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P80055

- CP2A7_PAPSP

UniProt

P80055 - CP2A7_PAPSP

Protein

Cytochrome P450 2A7

Gene

CYP2A7

Organism
Papio sp. (Baboon)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at protein leveli
  1. Functioni

    Exhibits a high coumarin 7-hydroxylase activity.

    Catalytic activityi

    RH + reduced flavoprotein + O2 = ROH + oxidized flavoprotein + H2O.

    Cofactori

    Heme group.By similarity

    GO - Molecular functioni

    1. aromatase activity Source: UniProtKB-EC
    2. metal ion binding Source: UniProtKB-KW

    Keywords - Molecular functioni

    Monooxygenase, Oxidoreductase

    Keywords - Ligandi

    Heme, Iron, Metal-binding

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Cytochrome P450 2A7 (EC:1.14.14.1)
    Alternative name(s):
    CYPIIA7
    Coumarin 7-hydroxylase
    Cytochrome P450 FI
    Gene namesi
    Name:CYP2A7
    OrganismiPapio sp. (Baboon)
    Taxonomic identifieri61183 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniCercopithecidaeCercopithecinaePapio

    Subcellular locationi

    GO - Cellular componenti

    1. endoplasmic reticulum membrane Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Endoplasmic reticulum, Membrane, Microsome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – ›20›20Cytochrome P450 2A7PRO_0000051670Add
    BLAST

    Expressioni

    Inductioni

    By phenobarbital.

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the cytochrome P450 family.Curated

    Sequencei

    Sequence statusi: Fragment.

    P80055-1 [UniParc]FASTAAdd to Basket

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    MLASGLLLVA LLACLTVMVL                                    20
    Length:20
    Mass (Da):2,045
    Last modified:February 1, 1994 - v2
    Checksum:i693102A1F0B50C96
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence uncertaintyi14 – 141
    Non-terminal residuei20 – 201

    Sequence databases

    PIRiS21737.

    Cross-referencesi

    Sequence databases

    PIRi S21737.

    3D structure databases

    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Family and domain databases

    ProtoNeti Search...

    Publicationsi

    1. "Purification of two cytochrome P450 isozymes related to CYP2A and CYP3A gene families from monkey (baboon, Papio papio) liver microsomes. Cross reactivity with human forms."
      Dalet-Beluche I., Boulenc X., Fabre G., Maurel P., Bonfils C.
      Eur. J. Biochem. 204:641-648(1992) [PubMed] [Europe PMC] [Abstract]
      Cited for: PROTEIN SEQUENCE.
      Tissue: Liver.

    Entry informationi

    Entry nameiCP2A7_PAPSP
    AccessioniPrimary (citable) accession number: P80055
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: May 1, 1992
    Last sequence update: February 1, 1994
    Last modified: October 1, 2014
    This is version 70 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Direct protein sequencing

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3