Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Basket 0
(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

P80053

- DHE2_SULSO

UniProt

P80053 - DHE2_SULSO

Protein

Glutamate dehydrogenase 2

Gene

gdhA-2

Organism
Sulfolobus solfataricus (strain ATCC 35092 / DSM 1617 / JCM 11322 / P2)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at protein leveli
    • BLAST
    • Align
    • Format
    • Add to basket
    • History
      Entry version 95 (01 Oct 2014)
      Sequence version 3 (18 Mar 2008)
      Previous versions | rss
    • Help video
    • Feedback
    • Comment

    Functioni

    Catalytic activityi

    L-glutamate + H2O + NAD(P)+ = 2-oxoglutarate + NH3 + NAD(P)H.PROSITE-ProRule annotation

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei109 – 1091PROSITE-ProRule annotation

    GO - Molecular functioni

    1. glutamate dehydrogenase [NAD(P)+] activity Source: UniProtKB-EC

    GO - Biological processi

    1. cellular amino acid metabolic process Source: InterPro

    Keywords - Molecular functioni

    Oxidoreductase

    Keywords - Ligandi

    NAD, NADP

    Enzyme and pathway databases

    BioCyciSSOL273057:GCH2-1784-MONOMER.
    SABIO-RKP80053.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Glutamate dehydrogenase 2 (EC:1.4.1.3)
    Short name:
    GDH-2
    Gene namesi
    Name:gdhA-2
    Synonyms:gdhA
    Ordered Locus Names:SSO1907
    OrganismiSulfolobus solfataricus (strain ATCC 35092 / DSM 1617 / JCM 11322 / P2)
    Taxonomic identifieri273057 [NCBI]
    Taxonomic lineageiArchaeaCrenarchaeotaThermoproteiSulfolobalesSulfolobaceaeSulfolobus
    ProteomesiUP000001974: Chromosome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Initiator methioninei1 – 11Removed1 Publication
    Chaini2 – 420419Glutamate dehydrogenase 2PRO_0000182761Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei2 – 21N-acetylmethionine
    Modified residuei254 – 2541N6-methyllysine
    Modified residuei260 – 2601N6-methyllysine
    Modified residuei372 – 3721N6-methyllysine
    Modified residuei391 – 3911N6-methyllysine
    Modified residuei392 – 3921N6-methyllysine

    Post-translational modificationi

    Methylation of lysine residues may play a role in the thermal stability of this enzyme.

    Keywords - PTMi

    Acetylation, Methylation

    Interactioni

    Subunit structurei

    Homohexamer.

    Protein-protein interaction databases

    STRINGi273057.SSO1907.

    Structurei

    3D structure databases

    ProteinModelPortaliP80053.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Phylogenomic databases

    eggNOGiCOG0334.
    HOGENOMiHOG000243801.
    KOiK00261.
    OMAiNANDIMA.

    Family and domain databases

    Gene3Di3.40.50.720. 1 hit.
    InterProiIPR006095. Glu/Leu/Phe/Val_DH.
    IPR006096. Glu/Leu/Phe/Val_DH_C.
    IPR006097. Glu/Leu/Phe/Val_DH_dimer_dom.
    IPR014362. Glu_DH.
    IPR016040. NAD(P)-bd_dom.
    [Graphical view]
    PfamiPF00208. ELFV_dehydrog. 1 hit.
    PF02812. ELFV_dehydrog_N. 1 hit.
    [Graphical view]
    PIRSFiPIRSF000185. Glu_DH. 1 hit.
    PRINTSiPR00082. GLFDHDRGNASE.
    SMARTiSM00839. ELFV_dehydrog. 1 hit.
    [Graphical view]
    PROSITEiPS00074. GLFV_DEHYDROGENASE. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    P80053-1 [UniParc]FASTAAdd to Basket

