biotechi

Organism-specific databases

DisGeNETi6354.
OpenTargetsiENSG00000108688.
PharmGKBiPA35566.

Chemistry databases

ChEMBLiCHEMBL3217391.

Polymorphism and mutation databases

DMDMi1170890.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 231 PublicationAdd BLAST23
ChainiPRO_000000518324 – 99C-C motif chemokine 7Add BLAST76

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei24Pyrrolidone carboxylic acid1 Publication1
Glycosylationi29N-linked (GlcNAc...)Sequence analysis1
Disulfide bondi34 ↔ 59
Disulfide bondi35 ↔ 75

Post-translational modificationi

O-glycosylated.

Keywords - PTMi

Disulfide bond, Glycoprotein, Pyrrolidone carboxylic acid

Proteomic databases

PaxDbiP80098.
PeptideAtlasiP80098.
PRIDEiP80098.

Miscellaneous databases

PMAP-CutDBP80098.

Expressioni

Gene expression databases

BgeeiENSG00000108688.
CleanExiHS_CCL7.
ExpressionAtlasiP80098. baseline and differential.
GenevisibleiP80098. HS.

Interactioni

Subunit structurei

Monomer.1 Publication

Binary interactionsi

WithEntry#Exp.IntActNotes
TNFAIP6P980662EBI-11711410,EBI-11700693
UBQLN1Q9UMX03EBI-718759,EBI-741480
UBQLN1Q9UMX0-23EBI-718759,EBI-10173939

GO - Molecular functioni

  • CCR1 chemokine receptor binding Source: UniProtKB
  • chemokine activity Source: UniProtKB

Protein-protein interaction databases

BioGridi112257. 8 interactors.
DIPiDIP-5847N.
IntActiP80098. 5 interactors.
MINTiMINT-103194.
STRINGi9606.ENSP00000367832.

Structurei

Secondary structure

199
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi29 – 31Combined sources3
Beta strandi34 – 36Combined sources3
Turni45 – 47Combined sources3
Beta strandi48 – 53Combined sources6
Turni56 – 58Combined sources3
Beta strandi64 – 68Combined sources5
Beta strandi74 – 76Combined sources3
Helixi81 – 90Combined sources10

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1BO0NMR-A24-99[»]
1NCVNMR-A/B24-99[»]
4ZKCX-ray3.15B24-99[»]
ProteinModelPortaliP80098.
SMRiP80098.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP80098.

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG410J1ST. Eukaryota.
ENOG410YXJU. LUCA.
GeneTreeiENSGT00860000133690.
HOGENOMiHOG000036686.
HOVERGENiHBG017871.
InParanoidiP80098.
KOiK05509.
OMAiTTCCYRF.
OrthoDBiEOG091G14KV.
PhylomeDBiP80098.
TreeFamiTF334888.

Family and domain databases

InterProiIPR000827. Chemokine_CC_CS.
IPR001811. Chemokine_IL8-like_dom.
[Graphical view]
PfamiPF00048. IL8. 1 hit.
[Graphical view]
SMARTiSM00199. SCY. 1 hit.
[Graphical view]
SUPFAMiSSF54117. SSF54117. 1 hit.
PROSITEiPS00472. SMALL_CYTOKINES_CC. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P80098-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKASAALLCL LLTAAAFSPQ GLAQPVGINT STTCCYRFIN KKIPKQRLES
60 70 80 90
YRRTTSSHCP REAVIFKTKL DKEICADPTQ KWVQDFMKHL DKKTQTPKL
Length:99
Mass (Da):11,200
Last modified:November 1, 1995 - v3
Checksum:i96048B371C25D00E
GO

Sequence cautioni

The sequence CAA50405 differs from that shown. Reason: Erroneous initiation.Curated
The sequence CAA50406 differs from that shown. Reason: Erroneous initiation.Curated
The sequence CAA51055 differs from that shown. Reason: Erroneous initiation.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti30T → K AA sequence (PubMed:1613466).Curated1
Sequence conflicti68 – 70Missing AA sequence (PubMed:1613466).Curated3

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X72308 mRNA. Translation: CAA51055.1. Different initiation.
X72309 Genomic DNA. No translation available.
X71087 mRNA. Translation: CAA50407.1.
X71087 mRNA. Translation: CAA50406.1. Different initiation.
X71087 mRNA. Translation: CAA50405.1. Different initiation.
BC092436 mRNA. Translation: AAH92436.1.
BC112258 mRNA. Translation: AAI12259.1.
BC112260 mRNA. Translation: AAI12261.1.
AF043338 mRNA. Translation: AAC03538.1.
CCDSiCCDS11278.1.
RefSeqiNP_006264.2. NM_006273.3.
UniGeneiHs.251526.

