Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

4-hydroxyphenylpyruvate dioxygenase

Gene

hpd

Organism
Pseudomonas sp. (strain P.J. 874)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Catalytic activityi

4-hydroxyphenylpyruvate + O2 = homogentisate + CO2.

Cofactori

Fe cationNote: Binds 1 Fe cation per subunit.

Pathwayi: L-phenylalanine degradation

This protein is involved in step 3 of the subpathway that synthesizes acetoacetate and fumarate from L-phenylalanine.
Proteins known to be involved in the 6 steps of the subpathway in this organism are:
  1. no protein annotated in this organism
  2. no protein annotated in this organism
  3. 4-hydroxyphenylpyruvate dioxygenase (hpd)
  4. no protein annotated in this organism
  5. no protein annotated in this organism
  6. no protein annotated in this organism
This subpathway is part of the pathway L-phenylalanine degradation, which is itself part of Amino-acid degradation.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes acetoacetate and fumarate from L-phenylalanine, the pathway L-phenylalanine degradation and in Amino-acid degradation.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi161Iron1
Metal bindingi240Iron1
Metal bindingi322Iron1

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Dioxygenase, Oxidoreductase

Keywords - Biological processi

Phenylalanine catabolism, Tyrosine catabolism

Keywords - Ligandi

Iron, Metal-binding

Enzyme and pathway databases

BioCyciMetaCyc:MONOMER-12032.
BRENDAi1.13.11.27. 5121.
UniPathwayiUPA00139; UER00362.

Names & Taxonomyi

Protein namesi
Recommended name:
4-hydroxyphenylpyruvate dioxygenase (EC:1.13.11.27)
Short name:
4HPPD
Short name:
HPD
Short name:
HPPDase
Gene namesi
Name:hpd
OrganismiPseudomonas sp. (strain P.J. 874)
Taxonomic identifieri72587 [NCBI]
Taxonomic lineageiBacteriaProteobacteria

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000884081 – 3574-hydroxyphenylpyruvate dioxygenaseAdd BLAST357

2D gel databases

World-2DPAGE0008:P80064.

Interactioni

Subunit structurei

Homotetramer.

Structurei

Secondary structure

1357
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi10 – 19Combined sources10
Helixi27 – 32Combined sources6
Beta strandi36 – 51Combined sources16
Beta strandi54 – 59Combined sources6
Beta strandi62 – 64Combined sources3
Helixi65 – 73Combined sources9
Beta strandi74 – 85Combined sources12
Helixi87 – 96Combined sources10
Beta strandi115 – 117Combined sources3
Helixi119 – 121Combined sources3
Beta strandi123 – 127Combined sources5
Beta strandi131 – 133Combined sources3
Helixi136 – 140Combined sources5
Beta strandi141 – 143Combined sources3
Beta strandi155 – 162Combined sources8
Helixi170 – 182Combined sources13
Beta strandi185 – 193Combined sources9
Beta strandi198 – 205Combined sources8
Beta strandi212 – 218Combined sources7
Helixi225 – 233Combined sources9
Beta strandi235 – 237Combined sources3
Beta strandi240 – 246Combined sources7
Helixi248 – 257Combined sources10
Helixi268 – 272Combined sources5
Helixi274 – 277Combined sources4
Helixi285 – 291Combined sources7
Beta strandi294 – 300Combined sources7
Beta strandi303 – 312Combined sources10
Beta strandi319 – 328Combined sources10
Helixi334 – 351Combined sources18

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1CJXX-ray2.40A/B/C/D1-357[»]
ProteinModelPortaliP80064.
SMRiP80064.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP80064.

Family & Domainsi

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi167 – 196Tyr-richAdd BLAST30

Sequence similaritiesi

Belongs to the 4HPPD family.Curated

Family and domain databases

Gene3Di3.10.180.10. 2 hits.
InterProiIPR005956. 4OHPhenylPyrv_dOase.
IPR029068. Glyas_Bleomycin-R_OHBP_Dase.
IPR004360. Glyas_Fos-R_dOase_dom.
[Graphical view]
PANTHERiPTHR11959. PTHR11959. 1 hit.
PfamiPF00903. Glyoxalase. 1 hit.
[Graphical view]
PIRSFiPIRSF009283. HPP_dOase. 1 hit.
SUPFAMiSSF54593. SSF54593. 1 hit.
TIGRFAMsiTIGR01263. 4HPPD. 1 hit.

Sequencei

Sequence statusi: Complete.

P80064-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
ADLYENPMGL MGFEFIELAS PTPNTLEPIF EIMGFTKVAT HRSKDVHLYR
60 70 80 90 100
QGAINLILNN EPHSVASYFA AEHGPSVCGM AFRVKDSQKA YKRALELGAQ
110 120 130 140 150
PIHIETGPME LNLPAIKGIG GAPLYLIDRF GEGSSIYDID FVFLEGVDRH
160 170 180 190 200
PVGAGLKIID HLTHNVYRGR MAYWANFYEK LFNFREIRYF DIKGEYTGLT
210 220 230 240 250
SKAMTAPDGM IRIPLNEESS KGAGQIEEFL MQFNGEGIQH VAFLSDDLIK
260 270 280 290 300
TWDHLKSIGM RFMTAPPDTY YEMLEGRLPN HGEPVGELQA RGILLDGSSE
310 320 330 340 350
SGDKRLLLQI FSETLMGPVF FEFIQRKGDD GFGEGNFKAL FESIERDQVR

RGVLSTD
Length:357
Mass (Da):40,061
Last modified:May 1, 1992 - v1
Checksum:i26CF4A80B1484BD0
GO

Sequence databases

PIRiS21209.

Cross-referencesi

Sequence databases

PIRiS21209.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1CJXX-ray2.40A/B/C/D1-357[»]
ProteinModelPortaliP80064.
SMRiP80064.
ModBaseiSearch...
MobiDBiSearch...

2D gel databases

World-2DPAGE0008:P80064.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Enzyme and pathway databases

UniPathwayiUPA00139; UER00362.
BioCyciMetaCyc:MONOMER-12032.
BRENDAi1.13.11.27. 5121.

Miscellaneous databases

EvolutionaryTraceiP80064.

Family and domain databases

Gene3Di3.10.180.10. 2 hits.
InterProiIPR005956. 4OHPhenylPyrv_dOase.
IPR029068. Glyas_Bleomycin-R_OHBP_Dase.
IPR004360. Glyas_Fos-R_dOase_dom.
[Graphical view]
PANTHERiPTHR11959. PTHR11959. 1 hit.
PfamiPF00903. Glyoxalase. 1 hit.
[Graphical view]
PIRSFiPIRSF009283. HPP_dOase. 1 hit.
SUPFAMiSSF54593. SSF54593. 1 hit.
TIGRFAMsiTIGR01263. 4HPPD. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiHPPD_PSEUJ
AccessioniPrimary (citable) accession number: P80064
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 1, 1992
Last sequence update: May 1, 1992
Last modified: November 2, 2016
This is version 94 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Direct protein sequencing

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.