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P80044

- HBB_TREBE

UniProt

P80044 - HBB_TREBE

Protein

Hemoglobin subunit beta

Gene

hbb

Organism
Trematomus bernacchii (Emerald rockcod) (Pagothenia bernacchii)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at protein leveli
  1. Functioni

    Involved in oxygen transport from gills to the various peripheral tissues.1 Publication

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Metal bindingi64 – 641Iron (heme distal ligand)
    Metal bindingi93 – 931Iron (heme proximal ligand)

    GO - Molecular functioni

    1. heme binding Source: InterPro
    2. iron ion binding Source: InterPro
    3. oxygen binding Source: InterPro
    4. oxygen transporter activity Source: UniProtKB-KW

    Keywords - Biological processi

    Oxygen transport, Transport

    Keywords - Ligandi

    Heme, Iron, Metal-binding

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Hemoglobin subunit beta
    Alternative name(s):
    Beta-globin
    Hemoglobin beta chain
    Gene namesi
    Name:hbb
    OrganismiTrematomus bernacchii (Emerald rockcod) (Pagothenia bernacchii)
    Taxonomic identifieri40690 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiActinopterygiiNeopterygiiTeleosteiNeoteleosteiAcanthomorphataPercomorphariaPerciformesNotothenioideiNototheniidaeTrematomus

    Subcellular locationi

    GO - Cellular componenti

    1. hemoglobin complex Source: InterPro

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Initiator methioninei1 – 11Removed1 Publication
    Chaini2 – 147146Hemoglobin subunit betaPRO_0000053046Add
    BLAST

    Expressioni

    Tissue specificityi

    Red blood cells.

    Interactioni

    Subunit structurei

    Hb1 is a heterotetramer of two alpha chains and two beta chains.1 Publication

    Protein-protein interaction databases

    MINTiMINT-1507087.

    Structurei

    Secondary structure

    1
    147
    Legend: HelixTurnBeta strand
    Show more details
    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Helixi6 – 1813
    Helixi21 – 3515
    Helixi37 – 426
    Helixi44 – 463
    Helixi52 – 565
    Helixi59 – 7012
    Helixi73 – 764
    Turni77 – 804
    Helixi82 – 854
    Helixi87 – 959
    Helixi102 – 11918
    Helixi120 – 1223
    Helixi125 – 14420

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    EntryMethodResolution (Å)ChainPositionsPDBsum
    1HBHX-ray2.20B/D2-147[»]
    1PBXX-ray2.50B2-147[»]
    1S5XX-ray2.40B2-147[»]
    1S5YX-ray2.50B/D2-147[»]
    2H8DX-ray1.78B/D2-147[»]
    2H8FX-ray1.30B/D2-147[»]
    2PEGX-ray1.48B2-147[»]
    3GKVX-ray1.40B2-147[»]
    3GQGX-ray1.73B/D2-147[»]
    4G51X-ray2.50B/D2-147[»]
    4IROX-ray2.20B/D2-147[»]
    ProteinModelPortaliP80044.
    SMRiP80044. Positions 2-147.
    ModBaseiSearch...
    MobiDBiSearch...

    Miscellaneous databases

    EvolutionaryTraceiP80044.

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the globin family.PROSITE-ProRule annotation

    Phylogenomic databases

    HOVERGENiHBG009709.

    Family and domain databases

    Gene3Di1.10.490.10. 1 hit.
    InterProiIPR000971. Globin.
    IPR009050. Globin-like.
    IPR012292. Globin_dom.
    IPR002337. Haemoglobin_b.
    [Graphical view]
    PANTHERiPTHR11442:SF7. PTHR11442:SF7. 1 hit.
    PfamiPF00042. Globin. 1 hit.
    [Graphical view]
    PRINTSiPR00814. BETAHAEM.
    SUPFAMiSSF46458. SSF46458. 1 hit.
    PROSITEiPS01033. GLOBIN. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    P80044-1 [UniParc]FASTAAdd to Basket

    « Hide

    MVEWTDKERS IISDIFSHMD YDDIGPKALS RCLIVYPWTQ RHFSGFGNLY    50
    NAEAIIGNAN VAAHGIKVLH GLDRGVKNMD NIAATYADLS TLHSEKLHVD 100
    PDNFKLLSDC ITIVLAAKMG HAFTAETQGA FQKFLAVVVS ALGKQYH 147
    Length:147
    Mass (Da):16,264
    Last modified:January 23, 2007 - v2
    Checksum:i0C9A4B07948A81B2
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF067570 mRNA. Translation: AAC41388.1.
    PIRiS21678.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF067570 mRNA. Translation: AAC41388.1 .
    PIRi S21678.

