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P80043

- HBA_TREBE

UniProt

P80043 - HBA_TREBE

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Protein

Hemoglobin subunit alpha

Gene

hba

Organism
Trematomus bernacchii (Emerald rockcod) (Pagothenia bernacchii)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at protein leveli

Functioni

Involved in oxygen transport from gills to the various peripheral tissues.1 Publication

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi59 – 591Iron (heme distal ligand)
Metal bindingi88 – 881Iron (heme proximal ligand)

GO - Molecular functioni

  1. heme binding Source: InterPro
  2. iron ion binding Source: InterPro
  3. oxygen binding Source: InterPro
  4. oxygen transporter activity Source: UniProtKB

GO - Biological processi

  1. oxygen transport Source: UniProtKB
Complete GO annotation...

Keywords - Biological processi

Oxygen transport, Transport

Keywords - Ligandi

Heme, Iron, Metal-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Hemoglobin subunit alpha
Alternative name(s):
Alpha-globin
Hemoglobin alpha chain
Gene namesi
Name:hba
OrganismiTrematomus bernacchii (Emerald rockcod) (Pagothenia bernacchii)
Taxonomic identifieri40690 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiActinopterygiiNeopterygiiTeleosteiNeoteleosteiAcanthomorphataEupercariaPerciformesNotothenioideiNototheniidaeTrematomus

Subcellular locationi

GO - Cellular componenti

  1. hemoglobin complex Source: UniProtKB
Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 142142Hemoglobin subunit alphaPRO_0000052712Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei1 – 11N-acetylserine

Keywords - PTMi

Acetylation

Expressioni

Tissue specificityi

Red blood cells.

Interactioni

Subunit structurei

Hb1 is a heterotetramer of two alpha chains and two beta chains. HbC is a heterotetramer of two alpha chains and two beta-C chains.1 Publication

Protein-protein interaction databases

MINTiMINT-1507077.

Structurei

Secondary structure

1
142
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Helixi4 – 1714Combined sources
Helixi18 – 203Combined sources
Helixi21 – 3515Combined sources
Helixi37 – 437Combined sources
Beta strandi50 – 523Combined sources
Helixi54 – 7219Combined sources
Turni73 – 753Combined sources
Helixi77 – 804Combined sources
Helixi82 – 909Combined sources
Helixi97 – 11317Combined sources
Turni115 – 1173Combined sources
Helixi120 – 13718Combined sources
Turni138 – 1403Combined sources

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1HBHX-ray2.20A/C1-142[»]
1PBXX-ray2.50A1-142[»]
1S5XX-ray2.40A1-142[»]
1S5YX-ray2.50A/C1-142[»]
2H8DX-ray1.78A/C1-142[»]
2H8FX-ray1.30A/C1-142[»]
2PEGX-ray1.48A1-142[»]
3GKVX-ray1.40A1-142[»]
3GQGX-ray1.73A/C1-142[»]
4G51X-ray2.50A/C1-142[»]
4IROX-ray2.20A/C1-142[»]
ProteinModelPortaliP80043.
SMRiP80043. Positions 1-142.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP80043.

Family & Domainsi

Sequence similaritiesi

Belongs to the globin family.PROSITE-ProRule annotation

Phylogenomic databases

HOVERGENiHBG009709.

Family and domain databases

Gene3Di1.10.490.10. 1 hit.
InterProiIPR000971. Globin.
IPR009050. Globin-like.
IPR012292. Globin_dom.
IPR002338. Haemoglobin_a.
IPR002339. Haemoglobin_pi.
[Graphical view]
PfamiPF00042. Globin. 1 hit.
[Graphical view]
PRINTSiPR00612. ALPHAHAEM.
PR00815. PIHAEM.
SUPFAMiSSF46458. SSF46458. 1 hit.
PROSITEiPS01033. GLOBIN. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P80043-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
SLSDKDKAAV RALWSKIGKS ADAIGNDALS RMIVVYPQTK TYFSHWPDVT
60 70 80 90 100
PGSPHIKAHG KKVMGGIALA VSKIDDLKTG LMELSEQHAY KLRVDPANFK
110 120 130 140
ILNHCILVVI STMFPKEFTP EAHVSLDKFL SGVALALAER YR
Length:142
Mass (Da):15,632
Last modified:May 1, 1992 - v1
Checksum:i24C8759C565202A4
GO

Sequence databases

PIRiS21677.

Cross-referencesi

Sequence databases

PIRi S21677.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
Entry Method Resolution (Å) Chain Positions PDBsum
1HBH X-ray 2.20 A/C 1-142 [» ]
1PBX X-ray 2.50 A 1-142 [» ]
1S5X X-ray 2.40 A 1-142 [» ]
1S5Y X-ray 2.50 A/C 1-142 [» ]
2H8D X-ray 1.78 A/C 1-142 [» ]
2H8F X-ray 1.30 A/C 1-142 [» ]
2PEG X-ray 1.48 A 1-142 [» ]
3GKV X-ray 1.40 A 1-142 [» ]
3GQG X-ray 1.73 A/C 1-142 [» ]
4G51 X-ray 2.50 A/C 1-142 [» ]
4IRO X-ray 2.20 A/C 1-142 [» ]
ProteinModelPortali P80043.
SMRi P80043. Positions 1-142.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

MINTi MINT-1507077.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Phylogenomic databases

HOVERGENi HBG009709.

Miscellaneous databases

EvolutionaryTracei P80043.

Family and domain databases

Gene3Di 1.10.490.10. 1 hit.
InterProi IPR000971. Globin.
IPR009050. Globin-like.
IPR012292. Globin_dom.
IPR002338. Haemoglobin_a.
IPR002339. Haemoglobin_pi.
[Graphical view ]
Pfami PF00042. Globin. 1 hit.
[Graphical view ]
PRINTSi PR00612. ALPHAHAEM.
PR00815. PIHAEM.
SUPFAMi SSF46458. SSF46458. 1 hit.
PROSITEi PS01033. GLOBIN. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Haemoglobin of the antarctic fish Pagothenia bernacchii. Amino acid sequence, oxygen equilibria and crystal structure of its carbonmonoxy derivative."
    Camardella L., Caruso C., D'Avino R., di Prisco G., Rutigliano B., Tamburrini M., Fermi G., Perutz M.F.
    J. Mol. Biol. 224:449-460(1992) [PubMed] [Europe PMC] [Abstract]
    Cited for: PROTEIN SEQUENCE, FUNCTION, SUBUNIT, X-RAY CRYSTALLOGRAPHY (2.5 ANGSTROMS).
    Tissue: Blood.
  2. "Structure of deoxyhaemoglobin of the antarctic fish Pagothenia bernacchii with an analysis of the structural basis of the Root effect by comparison of the liganded and unliganded haemoglobin structures."
    Ito N., Komiyama N.H., Fermi G.
    J. Mol. Biol. 250:648-658(1995) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (2.2 ANGSTROMS).

Entry informationi

Entry nameiHBA_TREBE
AccessioniPrimary (citable) accession number: P80043
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 1, 1992
Last sequence update: May 1, 1992
Last modified: November 26, 2014
This is version 88 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Miscellaneous

This fish has three hemoglobins: Hb1 (major) and two minor hemoglobins (about 1-2% of the total). Hb1 has a strong alkaline Bohr effect, and at low pH exhibits the reduced ligand affinity and cooperativity that comprise the Root effect.

Keywords - Technical termi

3D-structure, Direct protein sequencing

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3