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P80043

- HBA_TREBE

UniProt

P80043 - HBA_TREBE

Protein

Hemoglobin subunit alpha

Gene

hba

Organism
Trematomus bernacchii (Emerald rockcod) (Pagothenia bernacchii)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at protein leveli
  1. Functioni

    Involved in oxygen transport from gills to the various peripheral tissues.1 Publication

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Metal bindingi59 – 591Iron (heme distal ligand)
    Metal bindingi88 – 881Iron (heme proximal ligand)

    GO - Molecular functioni

    1. heme binding Source: InterPro
    2. iron ion binding Source: InterPro
    3. oxygen binding Source: InterPro
    4. oxygen transporter activity Source: UniProtKB

    GO - Biological processi

    1. oxygen transport Source: UniProtKB

    Keywords - Biological processi

    Oxygen transport, Transport

    Keywords - Ligandi

    Heme, Iron, Metal-binding

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Hemoglobin subunit alpha
    Alternative name(s):
    Alpha-globin
    Hemoglobin alpha chain
    Gene namesi
    Name:hba
    OrganismiTrematomus bernacchii (Emerald rockcod) (Pagothenia bernacchii)
    Taxonomic identifieri40690 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiActinopterygiiNeopterygiiTeleosteiNeoteleosteiAcanthomorphataPercomorphariaPerciformesNotothenioideiNototheniidaeTrematomus

    Subcellular locationi

    GO - Cellular componenti

    1. hemoglobin complex Source: UniProtKB

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 142142Hemoglobin subunit alphaPRO_0000052712Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei1 – 11N-acetylserine

    Keywords - PTMi

    Acetylation

    Expressioni

    Tissue specificityi

    Red blood cells.

    Interactioni

    Subunit structurei

    Hb1 is a heterotetramer of two alpha chains and two beta chains. HbC is a heterotetramer of two alpha chains and two beta-C chains.1 Publication

    Protein-protein interaction databases

    MINTiMINT-1507077.

    Structurei

    Secondary structure

    1
    142
    Legend: HelixTurnBeta strand
    Show more details
    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Helixi4 – 1714
    Helixi18 – 203
    Helixi21 – 3515
    Helixi37 – 437
    Beta strandi50 – 523
    Helixi54 – 7219
    Turni73 – 753
    Helixi77 – 804
    Helixi82 – 909
    Helixi97 – 11317
    Turni115 – 1173
    Helixi120 – 13718
    Turni138 – 1403

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    EntryMethodResolution (Å)ChainPositionsPDBsum
    1HBHX-ray2.20A/C1-142[»]
    1PBXX-ray2.50A1-142[»]
    1S5XX-ray2.40A1-142[»]
    1S5YX-ray2.50A/C1-142[»]
    2H8DX-ray1.78A/C1-142[»]
    2H8FX-ray1.30A/C1-142[»]
    2PEGX-ray1.48A1-142[»]
    3GKVX-ray1.40A1-142[»]
    3GQGX-ray1.73A/C1-142[»]
    4G51X-ray2.50A/C1-142[»]
    4IROX-ray2.20A/C1-142[»]
    ProteinModelPortaliP80043.
    SMRiP80043. Positions 1-142.
    ModBaseiSearch...
    MobiDBiSearch...

    Miscellaneous databases

    EvolutionaryTraceiP80043.

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the globin family.PROSITE-ProRule annotation

    Phylogenomic databases

    HOVERGENiHBG009709.

    Family and domain databases

    Gene3Di1.10.490.10. 1 hit.
    InterProiIPR000971. Globin.
    IPR009050. Globin-like.
    IPR012292. Globin_dom.
    IPR002338. Haemoglobin_a.
    IPR002339. Haemoglobin_pi.
    [Graphical view]
    PfamiPF00042. Globin. 1 hit.
    [Graphical view]
    PRINTSiPR00612. ALPHAHAEM.
    PR00815. PIHAEM.
    SUPFAMiSSF46458. SSF46458. 1 hit.
    PROSITEiPS01033. GLOBIN. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    P80043-1 [UniParc]FASTAAdd to Basket

    « Hide

    SLSDKDKAAV RALWSKIGKS ADAIGNDALS RMIVVYPQTK TYFSHWPDVT    50
    PGSPHIKAHG KKVMGGIALA VSKIDDLKTG LMELSEQHAY KLRVDPANFK 100
    ILNHCILVVI STMFPKEFTP EAHVSLDKFL SGVALALAER YR 142
    Length:142
    Mass (Da):15,632
    Last modified:May 1, 1992 - v1
    Checksum:i24C8759C565202A4
    GO

    Sequence databases

    PIRiS21677.

