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Protein

Glutathione S-transferase P

Gene

GSTP1

Organism
Sus scrofa (Pig)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles. Regulates negatively CDK5 activity via p25/p35 translocation to prevent neurodegeneration (By similarity).By similarity

Catalytic activityi

RX + glutathione = HX + R-S-glutathione.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei7Glutathione1 Publication1
Binding sitei13Glutathione1 Publication1
Binding sitei38Glutathione1 Publication1
Binding sitei42Glutathione1 Publication1

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Transferase

Enzyme and pathway databases

BRENDAi2.5.1.18. 6170.
SABIO-RKP80031.

Names & Taxonomyi

Protein namesi
Recommended name:
Glutathione S-transferase P (EC:2.5.1.18)
Alternative name(s):
GST P1-1
GST class-pi
Gene namesi
Name:GSTP1
OrganismiSus scrofa (Pig)
Taxonomic identifieri9823 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaSuinaSuidaeSus
Proteomesi
  • UP000008227 Componenti: Unplaced

Subcellular locationi

  • Cytoplasm By similarity
  • Mitochondrion By similarity
  • Nucleus By similarity

  • Note: The 83 N-terminal amino acids function as un uncleaved transit peptide, and arginine residues within it are crucial for mitochondrial localization.By similarity

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Mitochondrion, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001859051 – 207Glutathione S-transferase PAdd BLAST207

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei3Phosphotyrosine; by EGFRBy similarity1
Modified residuei59PhosphothreonineBy similarity1
Modified residuei100N6-succinyllysineBy similarity1
Modified residuei113N6-succinyllysineBy similarity1
Modified residuei125N6-acetyllysineBy similarity1

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

PaxDbiP80031.
PeptideAtlasiP80031.
PRIDEiP80031.

Interactioni

Subunit structurei

Homodimer. Interacts with CDK5 (By similarity).By similarity

Protein-protein interaction databases

STRINGi9823.ENSSSCP00000013714.

Structurei

Secondary structure

1207
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi3 – 7Combined sources5
Beta strandi9 – 11Combined sources3
Turni12 – 14Combined sources3
Helixi15 – 23Combined sources9
Beta strandi29 – 32Combined sources4
Turni35 – 37Combined sources3
Helixi38 – 41Combined sources4
Helixi42 – 44Combined sources3
Beta strandi52 – 55Combined sources4
Beta strandi58 – 62Combined sources5
Helixi63 – 74Combined sources12
Helixi81 – 107Combined sources27
Helixi109 – 132Combined sources24
Helixi135 – 137Combined sources3
Beta strandi141 – 145Combined sources5
Helixi148 – 163Combined sources16
Helixi167 – 170Combined sources4
Helixi172 – 182Combined sources11
Helixi185 – 192Combined sources8
Helixi194 – 197Combined sources4

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2GSRX-ray2.11A/B1-206[»]
ProteinModelPortaliP80031.
SMRiP80031.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP80031.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini1 – 78GST N-terminalAdd BLAST78
Domaini80 – 201GST C-terminalAdd BLAST122

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni49 – 50Glutathione binding1 Publication2
Regioni62 – 63Glutathione binding1 Publication2

Sequence similaritiesi

Belongs to the GST superfamily. Pi family.Curated
Contains 1 GST C-terminal domain.Curated
Contains 1 GST N-terminal domain.Curated

Phylogenomic databases

eggNOGiKOG1695. Eukaryota.
ENOG4111VAU. LUCA.
HOGENOMiHOG000115733.
HOVERGENiHBG108324.
InParanoidiP80031.

Family and domain databases

Gene3Di1.20.1050.10. 1 hit.
3.40.30.10. 1 hit.
InterProiIPR010987. Glutathione-S-Trfase_C-like.
IPR004045. Glutathione_S-Trfase_N.
IPR004046. GST_C.
IPR003082. GST_pi.
IPR012336. Thioredoxin-like_fold.
[Graphical view]
PfamiPF14497. GST_C_3. 1 hit.
PF02798. GST_N. 1 hit.
[Graphical view]
PRINTSiPR01268. GSTRNSFRASEP.
SUPFAMiSSF47616. SSF47616. 1 hit.
SSF52833. SSF52833. 1 hit.
PROSITEiPS50405. GST_CTER. 1 hit.
PS50404. GST_NTER. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P80031-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
PPYTITYFPV RGRCEAMRML LADQDQSWKE EVVTMETWPP LKPSCLFRQL
60 70 80 90 100
PKFQDGDLTL YQSNAILRHL GRSFGLYGKD QKEAALVDMV NDGVEDLRCK
110 120 130 140 150
YATLIYTNYE AGKEKYVKEL PEHLKPFETL LSQNQGGQAF VVGSQISFAD
160 170 180 190 200
YNLLDLLRIH QVLNPSCLDA FPLLSAYVAR LSARPKIKAF LASPEHVNRP

INGNGKN
Length:207
Mass (Da):23,497
Last modified:June 1, 1994 - v2
Checksum:i2B638B60504BF4A0
GO

Sequence databases

PIRiS13780.

Cross-referencesi

Sequence databases

PIRiS13780.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2GSRX-ray2.11A/B1-206[»]
ProteinModelPortaliP80031.
SMRiP80031.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9823.ENSSSCP00000013714.

Proteomic databases

PaxDbiP80031.
PeptideAtlasiP80031.
PRIDEiP80031.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Phylogenomic databases

eggNOGiKOG1695. Eukaryota.
ENOG4111VAU. LUCA.
HOGENOMiHOG000115733.
HOVERGENiHBG108324.
InParanoidiP80031.

Enzyme and pathway databases

BRENDAi2.5.1.18. 6170.
SABIO-RKP80031.

Miscellaneous databases

EvolutionaryTraceiP80031.

Family and domain databases

Gene3Di1.20.1050.10. 1 hit.
3.40.30.10. 1 hit.
InterProiIPR010987. Glutathione-S-Trfase_C-like.
IPR004045. Glutathione_S-Trfase_N.
IPR004046. GST_C.
IPR003082. GST_pi.
IPR012336. Thioredoxin-like_fold.
[Graphical view]
PfamiPF14497. GST_C_3. 1 hit.
PF02798. GST_N. 1 hit.
[Graphical view]
PRINTSiPR01268. GSTRNSFRASEP.
SUPFAMiSSF47616. SSF47616. 1 hit.
SSF52833. SSF52833. 1 hit.
PROSITEiPS50405. GST_CTER. 1 hit.
PS50404. GST_NTER. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiGSTP1_PIG
AccessioniPrimary (citable) accession number: P80031
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 1, 1991
Last sequence update: June 1, 1994
Last modified: November 2, 2016
This is version 111 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.