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Protein

C-C motif chemokine 7

Gene

CCL7

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Chemotactic factor that attracts monocytes and eosinophils, but not neutrophils. Augments monocyte anti-tumor activity. Also induces the release of gelatinase B. This protein can bind heparin. Binds to CCR1, CCR2 and CCR3.

GO - Molecular functioni

  • CCR1 chemokine receptor binding Source: UniProtKB
  • chemokine activity Source: UniProtKB
  • heparin binding Source: UniProtKB-KW

GO - Biological processi

  • cell-cell signaling Source: ProtInc
  • cellular calcium ion homeostasis Source: ProtInc
  • cellular response to ethanol Source: Ensembl
  • chemotaxis Source: ProtInc
  • cytoskeleton organization Source: UniProtKB
  • eosinophil chemotaxis Source: UniProtKB
  • immune response Source: InterPro
  • inflammatory response Source: UniProtKB-KW
  • monocyte chemotaxis Source: UniProtKB
  • positive regulation of cell migration Source: UniProtKB
  • positive regulation of natural killer cell chemotaxis Source: UniProtKB
  • regulation of cell shape Source: UniProtKB
  • response to gamma radiation Source: Ensembl
  • signal transduction Source: ProtInc
Complete GO annotation...

Keywords - Molecular functioni

Cytokine

Keywords - Biological processi

Chemotaxis, Inflammatory response

Keywords - Ligandi

Heparin-binding

Enzyme and pathway databases

ReactomeiREACT_15344. Chemokine receptors bind chemokines.

Names & Taxonomyi

Protein namesi
Recommended name:
C-C motif chemokine 7
Alternative name(s):
Monocyte chemoattractant protein 3
Monocyte chemotactic protein 3
Short name:
MCP-3
NC28
Small-inducible cytokine A7
Gene namesi
Name:CCL7
Synonyms:MCP3, SCYA6, SCYA7
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640 Componenti: Chromosome 17

Organism-specific databases

HGNCiHGNC:10634. CCL7.

Subcellular locationi

GO - Cellular componenti

  • cell Source: GOC
  • extracellular region Source: Reactome
  • extracellular space Source: ProtInc
Complete GO annotation...

Keywords - Cellular componenti

Secreted

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA35566.

Polymorphism and mutation databases

DMDMi1170890.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 23231 PublicationAdd
BLAST
Chaini24 – 9976C-C motif chemokine 7PRO_0000005183Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei24 – 241Pyrrolidone carboxylic acid1 Publication
Glycosylationi29 – 291N-linked (GlcNAc...)Sequence Analysis
Disulfide bondi34 ↔ 59
Disulfide bondi35 ↔ 75

Post-translational modificationi

O-glycosylated.

Keywords - PTMi

Disulfide bond, Glycoprotein, Pyrrolidone carboxylic acid

Proteomic databases

PaxDbiP80098.
PRIDEiP80098.

Miscellaneous databases

PMAP-CutDBP80098.

Expressioni

Gene expression databases

BgeeiP80098.
CleanExiHS_CCL7.
ExpressionAtlasiP80098. baseline and differential.
GenevisibleiP80098. HS.

Interactioni

Subunit structurei

Monomer.1 Publication

Binary interactionsi

WithEntry#Exp.IntActNotes
UBQLN1Q9UMX03EBI-718759,EBI-741480
UBQLN1Q9UMX0-23EBI-718759,EBI-10173939

Protein-protein interaction databases

BioGridi112257. 8 interactions.
DIPiDIP-5847N.
IntActiP80098. 3 interactions.
MINTiMINT-103194.
STRINGi9606.ENSP00000367832.

Structurei

Secondary structure

1
99
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Beta strandi29 – 313Combined sources
Beta strandi33 – 353Combined sources
Turni45 – 473Combined sources
Beta strandi48 – 536Combined sources
Turni56 – 583Combined sources
Beta strandi64 – 685Combined sources
Beta strandi73 – 764Combined sources
Helixi81 – 9111Combined sources

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1BO0NMR-A24-99[»]
1NCVNMR-A/B24-99[»]
ProteinModelPortaliP80098.
SMRiP80098. Positions 24-99.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP80098.

