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P80098

- CCL7_HUMAN

UniProt

P80098 - CCL7_HUMAN

Protein

C-C motif chemokine 7

Gene

CCL7

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
  1. Functioni

    Chemotactic factor that attracts monocytes and eosinophils, but not neutrophils. Augments monocyte anti-tumor activity. Also induces the release of gelatinase B. This protein can bind heparin. Binds to CCR1, CCR2 and CCR3.

    GO - Molecular functioni

    1. CCR1 chemokine receptor binding Source: UniProtKB
    2. chemokine activity Source: UniProtKB
    3. heparin binding Source: UniProtKB-KW

    GO - Biological processi

    1. cell-cell signaling Source: ProtInc
    2. cellular calcium ion homeostasis Source: ProtInc
    3. cellular response to ethanol Source: Ensembl
    4. chemotaxis Source: ProtInc
    5. cytoskeleton organization Source: UniProtKB
    6. eosinophil chemotaxis Source: UniProtKB
    7. immune response Source: InterPro
    8. inflammatory response Source: UniProtKB-KW
    9. monocyte chemotaxis Source: UniProtKB
    10. positive regulation of cell migration Source: UniProtKB
    11. positive regulation of natural killer cell chemotaxis Source: UniProtKB
    12. regulation of cell shape Source: UniProtKB
    13. response to gamma radiation Source: Ensembl
    14. signal transduction Source: ProtInc

    Keywords - Molecular functioni

    Cytokine

    Keywords - Biological processi

    Chemotaxis, Inflammatory response

    Keywords - Ligandi

    Heparin-binding

    Enzyme and pathway databases

    ReactomeiREACT_15344. Chemokine receptors bind chemokines.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    C-C motif chemokine 7
    Alternative name(s):
    Monocyte chemoattractant protein 3
    Monocyte chemotactic protein 3
    Short name:
    MCP-3
    NC28
    Small-inducible cytokine A7
    Gene namesi
    Name:CCL7
    Synonyms:MCP3, SCYA6, SCYA7
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 17

    Organism-specific databases

    HGNCiHGNC:10634. CCL7.

    Subcellular locationi

    GO - Cellular componenti

    1. extracellular region Source: Reactome
    2. extracellular space Source: ProtInc

    Keywords - Cellular componenti

    Secreted

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA35566.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 23231 PublicationAdd
    BLAST
    Chaini24 – 9976C-C motif chemokine 7PRO_0000005183Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei24 – 241Pyrrolidone carboxylic acid1 Publication
    Glycosylationi29 – 291N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi34 ↔ 59
    Disulfide bondi35 ↔ 75

    Post-translational modificationi

    O-glycosylated.

    Keywords - PTMi

    Disulfide bond, Glycoprotein, Pyrrolidone carboxylic acid

    Proteomic databases

    PaxDbiP80098.
    PRIDEiP80098.

    Miscellaneous databases

    PMAP-CutDBP80098.

    Expressioni

    Gene expression databases

    ArrayExpressiP80098.
    BgeeiP80098.
    CleanExiHS_CCL7.
    GenevestigatoriP80098.

    Interactioni

    Subunit structurei

    Monomer.1 Publication

    Protein-protein interaction databases

    BioGridi112257. 7 interactions.
    DIPiDIP-5847N.
    IntActiP80098. 2 interactions.
    MINTiMINT-103194.
    STRINGi9606.ENSP00000200307.

    Structurei

    Secondary structure

    1
    99
    Legend: HelixTurnBeta strand
    Show more details
    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Beta strandi29 – 313
    Beta strandi33 – 353
    Turni45 – 473
    Beta strandi48 – 536
    Turni56 – 583
    Beta strandi64 – 685
    Beta strandi73 – 764
    Helixi81 – 9111

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    EntryMethodResolution (Å)ChainPositionsPDBsum
    1BO0NMR-A24-99[»]
    1NCVNMR-A/B24-99[»]
    ProteinModelPortaliP80098.
    SMRiP80098. Positions 24-99.
    ModBaseiSearch...
    MobiDBiSearch...

    Miscellaneous databases

    EvolutionaryTraceiP80098.

    Family & Domainsi

    Sequence similaritiesi

    Keywords - Domaini

    Signal

    Phylogenomic databases

    eggNOGiNOG140372.
    HOGENOMiHOG000036686.
    HOVERGENiHBG017871.
    InParanoidiP80098.
    KOiK05509.
    OrthoDBiEOG7C5MC2.
    PhylomeDBiP80098.
    TreeFamiTF334888.

