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Protein

Cytochrome P450 2A7

Gene

CYP2A7

Organism
Papio sp. (Baboon)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Exhibits a high coumarin 7-hydroxylase activity.

Catalytic activityi

RH + [reduced NADPH--hemoprotein reductase] + O2 = ROH + [oxidized NADPH--hemoprotein reductase] + H2O.

Cofactori

hemeBy similarity

GO - Molecular functioni

Complete GO annotation...

Keywords - Molecular functioni

Monooxygenase, Oxidoreductase

Keywords - Ligandi

Heme, Iron, Metal-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Cytochrome P450 2A7 (EC:1.14.14.1)
Alternative name(s):
CYPIIA7
Coumarin 7-hydroxylase
Cytochrome P450 FI
Gene namesi
Name:CYP2A7
OrganismiPapio sp. (Baboon)
Taxonomic identifieri61183 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniCercopithecidaeCercopithecinaePapio

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Endoplasmic reticulum, Membrane, Microsome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000516701 – ›20Cytochrome P450 2A7Add BLAST›20

Expressioni

Inductioni

By phenobarbital.

Family & Domainsi

Sequence similaritiesi

Belongs to the cytochrome P450 family.Curated

Sequencei

Sequence statusi: Fragment.

P80055-1 [UniParc]FASTAAdd to basket

« Hide

        10         20
MLASGLLLVA LLACLTVMVL
Length:20
Mass (Da):2,045
Last modified:February 1, 1994 - v2
Checksum:i693102A1F0B50C96
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence uncertaintyi141
Non-terminal residuei201

Sequence databases

PIRiS21737.

Cross-referencesi

Sequence databases

PIRiS21737.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Family and domain databases

ProtoNetiSearch...

Entry informationi

Entry nameiCP2A7_PAPSP
AccessioniPrimary (citable) accession number: P80055
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 1, 1992
Last sequence update: February 1, 1994
Last modified: October 5, 2016
This is version 75 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Direct protein sequencing

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.