true1992-05-012024-03-27121HBA_TREBEHaemoglobin of the antarctic fish Pagothenia bernacchii. Amino acid sequence, oxygen equilibria and crystal structure of its carbonmonoxy derivative.Camardella L.Caruso C.D'Avino R.di Prisco G.Rutigliano B.Tamburrini M.Fermi G.Perutz M.F.doi:10.1016/0022-2836(92)91007-c1992J. Mol. Biol.224449-460PROTEIN SEQUENCEFUNCTIONSUBUNITX-RAY CRYSTALLOGRAPHY (2.5 ANGSTROMS)BloodStructure of deoxyhaemoglobin of the antarctic fish Pagothenia bernacchii with an analysis of the structural basis of the Root effect by comparison of the liganded and unliganded haemoglobin structures.Ito N.Komiyama N.H.Fermi G.doi:10.1006/jmbi.1995.04051995J. Mol. Biol.250648-658X-RAY CRYSTALLOGRAPHY (2.2 ANGSTROMS)ACETYLATION AT SER-12.20A/C=1-1422.50A=1-1422.40A=1-1422.50A/C=1-1421.78A/C=1-1421.30A/C=1-1421.48A=1-1421.40A=1-1421.73A/C=1-1422.50A/C=1-1422.20A/C=1-1421.54A=1-142Hb-alpha-likeGlobinsGlobinGlobin-like_sfGlobin/ProtoHemoglobin_a-typHemoglobin_piHEMOGLOBIN FAMILY MEMBERHEMOGLOBIN SUBUNIT ALPHAGlobinALPHAHAEMPIHAEMGlobin-likeGLOBINHemoglobin subunit alphaAlpha-globinHemoglobin alpha chainhbaInvolved in oxygen transport from gills to the various peripheral tissues.Hb1 is a heterotetramer of two alpha chains and two beta chains. HbC is a heterotetramer of two alpha chains and two beta-C chains.Red blood cells.This fish has three hemoglobins: Hb1 (major) and two minor hemoglobins (about 1-2% of the total). Hb1 has a strong alkaline Bohr effect, and at low pH exhibits the reduced ligand affinity and cooperativity that comprise the Root effect.Belongs to the globin family.Hemoglobin subunit alpha15632114259proximal binding residue88N-acetylserine41718202135374350525472737577808290971131151171201371381401992-05-01115632dc89ae546bc7aa714d0edb5b073f6cb0SLSDKDKAAVRALWSKIGKSADAIGNDALSRMIVVYPQTKTYFSHWPDVTPGSPHIKAHGKKVMGGIALAVSKIDDLKTGLMELSEQHAYKLRVDPANFKILNHCILVVISTMFPKEFTPEAHVSLDKFLSGVALALAERYRtruetruetruetrue