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P80064

- HPPD_PSEUJ

UniProt

P80064 - HPPD_PSEUJ

Protein

4-hydroxyphenylpyruvate dioxygenase

Gene

hpd

Organism
Pseudomonas sp. (strain P.J. 874)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 88 (01 Oct 2014)
      Sequence version 1 (01 May 1992)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    4-hydroxyphenylpyruvate + O2 = homogentisate + CO2.

    Cofactori

    Binds 1 iron ion per subunit.

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Metal bindingi161 – 1611Iron
    Metal bindingi240 – 2401Iron
    Metal bindingi322 – 3221Iron

    GO - Molecular functioni

    1. 4-hydroxyphenylpyruvate dioxygenase activity Source: UniProtKB-EC
    2. metal ion binding Source: UniProtKB-KW

    GO - Biological processi

    1. L-phenylalanine catabolic process Source: UniProtKB-UniPathway
    2. tyrosine catabolic process Source: UniProtKB-KW

    Keywords - Molecular functioni

    Dioxygenase, Oxidoreductase

    Keywords - Biological processi

    Phenylalanine catabolism, Tyrosine catabolism

    Keywords - Ligandi

    Iron, Metal-binding

    Enzyme and pathway databases

    BioCyciMetaCyc:MONOMER-12032.
    UniPathwayiUPA00139; UER00362.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    4-hydroxyphenylpyruvate dioxygenase (EC:1.13.11.27)
    Short name:
    4HPPD
    Short name:
    HPD
    Short name:
    HPPDase
    Gene namesi
    Name:hpd
    OrganismiPseudomonas sp. (strain P.J. 874)
    Taxonomic identifieri72587 [NCBI]
    Taxonomic lineageiBacteriaProteobacteria

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 3573574-hydroxyphenylpyruvate dioxygenasePRO_0000088408Add
    BLAST

    2D gel databases

    World-2DPAGE0008:P80064.

    Interactioni

    Subunit structurei

    Homotetramer.

    Structurei

    Secondary structure

    1
    357
    Legend: HelixTurnBeta strand
    Show more details
    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Beta strandi10 – 1910
    Helixi27 – 326
    Beta strandi36 – 5116
    Beta strandi54 – 596
    Beta strandi62 – 643
    Helixi65 – 739
    Beta strandi74 – 8512
    Helixi87 – 9610
    Beta strandi115 – 1173
    Helixi119 – 1213
    Beta strandi123 – 1275
    Beta strandi131 – 1333
    Helixi136 – 1405
    Beta strandi141 – 1433
    Beta strandi155 – 1628
    Helixi170 – 18213
    Beta strandi185 – 1939
    Beta strandi198 – 2058
    Beta strandi212 – 2187
    Helixi225 – 2339
    Beta strandi235 – 2373
    Beta strandi240 – 2467
    Helixi248 – 25710
    Helixi268 – 2725
    Helixi274 – 2774
    Helixi285 – 2917
    Beta strandi294 – 3007
    Beta strandi303 – 31210
    Beta strandi319 – 32810
    Helixi334 – 35118

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    EntryMethodResolution (Å)ChainPositionsPDBsum
    1CJXX-ray2.40A/B/C/D1-357[»]
    ProteinModelPortaliP80064.
    SMRiP80064. Positions 4-355.
    ModBaseiSearch...
    MobiDBiSearch...

    Miscellaneous databases

    EvolutionaryTraceiP80064.

