Skip Header

You are using a version of Internet Explorer that may not display all features of this website. Please upgrade to a modern browser.
Contribute Send feedback
Read comments (?) or add your own

P80043 (HBA_TREBE) Reviewed, UniProtKB/Swiss-Prot

Last modified June 11, 2014. Version 85. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Hemoglobin subunit alpha
Alternative name(s):
Alpha-globin
Hemoglobin alpha chain
Gene names
Name:hba
OrganismTrematomus bernacchii (Emerald rockcod) (Pagothenia bernacchii)
Taxonomic identifier40690 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiActinopterygiiNeopterygiiTeleosteiNeoteleosteiAcanthomorphataPercomorphariaPerciformesNotothenioideiNototheniidaeTrematomus

Protein attributes

Sequence length142 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Involved in oxygen transport from gills to the various peripheral tissues. Ref.1

Subunit structure

Hb1 is a heterotetramer of two alpha chains and two beta chains. HbC is a heterotetramer of two alpha chains and two beta-C chains. Ref.1

Tissue specificity

Red blood cells.

Miscellaneous

This fish has three hemoglobins: Hb1 (major) and two minor hemoglobins (about 1-2% of the total). Hb1 has a strong alkaline Bohr effect, and at low pH exhibits the reduced ligand affinity and cooperativity that comprise the Root effect.

Sequence similarities

Belongs to the globin family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 142142Hemoglobin subunit alpha
PRO_0000052712

Sites

Metal binding591Iron (heme distal ligand)
Metal binding881Iron (heme proximal ligand)

Amino acid modifications

Modified residue11N-acetylserine

Secondary structure

....................... 142
Helix Strand Turn

Details...

Sequences

Sequence LengthMass (Da)Tools
P80043 [UniParc].

Last modified May 1, 1992. Version 1.
Checksum: 24C8759C565202A4

FASTA14215,632
        10         20         30         40         50         60 
SLSDKDKAAV RALWSKIGKS ADAIGNDALS RMIVVYPQTK TYFSHWPDVT PGSPHIKAHG 

        70         80         90        100        110        120 
KKVMGGIALA VSKIDDLKTG LMELSEQHAY KLRVDPANFK ILNHCILVVI STMFPKEFTP 

       130        140 
EAHVSLDKFL SGVALALAER YR 

« Hide

References

[1]"Haemoglobin of the antarctic fish Pagothenia bernacchii. Amino acid sequence, oxygen equilibria and crystal structure of its carbonmonoxy derivative."
Camardella L., Caruso C., D'Avino R., di Prisco G., Rutigliano B., Tamburrini M., Fermi G., Perutz M.F.
J. Mol. Biol. 224:449-460(1992) [PubMed] [Europe PMC] [Abstract]
Cited for: PROTEIN SEQUENCE, FUNCTION, SUBUNIT, X-RAY CRYSTALLOGRAPHY (2.5 ANGSTROMS).
Tissue: Blood.
[2]"Structure of deoxyhaemoglobin of the antarctic fish Pagothenia bernacchii with an analysis of the structural basis of the Root effect by comparison of the liganded and unliganded haemoglobin structures."
Ito N., Komiyama N.H., Fermi G.
J. Mol. Biol. 250:648-658(1995) [PubMed] [Europe PMC] [Abstract]
Cited for: X-RAY CRYSTALLOGRAPHY (2.2 ANGSTROMS).
+Additional computationally mapped references.

Cross-references

Sequence databases

PIRS21677.

3D structure databases

PDBe
RCSB-PDB
PDBj
EntryMethodResolution (Å)ChainPositionsPDBsum
1HBHX-ray2.20A/C1-142[»]
1PBXX-ray2.50A1-142[»]
1S5XX-ray2.40A1-142[»]
1S5YX-ray2.50A/C1-142[»]
2H8DX-ray1.78A/C1-142[»]
2H8FX-ray1.30A/C1-142[»]
2PEGX-ray1.48A1-142[»]
3GKVX-ray1.40A1-142[»]
3GQGX-ray1.73A/C1-142[»]
4G51X-ray2.50A/C1-142[»]
4IROX-ray2.20A/C1-142[»]
ProteinModelPortalP80043.
SMRP80043. Positions 1-142.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

MINTMINT-1507077.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Phylogenomic databases

HOVERGENHBG009709.

Family and domain databases

Gene3D1.10.490.10. 1 hit.
InterProIPR000971. Globin.
IPR009050. Globin-like.
IPR012292. Globin_dom.
IPR002338. Haemoglobin_a.
IPR002339. Haemoglobin_pi.
[Graphical view]
PfamPF00042. Globin. 1 hit.
[Graphical view]
PRINTSPR00612. ALPHAHAEM.
PR00815. PIHAEM.
SUPFAMSSF46458. SSF46458. 1 hit.
PROSITEPS01033. GLOBIN. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

EvolutionaryTraceP80043.

Entry information

Entry nameHBA_TREBE
AccessionPrimary (citable) accession number: P80043
Entry history
Integrated into UniProtKB/Swiss-Prot: May 1, 1992
Last sequence update: May 1, 1992
Last modified: June 11, 2014
This is version 85 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

PDB cross-references

Index of Protein Data Bank (PDB) cross-references