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P80053 (DHE2_SULSO) Reviewed, UniProtKB/Swiss-Prot

Last modified October 16, 2013. Version 93. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Glutamate dehydrogenase 2

Short name=GDH-2
EC=1.4.1.3
Gene names
Name:gdhA-2
Synonyms:gdhA
Ordered Locus Names:SSO1907
OrganismSulfolobus solfataricus (strain ATCC 35092 / DSM 1617 / JCM 11322 / P2) [Reference proteome] [HAMAP]
Taxonomic identifier273057 [NCBI]
Taxonomic lineageArchaeaCrenarchaeotaThermoproteiSulfolobalesSulfolobaceaeSulfolobus

Protein attributes

Sequence length420 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at protein level

General annotation (Comments)

Catalytic activity

L-glutamate + H2O + NAD(P)+ = 2-oxoglutarate + NH3 + NAD(P)H.

Subunit structure

Homohexamer.

Post-translational modification

Methylation of lysine residues may play a role in the thermal stability of this enzyme.

Sequence similarities

Belongs to the Glu/Leu/Phe/Val dehydrogenases family.

Ontologies

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Initiator methionine11Removed Ref.2
Chain2 – 420419Glutamate dehydrogenase 2
PRO_0000182761

Sites

Active site1091 By similarity

Amino acid modifications

Modified residue21N-acetylmethionine
Modified residue2541N6-methyllysine
Modified residue2601N6-methyllysine
Modified residue3721N6-methyllysine
Modified residue3911N6-methyllysine
Modified residue3921N6-methyllysine

Experimental info

Sequence conflict2031E → EE AA sequence Ref.2
Sequence conflict3921K → KK AA sequence Ref.2

Sequences

Sequence LengthMass (Da)Tools
P80053 [UniParc].

Last modified March 18, 2008. Version 3.
Checksum: D9283C66D305EED5

FASTA42046,031
        10         20         30         40         50         60 
MMEEVLSSSL YTQQVKKLYK VGELLGLDNE TLETLSQPER IIQVKIQIRG SDGKLKTFMG 

        70         80         90        100        110        120 
WRSQHNSALG PYKGGVRYHP NVTQDEVEAL SMIMTWKNSL LLLPYGGGKG GVRVDPKKLT 

       130        140        150        160        170        180 
REELEQLSRK YIQAIYKYLG SELDIPAPDV NTDSQTMAWF LDEYIKITGK VDFAVFTGKP 

       190        200        210        220        230        240 
VELGGIGVRL YSTGLGVATI AKEAANKFIG GVEEARVIIQ GFGNVGYYAG KFLSEMGAKI 

       250        260        270        280        290        300 
VGVSDSKGGV INEKGIDVGK AIEIKEKTGS VINYPEGRKV TNEELLISDC DILIPAALEN 

       310        320        330        340        350        360 
VINKFNAPKV KAKLIVEGAN GPLTADADEI MRQRGIAVVP DILANAGGVV GSYVEWANNK 

       370        380        390        400        410        420 
MGEIISDEEA KKLIVDRMNN AFNTLYDYHQ KKLEDHDLRT AAMALAVDRV VRAMKARGIL 

« Hide

References

« Hide 'large scale' references
[1]"The complete genome of the crenarchaeon Sulfolobus solfataricus P2."
She Q., Singh R.K., Confalonieri F., Zivanovic Y., Allard G., Awayez M.J., Chan-Weiher C.C.-Y., Clausen I.G., Curtis B.A., De Moors A., Erauso G., Fletcher C., Gordon P.M.K., Heikamp-de Jong I., Jeffries A.C., Kozera C.J., Medina N., Peng X. expand/collapse author list , Thi-Ngoc H.P., Redder P., Schenk M.E., Theriault C., Tolstrup N., Charlebois R.L., Doolittle W.F., Duguet M., Gaasterland T., Garrett R.A., Ragan M.A., Sensen C.W., Van der Oost J.
Proc. Natl. Acad. Sci. U.S.A. 98:7835-7840(2001) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: ATCC 35092 / DSM 1617 / JCM 11322 / P2.
[2]"The protein sequence of glutamate dehydrogenase from Sulfolobus solfataricus, a thermoacidophilic archaebacterium. Is the presence of N-epsilon-methyllysine related to thermostability?"
Maras B., Consalvi V., Chiaraluce R., Politi L., de Rosa M., Bossa F., Scandurra R., Barra D.
Eur. J. Biochem. 203:81-87(1992) [PubMed] [Europe PMC] [Abstract]
Cited for: PROTEIN SEQUENCE OF 2-420.
Strain: DSM 5833 / MT-4.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AE006641 Genomic DNA. Translation: AAK42099.1.
PIRD90355.
S20286.
RefSeqNP_343309.1. NC_002754.1.

3D structure databases

ProteinModelPortalP80053.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING273057.SSO1907.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaAAK42099; AAK42099; SSO1907.
GeneID1453426.
KEGGsso:SSO1907.

Phylogenomic databases

eggNOGCOG0334.
HOGENOMHOG000243801.
KOK00261.
OMAHIKAMCK.
ProtClustDBCLSK803108.

Enzyme and pathway databases

BioCycSSOL273057:GCH2-1784-MONOMER.
SABIO-RKP80053.

Family and domain databases

Gene3D3.40.50.720. 1 hit.
InterProIPR006095. Glu/Leu/Phe/Val_DH.
IPR006096. Glu/Leu/Phe/Val_DH_C.
IPR006097. Glu/Leu/Phe/Val_DH_dimer_dom.
IPR014362. Glu_DH.
IPR016040. NAD(P)-bd_dom.
[Graphical view]
PfamPF00208. ELFV_dehydrog. 1 hit.
PF02812. ELFV_dehydrog_N. 1 hit.
[Graphical view]
PIRSFPIRSF000185. Glu_DH. 1 hit.
PRINTSPR00082. GLFDHDRGNASE.
SMARTSM00839. ELFV_dehydrog. 1 hit.
[Graphical view]
PROSITEPS00074. GLFV_DEHYDROGENASE. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameDHE2_SULSO
AccessionPrimary (citable) accession number: P80053
Entry history
Integrated into UniProtKB/Swiss-Prot: March 1, 1992
Last sequence update: March 18, 2008
Last modified: October 16, 2013
This is version 93 of the entry and version 3 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families