    « Hide

    MMEEVLSSSL YTQQVKKLYK VGELLGLDNE TLETLSQPER IIQVKIQIRG    50
    SDGKLKTFMG WRSQHNSALG PYKGGVRYHP NVTQDEVEAL SMIMTWKNSL 100
    LLLPYGGGKG GVRVDPKKLT REELEQLSRK YIQAIYKYLG SELDIPAPDV 150
    NTDSQTMAWF LDEYIKITGK VDFAVFTGKP VELGGIGVRL YSTGLGVATI 200
    AKEAANKFIG GVEEARVIIQ GFGNVGYYAG KFLSEMGAKI VGVSDSKGGV 250
    INEKGIDVGK AIEIKEKTGS VINYPEGRKV TNEELLISDC DILIPAALEN 300
    VINKFNAPKV KAKLIVEGAN GPLTADADEI MRQRGIAVVP DILANAGGVV 350
    GSYVEWANNK MGEIISDEEA KKLIVDRMNN AFNTLYDYHQ KKLEDHDLRT 400
    AAMALAVDRV VRAMKARGIL 420
    Length:420
    Mass (Da):46,031
    Last modified:March 18, 2008 - v3
    Checksum:iD9283C66D305EED5
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti203 – 2031E → EE AA sequence (PubMed:1730244)Curated
    Sequence conflicti392 – 3921K → KK AA sequence (PubMed:1730244)Curated

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AE006641 Genomic DNA. Translation: AAK42099.1.
    PIRiD90355.
    S20286.
    RefSeqiNP_343309.1. NC_002754.1.

    Genome annotation databases

    EnsemblBacteriaiAAK42099; AAK42099; SSO1907.
    GeneIDi1453426.
    KEGGisso:SSO1907.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AE006641 Genomic DNA. Translation: AAK42099.1 .
    PIRi D90355.
    S20286.
    RefSeqi NP_343309.1. NC_002754.1.

    3D structure databases

    ProteinModelPortali P80053.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 273057.SSO1907.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai AAK42099 ; AAK42099 ; SSO1907 .
    GeneIDi 1453426.
    KEGGi sso:SSO1907.

    Phylogenomic databases

    eggNOGi COG0334.
    HOGENOMi HOG000243801.
    KOi K00261.
    OMAi NANDIMA.

    Enzyme and pathway databases

    BioCyci SSOL273057:GCH2-1784-MONOMER.
    SABIO-RK P80053.

    Family and domain databases

    Gene3Di 3.40.50.720. 1 hit.
    InterProi IPR006095. Glu/Leu/Phe/Val_DH.
    IPR006096. Glu/Leu/Phe/Val_DH_C.
    IPR006097. Glu/Leu/Phe/Val_DH_dimer_dom.
    IPR014362. Glu_DH.
    IPR016040. NAD(P)-bd_dom.
    [Graphical view ]
    Pfami PF00208. ELFV_dehydrog. 1 hit.
    PF02812. ELFV_dehydrog_N. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF000185. Glu_DH. 1 hit.
    PRINTSi PR00082. GLFDHDRGNASE.
    SMARTi SM00839. ELFV_dehydrog. 1 hit.
    [Graphical view ]
    PROSITEi PS00074. GLFV_DEHYDROGENASE. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC 35092 / DSM 1617 / JCM 11322 / P2.
    2. "The protein sequence of glutamate dehydrogenase from Sulfolobus solfataricus, a thermoacidophilic archaebacterium. Is the presence of N-epsilon-methyllysine related to thermostability?"
      Maras B., Consalvi V., Chiaraluce R., Politi L., de Rosa M., Bossa F., Scandurra R., Barra D.
      Eur. J. Biochem. 203:81-87(1992) [PubMed] [Europe PMC] [Abstract]
      Cited for: PROTEIN SEQUENCE OF 2-420.
      Strain: DSM 5833 / MT-4.

    Entry informationi

    Entry nameiDHE2_SULSO
    AccessioniPrimary (citable) accession number: P80053
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: March 1, 1992
    Last sequence update: March 18, 2008
    Last modified: October 1, 2014
    This is version 95 of the entry and version 3 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Direct protein sequencing, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3