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Protein

Hemoglobin subunit beta

Gene

hbb

Organism
Trematomus bernacchii (Emerald rockcod) (Pagothenia bernacchii)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Involved in oxygen transport from gills to the various peripheral tissues.1 Publication

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi64Iron (heme distal ligand)Combined sources1
Metal bindingi93Iron (heme proximal ligand)Combined sources1 Publication1

GO - Molecular functioni

Complete GO annotation...

Keywords - Biological processi

Oxygen transport, Transport

Keywords - Ligandi

Heme, Iron, Metal-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Hemoglobin subunit beta
Alternative name(s):
Beta-globin
Hemoglobin beta chain
Gene namesi
Name:hbb
OrganismiTrematomus bernacchii (Emerald rockcod) (Pagothenia bernacchii)
Taxonomic identifieri40690 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiActinopterygiiNeopterygiiTeleosteiNeoteleosteiAcanthomorphataEupercariaPerciformesNotothenioideiNototheniidaeTrematomus

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemoved1 Publication
ChainiPRO_00000530462 – 147Hemoglobin subunit betaAdd BLAST146

Expressioni

Tissue specificityi

Red blood cells.

Interactioni

Subunit structurei

Hb1 is a heterotetramer of two alpha chains and two beta chains.1 Publication

Protein-protein interaction databases

MINTiMINT-1507087.

Structurei

Secondary structure

1147
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Helixi6 – 18Combined sources13
Helixi21 – 35Combined sources15
Helixi37 – 42Combined sources6
Helixi44 – 46Combined sources3
Helixi52 – 56Combined sources5
Helixi59 – 70Combined sources12
Helixi73 – 76Combined sources4
Turni77 – 80Combined sources4
Helixi82 – 85Combined sources4
Helixi87 – 95Combined sources9
Helixi102 – 119Combined sources18
Helixi120 – 122Combined sources3
Helixi125 – 144Combined sources20

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1HBHX-ray2.20B/D2-147[»]
1PBXX-ray2.50B2-147[»]
1S5XX-ray2.40B2-147[»]
1S5YX-ray2.50B/D2-147[»]
2H8DX-ray1.78B/D2-147[»]
2H8FX-ray1.30B/D2-147[»]
2PEGX-ray1.48B2-147[»]
3GKVX-ray1.40B2-147[»]
3GQGX-ray1.73B/D2-147[»]
4G51X-ray2.50B/D2-147[»]
4IROX-ray2.20B/D2-147[»]
4ODCX-ray1.54B2-147[»]
ProteinModelPortaliP80044.
SMRiP80044.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP80044.

Family & Domainsi

Sequence similaritiesi

Belongs to the globin family.PROSITE-ProRule annotation

Phylogenomic databases

HOVERGENiHBG009709.

Family and domain databases

CDDicd08925. Hb-beta_like. 1 hit.
Gene3Di1.10.490.10. 1 hit.
InterProiIPR000971. Globin.
IPR009050. Globin-like.
IPR012292. Globin/Proto.
IPR002337. Haemoglobin_b.
[Graphical view]
PfamiPF00042. Globin. 1 hit.
[Graphical view]
PRINTSiPR00814. BETAHAEM.
SUPFAMiSSF46458. SSF46458. 1 hit.
PROSITEiPS01033. GLOBIN. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P80044-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MVEWTDKERS IISDIFSHMD YDDIGPKALS RCLIVYPWTQ RHFSGFGNLY
60 70 80 90 100
NAEAIIGNAN VAAHGIKVLH GLDRGVKNMD NIAATYADLS TLHSEKLHVD
110 120 130 140
PDNFKLLSDC ITIVLAAKMG HAFTAETQGA FQKFLAVVVS ALGKQYH
Length:147
Mass (Da):16,264
Last modified:January 23, 2007 - v2
Checksum:i0C9A4B07948A81B2
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF067570 mRNA. Translation: AAC41388.1.
PIRiS21678.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF067570 mRNA. Translation: AAC41388.1.
PIRiS21678.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1HBHX-ray2.20B/D2-147[»]
1PBXX-ray2.50B2-147[»]
1S5XX-ray2.40B2-147[»]
1S5YX-ray2.50B/D2-147[»]
2H8DX-ray1.78B/D2-147[»]
2H8FX-ray1.30B/D2-147[»]
2PEGX-ray1.48B2-147[»]
3GKVX-ray1.40B2-147[»]
3GQGX-ray1.73B/D2-147[»]
4G51X-ray2.50B/D2-147[»]
4IROX-ray2.20B/D2-147[»]
4ODCX-ray1.54B2-147[»]
ProteinModelPortaliP80044.
SMRiP80044.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

MINTiMINT-1507087.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Phylogenomic databases

HOVERGENiHBG009709.

Miscellaneous databases

EvolutionaryTraceiP80044.

Family and domain databases

CDDicd08925. Hb-beta_like. 1 hit.
Gene3Di1.10.490.10. 1 hit.
InterProiIPR000971. Globin.
IPR009050. Globin-like.
IPR012292. Globin/Proto.
IPR002337. Haemoglobin_b.
[Graphical view]
PfamiPF00042. Globin. 1 hit.
[Graphical view]
PRINTSiPR00814. BETAHAEM.
SUPFAMiSSF46458. SSF46458. 1 hit.
PROSITEiPS01033. GLOBIN. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiHBB_TREBE
AccessioniPrimary (citable) accession number: P80044
Secondary accession number(s): O93350
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 1, 1992
Last sequence update: January 23, 2007
Last modified: November 2, 2016
This is version 111 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Miscellaneous

This fish has three hemoglobins: Hb1 (major) and two minor hemoglobins (about 1-2% of the total). Hb1 has a strong alkaline Bohr effect, and at low pH exhibits the reduced ligand affinity and cooperativity that comprise the Root effect.

Keywords - Technical termi

3D-structure, Direct protein sequencing

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.