Genome annotation databases

EnsembliENST00000378569; ENSP00000367832; ENSG00000108688.
GeneIDi6354.
KEGGihsa:6354.
UCSCiuc002hhz.5. human.

Cross-referencesi

Web resourcesi

Wikipedia

CCL7 entry

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X72308 mRNA. Translation: CAA51055.1. Different initiation.
X72309 Genomic DNA. No translation available.
X71087 mRNA. Translation: CAA50407.1.
X71087 mRNA. Translation: CAA50406.1. Different initiation.
X71087 mRNA. Translation: CAA50405.1. Different initiation.
BC092436 mRNA. Translation: AAH92436.1.
BC112258 mRNA. Translation: AAI12259.1.
BC112260 mRNA. Translation: AAI12261.1.
AF043338 mRNA. Translation: AAC03538.1.
CCDSiCCDS11278.1.
RefSeqiNP_006264.2. NM_006273.3.
UniGeneiHs.251526.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1BO0NMR-A24-99[»]
1NCVNMR-A/B24-99[»]
4ZKCX-ray3.15B24-99[»]
ProteinModelPortaliP80098.
SMRiP80098.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi112257. 8 interactors.
DIPiDIP-5847N.
IntActiP80098. 5 interactors.
MINTiMINT-103194.
STRINGi9606.ENSP00000367832.

Chemistry databases

ChEMBLiCHEMBL3217391.

Polymorphism and mutation databases

DMDMi1170890.

Proteomic databases

PaxDbiP80098.
PeptideAtlasiP80098.
PRIDEiP80098.

Protocols and materials databases

DNASUi6354.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000378569; ENSP00000367832; ENSG00000108688.
GeneIDi6354.
KEGGihsa:6354.
UCSCiuc002hhz.5. human.

Organism-specific databases

CTDi6354.
DisGeNETi6354.
GeneCardsiCCL7.
HGNCiHGNC:10634. CCL7.
MIMi158106. gene.
neXtProtiNX_P80098.
OpenTargetsiENSG00000108688.
PharmGKBiPA35566.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410J1ST. Eukaryota.
ENOG410YXJU. LUCA.
GeneTreeiENSGT00860000133690.
HOGENOMiHOG000036686.
HOVERGENiHBG017871.
InParanoidiP80098.
KOiK05509.
OMAiTTCCYRF.
OrthoDBiEOG091G14KV.
PhylomeDBiP80098.
TreeFamiTF334888.

Enzyme and pathway databases

BioCyciZFISH:ENSG00000108688-MONOMER.

Miscellaneous databases

EvolutionaryTraceiP80098.
GeneWikiiCCL7.
GenomeRNAii6354.
PMAP-CutDBP80098.
PROiP80098.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000108688.
CleanExiHS_CCL7.
ExpressionAtlasiP80098. baseline and differential.
GenevisibleiP80098. HS.

Family and domain databases

InterProiIPR000827. Chemokine_CC_CS.
IPR001811. Chemokine_IL8-like_dom.
[Graphical view]
PfamiPF00048. IL8. 1 hit.
[Graphical view]
SMARTiSM00199. SCY. 1 hit.
[Graphical view]
SUPFAMiSSF54117. SSF54117. 1 hit.
PROSITEiPS00472. SMALL_CYTOKINES_CC. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiCCL7_HUMAN
AccessioniPrimary (citable) accession number: P80098
Secondary accession number(s): Q569J6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 1, 1992
Last sequence update: November 1, 1995
Last modified: November 30, 2016
This is version 157 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Human chromosome 17
    Human chromosome 17: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  4. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.