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Protein

Parvalbumin, muscle

Gene
N/A
Organism
Gallus gallus (Chicken)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Functioni

In muscle, parvalbumin is thought to be involved in relaxation after contraction. It binds two calcium ions (By similarity).By similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Calcium bindingi51 – 62121PROSITE-ProRule annotationAdd
BLAST
Calcium bindingi90 – 101122PROSITE-ProRule annotationAdd
BLAST

GO - Molecular functioni

Complete GO annotation...

Keywords - Molecular functioni

Muscle protein

Keywords - Ligandi

Calcium, Metal-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Parvalbumin, muscle
OrganismiGallus gallus (Chicken)
Taxonomic identifieri9031 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiArchelosauriaArchosauriaDinosauriaSaurischiaTheropodaCoelurosauriaAvesNeognathaeGalloanseraeGalliformesPhasianidaePhasianinaeGallus
Proteomesi
  • UP000000539 Componenti: Unplaced

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Pathology & Biotechi

Protein family/group databases

Allergomei6107. Gal d 8.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 109109Parvalbumin, musclePRO_0000073625Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei1 – 11N-acetylalanine1 Publication

Keywords - PTMi

Acetylation

Proteomic databases

PaxDbiP80026.

Expressioni

Gene expression databases

ExpressionAtlasiP80026. baseline and differential.

Interactioni

Protein-protein interaction databases

BioGridi676708. 1 interaction.
IntActiP80026. 1 interaction.
STRINGi9031.ENSGALP00000020426.

Structurei

3D structure databases

ProteinModelPortaliP80026.
SMRiP80026. Positions 1-109.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini38 – 7336EF-hand 1PROSITE-ProRule annotationAdd
BLAST
Domaini77 – 10933EF-hand 2PROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Belongs to the parvalbumin family.Curated
Contains 2 EF-hand domains.PROSITE-ProRule annotation

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiKOG0027. Eukaryota.
COG5126. LUCA.
HOVERGENiHBG107490.
OMAiAVDSFDH.

Family and domain databases

Gene3Di1.10.238.10. 1 hit.
InterProiIPR011992. EF-hand-dom_pair.
IPR018247. EF_Hand_1_Ca_BS.
IPR002048. EF_hand_dom.
IPR008080. Parvalbumin.
[Graphical view]
PANTHERiPTHR11653. PTHR11653. 1 hit.
PfamiPF13499. EF-hand_7. 1 hit.
[Graphical view]
SMARTiSM00054. EFh. 2 hits.
[Graphical view]
SUPFAMiSSF47473. SSF47473. 1 hit.
PROSITEiPS00018. EF_HAND_1. 2 hits.
PS50222. EF_HAND_2. 2 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P80026-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
AMTDVLSAED IKKAVGAFSA AESFNYKKFF EMVGLKKKSP EDVKKVFHIL
60 70 80 90 100
DKDRSGFIEE EELKFVLKGF TPDGRDLSDK ETKALLAAGD KDGDGKIGAD

EFATMVAES
Length:109
Mass (Da):11,942
Last modified:August 1, 1991 - v1
Checksum:i1226953FBA63E9CB
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti61 – 611E → D in AAA49004 (PubMed:1708248).Curated
Sequence conflicti99 – 1013ADE → VEK in AAA49004 (PubMed:1708248).Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M65068 mRNA. Translation: AAA49004.1.
PIRiJT0973. PVCHA.
RefSeqiNP_001152787.1. NM_001159315.1.
XP_015140054.1. XM_015284568.1.
XP_015140060.1. XM_015284574.1.
XP_015140066.1. XM_015284580.1.
UniGeneiGga.4096.

Genome annotation databases

GeneIDi396459.
KEGGigga:396459.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M65068 mRNA. Translation: AAA49004.1.
PIRiJT0973. PVCHA.
RefSeqiNP_001152787.1. NM_001159315.1.
XP_015140054.1. XM_015284568.1.
XP_015140060.1. XM_015284574.1.
XP_015140066.1. XM_015284580.1.
UniGeneiGga.4096.

3D structure databases

ProteinModelPortaliP80026.
SMRiP80026. Positions 1-109.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi676708. 1 interaction.
IntActiP80026. 1 interaction.
STRINGi9031.ENSGALP00000020426.

Protein family/group databases

Allergomei6107. Gal d 8.

Proteomic databases

PaxDbiP80026.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi396459.
KEGGigga:396459.

Organism-specific databases

CTDi5816.

Phylogenomic databases

eggNOGiKOG0027. Eukaryota.
COG5126. LUCA.
HOVERGENiHBG107490.
OMAiAVDSFDH.

Miscellaneous databases

PROiP80026.

Gene expression databases

ExpressionAtlasiP80026. baseline and differential.

Family and domain databases

Gene3Di1.10.238.10. 1 hit.
InterProiIPR011992. EF-hand-dom_pair.
IPR018247. EF_Hand_1_Ca_BS.
IPR002048. EF_hand_dom.
IPR008080. Parvalbumin.
[Graphical view]
PANTHERiPTHR11653. PTHR11653. 1 hit.
PfamiPF13499. EF-hand_7. 1 hit.
[Graphical view]
SMARTiSM00054. EFh. 2 hits.
[Graphical view]
SUPFAMiSSF47473. SSF47473. 1 hit.
PROSITEiPS00018. EF_HAND_1. 2 hits.
PS50222. EF_HAND_2. 2 hits.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Parvalbumin isoforms in chicken muscle and thymus. Amino acid sequence analysis of muscle parvalbumin by tandem mass spectrometry."
    Kuster T., Staudenmann W., Hughes G.J., Heizmann C.W.
    Biochemistry 30:8812-8816(1991) [PubMed] [Europe PMC] [Abstract]
    Cited for: PROTEIN SEQUENCE, ACETYLATION AT ALA-1.
  2. "Comparison of the amino acid sequences of tissue-specific parvalbumins from chicken muscle and thymus and possible evolutionary significance."
    Brewer J.M., Arnold J., Beach G.G., Ragland W.L., Wunderlich J.K.
    Biochem. Biophys. Res. Commun. 181:226-231(1991) [PubMed] [Europe PMC] [Abstract]
    Cited for: PROTEIN SEQUENCE.
  3. "Avian thymic hormone and chicken (muscle) parvalbumin are distinct proteins: isolation of a muscle parvalbumin cDNA fragment by PCR."
    Palmisano W.A., Henzl M.T.
    Biochem. Biophys. Res. Commun. 176:328-334(1991) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 57-101.

Entry informationi

Entry nameiPRVM_CHICK
AccessioniPrimary (citable) accession number: P80026
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 1, 1991
Last sequence update: August 1, 1991
Last modified: June 8, 2016
This is version 114 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Miscellaneous

This parvalbumin has an isoelectric point of 5.2.

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.