    Family and domain databases

    InterProiIPR000827. Chemokine_CC_CS.
    IPR001811. Chemokine_IL8-like_dom.
    [Graphical view]
    PfamiPF00048. IL8. 1 hit.
    [Graphical view]
    SMARTiSM00199. SCY. 1 hit.
    [Graphical view]
    SUPFAMiSSF54117. SSF54117. 1 hit.
    PROSITEiPS00472. SMALL_CYTOKINES_CC. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    P80098-1 [UniParc]FASTAAdd to Basket

    « Hide

    MKASAALLCL LLTAAAFSPQ GLAQPVGINT STTCCYRFIN KKIPKQRLES   50
    YRRTTSSHCP REAVIFKTKL DKEICADPTQ KWVQDFMKHL DKKTQTPKL 99
    Length:99
    Mass (Da):11,200
    Last modified:November 1, 1995 - v3
    Checksum:i96048B371C25D00E
    GO

    Sequence cautioni

    The sequence CAA50405.1 differs from that shown. Reason: Erroneous initiation.
    The sequence CAA50406.1 differs from that shown. Reason: Erroneous initiation.
    The sequence CAA51055.1 differs from that shown. Reason: Erroneous initiation.

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti30 – 301T → K AA sequence (PubMed:1613466)Curated
    Sequence conflicti68 – 703Missing AA sequence (PubMed:1613466)Curated

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X72308 mRNA. Translation: CAA51055.1. Different initiation.
    X72309 Genomic DNA. No translation available.
    X71087 mRNA. Translation: CAA50407.1.
    X71087 mRNA. Translation: CAA50406.1. Different initiation.
    X71087 mRNA. Translation: CAA50405.1. Different initiation.
    BC092436 mRNA. Translation: AAH92436.1.
    BC112258 mRNA. Translation: AAI12259.1.
    BC112260 mRNA. Translation: AAI12261.1.
    AF043338 mRNA. Translation: AAC03538.1.
    CCDSiCCDS11278.1.
    RefSeqiNP_006264.2. NM_006273.3.
    UniGeneiHs.251526.

    Genome annotation databases

    EnsembliENST00000378569; ENSP00000367832; ENSG00000108688.
    GeneIDi6354.
    KEGGihsa:6354.
    UCSCiuc002hhz.4. human.

    Polymorphism databases

    DMDMi1170890.

    Cross-referencesi

    Web resourcesi

    Wikipedia

    CCL7 entry

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X72308 mRNA. Translation: CAA51055.1 . Different initiation.
    X72309 Genomic DNA. No translation available.
    X71087 mRNA. Translation: CAA50407.1 .
    X71087 mRNA. Translation: CAA50406.1 . Different initiation.
    X71087 mRNA. Translation: CAA50405.1 . Different initiation.
    BC092436 mRNA. Translation: AAH92436.1 .
    BC112258 mRNA. Translation: AAI12259.1 .
    BC112260 mRNA. Translation: AAI12261.1 .
    AF043338 mRNA. Translation: AAC03538.1 .
    CCDSi CCDS11278.1.
    RefSeqi NP_006264.2. NM_006273.3.
    UniGenei Hs.251526.

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    Entry Method Resolution (Å) Chain Positions PDBsum
    1BO0 NMR - A 24-99 [» ]
    1NCV NMR - A/B 24-99 [» ]
    ProteinModelPortali P80098.
    SMRi P80098. Positions 24-99.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 112257. 7 interactions.
    DIPi DIP-5847N.
    IntActi P80098. 2 interactions.
    MINTi MINT-103194.
    STRINGi 9606.ENSP00000200307.

    Polymorphism databases

    DMDMi 1170890.

    Proteomic databases

    PaxDbi P80098.
    PRIDEi P80098.

    Protocols and materials databases

    DNASUi 6354.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000378569 ; ENSP00000367832 ; ENSG00000108688 .
    GeneIDi 6354.
    KEGGi hsa:6354.
    UCSCi uc002hhz.4. human.

    Organism-specific databases

    CTDi 6354.
    GeneCardsi GC17P032597.
    HGNCi HGNC:10634. CCL7.
    MIMi 158106. gene.
    neXtProti NX_P80098.
    PharmGKBi PA35566.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG140372.
    HOGENOMi HOG000036686.
    HOVERGENi HBG017871.
    InParanoidi P80098.
    KOi K05509.
    OrthoDBi EOG7C5MC2.
    PhylomeDBi P80098.
    TreeFami TF334888.

