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Protein

Protease inhibitors

Gene
N/A
Organism
Locusta migratoria (Migratory locust)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Both LCMI I and II are inhibitors of chymotrypsin and elastase (in vitro). They both inhibit the prophenol oxidase activation cascade.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sitei48 – 49Reactive bond2
Sitei86 – 87Reactive bond2

GO - Molecular functioni

Complete GO annotation...

Keywords - Molecular functioni

Protease inhibitor, Serine protease inhibitor

Protein family/group databases

MEROPSiI19.001.

Names & Taxonomyi

Protein namesi
Recommended name:
Protease inhibitors
Cleaved into the following 2 chains:
Alternative name(s):
PARS intercerebralis major peptide D2
Short name:
PMP-D2
Alternative name(s):
PARS intercerebralis major peptide C
Short name:
PMP-C
OrganismiLocusta migratoria (Migratory locust)
Taxonomic identifieri7004 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraOrthopteroideaOrthopteraCaeliferaAcridomorphaAcridoideaAcrididaeOedipodinaeLocusta

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 192 PublicationsAdd BLAST19
PeptideiPRO_000002670820 – 54Protease inhibitor LCMI-IAdd BLAST35
PeptideiPRO_000002670957 – 92Protease inhibitor LCMI-IIAdd BLAST36

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi23 ↔ 38PROSITE-ProRule annotation1 Publication
Disulfide bondi33 ↔ 51PROSITE-ProRule annotation1 Publication
Disulfide bondi36 ↔ 46PROSITE-ProRule annotation1 Publication
Disulfide bondi60 ↔ 75PROSITE-ProRule annotation1 Publication
Glycosylationi65O-linked (Fuc)1 Publication1
Disulfide bondi70 ↔ 89PROSITE-ProRule annotation1 Publication
Disulfide bondi73 ↔ 84PROSITE-ProRule annotation1 Publication

Keywords - PTMi

Cleavage on pair of basic residues, Disulfide bond, Glycoprotein

Expressioni

Tissue specificityi

Brain and fat body.

Interactioni

Protein-protein interaction databases

MINTiMINT-206895.

Structurei

Secondary structure

192
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi28 – 30Combined sources3
Beta strandi35 – 38Combined sources4
Beta strandi44 – 47Combined sources4
Beta strandi65 – 67Combined sources3
Beta strandi69 – 75Combined sources7
Beta strandi82 – 85Combined sources4

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1GL0X-ray3.00I20-54[»]
1GL1X-ray2.10I/J/K57-92[»]
1PMCNMR-A57-92[»]
ProteinModelPortaliP80060.
SMRiP80060.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP80060.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini20 – 54Pacifastin 1PROSITE-ProRule annotationAdd BLAST35
Domaini57 – 92Pacifastin 2PROSITE-ProRule annotationAdd BLAST36

Sequence similaritiesi

Belongs to the protease inhibitor I19 family. [View classification]PROSITE-ProRule annotation
Contains 2 pacifastin domains.PROSITE-ProRule annotation

Keywords - Domaini

Repeat, Signal

Family and domain databases

InterProiIPR008037. Pacifastin_dom.
[Graphical view]
PfamiPF05375. Pacifastin_I. 2 hits.
[Graphical view]
SUPFAMiSSF57283. SSF57283. 2 hits.
PROSITEiPS51446. PACIFASTIN. 2 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P80060-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKFALALCAA VLLVVLVQAE EKCTPGQVKQ QDCNTCTCTP TGVWGCTRKG
60 70 80 90
CQPAKREISC EPGKTFKDKC NTCRCGADGK SAACTLKACP NQ
Length:92
Mass (Da):9,760
Last modified:July 15, 1998 - v2
Checksum:i2A53F9E3D97D290A
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z22805 mRNA. Translation: CAA80462.1.
PIRiS36658.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z22805 mRNA. Translation: CAA80462.1.
PIRiS36658.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1GL0X-ray3.00I20-54[»]
1GL1X-ray2.10I/J/K57-92[»]
1PMCNMR-A57-92[»]
ProteinModelPortaliP80060.
SMRiP80060.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

MINTiMINT-206895.

Protein family/group databases

MEROPSiI19.001.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Miscellaneous databases

EvolutionaryTraceiP80060.

Family and domain databases

InterProiIPR008037. Pacifastin_dom.
[Graphical view]
PfamiPF05375. Pacifastin_I. 2 hits.
[Graphical view]
SUPFAMiSSF57283. SSF57283. 2 hits.
PROSITEiPS51446. PACIFASTIN. 2 hits.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiLCM_LOCMI
AccessioniPrimary (citable) accession number: P80060
Secondary accession number(s): P80058
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 1, 1992
Last sequence update: July 15, 1998
Last modified: November 2, 2016
This is version 95 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)

Miscellaneousi

Keywords - Technical termi

3D-structure, Direct protein sequencing

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.