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P80044 (HBB_TREBE) Reviewed, UniProtKB/Swiss-Prot

Last modified October 16, 2013. Version 92. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Hemoglobin subunit beta
Alternative name(s):
Beta-globin
Hemoglobin beta chain
Gene names
Name:hbb
OrganismTrematomus bernacchii (Emerald rockcod) (Pagothenia bernacchii)
Taxonomic identifier40690 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiActinopterygiiNeopterygiiTeleosteiEuteleosteiNeoteleosteiAcanthomorphaAcanthopterygiiPercomorphaPerciformesNotothenioideiNototheniidaeTrematomus

Protein attributes

Sequence length147 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Involved in oxygen transport from gills to the various peripheral tissues. Ref.2

Subunit structure

Hb1 is a heterotetramer of two alpha chains and two beta chains. Ref.2

Tissue specificity

Red blood cells.

Miscellaneous

This fish has three hemoglobins: Hb1 (major) and two minor hemoglobins (about 1-2% of the total). Hb1 has a strong alkaline Bohr effect, and at low pH exhibits the reduced ligand affinity and cooperativity that comprise the Root effect.

Sequence similarities

Belongs to the globin family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Initiator methionine11Removed Ref.2
Chain2 – 147146Hemoglobin subunit beta
PRO_0000053046

Sites

Metal binding641Iron (heme distal ligand)
Metal binding931Iron (heme proximal ligand)

Secondary structure

......................... 147
Helix Strand Turn

Details...

Sequences

Sequence LengthMass (Da)Tools
P80044 [UniParc].

Last modified January 23, 2007. Version 2.
Checksum: 0C9A4B07948A81B2

FASTA14716,264
        10         20         30         40         50         60 
MVEWTDKERS IISDIFSHMD YDDIGPKALS RCLIVYPWTQ RHFSGFGNLY NAEAIIGNAN 

        70         80         90        100        110        120 
VAAHGIKVLH GLDRGVKNMD NIAATYADLS TLHSEKLHVD PDNFKLLSDC ITIVLAAKMG 

       130        140 
HAFTAETQGA FQKFLAVVVS ALGKQYH 

« Hide

References

[1]"Antarctic fish hemoglobins: evidence for adaptive evolution at subzero temperature."
Bargelloni L., Marcato S., Patarnello T.
Proc. Natl. Acad. Sci. U.S.A. 95:8670-8675(1998) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[2]"Haemoglobin of the antarctic fish Pagothenia bernacchii. Amino acid sequence, oxygen equilibria and crystal structure of its carbonmonoxy derivative."
Camardella L., Caruso C., D'Avino R., di Prisco G., Rutigliano B., Tamburrini M., Fermi G., Perutz M.F.
J. Mol. Biol. 224:449-460(1992) [PubMed] [Europe PMC] [Abstract]
Cited for: PROTEIN SEQUENCE OF 2-147, FUNCTION, SUBUNIT, X-RAY CRYSTALLOGRAPHY (2.5 ANGSTROMS).
Tissue: Blood.
[3]"Structure of deoxyhaemoglobin of the antarctic fish Pagothenia bernacchii with an analysis of the structural basis of the Root effect by comparison of the liganded and unliganded haemoglobin structures."
Ito N., Komiyama N.H., Fermi G.
J. Mol. Biol. 250:648-658(1995) [PubMed] [Europe PMC] [Abstract]
Cited for: X-RAY CRYSTALLOGRAPHY (2.2 ANGSTROMS).
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AF067570 mRNA. Translation: AAC41388.1.
PIRS21678.

3D structure databases

PDBe
RCSB PDB
PDBj
EntryMethodResolution (Å)ChainPositionsPDBsum
1HBHX-ray2.20B/D2-147[»]
1PBXX-ray2.50B2-147[»]
1S5XX-ray2.40B2-146[»]
1S5YX-ray2.50B/D2-146[»]
2H8DX-ray1.78B/D2-146[»]
2H8FX-ray1.30B/D2-146[»]
2PEGX-ray1.48B2-147[»]
3GKVX-ray1.40B2-147[»]
3GQGX-ray1.73B/D2-147[»]
4G51X-ray2.50B/D2-147[»]
4IROX-ray2.20B/D2-147[»]
ProteinModelPortalP80044.
SMRP80044. Positions 2-147.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

MINTMINT-1507087.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Phylogenomic databases

HOVERGENHBG009709.

Family and domain databases

Gene3D1.10.490.10. 1 hit.
InterProIPR000971. Globin.
IPR009050. Globin-like.
IPR012292. Globin_dom.
IPR002337. Haemoglobin_b.
[Graphical view]
PANTHERPTHR11442:SF7. PTHR11442:SF7. 1 hit.
PfamPF00042. Globin. 1 hit.
[Graphical view]
PRINTSPR00814. BETAHAEM.
SUPFAMSSF46458. SSF46458. 1 hit.
PROSITEPS01033. GLOBIN. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

EvolutionaryTraceP80044.

Entry information

Entry nameHBB_TREBE
AccessionPrimary (citable) accession number: P80044
Secondary accession number(s): O93350
Entry history
Integrated into UniProtKB/Swiss-Prot: May 1, 1992
Last sequence update: January 23, 2007
Last modified: October 16, 2013
This is version 92 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

PDB cross-references

Index of Protein Data Bank (PDB) cross-references