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P80055

- CP2A7_PAPSP

UniProt

P80055 - CP2A7_PAPSP

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Protein

Cytochrome P450 2A7

Gene

CYP2A7

Organism
Papio sp. (Baboon)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at protein leveli

Functioni

Exhibits a high coumarin 7-hydroxylase activity.

Catalytic activityi

RH + reduced flavoprotein + O2 = ROH + oxidized flavoprotein + H2O.

Cofactori

Heme group.By similarity

GO - Molecular functioni

  1. aromatase activity Source: UniProtKB-EC
  2. metal ion binding Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Monooxygenase, Oxidoreductase

Keywords - Ligandi

Heme, Iron, Metal-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Cytochrome P450 2A7 (EC:1.14.14.1)
Alternative name(s):
CYPIIA7
Coumarin 7-hydroxylase
Cytochrome P450 FI
Gene namesi
Name:CYP2A7
OrganismiPapio sp. (Baboon)
Taxonomic identifieri61183 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniCercopithecidaeCercopithecinaePapio

Subcellular locationi

GO - Cellular componenti

  1. endoplasmic reticulum Source: UniProtKB-KW
  2. membrane Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Endoplasmic reticulum, Membrane, Microsome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – ›20›20Cytochrome P450 2A7PRO_0000051670Add
BLAST

Expressioni

Inductioni

By phenobarbital.

Family & Domainsi

Sequence similaritiesi

Belongs to the cytochrome P450 family.Curated

Sequencei

Sequence statusi: Fragment.

P80055-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20
MLASGLLLVA LLACLTVMVL
Length:20
Mass (Da):2,045
Last modified:February 1, 1994 - v2
Checksum:i693102A1F0B50C96
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence uncertaintyi14 – 141
Non-terminal residuei20 – 201

Sequence databases

PIRiS21737.

Cross-referencesi

Sequence databases

PIRi S21737.

3D structure databases

ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Family and domain databases

ProtoNeti Search...

Publicationsi

  1. "Purification of two cytochrome P450 isozymes related to CYP2A and CYP3A gene families from monkey (baboon, Papio papio) liver microsomes. Cross reactivity with human forms."
    Dalet-Beluche I., Boulenc X., Fabre G., Maurel P., Bonfils C.
    Eur. J. Biochem. 204:641-648(1992) [PubMed] [Europe PMC] [Abstract]
    Cited for: PROTEIN SEQUENCE.
    Tissue: Liver.

Entry informationi

Entry nameiCP2A7_PAPSP
AccessioniPrimary (citable) accession number: P80055
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 1, 1992
Last sequence update: February 1, 1994
Last modified: October 29, 2014
This is version 71 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Direct protein sequencing

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3