    Family & Domainsi

    Compositional bias

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Compositional biasi167 – 19630Tyr-richAdd
    BLAST

    Sequence similaritiesi

    Belongs to the 4HPPD family.Curated

    Family and domain databases

    Gene3Di3.10.180.10. 2 hits.
    InterProiIPR005956. 4OHPhenylPyrv_dOase.
    IPR029068. Glyas_Bleomycin-R_OHBP_Dase.
    IPR004360. Glyas_Fos-R_dOase_dom.
    [Graphical view]
    PANTHERiPTHR11959. PTHR11959. 1 hit.
    PfamiPF00903. Glyoxalase. 1 hit.
    [Graphical view]
    PIRSFiPIRSF009283. HPP_dOase. 1 hit.
    SUPFAMiSSF54593. SSF54593. 1 hit.
    TIGRFAMsiTIGR01263. 4HPPD. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    P80064-1 [UniParc]FASTAAdd to Basket

    « Hide

    ADLYENPMGL MGFEFIELAS PTPNTLEPIF EIMGFTKVAT HRSKDVHLYR    50
    QGAINLILNN EPHSVASYFA AEHGPSVCGM AFRVKDSQKA YKRALELGAQ 100
    PIHIETGPME LNLPAIKGIG GAPLYLIDRF GEGSSIYDID FVFLEGVDRH 150
    PVGAGLKIID HLTHNVYRGR MAYWANFYEK LFNFREIRYF DIKGEYTGLT 200
    SKAMTAPDGM IRIPLNEESS KGAGQIEEFL MQFNGEGIQH VAFLSDDLIK 250
    TWDHLKSIGM RFMTAPPDTY YEMLEGRLPN HGEPVGELQA RGILLDGSSE 300
    SGDKRLLLQI FSETLMGPVF FEFIQRKGDD GFGEGNFKAL FESIERDQVR 350
    RGVLSTD 357
    Length:357
    Mass (Da):40,061
    Last modified:May 1, 1992 - v1
    Checksum:i26CF4A80B1484BD0
    GO

    Sequence databases

    PIRiS21209.

    Cross-referencesi

    Sequence databases

    PIRi S21209.

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    Entry Method Resolution (Å) Chain Positions PDBsum
    1CJX X-ray 2.40 A/B/C/D 1-357 [» ]
    ProteinModelPortali P80064.
    SMRi P80064. Positions 4-355.
    ModBasei Search...
    MobiDBi Search...

    2D gel databases

    World-2DPAGE 0008:P80064.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Enzyme and pathway databases

    UniPathwayi UPA00139 ; UER00362 .
    BioCyci MetaCyc:MONOMER-12032.

    Miscellaneous databases

    EvolutionaryTracei P80064.

    Family and domain databases

    Gene3Di 3.10.180.10. 2 hits.
    InterProi IPR005956. 4OHPhenylPyrv_dOase.
    IPR029068. Glyas_Bleomycin-R_OHBP_Dase.
    IPR004360. Glyas_Fos-R_dOase_dom.
    [Graphical view ]
    PANTHERi PTHR11959. PTHR11959. 1 hit.
    Pfami PF00903. Glyoxalase. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF009283. HPP_dOase. 1 hit.
    SUPFAMi SSF54593. SSF54593. 1 hit.
    TIGRFAMsi TIGR01263. 4HPPD. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "Characterization of 4-hydroxyphenylpyruvate dioxygenase. Primary structure of the Pseudomonas enzyme."
      Rueetschi U., Odelhoeg B., Lindstedt S., Barros-Soederling J., Persson B., Joernvall H.
      Eur. J. Biochem. 205:459-466(1992) [PubMed] [Europe PMC] [Abstract]
      Cited for: PROTEIN SEQUENCE.
    2. "Crystal structure of Pseudomonas fluorescens 4-hydroxyphenylpyruvate dioxygenase: an enzyme involved in the tyrosine degradation pathway."
      Serre L., Sailland A., Sy D., Boudec P., Rolland A., Pebay-Peyroula E., Cohen-Addad C.
      Structure 7:977-988(1999) [PubMed] [Europe PMC] [Abstract]
      Cited for: X-RAY CRYSTALLOGRAPHY (2.4 ANGSTROMS).

    Entry informationi

    Entry nameiHPPD_PSEUJ
    AccessioniPrimary (citable) accession number: P80064
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: May 1, 1992
    Last sequence update: May 1, 1992
    Last modified: October 1, 2014
    This is version 88 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    3D-structure, Direct protein sequencing

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. PDB cross-references
      Index of Protein Data Bank (PDB) cross-references
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3