P80026 (PRVM_CHICK) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names	Recommended name: Parvalbumin, muscle
Organism	Gallus gallus (Chicken) [Reference proteome]
Taxonomic identifier	9031 [NCBI]
Taxonomic lineage	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Sauropsida › Sauria › Archosauria › Dinosauria › Saurischia › Theropoda › Coelurosauria › Aves › Neognathae › Galliformes › Phasianidae › Phasianinae › Gallus

Protein attributes

Sequence length	109 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	In muscle, parvalbumin is thought to be involved in relaxation after contraction. It binds two calcium ions By similarity.
Miscellaneous	This parvalbumin has an isoelectric point of 5.2.
Sequence similarities	Belongs to the parvalbumin family. Contains 2 EF-hand domains.

Ontologies

Keywords
Domain	Repeat
Ligand	Calcium Metal-binding
Molecular function	Muscle protein
PTM	Acetylation
Technical term	Complete proteome Direct protein sequencing Reference proteome
Gene Ontology (GO)
Cellular_component	axon Inferred from electronic annotation. Source: Compara cytoplasm Inferred from electronic annotation. Source: Compara
Molecular_function	calcium ion binding Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 109	109	Parvalbumin, muscle		PRO_0000073625
Regions
	Domain	38 – 73	36	EF-hand 1
	Domain	77 – 109	33	EF-hand 2
	Calcium binding	51 – 62	12	1 By similarity
	Calcium binding	90 – 101	12	2 By similarity
Amino acid modifications
	Modified residue	1	1	N-acetylalanine Ref.1
Experimental info
	Sequence conflict	61	1	E → D in AAA49004. Ref.3
	Sequence conflict	99 – 101	3	ADE → VEK in AAA49004. Ref.3

Sequences

	Sequence		Length	Mass (Da)
	P80026 [UniParc]. Last modified August 1, 1991. Version 1. Checksum: 1226953FBA63E9CB	FASTA	109	11,942
	10 20 30 40 50 60 AMTDVLSAED IKKAVGAFSA AESFNYKKFF EMVGLKKKSP EDVKKVFHIL DKDRSGFIEE 70 80 90 100 EELKFVLKGF TPDGRDLSDK ETKALLAAGD KDGDGKIGAD EFATMVAES

References

[1]	"Parvalbumin isoforms in chicken muscle and thymus. Amino acid sequence analysis of muscle parvalbumin by tandem mass spectrometry." Kuster T., Staudenmann W., Hughes G.J., Heizmann C.W. Biochemistry 30:8812-8816(1991) [PubMed] [Europe PMC] [Abstract] Cited for: PROTEIN SEQUENCE.
[2]	"Comparison of the amino acid sequences of tissue-specific parvalbumins from chicken muscle and thymus and possible evolutionary significance." Brewer J.M., Arnold J., Beach G.G., Ragland W.L., Wunderlich J.K. Biochem. Biophys. Res. Commun. 181:226-231(1991) [PubMed] [Europe PMC] [Abstract] Cited for: PROTEIN SEQUENCE.
[3]	"Avian thymic hormone and chicken (muscle) parvalbumin are distinct proteins: isolation of a muscle parvalbumin cDNA fragment by PCR." Palmisano W.A., Henzl M.T. Biochem. Biophys. Res. Commun. 176:328-334(1991) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 57-101.

Cross-references

Sequence databases
EMBL GenBank DDBJ	M65068 mRNA. Translation: AAA49004.1.
IPI	IPI00573264.
PIR	PVCHA. JT0973.
RefSeq	NP_001152787.1. NM_001159315.1.
UniGene	Gga.4096.
3D structure databases
ProteinModelPortal	P80026.
SMR	P80026. Positions 1-109.
ModBase	Search...
Protein-protein interaction databases
IntAct	P80026. 1 interaction.
Protein family/group databases
Allergome	6107. Gal d PRVB.
Proteomic databases
PaxDb	P80026.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	396459.
KEGG	gga:396459.
Organism-specific databases
CTD	5816.
Phylogenomic databases
eggNOG	NOG278774.
HOVERGEN	HBG107490.
InParanoid	P80026.
OMA	AVDSFDH.
Family and domain databases
Gene3D	1.10.238.10. 1 hit.
InterPro	IPR011992. EF-hand-like_dom. IPR018247. EF_Hand_1_Ca_BS. IPR002048. EF_hand_dom. IPR008080. Parvalbumin. [Graphical view]
PANTHER	PTHR11653. PTHR11653. 1 hit.
Pfam	PF13499. EF_hand_5. 1 hit. [Graphical view]
SMART	SM00054. EFh. 2 hits. [Graphical view]
PROSITE	PS00018. EF_HAND_1. 2 hits. PS50222. EF_HAND_2. 2 hits. [Graphical view]
ProtoNet	Search...
Other
NextBio	20816500.

Entry information

Entry name

PRVM_CHICK

Accession

Primary (citable) accession number: P80026

Entry history

Integrated into UniProtKB/Swiss-Prot:	August 1, 1991
Last sequence update:	August 1, 1991
Last modified:	May 1, 2013
This is version 94 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program