    Enzyme and pathway databases

    Reactomei REACT_15344. Chemokine receptors bind chemokines.

    Miscellaneous databases

    EvolutionaryTracei P80098.
    GeneWikii CCL7.
    GenomeRNAii 6354.
    NextBioi 24680.
    PMAP-CutDB P80098.
    PROi P80098.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi P80098.
    Bgeei P80098.
    CleanExi HS_CCL7.
    Genevestigatori P80098.

    Family and domain databases

    InterProi IPR000827. Chemokine_CC_CS.
    IPR001811. Chemokine_IL8-like_dom.
    [Graphical view ]
    Pfami PF00048. IL8. 1 hit.
    [Graphical view ]
    SMARTi SM00199. SCY. 1 hit.
    [Graphical view ]
    SUPFAMi SSF54117. SSF54117. 1 hit.
    PROSITEi PS00472. SMALL_CYTOKINES_CC. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Human monocyte chemotactic protein-3 (MCP-3): molecular cloning of the cDNA and comparison with other chemokines."
      Opdenakker G., Froyen G., Fiten P., Proost P., van Damme J.
      Biochem. Biophys. Res. Commun. 191:535-542(1993) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA], PROTEIN SEQUENCE OF 31-67 AND 71-99.
    2. "The human MCP-3 gene (SCYA7): cloning, sequence analysis, and assignment to the C-C chemokine gene cluster on chromosome 17q11.2-q12."
      Opdenakker G., Fiten P., Nys G., Froyen G., van Roy N., Speleman F., Laureys G., van Damme J.
      Genomics 21:403-408(1994) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA].
    3. "Molecular cloning of the MCP-3 chemokine gene and regulation of its expression."
      Minty A., Chalon P., Guillemot J.-C., Kaghad M., Liauzun P., Magazin M., Miloux B., Minty C., Ramond P., Vita N., Lupker J., Shire D., Ferrara P., Caput D.
      Eur. Cytokine Netw. 4:99-110(1993) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Blood and Colon.
    5. Jang J.S., Kim B.E.
      Submitted (JAN-1998) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 24-99.
    6. "Structural and functional identification of two human, tumor-derived monocyte chemotactic proteins (MCP-2 and MCP-3) belonging to the chemokine family."
      van Damme J., Proost P., Lenaerts J.-P., Opdenakker G.
      J. Exp. Med. 176:59-65(1992) [PubMed] [Europe PMC] [Abstract]
      Cited for: PROTEIN SEQUENCE OF 30-99.
      Tissue: Osteosarcoma.
    7. "Signal peptide prediction based on analysis of experimentally verified cleavage sites."
      Zhang Z., Henzel W.J.
      Protein Sci. 13:2819-2824(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: PROTEIN SEQUENCE OF 24-38, PYROGLUTAMATE FORMATION AT GLN-24.
    8. "Structural characterization of a monomeric chemokine: monocyte chemoattractant protein-3."
      Kim K.-S., Rajarathnam K., Clark-Lewis I., Sykes B.D.
      FEBS Lett. 395:277-282(1996) [PubMed] [Europe PMC] [Abstract]
      Cited for: STRUCTURE BY NMR, SUBUNIT.
    9. "Determination of the three-dimensional structure of CC chemokine monocyte chemoattractant protein 3 by 1H two-dimensional NMR spectroscopy."
      Meunier S., Bernassau J.-M., Guillemot J.-C., Ferrara P., Darbon H.
      Biochemistry 36:4412-4422(1997) [PubMed] [Europe PMC] [Abstract]
      Cited for: STRUCTURE BY NMR.
    10. Kwon D., Lee D., Sykes B.D., Kim K.-S.
      Submitted (AUG-1998) to the PDB data bank
      Cited for: STRUCTURE BY NMR.

    Entry informationi

    Entry nameiCCL7_HUMAN
    AccessioniPrimary (citable) accession number: P80098
    Secondary accession number(s): Q569J6
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: December 1, 1992
    Last sequence update: November 1, 1995
    Last modified: October 1, 2014
    This is version 138 of the entry and version 3 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

    Documents

    1. Human chromosome 17
      Human chromosome 17: entries, gene names and cross-references to MIM
    2. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    3. PDB cross-references
      Index of Protein Data Bank (PDB) cross-references
    4. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3