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiNOG140372.
GeneTreeiENSGT00730000110714.
HOGENOMiHOG000036686.
HOVERGENiHBG017871.
InParanoidiP80098.
KOiK05509.
OMAiTTCCYRF.
OrthoDBiEOG7C5MC2.
PhylomeDBiP80098.
TreeFamiTF334888.

Family and domain databases

InterProiIPR000827. Chemokine_CC_CS.
IPR001811. Chemokine_IL8-like_dom.
[Graphical view]
PfamiPF00048. IL8. 1 hit.
[Graphical view]
SMARTiSM00199. SCY. 1 hit.
[Graphical view]
SUPFAMiSSF54117. SSF54117. 1 hit.
PROSITEiPS00472. SMALL_CYTOKINES_CC. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P80098-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKASAALLCL LLTAAAFSPQ GLAQPVGINT STTCCYRFIN KKIPKQRLES
60 70 80 90
YRRTTSSHCP REAVIFKTKL DKEICADPTQ KWVQDFMKHL DKKTQTPKL
Length:99
Mass (Da):11,200
Last modified:November 1, 1995 - v3
Checksum:i96048B371C25D00E
GO

Sequence cautioni

The sequence CAA50405.1 differs from that shown. Reason: Erroneous initiation. Curated
The sequence CAA50406.1 differs from that shown. Reason: Erroneous initiation. Curated
The sequence CAA51055.1 differs from that shown. Reason: Erroneous initiation. Curated

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti30 – 301T → K AA sequence (PubMed:1613466).Curated
Sequence conflicti68 – 703Missing AA sequence (PubMed:1613466).Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X72308 mRNA. Translation: CAA51055.1. Different initiation.
X72309 Genomic DNA. No translation available.
X71087 mRNA. Translation: CAA50407.1.
X71087 mRNA. Translation: CAA50406.1. Different initiation.
X71087 mRNA. Translation: CAA50405.1. Different initiation.
BC092436 mRNA. Translation: AAH92436.1.
BC112258 mRNA. Translation: AAI12259.1.
BC112260 mRNA. Translation: AAI12261.1.
AF043338 mRNA. Translation: AAC03538.1.
CCDSiCCDS11278.1.
RefSeqiNP_006264.2. NM_006273.3.
UniGeneiHs.251526.

Genome annotation databases

EnsembliENST00000378569; ENSP00000367832; ENSG00000108688.
GeneIDi6354.
KEGGihsa:6354.
UCSCiuc002hhz.4. human.

Cross-referencesi

Web resourcesi

Wikipedia

CCL7 entry

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X72308 mRNA. Translation: CAA51055.1. Different initiation.
X72309 Genomic DNA. No translation available.
X71087 mRNA. Translation: CAA50407.1.
X71087 mRNA. Translation: CAA50406.1. Different initiation.
X71087 mRNA. Translation: CAA50405.1. Different initiation.
BC092436 mRNA. Translation: AAH92436.1.
BC112258 mRNA. Translation: AAI12259.1.
BC112260 mRNA. Translation: AAI12261.1.
AF043338 mRNA. Translation: AAC03538.1.
CCDSiCCDS11278.1.
RefSeqiNP_006264.2. NM_006273.3.
UniGeneiHs.251526.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1BO0NMR-A24-99[»]
1NCVNMR-A/B24-99[»]
ProteinModelPortaliP80098.
SMRiP80098. Positions 24-99.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi112257. 8 interactions.
DIPiDIP-5847N.
IntActiP80098. 3 interactions.
MINTiMINT-103194.
STRINGi9606.ENSP00000367832.

Chemistry

ChEMBLiCHEMBL3217391.

Polymorphism and mutation databases

DMDMi1170890.

Proteomic databases

PaxDbiP80098.
PRIDEiP80098.

Protocols and materials databases

DNASUi6354.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000378569; ENSP00000367832; ENSG00000108688.
GeneIDi6354.
KEGGihsa:6354.
UCSCiuc002hhz.4. human.

Organism-specific databases

CTDi6354.
GeneCardsiGC17P032597.
HGNCiHGNC:10634. CCL7.
MIMi158106. gene.
neXtProtiNX_P80098.
PharmGKBiPA35566.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiNOG140372.
GeneTreeiENSGT00730000110714.
HOGENOMiHOG000036686.
HOVERGENiHBG017871.
InParanoidiP80098.
KOiK05509.
OMAiTTCCYRF.
OrthoDBiEOG7C5MC2.
PhylomeDBiP80098.
TreeFamiTF334888.

