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Protein

Hemoglobin subunit beta

Gene

hbb

Organism
Pseudotrematomus bernacchii (Emerald rockcod) (Trematomus bernacchii)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Involved in oxygen transport from gills to the various peripheral tissues.1 Publication

Miscellaneous

This fish has three hemoglobins: Hb1 (major) and two minor hemoglobins (about 1-2% of the total). Hb1 has a strong alkaline Bohr effect, and at low pH exhibits the reduced ligand affinity and cooperativity that comprise the Root effect.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi64Iron (heme distal ligand)Combined sources1
Metal bindingi93Iron (heme proximal ligand)Combined sources1 Publication1

GO - Molecular functioni

Keywordsi

Biological processOxygen transport, Transport
LigandHeme, Iron, Metal-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Hemoglobin subunit beta
Alternative name(s):
Beta-globin
Hemoglobin beta chain
Gene namesi
Name:hbb
OrganismiPseudotrematomus bernacchii (Emerald rockcod) (Trematomus bernacchii)
Taxonomic identifieri40690 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiActinopterygiiNeopterygiiTeleosteiNeoteleosteiAcanthomorphataEupercariaPerciformesNotothenioideiNototheniidaeTrematomus

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemoved1 Publication
ChainiPRO_00000530462 – 147Hemoglobin subunit betaAdd BLAST146

Expressioni

Tissue specificityi

Red blood cells.

Interactioni

Subunit structurei

Hb1 is a heterotetramer of two alpha chains and two beta chains.1 Publication

Protein-protein interaction databases

IntActiP80044, 1 interactor
MINTiP80044

Structurei

Secondary structure

1147
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Helixi6 – 18Combined sources13
Helixi21 – 35Combined sources15
Helixi37 – 42Combined sources6
Helixi44 – 46Combined sources3
Helixi52 – 56Combined sources5
Helixi59 – 70Combined sources12
Helixi73 – 76Combined sources4
Turni77 – 80Combined sources4
Helixi82 – 85Combined sources4
Helixi87 – 95Combined sources9
Helixi102 – 119Combined sources18
Helixi120 – 122Combined sources3
Helixi125 – 144Combined sources20

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1HBHX-ray2.20B/D2-147[»]
1PBXX-ray2.50B2-147[»]
1S5XX-ray2.40B2-147[»]
1S5YX-ray2.50B/D2-147[»]
2H8DX-ray1.78B/D2-147[»]
2H8FX-ray1.30B/D2-147[»]
2PEGX-ray1.48B2-147[»]
3GKVX-ray1.40B2-147[»]
3GQGX-ray1.73B/D2-147[»]
4G51X-ray2.50B/D2-147[»]
4IROX-ray2.20B/D2-147[»]
4ODCX-ray1.54B2-147[»]
ProteinModelPortaliP80044
SMRiP80044
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP80044

Family & Domainsi

Sequence similaritiesi

Belongs to the globin family.PROSITE-ProRule annotation

Phylogenomic databases

HOVERGENiHBG009709

Family and domain databases

CDDicd08925 Hb-beta_like, 1 hit
Gene3Di1.10.490.10, 1 hit
InterProiView protein in InterPro
IPR000971 Globin
IPR009050 Globin-like_sf
IPR012292 Globin/Proto
IPR002337 Haemoglobin_b
PfamiView protein in Pfam
PF00042 Globin, 1 hit
PRINTSiPR00814 BETAHAEM
SUPFAMiSSF46458 SSF46458, 1 hit
PROSITEiView protein in PROSITE
PS01033 GLOBIN, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P80044-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MVEWTDKERS IISDIFSHMD YDDIGPKALS RCLIVYPWTQ RHFSGFGNLY
60 70 80 90 100
NAEAIIGNAN VAAHGIKVLH GLDRGVKNMD NIAATYADLS TLHSEKLHVD
110 120 130 140
PDNFKLLSDC ITIVLAAKMG HAFTAETQGA FQKFLAVVVS ALGKQYH
Length:147
Mass (Da):16,264
Last modified:January 23, 2007 - v2
Checksum:i0C9A4B07948A81B2
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF067570 mRNA Translation: AAC41388.1
PIRiS21678

Similar proteinsi

Entry informationi

Entry nameiHBB_PSEBE
AccessioniPrimary (citable) accession number: P80044
Secondary accession number(s): O93350
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 1, 1992
Last sequence update: January 23, 2007
Last modified: April 25, 2018
This is version 118 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Direct protein sequencing
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Main funding by: National Institutes of Health