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P80064 (HPPD_PSEUJ) Reviewed, UniProtKB/Swiss-Prot

Last modified October 16, 2013. Version 86. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
4-hydroxyphenylpyruvate dioxygenase

Short name=4HPPD
Short name=HPD
Short name=HPPDase
EC=1.13.11.27
Gene names
Name:hpd
OrganismPseudomonas sp. (strain P.J. 874)
Taxonomic identifier72587 [NCBI]
Taxonomic lineageBacteriaProteobacteria

Protein attributes

Sequence length357 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Catalytic activity

4-hydroxyphenylpyruvate + O2 = homogentisate + CO2.

Cofactor

Binds 1 iron ion per subunit.

Pathway

Amino-acid degradation; L-phenylalanine degradation; acetoacetate and fumarate from L-phenylalanine: step 3/6.

Subunit structure

Homotetramer.

Sequence similarities

Belongs to the 4HPPD family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 3573574-hydroxyphenylpyruvate dioxygenase
PRO_0000088408

Regions

Compositional bias167 – 19630Tyr-rich

Sites

Metal binding1611Iron
Metal binding2401Iron
Metal binding3221Iron

Secondary structure

.......................................................... 357
Helix Strand Turn

Details...

Sequences

Sequence LengthMass (Da)Tools
P80064 [UniParc].

Last modified May 1, 1992. Version 1.
Checksum: 26CF4A80B1484BD0

FASTA35740,061
        10         20         30         40         50         60 
ADLYENPMGL MGFEFIELAS PTPNTLEPIF EIMGFTKVAT HRSKDVHLYR QGAINLILNN 

        70         80         90        100        110        120 
EPHSVASYFA AEHGPSVCGM AFRVKDSQKA YKRALELGAQ PIHIETGPME LNLPAIKGIG 

       130        140        150        160        170        180 
GAPLYLIDRF GEGSSIYDID FVFLEGVDRH PVGAGLKIID HLTHNVYRGR MAYWANFYEK 

       190        200        210        220        230        240 
LFNFREIRYF DIKGEYTGLT SKAMTAPDGM IRIPLNEESS KGAGQIEEFL MQFNGEGIQH 

       250        260        270        280        290        300 
VAFLSDDLIK TWDHLKSIGM RFMTAPPDTY YEMLEGRLPN HGEPVGELQA RGILLDGSSE 

       310        320        330        340        350 
SGDKRLLLQI FSETLMGPVF FEFIQRKGDD GFGEGNFKAL FESIERDQVR RGVLSTD 

« Hide

References

[1]"Characterization of 4-hydroxyphenylpyruvate dioxygenase. Primary structure of the Pseudomonas enzyme."
Rueetschi U., Odelhoeg B., Lindstedt S., Barros-Soederling J., Persson B., Joernvall H.
Eur. J. Biochem. 205:459-466(1992) [PubMed] [Europe PMC] [Abstract]
Cited for: PROTEIN SEQUENCE.
[2]"Crystal structure of Pseudomonas fluorescens 4-hydroxyphenylpyruvate dioxygenase: an enzyme involved in the tyrosine degradation pathway."
Serre L., Sailland A., Sy D., Boudec P., Rolland A., Pebay-Peyroula E., Cohen-Addad C.
Structure 7:977-988(1999) [PubMed] [Europe PMC] [Abstract]
Cited for: X-RAY CRYSTALLOGRAPHY (2.4 ANGSTROMS).

Cross-references

Sequence databases

PIRS21209.

3D structure databases

PDBe
RCSB PDB
PDBj
EntryMethodResolution (Å)ChainPositionsPDBsum
1CJXX-ray2.40A/B/C/D1-357[»]
ProteinModelPortalP80064.
SMRP80064. Positions 4-355.
ModBaseSearch...
MobiDBSearch...

2D gel databases

World-2DPAGE0008:P80064.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Enzyme and pathway databases

BioCycMetaCyc:MONOMER-12032.
UniPathwayUPA00139; UER00362.

Family and domain databases

InterProIPR005956. 4OHPhenylPyrv_dOase.
IPR004360. Glyas_Fos-R_dOase_dom.
[Graphical view]
PANTHERPTHR11959. PTHR11959. 1 hit.
PfamPF00903. Glyoxalase. 1 hit.
[Graphical view]
PIRSFPIRSF009283. HPP_dOase. 1 hit.
TIGRFAMsTIGR01263. 4HPPD. 1 hit.
ProtoNetSearch...

Other

EvolutionaryTraceP80064.

Entry information

Entry nameHPPD_PSEUJ
AccessionPrimary (citable) accession number: P80064
Entry history
Integrated into UniProtKB/Swiss-Prot: May 1, 1992
Last sequence update: May 1, 1992
Last modified: October 16, 2013
This is version 86 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

PDB cross-references

Index of Protein Data Bank (PDB) cross-references

PATHWAY comments

Index of metabolic and biosynthesis pathways