Enzyme and pathway databases

ReactomeiREACT_15344. Chemokine receptors bind chemokines.

Miscellaneous databases

EvolutionaryTraceiP80098.
GeneWikiiCCL7.
GenomeRNAii6354.
NextBioi24680.
PMAP-CutDBP80098.
PROiP80098.
SOURCEiSearch...

Gene expression databases

BgeeiP80098.
CleanExiHS_CCL7.
ExpressionAtlasiP80098. baseline and differential.
GenevisibleiP80098. HS.

Family and domain databases

InterProiIPR000827. Chemokine_CC_CS.
IPR001811. Chemokine_IL8-like_dom.
[Graphical view]
PfamiPF00048. IL8. 1 hit.
[Graphical view]
SMARTiSM00199. SCY. 1 hit.
[Graphical view]
SUPFAMiSSF54117. SSF54117. 1 hit.
PROSITEiPS00472. SMALL_CYTOKINES_CC. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Human monocyte chemotactic protein-3 (MCP-3): molecular cloning of the cDNA and comparison with other chemokines."
    Opdenakker G., Froyen G., Fiten P., Proost P., van Damme J.
    Biochem. Biophys. Res. Commun. 191:535-542(1993) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], PROTEIN SEQUENCE OF 31-67 AND 71-99.
  2. "The human MCP-3 gene (SCYA7): cloning, sequence analysis, and assignment to the C-C chemokine gene cluster on chromosome 17q11.2-q12."
    Opdenakker G., Fiten P., Nys G., Froyen G., van Roy N., Speleman F., Laureys G., van Damme J.
    Genomics 21:403-408(1994) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA].
  3. "Molecular cloning of the MCP-3 chemokine gene and regulation of its expression."
    Minty A., Chalon P., Guillemot J.-C., Kaghad M., Liauzun P., Magazin M., Miloux B., Minty C., Ramond P., Vita N., Lupker J., Shire D., Ferrara P., Caput D.
    Eur. Cytokine Netw. 4:99-110(1993) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Blood and Colon.
  5. Jang J.S., Kim B.E.
    Submitted (JAN-1998) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 24-99.
  6. "Structural and functional identification of two human, tumor-derived monocyte chemotactic proteins (MCP-2 and MCP-3) belonging to the chemokine family."
    van Damme J., Proost P., Lenaerts J.-P., Opdenakker G.
    J. Exp. Med. 176:59-65(1992) [PubMed] [Europe PMC] [Abstract]
    Cited for: PROTEIN SEQUENCE OF 30-99.
    Tissue: Osteosarcoma.
  7. "Signal peptide prediction based on analysis of experimentally verified cleavage sites."
    Zhang Z., Henzel W.J.
    Protein Sci. 13:2819-2824(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: PROTEIN SEQUENCE OF 24-38, PYROGLUTAMATE FORMATION AT GLN-24.
  8. "Structural characterization of a monomeric chemokine: monocyte chemoattractant protein-3."
    Kim K.-S., Rajarathnam K., Clark-Lewis I., Sykes B.D.
    FEBS Lett. 395:277-282(1996) [PubMed] [Europe PMC] [Abstract]
    Cited for: STRUCTURE BY NMR, SUBUNIT.
  9. "Determination of the three-dimensional structure of CC chemokine monocyte chemoattractant protein 3 by 1H two-dimensional NMR spectroscopy."
    Meunier S., Bernassau J.-M., Guillemot J.-C., Ferrara P., Darbon H.
    Biochemistry 36:4412-4422(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: STRUCTURE BY NMR.
  10. Kwon D., Lee D., Sykes B.D., Kim K.-S.
    Submitted (AUG-1998) to the PDB data bank
    Cited for: STRUCTURE BY NMR.

Entry informationi

Entry nameiCCL7_HUMAN
AccessioniPrimary (citable) accession number: P80098
Secondary accession number(s): Q569J6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 1, 1992
Last sequence update: November 1, 1995
Last modified: July 22, 2015
This is version 146 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Human chromosome 17
    Human chromosome 17: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  4. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.