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    Entry Method Resolution (Å) Chain Positions PDBsum
    1HBH X-ray 2.20 B/D 2-147 [» ]
    1PBX X-ray 2.50 B 2-147 [» ]
    1S5X X-ray 2.40 B 2-147 [» ]
    1S5Y X-ray 2.50 B/D 2-147 [» ]
    2H8D X-ray 1.78 B/D 2-147 [» ]
    2H8F X-ray 1.30 B/D 2-147 [» ]
    2PEG X-ray 1.48 B 2-147 [» ]
    3GKV X-ray 1.40 B 2-147 [» ]
    3GQG X-ray 1.73 B/D 2-147 [» ]
    4G51 X-ray 2.50 B/D 2-147 [» ]
    4IRO X-ray 2.20 B/D 2-147 [» ]
    ProteinModelPortali P80044.
    SMRi P80044. Positions 2-147.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    MINTi MINT-1507087.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Phylogenomic databases

    HOVERGENi HBG009709.

    Miscellaneous databases

    EvolutionaryTracei P80044.

    Family and domain databases

    Gene3Di 1.10.490.10. 1 hit.
    InterProi IPR000971. Globin.
    IPR009050. Globin-like.
    IPR012292. Globin_dom.
    IPR002337. Haemoglobin_b.
    [Graphical view ]
    PANTHERi PTHR11442:SF7. PTHR11442:SF7. 1 hit.
    Pfami PF00042. Globin. 1 hit.
    [Graphical view ]
    PRINTSi PR00814. BETAHAEM.
    SUPFAMi SSF46458. SSF46458. 1 hit.
    PROSITEi PS01033. GLOBIN. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Antarctic fish hemoglobins: evidence for adaptive evolution at subzero temperature."
      Bargelloni L., Marcato S., Patarnello T.
      Proc. Natl. Acad. Sci. U.S.A. 95:8670-8675(1998) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    2. "Haemoglobin of the antarctic fish Pagothenia bernacchii. Amino acid sequence, oxygen equilibria and crystal structure of its carbonmonoxy derivative."
      Camardella L., Caruso C., D'Avino R., di Prisco G., Rutigliano B., Tamburrini M., Fermi G., Perutz M.F.
      J. Mol. Biol. 224:449-460(1992) [PubMed] [Europe PMC] [Abstract]
      Cited for: PROTEIN SEQUENCE OF 2-147, FUNCTION, SUBUNIT, X-RAY CRYSTALLOGRAPHY (2.5 ANGSTROMS).
      Tissue: Blood.
    3. "Structure of deoxyhaemoglobin of the antarctic fish Pagothenia bernacchii with an analysis of the structural basis of the Root effect by comparison of the liganded and unliganded haemoglobin structures."
      Ito N., Komiyama N.H., Fermi G.
      J. Mol. Biol. 250:648-658(1995) [PubMed] [Europe PMC] [Abstract]
      Cited for: X-RAY CRYSTALLOGRAPHY (2.2 ANGSTROMS).

    Entry informationi

    Entry nameiHBB_TREBE
    AccessioniPrimary (citable) accession number: P80044
    Secondary accession number(s): O93350
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: May 1, 1992
    Last sequence update: January 23, 2007
    Last modified: October 1, 2014
    This is version 95 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Miscellaneous

    This fish has three hemoglobins: Hb1 (major) and two minor hemoglobins (about 1-2% of the total). Hb1 has a strong alkaline Bohr effect, and at low pH exhibits the reduced ligand affinity and cooperativity that comprise the Root effect.

    Keywords - Technical termi

    3D-structure, Direct protein sequencing

    Documents

    1. PDB cross-references
      Index of Protein Data Bank (PDB) cross-references
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3