    Cross-referencesi

    Sequence databases

    PIRi S21677.

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    Entry Method Resolution (Å) Chain Positions PDBsum
    1HBH X-ray 2.20 A/C 1-142 [» ]
    1PBX X-ray 2.50 A 1-142 [» ]
    1S5X X-ray 2.40 A 1-142 [» ]
    1S5Y X-ray 2.50 A/C 1-142 [» ]
    2H8D X-ray 1.78 A/C 1-142 [» ]
    2H8F X-ray 1.30 A/C 1-142 [» ]
    2PEG X-ray 1.48 A 1-142 [» ]
    3GKV X-ray 1.40 A 1-142 [» ]
    3GQG X-ray 1.73 A/C 1-142 [» ]
    4G51 X-ray 2.50 A/C 1-142 [» ]
    4IRO X-ray 2.20 A/C 1-142 [» ]
    ProteinModelPortali P80043.
    SMRi P80043. Positions 1-142.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    MINTi MINT-1507077.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Phylogenomic databases

    HOVERGENi HBG009709.

    Miscellaneous databases

    EvolutionaryTracei P80043.

    Family and domain databases

    Gene3Di 1.10.490.10. 1 hit.
    InterProi IPR000971. Globin.
    IPR009050. Globin-like.
    IPR012292. Globin_dom.
    IPR002338. Haemoglobin_a.
    IPR002339. Haemoglobin_pi.
    [Graphical view ]
    Pfami PF00042. Globin. 1 hit.
    [Graphical view ]
    PRINTSi PR00612. ALPHAHAEM.
    PR00815. PIHAEM.
    SUPFAMi SSF46458. SSF46458. 1 hit.
    PROSITEi PS01033. GLOBIN. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Haemoglobin of the antarctic fish Pagothenia bernacchii. Amino acid sequence, oxygen equilibria and crystal structure of its carbonmonoxy derivative."
      Camardella L., Caruso C., D'Avino R., di Prisco G., Rutigliano B., Tamburrini M., Fermi G., Perutz M.F.
      J. Mol. Biol. 224:449-460(1992) [PubMed] [Europe PMC] [Abstract]
      Cited for: PROTEIN SEQUENCE, FUNCTION, SUBUNIT, X-RAY CRYSTALLOGRAPHY (2.5 ANGSTROMS).
      Tissue: Blood.
    2. "Structure of deoxyhaemoglobin of the antarctic fish Pagothenia bernacchii with an analysis of the structural basis of the Root effect by comparison of the liganded and unliganded haemoglobin structures."
      Ito N., Komiyama N.H., Fermi G.
      J. Mol. Biol. 250:648-658(1995) [PubMed] [Europe PMC] [Abstract]
      Cited for: X-RAY CRYSTALLOGRAPHY (2.2 ANGSTROMS).

    Entry informationi

    Entry nameiHBA_TREBE
    AccessioniPrimary (citable) accession number: P80043
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: May 1, 1992
    Last sequence update: May 1, 1992
    Last modified: October 1, 2014
    This is version 86 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Miscellaneous

    This fish has three hemoglobins: Hb1 (major) and two minor hemoglobins (about 1-2% of the total). Hb1 has a strong alkaline Bohr effect, and at low pH exhibits the reduced ligand affinity and cooperativity that comprise the Root effect.

    Keywords - Technical termi

    3D-structure, Direct protein sequencing

    Documents

    1. PDB cross-references
      Index of Protein Data Bank (PDB) cross-references
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3