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P80056

- CP3A5_PAPSP

UniProt

P80056 - CP3A5_PAPSP

Protein

Cytochrome P450 3A5

Gene
N/A
Organism
Papio sp. (Baboon)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at protein leveli
  1. Functioni

    6-beta-testosterone hydroxylase.

    Catalytic activityi

    RH + reduced flavoprotein + O2 = ROH + oxidized flavoprotein + H2O.

    Cofactori

    Heme group.By similarity

    GO - Molecular functioni

    1. aromatase activity Source: UniProtKB-EC
    2. metal ion binding Source: UniProtKB-KW

    Keywords - Molecular functioni

    Monooxygenase, Oxidoreductase

    Keywords - Ligandi

    Heme, Iron, Metal-binding

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Cytochrome P450 3A5 (EC:1.14.14.1)
    Alternative name(s):
    6-beta-testosterone hydroxylase
    CYPIIIA5
    Cytochrome P450 FA
    OrganismiPapio sp. (Baboon)
    Taxonomic identifieri61183 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniCercopithecidaeCercopithecinaePapio

    Subcellular locationi

    GO - Cellular componenti

    1. endoplasmic reticulum membrane Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Endoplasmic reticulum, Membrane, Microsome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – ›20›20Cytochrome P450 3A5PRO_0000051788Add
    BLAST

    Expressioni

    Inductioni

    By phenobarbital.

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the cytochrome P450 family.Curated

    Sequencei

    Sequence statusi: Fragment.

    P80056-1 [UniParc]FASTAAdd to Basket

    « Hide

    MDLIPDLAVE TWLLLAVTLV                                    20
    Length:20
    Mass (Da):2,226
    Last modified:May 1, 1992 - v1
    Checksum:i3FEF8B6E62BC0F36
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Non-terminal residuei20 – 201

    Cross-referencesi

    3D structure databases

    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Family and domain databases

    ProtoNeti Search...

    Publicationsi

    1. "Purification of two cytochrome P450 isozymes related to CYP2A and CYP3A gene families from monkey (baboon, Papio papio) liver microsomes. Cross reactivity with human forms."
      Dalet-Beluche I., Boulenc X., Fabre G., Maurel P., Bonfils C.
      Eur. J. Biochem. 204:641-648(1992) [PubMed] [Europe PMC] [Abstract]
      Cited for: PROTEIN SEQUENCE.
      Tissue: Liver.

    Entry informationi

    Entry nameiCP3A5_PAPSP
    AccessioniPrimary (citable) accession number: P80056
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: May 1, 1992
    Last sequence update: May 1, 1992
    Last modified: October 1, 2014
    This is version 66 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Direct protein sequencing

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3