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P80042 (GGPPS_CAPAN) Reviewed, UniProtKB/Swiss-Prot

Last modified September 21, 2011. Version 75. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Geranylgeranyl pyrophosphate synthase, chloroplastic
Short name=GGPP synthase
Short name=GGPS
Alternative name(s):
(2E,6E)-farnesyl diphosphate synthase
Dimethylallyltranstransferase
EC=2.5.1.1
Farnesyl diphosphate synthase
Farnesyltranstransferase
EC=2.5.1.29
Geranyltranstransferase
EC=2.5.1.10
Gene names
Name:GGPS1
OrganismCapsicum annuum (Bell pepper)
Taxonomic identifier4072 [NCBI]
Taxonomic lineageEukaryota › Viridiplantae › Streptophyta › Embryophyta › Tracheophyta › Spermatophyta › Magnoliophyta › eudicotyledons › core eudicotyledons › asterids › lamiids › Solanales › Solanaceae › Solanoideae › Capsiceae › Capsicum

Protein attributes

Sequence length369 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceInferred from homology

General annotation (Comments)

Function

Catalyzes the trans-addition of the three molecules of IPP onto DMAPP to form geranylgeranyl pyrophosphate.

Catalytic activity

Dimethylallyl diphosphate + isopentenyl diphosphate = diphosphate + geranyl diphosphate.

Geranyl diphosphate + isopentenyl diphosphate = diphosphate + (2E,6E)-farnesyl diphosphate.

(2E,6E)-farnesyl diphosphate + isopentenyl diphosphate = diphosphate + geranylgeranyl diphosphate.

Cofactor

Binds 3 magnesium ions per subunit By similarity.

Pathway

Isoprenoid biosynthesis; farnesyl diphosphate biosynthesis; farnesyl diphosphate from geranyl diphosphate and isopentenyl diphosphate: step 1/1.

Isoprenoid biosynthesis; geranyl diphosphate biosynthesis; geranyl diphosphate from dimethylallyl diphosphate and isopentenyl diphosphate: step 1/1.

Isoprenoid biosynthesis; geranylgeranyl diphosphate biosynthesis; geranylgeranyl diphosphate from farnesyl diphosphate and isopentenyl diphosphate: step 1/1.

Subunit structure

Monomer.

Subcellular location

Plastid › chloroplast.

Sequence similarities

Belongs to the FPP/GGPP synthase family.

Ontologies

Keywords
   Biological processCarotenoid biosynthesis
Isoprene biosynthesis
   Cellular componentChloroplast
Plastid
   DomainTransit peptide
   LigandMagnesium
Metal-binding
   Molecular functionTransferase
Gene Ontology (GO)
   Biological processcarotenoid biosynthetic process

Inferred from electronic annotation. Source: UniProtKB-KW

   Cellular componentchloroplast

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular functiondimethylallyltranstransferase activity

Inferred from direct assay Ref.1. Source: UniProtKB

farnesyltranstransferase activity

Inferred from direct assay Ref.1. Source: UniProtKB

geranyltranstransferase activity

Inferred from direct assay Ref.1. Source: UniProtKB

metal ion binding

Inferred from electronic annotation. Source: UniProtKB-KW

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Transit peptide1 – ?Chloroplast
Chain? – 369Geranylgeranyl pyrophosphate synthase, chloroplasticPRO_0000016472

Sites

Metal binding1571Magnesium 1 By similarity
Metal binding1571Magnesium 2 By similarity
Metal binding1631Magnesium 1 By similarity
Metal binding1631Magnesium 2 By similarity
Metal binding2951Magnesium 3 By similarity
Binding site1181Isopentenyl diphosphate By similarity
Binding site1211Isopentenyl diphosphate By similarity
Binding site1501Isopentenyl diphosphate By similarity
Binding site1681Dimethylallyl diphosphate By similarity
Binding site1691Isopentenyl diphosphate By similarity
Binding site2541Dimethylallyl diphosphate By similarity
Binding site2551Dimethylallyl diphosphate By similarity
Binding site2921Dimethylallyl diphosphate By similarity
Binding site3091Dimethylallyl diphosphate By similarity
Binding site3191Dimethylallyl diphosphate By similarity

Sequences

Sequence LengthMass (Da)Tools
P80042 [UniParc].

Last modified May 1, 1992. Version 1.
Checksum: 2D527F5E43A29C6F

FASTA36940,173
        10         20         30         40         50         60 
MRSMNLVDLW AQQACLVFNQ TLSYKSFNGF MKIPLKNSKI NPKLNKKRPF SPLTVSAIAT 

        70         80         90        100        110        120 
TKEDERIEAA QTEEPFNFKI YVTEKAISVN KALDEAIIVK EPHVIHEAMR YSLLAGGKRV 

       130        140        150        160        170        180 
RPMLCLAACE LVGGNQENAM AAACAVEMIH TMSLIHDDLP CMDNDDLRRG KPTNHKIYGE 

       190        200        210        220        230        240 
DVAVLAGDSL LAFAFEHIVN STAGVTPSRI VGAVAELAKS IGTEGLVAGQ VADIKCTGNA 

       250        260        270        280        290        300 
SVSLETLEFI HVHKTAALLE SSVVLGAILG GGTNVEVEKL RRFARCIGLL FQVVDDILDV 

       310        320        330        340        350        360 
TKSSEELGKT AGKDLVVDKT TYPKLLGLEK AKEFAAELNR EAKQQLEGFD SRKAAPLIAL 


ADYIAYRDN

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References

[1]"Identification of a cDNA for the plastid-located geranylgeranyl pyrophosphate synthase from Capsicum annuum: correlative increase in enzyme activity and transcript level during fruit ripening."
Kuntz M., Roemer S., Suire C., Hugueney P., Weil J.H., Schantz R., Camara B.
Plant J. 2:25-34(1992) [PubMed: 1303794] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
Strain: cv. Lamuyo.
Tissue: Fruit.
[2]"Structure of a functional geranylgeranyl pyrophosphate synthase gene from Capsicum annuum."
Badillo A., Steppuhn J., Deruere J., Camara B., Kuntz M.
Plant Mol. Biol. 27:425-428(1995) [PubMed: 7888631] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
Strain: cv. Yolo Wonder.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		X80267 Genomic DNA. Translation: CAA56554.1.
PIRS53722.

3D structure databases

ProteinModelPortalP80042.
SMRP80042. Positions 81-369.
ModBaseSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Enzyme and pathway databases

BioCycMetaCyc:MONOMER-12171.

Family and domain databases

InterProIPR000092. Polyprenyl_synt.
IPR017446. Polyprenyl_synth-rel.
IPR008949. Terpenoid_synth.
[Graphical view]
Gene3DG3DSA:1.10.600.10. Terpenoid_synth. 1 hit.
PANTHERPTHR12001. Polyprenyl_synt. 1 hit.
PfamPF00348. polyprenyl_synt. 1 hit.
[Graphical view]
SUPFAMSSF48576. Terpenoid_synth. 1 hit.
PROSITEPS00723. POLYPRENYL_SYNTHASE_1. 1 hit.
PS00444. POLYPRENYL_SYNTHASE_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameGGPPS_CAPAN
AccessionPrimary (citable) accession number: P80042
Entry history
Integrated into UniProtKB/Swiss-Prot: May 1, 1992
Last sequence update: May 1, 1992
Last modified: September 21, 2011
This is version 75 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Relevant documents

PATHWAY comments

Index of metabolic and biosynthesis pathways

SIMILARITY comments

Index of protein domains and families

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